EFTS - BACSU - GREMLIN Contacts

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EFTS - Elongation factor Ts

UniProt:	P80700	Sequences: MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKGIAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLANTPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGGRIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGKPENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGIEKRQENFAEEVMNQVKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	293 (268)
Sequences:	2688 (1512)
Seq/√Len:	92.4

ECOLI - EFTS
BACSU - EFTS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_D	109_E	3.475	1.00
169_N	263_T	3.329	1.00
179_D	247_K	3.109	1.00
199_E	203_N	3.060	1.00
193_S	196_Q	3.046	1.00
214_L	223_V	3.038	1.00
38_D	204_H	2.605	1.00
206_R	228_E	2.516	1.00
9_K	13_E	2.377	1.00
194_R	232_N	2.343	1.00
32_D	35_K	2.308	1.00
204_H	207_Q	2.301	1.00
29_T	39_L	2.225	1.00
119_S	127_S	2.204	1.00
179_D	245_F	2.202	1.00
176_T	256_V	2.116	1.00
255_Q	258_A	2.114	1.00
167_V	266_T	2.073	1.00
251_E	259_A	1.987	1.00
64_K	97_D	1.980	1.00
87_G	131_K	1.976	1.00
210_T	224_A	1.969	1.00
7_Q	33_M	1.932	1.00
193_S	241_L	1.914	1.00
194_R	242_D	1.906	1.00
75_V	92_L	1.903	1.00
5_A	8_V	1.856	1.00
212_Q	230_R	1.847	1.00
86_E	90_E	1.837	1.00
54_R	78_E	1.823	1.00
98_H	113_Q	1.810	1.00
73_L	95_L	1.806	1.00
214_L	220_E	1.806	1.00
248_N	251_E	1.801	1.00
7_Q	10_E	1.789	1.00
207_Q	211_Q	1.789	1.00
242_D	254_K	1.781	1.00
90_E	94_T	1.766	1.00
129_V	135_K	1.695	1.00
209_L	212_Q	1.687	1.00
30_D	35_K	1.677	1.00
69_K	103_T	1.676	1.00
168_L	177_A	1.663	1.00
91_L	128_A	1.656	1.00
69_K	143_V	1.610	1.00
97_D	101_A	1.595	1.00
225_K	228_E	1.592	1.00
61_T	163_G	1.589	1.00
171_T	262_A	1.586	1.00
211_Q	215_Q	1.547	1.00
125_I	138_L	1.538	1.00
169_N	265_Q	1.534	1.00
153_G	177_A	1.534	1.00
76_N	139_R	1.533	1.00
114_K	118_G	1.532	1.00
98_H	102_N	1.531	1.00
203_N	207_Q	1.530	1.00
103_T	143_V	1.507	1.00
144_L	266_T	1.489	1.00
94_T	117_N	1.483	1.00
254_K	258_A	1.480	1.00
112_G	122_E	1.479	1.00
14_K	37_I	1.473	1.00
213_A	230_R	1.472	1.00
93_N	97_D	1.454	1.00
74_E	140_R	1.450	1.00
91_L	125_I	1.437	0.99
146_K	167_V	1.428	0.99
69_K	145_T	1.427	0.99
203_N	206_R	1.425	0.99
114_K	123_E	1.420	0.99
211_Q	214_L	1.411	0.99
15_T	37_I	1.408	0.99
35_K	42_E	1.391	0.99
252_K	255_Q	1.362	0.99
95_L	121_V	1.355	0.99
239_C	242_D	1.354	0.99
210_T	214_L	1.345	0.99
144_L	268_V	1.337	0.99
188_N	271_E	1.337	0.99
213_A	216_E	1.334	0.99
120_T	123_E	1.332	0.99
232_N	236_E	1.324	0.99
28_E	39_L	1.322	0.99
122_E	126_T	1.316	0.99
