CLPP - BACSU - GREMLIN Contacts

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CLPP - ATP-dependent Clp protease proteolytic subunit

UniProt:	P80244	Sequences: MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAFLLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQPLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	197 (181)
Sequences:	4383 (1873)
Seq/√Len:	139.2

ECOLI - CLPP
BACSU - CLPP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
160_Q	164_V	4.464	1.00
137_E	141_K	3.613	1.00
168_D	183_Y	3.510	1.00
114_A	186_I	3.031	1.00
117_N	149_K	2.648	1.00
161_P	164_V	2.612	1.00
87_K	111_K	2.571	1.00
105_A	154_L	2.558	1.00
52_A	86_P	2.544	1.00
87_K	108_E	2.537	1.00
101_A	154_L	2.522	1.00
119_E	142_R	2.489	1.00
74_G	99_M	2.407	1.00
59_E	87_K	2.362	1.00
181_L	188_K	2.196	1.00
148_D	152_K	2.183	1.00
32_L	62_L	2.162	1.00
181_L	186_I	2.089	1.00
178_E	182_E	2.081	1.00
152_K	156_E	2.009	1.00
59_E	111_K	2.008	1.00
26_K	54_E	2.004	1.00
151_N	166_E	1.922	1.00
151_N	169_T	1.920	1.00
38_D	73_A	1.903	1.00
92_C	96_A	1.850	1.00
114_A	120_V	1.841	1.00
129_A	139_A	1.836	1.00
105_A	157_R	1.795	1.00
37_D	40_V	1.788	1.00
125_P	147_R	1.781	1.00
78_Y	157_R	1.732	1.00
113_Y	188_K	1.719	1.00
154_L	169_T	1.686	1.00
176_S	179_E	1.675	1.00
88_V	108_E	1.651	1.00
61_S	91_I	1.640	1.00
55_D	58_K	1.611	1.00
34_S	40_V	1.606	1.00
78_Y	82_Q	1.586	1.00
148_D	166_E	1.528	1.00
38_D	70_S	1.523	1.00
92_C	118_S	1.485	1.00
70_S	73_A	1.472	1.00
152_K	162_L	1.446	1.00
32_L	36_I	1.444	1.00
89_S	113_Y	1.430	1.00
104_L	120_V	1.422	1.00
102_F	154_L	1.417	1.00
154_L	165_I	1.387	1.00
82_Q	157_R	1.365	1.00
162_L	166_E	1.359	1.00
98_S	123_H	1.357	1.00
181_L	189_I	1.346	1.00
61_S	89_S	1.342	1.00
66_S	100_G	1.340	1.00
114_A	118_S	1.339	1.00
164_V	167_R	1.329	1.00
179_E	182_E	1.283	1.00
145_L	179_E	1.265	1.00
59_E	89_S	1.263	1.00
52_A	85_K	1.233	1.00
148_D	162_L	1.231	1.00
32_L	40_V	1.226	1.00
36_I	40_V	1.225	1.00
134_T	170_D	1.201	1.00
15_E	18_Y	1.196	1.00
153_V	157_R	1.194	1.00
90_T	107_G	1.180	1.00
82_Q	156_E	1.176	1.00
109_K	159_G	1.175	1.00
48_L	84_I	1.169	0.99
101_A	169_T	1.150	0.99
19_D	22_S	1.150	0.99
178_E	181_L	1.144	0.99
72_T	95_M	1.120	0.99
45_V	76_A	1.113	0.99
41_A	77_I	1.086	0.99
121_M	174_F	1.070	0.99
114_A	181_L	1.065	0.99
139_A	174_F	1.056	0.99
137_E	144_L	1.055	0.99
127_G	143_I	1.037	0.99
18_Y	26_K	1.031	0.99
