GREMLIN Database
TIG - Trigger factor
UniProt: P80698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (412)
Sequences: 3600 (2510)
Seq/√Len: 123.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_L213_K3.9301.00
212_E238_K3.8481.00
216_E232_P3.4841.00
160_V191_V3.3521.00
143_K146_Q3.2471.00
186_N240_H3.1801.00
155_K158_G2.9231.00
214_D234_V2.8511.00
154_V241_E2.8491.00
117_K301_E2.6321.00
277_E281_E2.6051.00
153_V246_E2.6041.00
174_V231_K2.6031.00
139_Q143_K2.5921.00
207_L239_I2.5831.00
306_Q310_D2.5741.00
171_E183_K2.5011.00
365_A369_A2.4851.00
40_S46_K2.4801.00
378_E415_K2.4741.00
270_E274_K2.4521.00
295_K298_E2.4501.00
75_E106_F2.4241.00
173_F236_K2.4101.00
294_L355_K2.3741.00
78_K82_E2.3721.00
171_E178_A2.3341.00
208_E211_A2.3191.00
171_E236_K2.3121.00
159_A208_E2.3111.00
99_E102_E2.2631.00
365_A368_K2.2551.00
226_E229_A2.2191.00
209_A242_I2.1971.00
136_E140_N2.1851.00
273_K277_E2.1591.00
135_D273_K2.1451.00
214_D236_K2.1281.00
216_E234_V2.1201.00
167_V240_H2.1031.00
384_T388_E2.0831.00
161_E244_A2.0611.00
169_D240_H2.0591.00
218_T232_P2.0511.00
139_Q269_T2.0451.00
162_E202_D2.0061.00
350_K354_E1.9801.00
382_E385_K1.9781.00
141_E144_A1.9531.00
266_A270_E1.9431.00
354_E358_K1.9331.00
174_V233_A1.9321.00
396_N399_Q1.9311.00
393_P396_N1.9251.00
18_E103_S1.9241.00
212_E236_K1.9121.00
134_T137_D1.9041.00
287_K291_E1.8951.00
136_E139_Q1.8931.00
147_E245_K1.8611.00
294_L298_E1.8541.00
271_K274_K1.8391.00
137_D280_K1.8291.00
274_K278_E1.8081.00
314_D346_K1.8021.00
341_D344_A1.7931.00
74_V78_K1.7911.00
143_K147_E1.7641.00
274_K277_E1.7451.00
344_A347_E1.7411.00
162_E205_V1.7081.00
347_E350_K1.7061.00
262_V271_K1.7061.00
160_V166_V1.6821.00
255_A265_L1.6811.00
97_K105_I1.6661.00
267_E270_E1.6641.00
263_E267_E1.6431.00
14_V107_T1.6391.00
167_V241_E1.6241.00
78_K81_E1.6131.00
18_E105_I1.6051.00
140_N143_K1.5601.00
318_K321_E1.5561.00
140_N144_A1.5431.00
381_A384_T1.5391.00
252_D255_A1.5381.00
146_Q250_L1.5371.00
146_Q247_L1.5221.00
25_K29_D1.5171.00
145_L268_L1.4801.00
173_F178_A1.4781.00
158_G244_A1.4721.00
264_T267_E1.4711.00
127_E291_E1.4681.00
163_G190_E1.4671.00
351_E354_E1.4621.00
204_L207_L1.4591.00
370_E419_F1.4591.00
119_G300_A1.4501.00
394_V398_K1.4481.00
265_L269_T1.4351.00
12_E111_T1.4271.00
121_Y370_E1.4231.00
6_E14_V1.4211.00
23_T26_T1.4191.00
382_E414_R1.4171.00
158_G164_N1.4121.00
168_L237_V1.4111.00
295_K299_N1.4001.00
120_E123_G1.3931.00
281_E285_D1.3741.00
290_E294_L1.3531.00
314_D318_K1.3461.00
418_D422_E1.3401.00
253_E256_K1.3391.00
33_K36_V1.3351.00
142_L265_L1.3281.00
380_D398_K1.3131.00