191_Y	197_V	1.315	0.99
144_L	167_V	1.280	0.99
206_R	210_T	1.265	0.99
70_G	165_L	1.260	0.99
236_E	252_K	1.259	0.99
105_A	109_E	1.245	0.98
164_V	185_A	1.244	0.98
257_I	262_A	1.242	0.98
73_L	96_A	1.232	0.98
202_T	235_F	1.231	0.98
91_L	95_L	1.230	0.98
142_T	268_V	1.223	0.98
190_R	201_E	1.221	0.98
228_E	232_N	1.218	0.98
194_R	239_C	1.218	0.98
115_M	124_Y	1.208	0.98
209_L	231_L	1.207	0.98
34_D	204_H	1.195	0.98
102_N	113_Q	1.192	0.98
10_E	14_K	1.191	0.98
201_E	234_F	1.180	0.98
173_D	260_K	1.173	0.98
221_N	225_K	1.169	0.98
166_T	181_A	1.168	0.98
107_V	111_M	1.156	0.98
89_K	93_N	1.154	0.98
146_K	150_S	1.154	0.98
94_T	115_M	1.145	0.97
119_S	123_E	1.143	0.97
62_L	92_L	1.140	0.97
251_E	255_Q	1.130	0.97
35_K	38_D	1.124	0.97
154_A	165_L	1.124	0.97
114_K	120_T	1.121	0.97
104_P	141_F	1.113	0.97
87_G	128_A	1.112	0.97
192_I	267_F	1.107	0.97
10_E	33_M	1.100	0.97
235_F	239_C	1.092	0.97
91_L	138_L	1.085	0.96
226_M	230_R	1.085	0.96
224_A	228_E	1.068	0.96
213_A	226_M	1.061	0.96
56_A	76_N	1.057	0.96
65_T	68_N	1.055	0.96
111_M	122_E	1.046	0.96
75_V	91_L	1.044	0.96
119_S	124_Y	1.042	0.95
176_T	257_I	1.039	0.95
222_I	226_M	1.033	0.95
192_I	196_Q	1.031	0.95
193_S	263_T	1.031	0.95
257_I	264_V	1.030	0.95
142_T	270_Y	1.028	0.95
72_I	163_G	1.024	0.95
96_A	100_L	1.023	0.95
103_T	145_T	1.022	0.95
142_T	266_T	1.017	0.95
213_A	223_V	1.003	0.94
191_Y	201_E	1.003	0.94
244_A	249_P	1.002	0.94
41_R	205_E	1.001	0.94
167_V	265_Q	0.993	0.94
35_K	39_L	0.988	0.94
146_K	152_F	0.988	0.94
150_S	167_V	0.987	0.94
175_E	179_D	0.981	0.94
69_K	100_L	0.978	0.94
207_Q	210_T	0.974	0.93
98_H	115_M	0.971	0.93
17_A	130_A	0.968	0.93
29_T	35_K	0.967	0.93
170_G	259_A	0.963	0.93
2_A	30_D	0.958	0.93
60_S	92_L	0.957	0.93
252_K	256_V	0.954	0.93
112_G	120_T	0.951	0.93
236_E	244_A	0.947	0.93
66_D	101_A	0.947	0.93
72_I	142_T	0.935	0.92
191_Y	198_S	0.933	0.92
176_T	180_I	0.928	0.92
34_D	37_I	0.927	0.92
104_P	113_Q	0.916	0.91
210_T	223_V	0.915	0.91
180_I	256_V	0.906	0.91
150_S	169_N	0.904	0.91
94_T	124_Y	0.901	0.91
129_V	136_I	0.896	0.90
42_E	211_Q	0.894	0.90
75_V	138_L	0.890	0.90
87_G	90_E	0.887	0.90
222_I	225_K	0.886	0.90
231_L	235_F	0.886	0.90
114_K	117_N	0.882	0.90
178_K	182_M	0.881	0.90
203_N	210_T	0.879	0.89
107_V	138_L	0.876	0.89
6_Q	9_K	0.874	0.89
219_P	226_M	0.872	0.89
251_E	256_V	0.872	0.89
8_V	22_C	0.867	0.89
248_N	259_A	0.867	0.89
171_T	261_N	0.866	0.89
24_K	27_T	0.863	0.89
71_V	143_V	0.861	0.88
204_H	208_I	0.854	0.88
99_L	141_F	0.850	0.88
253_V	256_V	0.848	0.88
184_V	267_F	0.846	0.88
71_V	100_L	0.843	0.87
115_M	121_V	0.842	0.87
57_A	139_R	0.840	0.87
