GREMLIN Database
EFTS - Elongation factor Ts
UniProt: P80700 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (268)
Sequences: 2688 (1512)
Seq/√Len: 92.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_D109_E3.4751.00
169_N263_T3.3291.00
179_D247_K3.1091.00
199_E203_N3.0601.00
193_S196_Q3.0461.00
214_L223_V3.0381.00
38_D204_H2.6051.00
206_R228_E2.5161.00
9_K13_E2.3771.00
194_R232_N2.3431.00
32_D35_K2.3081.00
204_H207_Q2.3011.00
29_T39_L2.2251.00
119_S127_S2.2041.00
179_D245_F2.2021.00
176_T256_V2.1161.00
255_Q258_A2.1141.00
167_V266_T2.0731.00
251_E259_A1.9871.00
64_K97_D1.9801.00
87_G131_K1.9761.00
210_T224_A1.9691.00
7_Q33_M1.9321.00
193_S241_L1.9141.00
194_R242_D1.9061.00
75_V92_L1.9031.00
5_A8_V1.8561.00
212_Q230_R1.8471.00
86_E90_E1.8371.00
54_R78_E1.8231.00
98_H113_Q1.8101.00
73_L95_L1.8061.00
214_L220_E1.8061.00
248_N251_E1.8011.00
7_Q10_E1.7891.00
207_Q211_Q1.7891.00
242_D254_K1.7811.00
90_E94_T1.7661.00
129_V135_K1.6951.00
209_L212_Q1.6871.00
30_D35_K1.6771.00
69_K103_T1.6761.00
168_L177_A1.6631.00
91_L128_A1.6561.00
69_K143_V1.6101.00
97_D101_A1.5951.00
225_K228_E1.5921.00
61_T163_G1.5891.00
171_T262_A1.5861.00
211_Q215_Q1.5471.00
125_I138_L1.5381.00
169_N265_Q1.5341.00
153_G177_A1.5341.00
76_N139_R1.5331.00
114_K118_G1.5321.00
98_H102_N1.5311.00
203_N207_Q1.5301.00
103_T143_V1.5071.00
144_L266_T1.4891.00
94_T117_N1.4831.00
254_K258_A1.4801.00
112_G122_E1.4791.00
14_K37_I1.4731.00
213_A230_R1.4721.00
93_N97_D1.4541.00
74_E140_R1.4501.00
91_L125_I1.4370.99
146_K167_V1.4280.99
69_K145_T1.4270.99
203_N206_R1.4250.99
114_K123_E1.4200.99
211_Q214_L1.4110.99
15_T37_I1.4080.99
35_K42_E1.3910.99
252_K255_Q1.3620.99
95_L121_V1.3550.99
239_C242_D1.3540.99
210_T214_L1.3450.99
144_L268_V1.3370.99
188_N271_E1.3370.99
213_A216_E1.3340.99
120_T123_E1.3320.99
232_N236_E1.3240.99
28_E39_L1.3220.99
122_E126_T1.3160.99
191_Y197_V1.3150.99
144_L167_V1.2800.99
206_R210_T1.2650.99
70_G165_L1.2600.99
236_E252_K1.2590.99
105_A109_E1.2450.98
164_V185_A1.2440.98
257_I262_A1.2420.98
73_L96_A1.2320.98
202_T235_F1.2310.98
91_L95_L1.2300.98
142_T268_V1.2230.98
190_R201_E1.2210.98
228_E232_N1.2180.98
194_R239_C1.2180.98
115_M124_Y1.2080.98
209_L231_L1.2070.98
34_D204_H1.1950.98
102_N113_Q1.1920.98
10_E14_K1.1910.98
201_E234_F1.1800.98
173_D260_K1.1730.98
221_N225_K1.1690.98
166_T181_A1.1680.98
107_V111_M1.1560.98
89_K93_N1.1540.98
146_K150_S1.1540.98
94_T115_M1.1450.97
119_S123_E1.1430.97
62_L92_L1.1400.97
251_E255_Q1.1300.97
35_K38_D1.1240.97
154_A165_L1.1240.97
114_K120_T1.1210.97
104_P141_F1.1130.97
87_G128_A1.1120.97
192_I267_F1.1070.97
10_E33_M1.1000.97
235_F239_C1.0920.97
91_L138_L1.0850.96
226_M230_R1.0850.96
224_A228_E1.0680.96
213_A226_M1.0610.96
56_A76_N1.0570.96
65_T68_N1.0550.96
111_M122_E1.0460.96
75_V91_L1.0440.96
119_S124_Y1.0420.95
176_T257_I1.0390.95
222_I226_M1.0330.95
