GREMLIN Database
GS26 - General stress protein 26
UniProt: P80238 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (134)
Sequences: 161 (128)
Seq/√Len: 11.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_G120_I4.9551.00
22_L64_V4.8211.00
63_N85_K3.1280.96
42_L80_V3.0910.95
64_V86_A2.6030.89
10_V42_L2.3130.82
20_G37_F2.2900.81
26_Q60_N2.2010.79
17_H115_L2.0980.75
96_D110_K2.0460.73
92_A96_D2.0150.72
95_K115_L1.8410.65
32_S68_L1.8300.64
87_K91_S1.7930.62
49_S114_N1.7660.61
49_S76_G1.7400.60
36_T84_G1.7130.59
64_V115_L1.6800.57
43_T119_E1.5990.53
46_T135_P1.5890.53
89_N119_E1.5790.52
56_E85_K1.5430.51
99_W113_P1.5380.50
13_V127_L1.5360.50
101_S104_E1.5320.50
6_I10_V1.5030.49
13_V82_V1.5030.49
89_N114_N1.4740.47
80_V136_V1.4600.47
14_L79_Y1.4380.46
19_V111_D1.4210.45
34_Y107_F1.4110.44
87_K119_E1.4020.44
25_V84_G1.3750.43
6_I71_D1.3730.43
46_T70_Y1.3290.41
40_D97_K1.3120.40
64_V95_K1.3070.39
41_G66_I1.2850.38
27_K123_E1.2700.38
87_K121_E1.2680.38
22_L81_E1.2580.37
25_V103_L1.2510.37
20_G45_Y1.2190.36
28_G125_I1.1950.34
47_P103_L1.1920.34
7_K126_R1.1920.34
50_K96_D1.1910.34
68_L80_V1.1790.34
21_S66_I1.1630.33
109_G112_D1.1470.32
80_V118_L1.1470.32
27_K104_E1.1410.32
58_I116_V1.1310.32
21_S79_Y1.1180.31
84_G116_V1.1120.31
40_D96_D1.1110.31
23_A96_D1.1110.31
37_F44_I1.1090.31
51_E114_N1.1080.31
20_G44_I1.0910.30
36_T46_T1.0740.29
70_Y81_E1.0710.29
57_E116_V1.0680.29
43_T56_E1.0660.29
27_K39_H1.0410.28
55_A84_G1.0400.28
31_H84_G1.0310.28
28_G60_N1.0230.27
34_Y127_L1.0090.27
17_H64_V0.9990.26
108_D123_E0.9990.26
82_V88_I0.9770.26
107_F128_M0.9730.26
106_W115_L0.9690.25
97_K102_K0.9640.25
25_V133_K0.9630.25
56_E134_T0.9520.25
10_V125_I0.9520.25
3_Q8_Q0.9490.25
25_V28_G0.9430.24
34_Y70_Y0.9330.24
65_H128_M0.9320.24
106_W120_I0.9320.24
13_V93_E0.9280.24
87_K104_E0.9110.23
15_D125_I0.9100.23
82_V96_D0.8940.23
74_G77_D0.8860.22
23_A130_A0.8790.22
27_K49_S0.8770.22
94_L104_E0.8680.22
13_V80_V0.8660.22
53_H83_A0.8590.22
126_R129_N0.8560.21
9_K12_D0.8500.21
100_S103_L0.8490.21
26_Q57_E0.8470.21
10_V104_E0.8470.21
34_Y129_N0.8440.21
27_K66_I0.8350.21
37_F46_T0.8300.21
48_T54_K0.8230.20
7_K51_E0.8150.20
50_K56_E0.8110.20
22_L63_N0.8080.20
52_T126_R0.8040.20
13_V90_N0.8040.20
54_K61_N0.8030.20
39_H125_I0.7950.20
73_E128_M0.7930.20
39_H120_I0.7930.20
68_L124_D0.7860.19
50_K90_N0.7660.19
22_L67_L0.7560.18
47_P134_T0.7510.18
14_L42_L0.7440.18
58_I64_V0.7390.18
21_S44_I0.7370.18
6_I136_V0.7340.18
36_T70_Y0.7310.18
77_D95_K0.7300.18
16_H104_E0.7270.18
22_L82_V0.7230.17
98_I117_I0.7170.17
92_A123_E0.7110.17
22_L37_F0.7010.17
19_V46_T0.6970.17
9_K75_F0.6920.17
77_D118_L0.6860.16
15_D111_D0.6800.16
32_S104_E0.6790.16
5_D53_H0.6720.16
57_E107_F0.6700.16
40_D60_N0.6680.16
34_Y131_G0.6650.16
47_P131_G0.6630.16
36_T118_L0.6570.16
11_L119_E0.6570.16
39_H45_Y0.6560.16
47_P126_R0.6560.16
37_F79_Y0.6500.16
90_N104_E0.6490.16
59_E120_I0.6400.15
47_P55_A0.6360.15
98_I107_F0.6340.15
3_Q80_V0.6300.15
68_L114_N0.6260.15
97_K110_K0.6240.15
87_K136_V0.6160.15
77_D129_N0.6120.15
78_A98_I0.6100.15
31_H126_R0.6070.14
20_G46_T0.6070.14
25_V77_D0.6040.14
24_T65_H0.6030.14
55_A82_V0.5970.14
8_Q15_D0.5930.14
53_H56_E0.5890.14
40_D93_E0.5870.14
27_K108_D0.5830.14
47_P106_W0.5830.14
71_D114_N0.5820.14
12_D82_V0.5790.14
14_L78_A0.5790.14
34_Y117_I0.5770.14
34_Y98_I0.5740.14
99_W109_G0.5720.14
12_D137_S0.5690.14
21_S103_L0.5600.13
23_A32_S0.5600.13
37_F81_E0.5570.13
47_P115_L0.5530.13
22_L66_I0.5510.13
12_D114_N0.5490.13
58_I89_N0.5470.13
91_S121_E0.5460.13
50_K113_P0.5460.13
21_S95_K0.5440.13
66_I117_I0.5350.13
20_G119_E0.5310.13
80_V98_I0.5310.13
76_G120_I0.5290.13
10_V116_V0.5280.13
43_T50_K0.5280.13
106_W113_P0.5260.13
25_V120_I0.5250.13
74_G129_N0.5250.13
107_F129_N0.5250.13
93_E117_I0.5240.13
37_F45_Y0.5240.13
18_K100_S0.5220.13
9_K64_V0.5210.13
70_Y77_D0.5190.12
12_D71_D0.5180.12
17_H131_G0.5100.12
68_L71_D0.5070.12
22_L46_T0.5060.12
15_D119_E0.5050.12
95_K110_K0.5030.12
11_L98_I0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ec6A 2 0.9214 99.9 0.63 Contact Map
3db0A 4 0.9071 99.9 0.662 Contact Map
3u35A 4 0.9714 99.9 0.663 Contact Map
2i02A 2 0.9643 99.8 0.665 Contact Map
2hhzA 2 0.9214 99.8 0.674 Contact Map
3ba3A 2 0.9643 99.8 0.677 Contact Map
2re7A 2 0.9071 99.8 0.679 Contact Map
2fhqA 2 0.9357 99.8 0.681 Contact Map
2qeaA 5 0.9571 99.8 0.682 Contact Map
3dmbA 5 0.9786 99.8 0.682 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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