132_I	136_I	0.839	0.87
219_P	222_I	0.837	0.87
3_I	27_T	0.836	0.87
42_E	215_Q	0.835	0.87
212_Q	215_Q	0.831	0.87
198_S	201_E	0.826	0.86
220_E	223_V	0.825	0.86
108_E	111_M	0.825	0.86
38_D	42_E	0.818	0.86
29_T	36_A	0.818	0.86
64_K	100_L	0.816	0.86
125_I	129_V	0.815	0.86
21_D	43_K	0.810	0.85
72_I	268_V	0.810	0.85
161_R	271_E	0.809	0.85
218_K	226_M	0.808	0.85
94_T	97_D	0.806	0.85
216_E	226_M	0.805	0.85
27_T	30_D	0.804	0.85
209_L	230_R	0.804	0.85
153_G	178_K	0.791	0.84
99_L	110_A	0.787	0.84
210_T	220_E	0.787	0.84
49_A	126_T	0.783	0.83
71_V	99_L	0.783	0.83
42_E	45_I	0.776	0.83
197_V	238_I	0.776	0.83
217_G	223_V	0.774	0.82
74_E	139_R	0.771	0.82
126_T	129_V	0.771	0.82
156_L	160_G	0.770	0.82
106_D	111_M	0.770	0.82
64_K	68_N	0.763	0.82
166_T	180_I	0.762	0.82
188_N	269_R	0.759	0.81
105_A	141_F	0.759	0.81
162_I	185_A	0.757	0.81
205_E	209_L	0.755	0.81
227_V	230_R	0.755	0.81
170_G	261_N	0.753	0.81
194_R	241_L	0.752	0.81
3_I	7_Q	0.751	0.81
182_M	186_A	0.751	0.81
62_L	96_A	0.750	0.80
98_H	121_V	0.748	0.80
2_A	7_Q	0.748	0.80
38_D	208_I	0.747	0.80
199_E	202_T	0.746	0.80
209_L	213_A	0.745	0.80
110_A	138_L	0.742	0.80
99_L	104_P	0.742	0.80
156_L	163_G	0.742	0.80
37_I	49_A	0.737	0.79
14_K	34_D	0.737	0.79
14_K	33_M	0.736	0.79
240_L	264_V	0.733	0.79
86_E	89_K	0.731	0.79
212_Q	226_M	0.731	0.79
221_N	224_A	0.722	0.78
176_T	262_A	0.720	0.78
200_E	203_N	0.720	0.78
152_F	165_L	0.717	0.77
76_N	140_R	0.715	0.77
258_A	263_T	0.714	0.77
128_A	131_K	0.710	0.77
115_M	119_S	0.706	0.76
104_P	109_E	0.706	0.76
230_R	233_K	0.706	0.76
60_S	160_G	0.701	0.76
123_E	126_T	0.700	0.76
2_A	27_T	0.698	0.76
140_R	270_Y	0.698	0.76
72_I	270_Y	0.695	0.75
66_D	97_D	0.695	0.75
213_A	222_I	0.694	0.75
258_A	261_N	0.694	0.75
4_T	7_Q	0.687	0.74
168_L	176_T	0.686	0.74
77_S	85_N	0.684	0.74
190_R	238_I	0.684	0.74
191_Y	196_Q	0.682	0.74
74_E	273_G	0.669	0.72
109_E	112_G	0.667	0.72
39_L	43_K	0.666	0.72
48_A	129_V	0.661	0.72
5_A	20_M	0.656	0.71
244_A	250_D	0.656	0.71
192_I	264_V	0.652	0.70
141_F	270_Y	0.651	0.70
158_M	161_R	0.650	0.70
48_A	133_G	0.648	0.70
151_A	174_E	0.646	0.70
114_K	119_S	0.644	0.70
53_D	135_K	0.640	0.69
95_L	125_I	0.635	0.68
216_E	222_I	0.634	0.68
196_Q	266_T	0.632	0.68
41_R	208_I	0.630	0.68
5_A	19_M	0.630	0.68
194_R	254_K	0.629	0.68
104_P	143_V	0.628	0.68
259_A	262_A	0.626	0.67
3_I	31_G	0.625	0.67
223_V	226_M	0.625	0.67
104_P	110_A	0.624	0.67
202_T	234_F	0.622	0.67
229_G	233_K	0.620	0.67
205_E	208_I	0.619	0.67
170_G	173_D	0.618	0.66
222_I	227_V	0.617	0.66
13_E	22_C	0.617	0.66
54_R	80_D	0.615	0.66
202_T	231_L	0.615	0.66
197_V	235_F	0.614	0.66