192_I196_Q1.0310.95
193_S263_T1.0310.95
257_I264_V1.0300.95
142_T270_Y1.0280.95
72_I163_G1.0240.95
96_A100_L1.0230.95
103_T145_T1.0220.95
142_T266_T1.0170.95
213_A223_V1.0030.94
191_Y201_E1.0030.94
244_A249_P1.0020.94
41_R205_E1.0010.94
167_V265_Q0.9930.94
35_K39_L0.9880.94
146_K152_F0.9880.94
150_S167_V0.9870.94
175_E179_D0.9810.94
69_K100_L0.9780.94
207_Q210_T0.9740.93
98_H115_M0.9710.93
17_A130_A0.9680.93
29_T35_K0.9670.93
170_G259_A0.9630.93
2_A30_D0.9580.93
60_S92_L0.9570.93
252_K256_V0.9540.93
112_G120_T0.9510.93
236_E244_A0.9470.93
66_D101_A0.9470.93
72_I142_T0.9350.92
191_Y198_S0.9330.92
176_T180_I0.9280.92
34_D37_I0.9270.92
104_P113_Q0.9160.91
210_T223_V0.9150.91
180_I256_V0.9060.91
150_S169_N0.9040.91
94_T124_Y0.9010.91
129_V136_I0.8960.90
42_E211_Q0.8940.90
75_V138_L0.8900.90
87_G90_E0.8870.90
222_I225_K0.8860.90
231_L235_F0.8860.90
114_K117_N0.8820.90
178_K182_M0.8810.90
203_N210_T0.8790.89
107_V138_L0.8760.89
6_Q9_K0.8740.89
219_P226_M0.8720.89
251_E256_V0.8720.89
8_V22_C0.8670.89
248_N259_A0.8670.89
171_T261_N0.8660.89
24_K27_T0.8630.89
71_V143_V0.8610.88
204_H208_I0.8540.88
99_L141_F0.8500.88
253_V256_V0.8480.88
184_V267_F0.8460.88
71_V100_L0.8430.87
115_M121_V0.8420.87
57_A139_R0.8400.87
132_I136_I0.8390.87
219_P222_I0.8370.87
3_I27_T0.8360.87
42_E215_Q0.8350.87
212_Q215_Q0.8310.87
198_S201_E0.8260.86
220_E223_V0.8250.86
108_E111_M0.8250.86
38_D42_E0.8180.86
29_T36_A0.8180.86
64_K100_L0.8160.86
125_I129_V0.8150.86
21_D43_K0.8100.85
72_I268_V0.8100.85
161_R271_E0.8090.85
218_K226_M0.8080.85
94_T97_D0.8060.85
216_E226_M0.8050.85
27_T30_D0.8040.85
209_L230_R0.8040.85
153_G178_K0.7910.84
99_L110_A0.7870.84
210_T220_E0.7870.84
49_A126_T0.7830.83
71_V99_L0.7830.83
42_E45_I0.7760.83
197_V238_I0.7760.83
217_G223_V0.7740.82
74_E139_R0.7710.82
126_T129_V0.7710.82
156_L160_G0.7700.82
106_D111_M0.7700.82
64_K68_N0.7630.82
166_T180_I0.7620.82
188_N269_R0.7590.81
105_A141_F0.7590.81
162_I185_A0.7570.81
205_E209_L0.7550.81
227_V230_R0.7550.81
170_G261_N0.7530.81
194_R241_L0.7520.81
3_I7_Q0.7510.81
182_M186_A0.7510.81
62_L96_A0.7500.80
98_H121_V0.7480.80
2_A7_Q0.7480.80
38_D208_I0.7470.80
199_E202_T0.7460.80
209_L213_A0.7450.80
110_A138_L0.7420.80
99_L104_P0.7420.80
156_L163_G0.7420.80
37_I49_A0.7370.79
14_K34_D0.7370.79
14_K33_M0.7360.79
240_L264_V0.7330.79
86_E89_K0.7310.79
212_Q226_M0.7310.79
221_N224_A0.7220.78
176_T262_A0.7200.78
200_E203_N0.7200.78
152_F165_L0.7170.77
76_N140_R0.7150.77
258_A263_T0.7140.77
128_A131_K0.7100.77
115_M119_S0.7060.76
104_P109_E0.7060.76
230_R233_K0.7060.76
60_S160_G0.7010.76
123_E126_T0.7000.76
2_A27_T0.6980.76
140_R270_Y0.6980.76
72_I270_Y0.6950.75
66_D97_D0.6950.75
213_A222_I0.6940.75
258_A261_N0.6940.75
4_T7_Q0.6870.74
168_L176_T0.6860.74
77_S85_N0.6840.74
190_R238_I0.6840.74
191_Y196_Q0.6820.74
74_E273_G0.6690.72
109_E112_G0.6670.72
39_L43_K0.6660.72