266_A269_T1.3111.00
152_L165_T1.2901.00
81_E84_G1.2901.00
167_V188_S1.2681.00
376_D408_K1.2541.00
374_V411_L1.2521.00
252_D264_T1.2501.00
300_A362_T1.2481.00
278_E282_N1.2481.00
306_Q350_K1.2471.00
169_D238_K1.2390.99
381_A385_K1.2270.99
213_K239_I1.2260.99
150_A245_K1.2230.99
178_A183_K1.2230.99
125_G295_K1.2130.99
51_R55_E1.2120.99
12_E109_K1.2100.99
10_G303_D1.2080.99
252_D256_K1.2070.99
383_L394_V1.1900.99
111_T307_A1.1860.99
375_S378_E1.1860.99
199_G202_D1.1830.99
167_V243_K1.1820.99
312_E356_R1.1810.99
20_D23_T1.1690.99
192_G201_E1.1570.99
29_D33_K1.1550.99
165_T190_E1.1550.99
378_E381_A1.1540.99
16_T105_I1.1540.99
310_D346_K1.1390.99
313_L350_K1.1380.99
190_E245_K1.1370.99
207_L215_V1.1320.99
17_V106_F1.1310.99
160_V239_I1.1290.99
250_L265_L1.1250.99
374_V412_K1.1250.99
204_L213_K1.1160.99
203_Q215_V1.1160.99
151_E246_E1.1110.99
142_L146_Q1.1070.99
32_F63_L1.0990.99
209_A241_E1.0980.99
376_D380_D1.0950.99
322_Q326_M1.0940.99
22_E25_K1.0880.99
168_L204_L1.0860.99
77_P81_E1.0840.99
26_T30_D1.0840.99
285_D421_V1.0830.99
304_V309_V1.0780.99
384_T394_V1.0750.99
377_E380_D1.0730.98
270_E273_K1.0720.98
255_A268_L1.0680.98
155_K244_A1.0680.98
395_E399_Q1.0670.98
122_K370_E1.0670.98
166_V242_I1.0670.98
129_D287_K1.0670.98
322_Q325_Q1.0640.98
377_E381_A1.0600.98
15_L79_A1.0600.98
310_D314_D1.0590.98
155_K161_E1.0560.98
215_V237_V1.0550.98
380_D384_T1.0490.98
19_V71_L1.0490.98
49_I54_F1.0460.98
141_E279_A1.0420.98
73_P77_P1.0420.98
318_K322_Q1.0410.98
367_A416_A1.0380.98
158_G161_E1.0310.98
52_G56_Q1.0280.98
173_F234_V1.0260.98
271_K275_R1.0260.98
363_L416_A1.0190.98
149_Q257_D1.0140.98
135_D139_Q1.0100.98
52_G55_E1.0090.98
116_V365_A1.0040.98
92_E109_K0.9950.98
313_L346_K0.9940.98
191_V205_V0.9930.98
343_A347_E0.9910.97
113_K364_E0.9900.97
135_D138_V0.9890.97
279_A283_E0.9890.97
144_A147_E0.9890.97
30_D70_I0.9870.97
169_D185_E0.9800.97
41_I49_I0.9790.97
31_A70_I0.9790.97
217_V235_F0.9780.97
3_V83_A0.9770.97
22_E103_S0.9750.97
31_A66_D0.9740.97
160_V204_L0.9720.97
173_F183_K0.9700.97
165_T243_K0.9690.97
146_Q265_L0.9690.97
351_E355_K0.9680.97
270_E277_E0.9660.97
207_L211_A0.9650.97
129_D288_L0.9640.97
340_Q348_Q0.9600.97
23_T74_V0.9600.97
97_K102_E0.9600.97
22_E26_T0.9570.97
302_I358_K0.9520.97
312_E315_R0.9520.97
179_F182_G0.9510.97
153_V244_A0.9500.97
251_D254_F0.9490.97
16_T107_T0.9490.97
27_A30_D0.9460.97
32_F54_F0.9450.97
189_L196_F0.9430.97
80_V87_P0.9420.97
319_E323_R0.9360.96
399_Q403_S0.9340.96
296_A362_T0.9320.96
29_D51_R0.9300.96
137_D140_N0.9300.96
317_L346_K0.9270.96
14_V109_K0.9230.96
297_S359_S0.9210.96
217_V233_A0.9200.96
