GREMLIN Database
CLPP - ATP-dependent Clp protease proteolytic subunit
UniProt: P80244 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (181)
Sequences: 4383 (1873)
Seq/√Len: 139.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_Q164_V4.4641.00
137_E141_K3.6131.00
168_D183_Y3.5101.00
114_A186_I3.0311.00
117_N149_K2.6481.00
161_P164_V2.6121.00
87_K111_K2.5711.00
105_A154_L2.5581.00
52_A86_P2.5441.00
87_K108_E2.5371.00
101_A154_L2.5221.00
119_E142_R2.4891.00
74_G99_M2.4071.00
59_E87_K2.3621.00
181_L188_K2.1961.00
148_D152_K2.1831.00
32_L62_L2.1621.00
181_L186_I2.0891.00
178_E182_E2.0811.00
152_K156_E2.0091.00
59_E111_K2.0081.00
26_K54_E2.0041.00
151_N166_E1.9221.00
151_N169_T1.9201.00
38_D73_A1.9031.00
92_C96_A1.8501.00
114_A120_V1.8411.00
129_A139_A1.8361.00
105_A157_R1.7951.00
37_D40_V1.7881.00
125_P147_R1.7811.00
78_Y157_R1.7321.00
113_Y188_K1.7191.00
154_L169_T1.6861.00
176_S179_E1.6751.00
88_V108_E1.6511.00
61_S91_I1.6401.00
55_D58_K1.6111.00
34_S40_V1.6061.00
78_Y82_Q1.5861.00
148_D166_E1.5281.00
38_D70_S1.5231.00
92_C118_S1.4851.00
70_S73_A1.4721.00
152_K162_L1.4461.00
32_L36_I1.4441.00
89_S113_Y1.4301.00
104_L120_V1.4221.00
102_F154_L1.4171.00
154_L165_I1.3871.00
82_Q157_R1.3651.00
162_L166_E1.3591.00
98_S123_H1.3571.00
181_L189_I1.3461.00
61_S89_S1.3421.00
66_S100_G1.3401.00
114_A118_S1.3391.00
164_V167_R1.3291.00
179_E182_E1.2831.00
145_L179_E1.2651.00
59_E89_S1.2631.00
52_A85_K1.2331.00
148_D162_L1.2311.00
32_L40_V1.2261.00
36_I40_V1.2251.00
134_T170_D1.2011.00
15_E18_Y1.1961.00
153_V157_R1.1941.00
90_T107_G1.1801.00
82_Q156_E1.1761.00
109_K159_G1.1751.00
48_L84_I1.1690.99
101_A169_T1.1500.99
19_D22_S1.1500.99
178_E181_L1.1440.99
72_T95_M1.1200.99
45_V76_A1.1130.99
41_A77_I1.0860.99
121_M174_F1.0700.99
114_A181_L1.0650.99
139_A174_F1.0560.99
137_E144_L1.0550.99
127_G143_I1.0370.99
18_Y26_K1.0310.99
124_Q170_D1.0310.99
151_N162_L1.0260.99
126_L169_T1.0180.99
23_R27_D1.0130.99
81_M88_V1.0120.99
105_A185_L0.9910.98
89_S111_K0.9650.98
32_L44_I0.9620.98
101_A122_I0.9610.98
95_M119_E0.9540.98
136_I140_A0.9380.98
33_G42_N0.9130.97
44_I77_I0.9030.97
62_L81_M0.8970.97
158_T165_I0.8920.97
133_A140_A0.8880.97
155_A162_L0.8870.97
92_C104_L0.8720.96
164_V168_D0.8630.96
134_T137_E0.8610.96
71_I99_M0.8590.96
33_G40_V0.8580.96
75_M99_M0.8550.96
133_A143_I0.8510.96
106_A157_R0.8500.96
177_A186_I0.8460.96
82_Q106_A0.8450.95
84_I88_V0.8410.95
78_Y153_V0.8350.95
71_I150_L0.8340.95
141_K145_L0.8230.95
98_S121_M0.8200.95
122_I169_T0.8160.95
167_R170_D0.8130.94
22_S25_L0.8130.94
178_E191_T0.8100.94
52_A56_P0.8090.94
37_D73_A0.8020.94
44_I62_L0.7990.94
71_I146_L0.7950.94
151_N165_I0.7920.94
145_L149_K0.7920.94
40_V62_L0.7900.94
69_G123_H0.7880.93
81_M106_A0.7850.93
96_A101_A0.7840.93
109_K157_R0.7830.93
57_E85_K0.7780.93
26_K50_F0.7750.93
75_M153_V0.7660.92
145_L176_S0.7640.92
40_V43_S0.7640.92
91_I113_Y0.7620.92
139_A142_R0.7600.92
111_K188_K0.7560.92
57_E86_P0.7550.92
142_R146_L0.7540.92
163_E166_E0.7510.92
102_F153_V0.7510.92