48_A129_V0.6610.72
5_A20_M0.6560.71
244_A250_D0.6560.71
192_I264_V0.6520.70
141_F270_Y0.6510.70
158_M161_R0.6500.70
48_A133_G0.6480.70
151_A174_E0.6460.70
114_K119_S0.6440.70
53_D135_K0.6400.69
95_L125_I0.6350.68
216_E222_I0.6340.68
196_Q266_T0.6320.68
41_R208_I0.6300.68
5_A19_M0.6300.68
194_R254_K0.6290.68
104_P143_V0.6280.68
259_A262_A0.6260.67
3_I31_G0.6250.67
223_V226_M0.6250.67
104_P110_A0.6240.67
202_T234_F0.6220.67
229_G233_K0.6200.67
205_E208_I0.6190.67
170_G173_D0.6180.66
222_I227_V0.6170.66
13_E22_C0.6170.66
54_R80_D0.6150.66
202_T231_L0.6150.66
197_V235_F0.6140.66
170_G262_A0.6130.66
228_E231_L0.6110.66
28_E43_K0.6090.65
70_G154_A0.6090.65
115_M118_G0.6070.65
183_H249_P0.6050.65
3_I10_E0.6030.64
190_R234_F0.6020.64
183_H246_V0.6010.64
217_G224_A0.5980.64
213_A227_V0.5980.64
3_I8_V0.5940.63
206_R227_V0.5940.63
65_T154_A0.5940.63
201_E238_I0.5910.63
8_V20_M0.5890.63
223_V227_V0.5860.62
64_K96_A0.5850.62
210_T217_G0.5840.62
193_S239_C0.5820.62
77_S92_L0.5820.62
153_G174_E0.5810.62
95_L98_H0.5790.61
171_T176_T0.5760.61
33_M37_I0.5750.61
123_E127_S0.5740.61
151_A168_L0.5740.61
186_A246_V0.5720.60
103_T141_F0.5710.60
98_H101_A0.5710.60
153_G168_L0.5710.60
218_K229_G0.5710.60
77_S136_I0.5700.60
216_E223_V0.5700.60
85_N132_I0.5700.60
255_Q259_A0.5680.60
218_K225_K0.5640.59
183_H186_A0.5630.59
17_A21_D0.5610.59
193_S242_D0.5610.59
66_D100_L0.5600.59
21_D44_G0.5590.59
6_Q13_E0.5560.58
244_A252_K0.5560.58
128_A136_I0.5550.58
64_K93_N0.5550.58
57_A76_N0.5540.58
247_K256_V0.5530.58
192_I266_T0.5520.58
191_Y239_C0.5490.57
70_G152_F0.5480.57
42_E207_Q0.5470.57
162_I271_E0.5430.57
89_K92_L0.5410.56
235_F242_D0.5410.56
137_T270_Y0.5400.56
241_L263_T0.5390.56
38_D207_Q0.5370.56
192_I241_L0.5370.56
139_R270_Y0.5360.56
206_R224_A0.5350.55
128_A132_I0.5330.55
54_R81_F0.5320.55
205_E234_F0.5320.55
210_T231_L0.5300.55
102_N110_A0.5280.54
194_R235_F0.5260.54
220_E224_A0.5260.54
22_C27_T0.5250.54
73_L138_L0.5230.54
110_A113_Q0.5220.54
192_I257_I0.5220.54
245_F248_N0.5220.54
202_T206_R0.5210.53
68_N150_S0.5160.53
55_I139_R0.5160.53
96_A141_F0.5090.52
124_Y128_A0.5060.51
179_D256_V0.5050.51
180_I257_I0.5050.51
101_A104_P0.5040.51
18_G21_D0.5030.51
214_L217_G0.5030.51
108_E112_G0.5020.51
92_L96_A0.5020.51
241_L254_K0.5020.51
129_V133_G0.5020.51
121_V138_L0.5010.51
122_E125_I0.5010.51
60_S89_K0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pc3C 1 0.9522 100 0.041 Contact Map
3avxA 1 0.959 100 0.103 Contact Map
1xb2B 1 0.8259 100 0.226 Contact Map
1aipC 2 0.6382 100 0.316 Contact Map
1tfeA 2 0.4573 100 0.583 Contact Map
2cp9A 1 0.1877 99.8 0.802 Contact Map
1wj7A 1 0.215 98.5 0.903 Contact Map
2g3qA 1 0.1468 98 0.914 Contact Map
2mr9A 1 0.1433 97.8 0.919 Contact Map
2dahA 1 0.157 97.6 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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