139_Q142_L0.9160.96
160_V205_V0.9150.96
366_I416_A0.9120.96
218_T221_E0.9060.96
373_E408_K0.9060.96
372_L419_F0.9030.96
160_V242_I0.9020.96
117_K369_A0.8970.95
35_V39_V0.8940.95
221_E230_G0.8940.95
187_Y195_S0.8900.95
168_L239_I0.8890.95
157_E208_E0.8860.95
86_E113_K0.8860.95
291_E295_K0.8820.95
133_V276_L0.8820.95
292_L420_L0.8800.95
259_D264_T0.8800.95
162_E190_E0.8730.95
128_K288_L0.8730.95
343_A346_K0.8710.95
385_K388_E0.8610.94
8_Q14_V0.8570.94
342_E346_K0.8570.94
76_Y110_V0.8550.94
170_F184_A0.8540.94
202_D205_V0.8530.94
368_K371_N0.8520.94
165_T188_S0.8490.94
282_N286_A0.8490.94
63_L67_A0.8460.94
75_E78_K0.8410.94
283_E287_K0.8400.94
160_V207_L0.8340.93
285_D418_D0.8260.93
68_L104_L0.8250.93
340_Q344_A0.8250.93
292_L421_V0.8210.93
301_E358_K0.8200.93
219_F223_Y0.8180.93
4_K16_T0.8130.92
316_M353_A0.8120.92
144_A148_R0.8120.92
215_V234_V0.8110.92
154_V209_A0.8100.92
157_E161_E0.8080.92
119_G299_N0.8080.92
366_I370_E0.8070.92
323_R327_Q0.8060.92
297_S300_A0.8050.92
23_T78_K0.8040.92
34_K38_Q0.8030.92
172_G223_Y0.8020.92
215_V233_A0.8010.92
65_Q69_D0.8010.92
94_D107_T0.8010.92
321_E325_Q0.8010.92
7_K13_G0.7990.92
27_A67_A0.7990.92
278_E281_E0.7970.92
136_E143_K0.7950.92
372_L416_A0.7940.92
39_V54_F0.7920.91
204_L239_I0.7860.91
167_V186_N0.7840.91
379_V408_K0.7840.91
142_L255_A0.7830.91
150_A247_L0.7830.91
152_L190_E0.7820.91
386_M397_I0.7800.91
416_A420_L0.7800.91
170_F187_Y0.7790.91
54_F58_F0.7790.91
135_D277_E0.7780.91
197_I223_Y0.7760.91
208_E242_I0.7730.90
76_Y87_P0.7730.90
19_V106_F0.7720.90
154_V243_K0.7700.90
367_A412_K0.7680.90
35_V63_L0.7680.90
158_G208_E0.7660.90
166_V191_V0.7640.90
175_D231_K0.7630.90
169_D186_N0.7630.90
31_A34_K0.7630.90
30_D34_K0.7620.90
166_V204_L0.7610.90
396_N400_A0.7610.90
135_D269_T0.7560.89
262_V267_E0.7540.89
46_K49_I0.7520.89
419_F422_E0.7510.89
382_E411_L0.7500.89
123_G299_N0.7500.89
142_L268_L0.7430.89
172_G179_F0.7410.88
311_T314_D0.7360.88
352_D355_K0.7350.88
310_D313_L0.7340.88
360_N413_V0.7330.88
152_L243_K0.7300.88
24_F71_L0.7300.88
89_D111_T0.7270.88
13_G112_V0.7270.88
306_Q354_E0.7240.87
138_V273_K0.7230.87
173_F176_G0.7220.87
194_G201_E0.7200.87
120_E299_N0.7200.87
177_E227_D0.7200.87
39_V63_L0.7170.87
200_F235_F0.7170.87
146_Q251_D0.7160.87
116_V300_A0.7150.87
38_Q46_K0.7100.86
142_L272_T0.7090.86
5_W13_G0.7090.86
310_D350_K0.7090.86
80_V85_I0.7090.86
368_K412_K0.7060.86
31_A67_A0.7040.86
161_E208_E0.7040.86
266_A273_K0.7040.86
173_F177_E0.7020.86
291_E294_L0.7010.86
151_E257_D0.7000.85
172_G219_F0.7000.85
380_D383_L0.6990.85
256_K263_E0.6970.85
32_F51_R0.6960.85