67_P97_A0.7510.92
177_A189_I0.7460.91
120_V186_I0.7450.91
142_R145_L0.7440.91
17_A22_S0.7370.91
17_A21_Y0.7320.91
108_E111_K0.7290.91
163_E167_R0.7240.90
78_Y106_A0.7230.90
164_V183_Y0.7230.90
129_A136_I0.7200.90
166_E170_D0.7160.90
30_I44_I0.7140.90
178_E189_I0.7130.90
139_A172_D0.7120.89
30_I48_L0.7100.89
71_I125_P0.7050.89
71_I98_S0.7030.89
119_E145_L0.7000.89
43_S47_Q0.6980.89
50_F54_E0.6950.88
39_N43_S0.6940.88
86_P108_E0.6860.88
36_I100_G0.6850.88
14_G17_A0.6840.88
95_M174_F0.6810.87
173_N185_L0.6790.87
164_V173_N0.6770.87
143_I146_L0.6760.87
69_G98_S0.6750.87
136_I143_I0.6730.87
95_M142_R0.6700.86
188_K191_T0.6700.86
158_T185_L0.6660.86
160_Q183_Y0.6640.86
18_Y22_S0.6640.86
113_Y190_L0.6640.86
119_E176_S0.6630.86
135_E171_R0.6590.86
17_A25_L0.6560.85
102_F157_R0.6540.85
160_Q168_D0.6490.85
126_L132_Q0.6420.84
25_L50_F0.6410.84
102_F105_A0.6400.84
114_A177_A0.6330.83
110_G187_D0.6330.83
119_E146_L0.6300.83
161_P167_R0.6250.82
22_S47_Q0.6250.82
89_S188_K0.6240.82
15_E25_L0.6220.82
34_S37_D0.6210.82
13_R16_R0.6180.82
163_E182_E0.6170.82
129_A143_I0.6170.82
36_I77_I0.6170.82
142_R174_F0.6170.82
29_I33_G0.6140.81
48_L62_L0.6140.81
21_Y43_S0.6100.81
74_G123_H0.6100.81
20_I23_R0.6080.81
24_L29_I0.6070.81
138_I142_R0.6040.80
168_D173_N0.6030.80
97_A174_F0.6030.80
78_Y103_L0.6020.80
133_A144_L0.6010.80
122_I185_L0.5990.80
15_E20_I0.5980.80
27_D53_A0.5960.79
99_M126_L0.5940.79
75_M146_L0.5940.79
147_R151_N0.5900.79
45_V93_I0.5900.79
74_G98_S0.5860.78
165_I183_Y0.5860.78
82_Q108_E0.5840.78
72_T146_L0.5830.78
149_K152_K0.5830.78
36_I126_L0.5790.77
99_M123_H0.5710.76
34_S38_D0.5670.76
18_Y25_L0.5570.75
121_M172_D0.5570.75
90_T112_R0.5560.75
132_Q135_E0.5550.74
80_T84_I0.5520.74
36_I103_L0.5510.74
158_T183_Y0.5480.73
104_L187_D0.5470.73
67_P98_S0.5460.73
34_S39_N0.5460.73
138_I171_R0.5420.73
105_A158_T0.5410.73
119_E125_P0.5340.72
28_R59_E0.5340.72
72_T75_M0.5320.71
52_A91_I0.5310.71
25_L47_Q0.5280.71
119_E139_A0.5270.71
14_G18_Y0.5240.70
35_A40_V0.5240.70
102_F150_L0.5200.70
13_R17_A0.5200.70
15_E22_S0.5180.69
86_P89_S0.5180.69
154_L168_D0.5180.69
160_Q165_I0.5180.69
146_L149_K0.5170.69
29_I63_Y0.5170.69
68_G123_H0.5170.69
79_D117_N0.5150.69
141_K148_D0.5130.69
12_N15_E0.5120.68
104_L112_R0.5120.68
84_I108_E0.5110.68
34_S42_N0.5110.68
122_I173_N0.5100.68
152_K155_A0.5080.68
21_Y42_N0.5080.68
132_Q170_D0.5080.68
79_D112_R0.5080.68
122_I154_L0.5070.68
124_Q147_R0.5050.67
98_S172_D0.5030.67
30_I157_R0.5030.67
38_D72_T0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tg6A 4 0.9492 100 0.277 Contact Map
1y7oA 5 0.8985 100 0.333 Contact Map
4gm2A 3 0.8731 100 0.362 Contact Map
2cbyA 3 0.8629 100 0.412 Contact Map
1yg6A 4 0.9797 100 0.431 Contact Map
3p2lA 4 0.9695 100 0.435 Contact Map
3qwdA 5 0.9695 100 0.443 Contact Map
2f6iA 5 0.9137 100 0.455 Contact Map
4u0gA 4 0.9949 100 0.456 Contact Map
4jcqA 5 0.8629 100 0.48 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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