GREMLIN Database
AHPC - Alkyl hydroperoxide reductase subunit C
UniProt: P80239 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (147)
Sequences: 9044 (5118)
Seq/√Len: 422.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_W127_P3.0941.00
12_E23_D3.0051.00
64_L153_K2.9701.00
42_D79_H2.8311.00
8_V108_F2.6081.00
12_E25_T2.5191.00
58_Y62_K2.4061.00
126_D132_Q2.3281.00
32_Q67_E2.3081.00
55_Q93_T2.2251.00
112_D119_D2.1921.00
14_K23_D2.1081.00
7_E130_V2.1011.00
3_L6_K1.9401.00
57_Q60_A1.9201.00
18_N22_I1.8321.00
10_P27_E1.8281.00
103_T107_N1.7871.00
73_T102_Q1.7841.00
58_Y93_T1.7441.00
25_T28_D1.7151.00
73_T105_S1.7111.00
13_A104_I1.6821.00
13_A97_I1.6761.00
57_Q145_A1.6531.00
66_V152_V1.6491.00
133_T151_K1.6431.00
43_F90_S1.5831.00
24_V29_L1.5591.00
19_G83_H1.5261.00
10_P25_T1.4981.00
126_D130_V1.4931.00
62_K67_E1.4721.00
43_F81_G1.4291.00
14_K76_H1.4291.00
55_Q94_Y1.4261.00
105_S118_A1.4201.00
60_A63_E1.4031.00
73_T118_A1.3511.00
102_Q106_R1.3501.00
80_K84_D1.3491.00
59_A63_E1.3251.00
51_L92_I1.3231.00
70_S96_M1.2681.00
30_K34_S1.2641.00
49_T142_G1.2491.00
135_E151_K1.2431.00
52_E56_E1.2391.00
35_V124_I1.2361.00
29_L34_S1.2111.00
34_S69_Y1.2081.00
57_Q146_S1.1971.00
18_N95_A1.1961.00
59_A62_K1.1931.00
2_S131_I1.1801.00
33_W66_V1.1721.00
147_N150_N1.1681.00
38_F71_V1.1661.00
29_L69_Y1.1481.00
102_Q111_L1.1351.00
106_R111_L1.1271.00
43_F85_S1.1201.00
146_S150_N1.0921.00
34_S67_E1.0841.00
85_S90_S1.0841.00
110_V123_F1.0831.00
110_V121_G1.0691.00
52_E55_Q1.0561.00
132_Q138_A1.0531.00
151_K154_A1.0511.00
77_F81_G1.0361.00
37_C51_L1.0291.00
125_I131_I1.0291.00
60_A149_V1.0231.00
104_I108_F1.0221.00
67_E95_A0.9921.00
35_V122_T0.9861.00
4_I133_T0.9851.00
37_C94_Y0.9851.00
53_D57_Q0.9811.00
60_A153_K0.9761.00
75_T78_V0.9701.00
33_W132_Q0.9621.00
76_H98_G0.9551.00
80_K83_H0.9521.00
124_I151_K0.9501.00
26_N34_S0.9471.00
65_G127_P0.9451.00
102_Q105_S0.9401.00
35_V66_V0.9361.00
8_V131_I0.9281.00
30_K129_G0.9231.00
150_N153_K0.9211.00
7_E30_K0.9111.00
124_I135_E0.9091.00
81_G84_D0.9061.00
123_F131_I0.9051.00
43_F78_V0.9011.00
149_V153_K0.8951.00
61_L149_V0.8931.00
11_F108_F0.8881.00
143_R146_S0.8851.00
14_K100_P0.8771.00
8_V125_I0.8771.00
4_I134_V0.8621.00
10_P26_N0.8611.00
20_E80_K0.8511.00
55_Q58_Y0.8411.00
54_L148_L0.8381.00
71_V104_I0.8381.00
34_S129_G0.8331.00
39_Y42_D0.8321.00
150_N154_A0.8171.00
54_L68_V0.8121.00
11_F104_I0.8081.00
50_E54_L0.8081.00
75_T100_P0.8081.00
27_E30_K0.8061.00