124_Q	170_D	1.031	0.99
151_N	162_L	1.026	0.99
126_L	169_T	1.018	0.99
23_R	27_D	1.013	0.99
81_M	88_V	1.012	0.99
105_A	185_L	0.991	0.98
89_S	111_K	0.965	0.98
32_L	44_I	0.962	0.98
101_A	122_I	0.961	0.98
95_M	119_E	0.954	0.98
136_I	140_A	0.938	0.98
33_G	42_N	0.913	0.97
44_I	77_I	0.903	0.97
62_L	81_M	0.897	0.97
158_T	165_I	0.892	0.97
133_A	140_A	0.888	0.97
155_A	162_L	0.887	0.97
92_C	104_L	0.872	0.96
164_V	168_D	0.863	0.96
134_T	137_E	0.861	0.96
71_I	99_M	0.859	0.96
33_G	40_V	0.858	0.96
75_M	99_M	0.855	0.96
133_A	143_I	0.851	0.96
106_A	157_R	0.850	0.96
177_A	186_I	0.846	0.96
82_Q	106_A	0.845	0.95
84_I	88_V	0.841	0.95
78_Y	153_V	0.835	0.95
71_I	150_L	0.834	0.95
141_K	145_L	0.823	0.95
98_S	121_M	0.820	0.95
122_I	169_T	0.816	0.95
167_R	170_D	0.813	0.94
22_S	25_L	0.813	0.94
178_E	191_T	0.810	0.94
52_A	56_P	0.809	0.94
37_D	73_A	0.802	0.94
44_I	62_L	0.799	0.94
71_I	146_L	0.795	0.94
151_N	165_I	0.792	0.94
145_L	149_K	0.792	0.94
40_V	62_L	0.790	0.94
69_G	123_H	0.788	0.93
81_M	106_A	0.785	0.93
96_A	101_A	0.784	0.93
109_K	157_R	0.783	0.93
57_E	85_K	0.778	0.93
26_K	50_F	0.775	0.93
75_M	153_V	0.766	0.92
145_L	176_S	0.764	0.92
40_V	43_S	0.764	0.92
91_I	113_Y	0.762	0.92
139_A	142_R	0.760	0.92
111_K	188_K	0.756	0.92
57_E	86_P	0.755	0.92
142_R	146_L	0.754	0.92
163_E	166_E	0.751	0.92
102_F	153_V	0.751	0.92
67_P	97_A	0.751	0.92
177_A	189_I	0.746	0.91
120_V	186_I	0.745	0.91
142_R	145_L	0.744	0.91
17_A	22_S	0.737	0.91
17_A	21_Y	0.732	0.91
108_E	111_K	0.729	0.91
163_E	167_R	0.724	0.90
78_Y	106_A	0.723	0.90
164_V	183_Y	0.723	0.90
129_A	136_I	0.720	0.90
166_E	170_D	0.716	0.90
30_I	44_I	0.714	0.90
178_E	189_I	0.713	0.90
139_A	172_D	0.712	0.89
30_I	48_L	0.710	0.89
71_I	125_P	0.705	0.89
71_I	98_S	0.703	0.89
119_E	145_L	0.700	0.89
43_S	47_Q	0.698	0.89
50_F	54_E	0.695	0.88
39_N	43_S	0.694	0.88
86_P	108_E	0.686	0.88
36_I	100_G	0.685	0.88
14_G	17_A	0.684	0.88
95_M	174_F	0.681	0.87
173_N	185_L	0.679	0.87
164_V	173_N	0.677	0.87
143_I	146_L	0.676	0.87
69_G	98_S	0.675	0.87
136_I	143_I	0.673	0.87
95_M	142_R	0.670	0.86
188_K	191_T	0.670	0.86
158_T	185_L	0.666	0.86
160_Q	183_Y	0.664	0.86
18_Y	22_S	0.664	0.86
113_Y	190_L	0.664	0.86
119_E	176_S	0.663	0.86
135_E	171_R	0.659	0.86
17_A	25_L	0.656	0.85
102_F	157_R	0.654	0.85
160_Q	168_D	0.649	0.85
126_L	132_Q	0.642	0.84
25_L	50_F	0.641	0.84
102_F	105_A	0.640	0.84
114_A	177_A	0.633	0.83