170_G	262_A	0.613	0.66
228_E	231_L	0.611	0.66
28_E	43_K	0.609	0.65
70_G	154_A	0.609	0.65
115_M	118_G	0.607	0.65
183_H	249_P	0.605	0.65
3_I	10_E	0.603	0.64
190_R	234_F	0.602	0.64
183_H	246_V	0.601	0.64
217_G	224_A	0.598	0.64
213_A	227_V	0.598	0.64
3_I	8_V	0.594	0.63
206_R	227_V	0.594	0.63
65_T	154_A	0.594	0.63
201_E	238_I	0.591	0.63
8_V	20_M	0.589	0.63
223_V	227_V	0.586	0.62
64_K	96_A	0.585	0.62
210_T	217_G	0.584	0.62
193_S	239_C	0.582	0.62
77_S	92_L	0.582	0.62
153_G	174_E	0.581	0.62
95_L	98_H	0.579	0.61
171_T	176_T	0.576	0.61
33_M	37_I	0.575	0.61
123_E	127_S	0.574	0.61
151_A	168_L	0.574	0.61
186_A	246_V	0.572	0.60
103_T	141_F	0.571	0.60
98_H	101_A	0.571	0.60
153_G	168_L	0.571	0.60
218_K	229_G	0.571	0.60
77_S	136_I	0.570	0.60
216_E	223_V	0.570	0.60
85_N	132_I	0.570	0.60
255_Q	259_A	0.568	0.60
218_K	225_K	0.564	0.59
183_H	186_A	0.563	0.59
17_A	21_D	0.561	0.59
193_S	242_D	0.561	0.59
66_D	100_L	0.560	0.59
21_D	44_G	0.559	0.59
6_Q	13_E	0.556	0.58
244_A	252_K	0.556	0.58
128_A	136_I	0.555	0.58
64_K	93_N	0.555	0.58
57_A	76_N	0.554	0.58
247_K	256_V	0.553	0.58
192_I	266_T	0.552	0.58
191_Y	239_C	0.549	0.57
70_G	152_F	0.548	0.57
42_E	207_Q	0.547	0.57
162_I	271_E	0.543	0.57
89_K	92_L	0.541	0.56
235_F	242_D	0.541	0.56
137_T	270_Y	0.540	0.56
241_L	263_T	0.539	0.56
38_D	207_Q	0.537	0.56
192_I	241_L	0.537	0.56
139_R	270_Y	0.536	0.56
206_R	224_A	0.535	0.55
128_A	132_I	0.533	0.55
54_R	81_F	0.532	0.55
205_E	234_F	0.532	0.55
210_T	231_L	0.530	0.55
102_N	110_A	0.528	0.54
194_R	235_F	0.526	0.54
220_E	224_A	0.526	0.54
22_C	27_T	0.525	0.54
73_L	138_L	0.523	0.54
110_A	113_Q	0.522	0.54
192_I	257_I	0.522	0.54
245_F	248_N	0.522	0.54
202_T	206_R	0.521	0.53
68_N	150_S	0.516	0.53
55_I	139_R	0.516	0.53
96_A	141_F	0.509	0.52
124_Y	128_A	0.506	0.51
179_D	256_V	0.505	0.51
180_I	257_I	0.505	0.51
101_A	104_P	0.504	0.51
18_G	21_D	0.503	0.51
214_L	217_G	0.503	0.51
108_E	112_G	0.502	0.51
92_L	96_A	0.502	0.51
241_L	254_K	0.502	0.51
129_V	133_G	0.502	0.51
121_V	138_L	0.501	0.51
122_E	125_I	0.501	0.51
60_S	89_K	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pc3C	1	0.9522	100	0.041	Contact Map
3avxA	1	0.959	100	0.103	Contact Map
1xb2B	1	0.8259	100	0.226	Contact Map
1aipC	2	0.6382	100	0.316	Contact Map
1tfeA	2	0.4573	100	0.583	Contact Map
2cp9A	1	0.1877	99.8	0.802	Contact Map
1wj7A	1	0.215	98.5	0.903	Contact Map
2g3qA	1	0.1468	98	0.914	Contact Map
2mr9A	1	0.1433	97.8	0.919	Contact Map
2dahA	1	0.157	97.6	0.922	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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