53_D56_E0.8051.00
49_T52_E0.8021.00
140_G143_R0.8011.00
24_V69_Y0.8011.00
36_F108_F0.8001.00
105_S111_L0.7881.00
121_G136_I0.7861.00
8_V26_N0.7821.00
18_N21_F0.7751.00
103_T106_R0.7741.00
132_Q155_A0.7691.00
60_A64_L0.7671.00
135_E148_L0.7651.00
33_W152_V0.7571.00
52_E90_S0.7501.00
34_S125_I0.7461.00
64_L149_V0.7401.00
35_V148_L0.7341.00
51_L70_S0.7281.00
36_F125_I0.7271.00
133_T147_N0.7261.00
41_A74_D0.7171.00
18_N24_V0.7161.00
4_I131_I0.7131.00
64_L152_V0.7131.00
122_T148_L0.7091.00
57_Q61_L0.7081.00
8_V104_I0.7071.00
69_Y97_I0.7051.00
119_D137_N0.7031.00
36_F71_V0.7021.00
112_D115_T0.7001.00
119_D138_A0.6981.00
31_G127_P0.6951.00
33_W65_G0.6931.00
143_R147_N0.6891.00
40_P44_S0.6891.00
41_A117_L0.6881.00
9_L107_N0.6861.00
10_P30_K0.6821.00
124_I133_T0.6751.00
29_L67_E0.6731.00
59_A93_T0.6640.99
131_I134_V0.6600.99
54_L145_A0.6500.99
114_E117_L0.6480.99
37_C70_S0.6460.99
39_Y70_S0.6440.99
51_L94_Y0.6420.99
58_Y68_V0.6360.99
42_D78_V0.6260.99
57_Q149_V0.6150.99
113_E116_G0.6130.99
77_F80_K0.6040.99
121_G134_V0.6020.99
134_V137_N0.6000.99
53_D145_A0.5990.99
44_S120_R0.5940.99
20_E83_H0.5850.99
19_G95_A0.5850.99
2_S6_K0.5750.99
3_L134_V0.5700.98
121_G137_N0.5690.98
76_H80_K0.5690.98
41_A75_T0.5670.98
38_F108_F0.5640.98
141_I154_A0.5620.98
8_V34_S0.5580.98
119_D139_G0.5580.98
62_K93_T0.5560.98
58_Y67_E0.5550.98
104_I107_N0.5530.98
45_F48_P0.5520.98
26_N29_L0.5520.98
37_C50_E0.5510.98
53_D146_S0.5510.98
38_F110_V0.5500.98
135_E147_N0.5500.98
73_T111_L0.5490.98
39_Y82_W0.5450.98
141_I155_A0.5430.98
11_F125_I0.5420.98
69_Y95_A0.5410.98
40_P120_R0.5410.98
35_V152_V0.5400.98
21_F80_K0.5370.98
66_V148_L0.5340.98
61_L66_V0.5340.98
97_I104_I0.5330.98
40_P82_W0.5300.98
39_Y79_H0.5280.97
78_V81_G0.5240.97
46_V141_I0.5220.97
138_A142_G0.5200.97
6_K131_I0.5170.97
6_K134_V0.5090.97
37_C79_H0.5070.97
122_T144_D0.5060.97
117_L139_G0.5060.97
82_W120_R0.5050.97
49_T141_I0.5010.97
68_V94_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v2gA 2 0.9733 100 0.275 Contact Map
3a2vA 5 0.9733 100 0.275 Contact Map
3w6gA 6 0.9679 100 0.282 Contact Map
1prxA 2 0.9733 100 0.284 Contact Map
1xccA 2 0.9733 100 0.286 Contact Map
3tjjA 3 0.8663 100 0.388 Contact Map
2c0dA 2 0.8877 100 0.397 Contact Map
2pn8A 4 0.9893 100 0.403 Contact Map
4rqxA 3 0.8663 100 0.408 Contact Map
3zl5A 3 0.8556 100 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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