110_G	187_D	0.633	0.83
119_E	146_L	0.630	0.83
161_P	167_R	0.625	0.82
22_S	47_Q	0.625	0.82
89_S	188_K	0.624	0.82
15_E	25_L	0.622	0.82
34_S	37_D	0.621	0.82
13_R	16_R	0.618	0.82
163_E	182_E	0.617	0.82
129_A	143_I	0.617	0.82
36_I	77_I	0.617	0.82
142_R	174_F	0.617	0.82
29_I	33_G	0.614	0.81
48_L	62_L	0.614	0.81
21_Y	43_S	0.610	0.81
74_G	123_H	0.610	0.81
20_I	23_R	0.608	0.81
24_L	29_I	0.607	0.81
138_I	142_R	0.604	0.80
168_D	173_N	0.603	0.80
97_A	174_F	0.603	0.80
78_Y	103_L	0.602	0.80
133_A	144_L	0.601	0.80
122_I	185_L	0.599	0.80
15_E	20_I	0.598	0.80
27_D	53_A	0.596	0.79
99_M	126_L	0.594	0.79
75_M	146_L	0.594	0.79
147_R	151_N	0.590	0.79
45_V	93_I	0.590	0.79
74_G	98_S	0.586	0.78
165_I	183_Y	0.586	0.78
82_Q	108_E	0.584	0.78
72_T	146_L	0.583	0.78
149_K	152_K	0.583	0.78
36_I	126_L	0.579	0.77
99_M	123_H	0.571	0.76
34_S	38_D	0.567	0.76
18_Y	25_L	0.557	0.75
121_M	172_D	0.557	0.75
90_T	112_R	0.556	0.75
132_Q	135_E	0.555	0.74
80_T	84_I	0.552	0.74
36_I	103_L	0.551	0.74
158_T	183_Y	0.548	0.73
104_L	187_D	0.547	0.73
67_P	98_S	0.546	0.73
34_S	39_N	0.546	0.73
138_I	171_R	0.542	0.73
105_A	158_T	0.541	0.73
119_E	125_P	0.534	0.72
28_R	59_E	0.534	0.72
72_T	75_M	0.532	0.71
52_A	91_I	0.531	0.71
25_L	47_Q	0.528	0.71
119_E	139_A	0.527	0.71
14_G	18_Y	0.524	0.70
35_A	40_V	0.524	0.70
102_F	150_L	0.520	0.70
13_R	17_A	0.520	0.70
15_E	22_S	0.518	0.69
86_P	89_S	0.518	0.69
154_L	168_D	0.518	0.69
160_Q	165_I	0.518	0.69
146_L	149_K	0.517	0.69
29_I	63_Y	0.517	0.69
68_G	123_H	0.517	0.69
79_D	117_N	0.515	0.69
141_K	148_D	0.513	0.69
12_N	15_E	0.512	0.68
104_L	112_R	0.512	0.68
84_I	108_E	0.511	0.68
34_S	42_N	0.511	0.68
122_I	173_N	0.510	0.68
152_K	155_A	0.508	0.68
21_Y	42_N	0.508	0.68
132_Q	170_D	0.508	0.68
79_D	112_R	0.508	0.68
122_I	154_L	0.507	0.68
124_Q	147_R	0.505	0.67
98_S	172_D	0.503	0.67
30_I	157_R	0.503	0.67
38_D	72_T	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1tg6A	4	0.9492	100	0.277	Contact Map
1y7oA	5	0.8985	100	0.333	Contact Map
4gm2A	3	0.8731	100	0.362	Contact Map
2cbyA	3	0.8629	100	0.412	Contact Map
1yg6A	4	0.9797	100	0.431	Contact Map
3p2lA	4	0.9695	100	0.435	Contact Map
3qwdA	5	0.9695	100	0.443	Contact Map
2f6iA	5	0.9137	100	0.455	Contact Map
4u0gA	4	0.9949	100	0.456	Contact Map
4jcqA	5	0.8629	100	0.48	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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