25_K101_G0.6940.85
248_P254_F0.6940.85
60_V100_K0.6930.85
20_D103_S0.6900.85
145_L254_F0.6880.85
412_K416_A0.6860.84
30_D33_K0.6860.84
161_E164_N0.6840.84
129_D291_E0.6830.84
228_L231_K0.6810.84
42_P57_R0.6810.84
280_K283_E0.6800.84
372_L412_K0.6800.84
379_V407_M0.6790.84
132_T135_D0.6790.84
392_M396_N0.6790.84
145_L148_R0.6780.84
298_E355_K0.6760.83
27_A71_L0.6760.83
347_E351_E0.6730.83
297_S358_K0.6730.83
29_D55_E0.6720.83
316_M349_M0.6720.83
9_E12_E0.6710.83
383_L387_A0.6710.83
189_L193_S0.6700.83
325_Q328_G0.6690.83
41_I53_L0.6690.83
162_E194_G0.6670.83
307_A311_T0.6670.83
251_D257_D0.6660.83
293_V359_S0.6650.82
21_A101_G0.6650.82
88_V308_M0.6650.82
251_D255_A0.6630.82
172_G200_F0.6630.82
128_K284_A0.6630.82
225_A228_L0.6590.82
166_V239_I0.6580.82
131_T284_A0.6580.82
171_E238_K0.6570.82
407_M411_L0.6550.82
132_T277_E0.6540.81
395_E398_K0.6530.81
388_E391_N0.6520.81
344_A348_Q0.6510.81
219_F222_E0.6480.81
259_D271_K0.6480.81
93_I108_A0.6480.81
61_E65_Q0.6460.81
160_V211_A0.6450.81
28_L63_L0.6450.81
126_I292_L0.6440.80
120_E124_L0.6440.80
276_L280_K0.6440.80
223_Y235_F0.6440.80
272_T275_R0.6430.80
220_P223_Y0.6430.80
172_G235_F0.6420.80
96_E105_I0.6410.80
313_L317_L0.6400.80
259_D262_V0.6400.80
393_P399_Q0.6380.80
51_R54_F0.6380.80
176_G234_V0.6370.80
199_G232_P0.6360.80
141_E275_R0.6360.80
325_Q330_N0.6340.79
357_V361_L0.6340.79
207_L212_E0.6310.79
204_L237_V0.6300.79
174_V222_E0.6280.79
275_R278_E0.6270.79
277_E280_K0.6270.79
96_E107_T0.6230.78
213_K237_V0.6230.78
124_L296_A0.6220.78
50_P53_L0.6200.78
130_D280_K0.6200.78
211_A242_I0.6190.78
49_I53_L0.6190.78
186_N238_K0.6180.78
76_Y80_V0.6180.78
152_L245_K0.6170.78
168_L195_S0.6140.77
314_D317_L0.6140.77
155_K242_I0.6140.77
345_L349_M0.6130.77
324_L328_G0.6120.77
288_L291_E0.6100.77
73_P106_F0.6090.77
26_T29_D0.6090.77
190_E195_S0.6080.77
85_I110_V0.6070.76
174_V177_E0.6070.76
246_E249_E0.6050.76
319_E356_R0.6030.76
366_I420_L0.6020.76
383_L398_K0.6020.76
126_I288_L0.6020.76
200_F220_P0.6010.76
11_N111_T0.6000.76
162_E191_V0.5970.75
121_Y366_I0.5960.75
302_I362_T0.5950.75
142_L250_L0.5930.75
119_G301_E0.5930.75
121_Y420_L0.5930.75
172_G182_G0.5920.75
197_I202_D0.5910.74
170_F219_F0.5910.74
288_L421_V0.5910.74
85_I112_V0.5900.74
124_L295_K0.5890.74
194_G198_P0.5890.74
116_V302_I0.5880.74
200_F223_Y0.5870.74
170_F223_Y0.5860.74
53_L56_Q0.5850.74
28_L64_Y0.5840.74
285_D414_R0.5840.74
193_S197_I0.5830.73
378_E411_L0.5820.73
189_L201_E0.5810.73
312_E360_N0.5800.73
191_V204_L0.5800.73
60_V64_Y0.5790.73
296_A420_L0.5790.73
315_R318_K0.5780.73
184_A187_Y0.5780.73
