GREMLIN Database
ACP - Acyl carrier protein
UniProt: P80643 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 77 (68)
Sequences: 23373 (18433)
Seq/√Len: 2235.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_E67_G2.3701.00
7_R50_E2.3191.00
56_S59_D2.1461.00
63_I72_Y2.0061.00
59_D72_Y1.9291.00
14_D46_E1.9201.00
65_T68_D1.8801.00
36_D39_D1.7591.00
28_S64_A1.7521.00
5_L25_L1.7341.00
29_F35_A1.6631.00
12_I35_A1.6411.00
24_K27_A1.5791.00
48_E54_E1.5151.00
7_R10_K1.4601.00
9_T25_L1.4501.00
9_T66_V1.4381.00
11_I46_E1.3861.00
11_I14_D1.3721.00
63_I68_D1.3641.00
28_S32_D1.3421.00
4_T74_Q1.3241.00
25_L67_G1.2681.00
10_K50_E1.2411.00
13_V22_D1.2391.00
9_T13_V1.2321.00
12_I66_V1.2241.00
46_E50_E1.2141.00
8_V70_V1.1821.00
44_V48_E1.1771.00
43_L60_A1.1671.00
8_V66_V1.0981.00
7_R11_I1.0911.00
25_L66_V1.0901.00
58_E62_K1.0771.00
39_D42_E1.0771.00
8_V47_L1.0441.00
12_I43_L1.0321.00
4_T7_R1.0321.00
11_I50_E1.0101.00
40_V60_A1.0071.00
15_R46_E1.0061.00
11_I43_L1.0041.00
6_E10_K1.0031.00
12_I69_A0.9821.00
7_R51_F0.9761.00
5_L67_G0.9731.00
40_V44_V0.9721.00
15_R43_L0.9541.00
37_S41_V0.9481.00
42_E46_E0.9391.00
5_L70_V0.9201.00
18_V21_A0.8891.00
59_D62_K0.8651.00
59_D63_I0.8561.00
9_T23_V0.8371.00
46_E49_D0.8291.00
16_L35_A0.7921.00
10_K13_V0.7901.00
48_E53_M0.7781.00
18_V22_D0.7511.00
15_R42_E0.7491.00
10_K14_D0.7321.00
53_M73_I0.7301.00
11_I47_L0.7271.00
47_L55_I0.7211.00
68_D71_N0.7191.00
40_V57_D0.7081.00
14_D50_E0.6981.00
27_A33_L0.6861.00
55_I69_A0.6721.00
6_E9_T0.6671.00
41_V45_M0.6611.00
30_K35_A0.6601.00
45_M49_D0.6501.00
43_L69_A0.6491.00
15_R39_D0.6401.00
5_L66_V0.6301.00
13_V21_A0.6201.00
30_K61_E0.6161.00
4_T73_I0.6101.00
18_V33_L0.6081.00
28_S65_T0.6011.00
60_A69_A0.5951.00
23_V33_L0.5901.00
47_L53_M0.5811.00
35_A39_D0.5721.00
35_A40_V0.5691.00
44_V57_D0.5631.00
66_V70_V0.5611.00
27_A32_D0.5491.00
13_V23_V0.5491.00
13_V18_V0.5411.00
18_V23_V0.5271.00
63_I71_N0.5271.00
30_K33_L0.5251.00
71_N74_Q0.5241.00
37_S61_E0.5231.00
4_T51_F0.5191.00
64_A68_D0.5101.00
17_G42_E0.5071.00
5_L9_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0mB 1 0.9221 99.6 0.072 Contact Map
2vsqA 1 0.961 99.6 0.086 Contact Map
2jgpA 1 0.961 99.6 0.09 Contact Map
4oqjA 2 0 99.5 0.096 Contact Map
4dg8A 1 0 99.5 0.129 Contact Map
4pxhB 1 0.9351 99.4 0.155 Contact Map
2cq8A 1 0.974 99.4 0.157 Contact Map
3tejA 1 0.9481 99.4 0.162 Contact Map
1dnyA 1 0.9351 99.4 0.164 Contact Map
2l22A 1 0.987 99.4 0.167 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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