139_Q266_A0.5760.73
118_L365_A0.5760.73
21_A25_K0.5760.73
87_P110_V0.5750.72
252_D262_V0.5740.72
188_S243_K0.5730.72
132_T273_K0.5720.72
146_Q249_E0.5710.72
398_K401_I0.5710.72
146_Q254_F0.5710.72
145_L258_I0.5700.72
39_V58_F0.5700.72
397_I401_I0.5700.72
374_V415_K0.5680.72
170_F200_F0.5680.72
352_D356_R0.5670.71
286_A290_E0.5670.71
27_A74_V0.5670.71
133_V138_V0.5660.71
285_D289_R0.5660.71
268_L272_T0.5650.71
194_G202_D0.5630.71
203_Q217_V0.5620.71
133_V273_K0.5620.71
182_G223_Y0.5600.70
304_V357_V0.5600.70
17_V75_E0.5600.70
170_F196_F0.5590.70
166_V237_V0.5590.70
12_E306_Q0.5560.70
3_V15_L0.5560.70
40_S49_I0.5550.70
43_G47_G0.5540.70
190_E193_S0.5520.69
224_H229_A0.5510.69
138_V272_T0.5500.69
68_L72_L0.5500.69
222_E232_P0.5500.69
24_F28_L0.5490.69
168_L189_L0.5490.69
121_Y369_A0.5470.69
28_L32_F0.5470.69
28_L67_A0.5470.69
304_V354_E0.5460.69
210_G240_H0.5450.68
97_K101_G0.5440.68
2_S18_E0.5440.68
36_V49_I0.5440.68
133_V277_E0.5440.68
296_A299_N0.5430.68
193_S201_E0.5430.68
252_D266_A0.5430.68
382_E386_M0.5430.68
133_V280_K0.5430.68
380_D394_V0.5420.68
58_F66_D0.5410.68
394_V397_I0.5400.68
154_V167_V0.5390.68
209_A239_I0.5390.68
5_W83_A0.5390.68
138_V269_T0.5370.67
196_F200_F0.5370.67
15_L110_V0.5360.67
409_E413_V0.5360.67
321_E331_L0.5360.67
261_E264_T0.5350.67
160_V209_A0.5350.67
155_K159_A0.5330.67
178_A181_G0.5330.67
131_T280_K0.5330.67
36_V54_F0.5320.67
117_K365_A0.5320.67
252_D265_L0.5310.66
408_K412_K0.5310.66
323_R326_M0.5290.66
220_P235_F0.5260.66
17_V79_A0.5260.66
272_T276_L0.5250.66
149_Q254_F0.5240.65
137_D276_L0.5220.65
184_A188_S0.5210.65
189_L197_I0.5200.65
141_E145_L0.5200.65
181_G223_Y0.5190.65
387_A397_I0.5190.65
316_M356_R0.5160.64
320_F324_L0.5150.64
317_L345_L0.5130.64
393_P400_A0.5130.64
93_I357_V0.5130.64
126_I295_K0.5110.64
169_D184_A0.5100.63
15_L108_A0.5090.63
194_G199_G0.5080.63
43_G50_P0.5080.63
223_Y233_A0.5070.63
172_G184_A0.5060.63
24_F67_A0.5060.63
203_Q233_A0.5050.63
31_A35_V0.5040.62
99_E103_S0.5030.62
225_A229_A0.5030.62
309_V354_E0.5030.62
66_D70_I0.5010.62
196_F235_F0.5010.62
142_L269_T0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w26A 1 0.9693 100 0.11 Contact Map
1t11A 3 0.8844 100 0.126 Contact Map
3gtyX 1 0.9387 100 0.147 Contact Map
1p9yA 1 0.2759 100 0.696 Contact Map
1zxjA 4 0.4245 100 0.708 Contact Map
2d3o1 1 0.2358 100 0.713 Contact Map
2nsaA 2 0.3726 100 0.724 Contact Map
2nscA 2 0.2571 99.9 0.729 Contact Map
1hxvA 1 0.2005 99.7 0.812 Contact Map
3prbA 2 0.3632 99.7 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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