GREMLIN Database
URE3 - Urease subunit gamma
UniProt: P75030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (100)
Sequences: 1011 (330)
Seq/√Len: 33.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K68_D5.1921.00
26_R49_D4.6001.00
47_A84_A3.4101.00
18_E22_Q2.7431.00
14_F18_E2.4951.00
14_F22_Q2.4591.00
17_G41_C2.4290.99
61_R100_S2.3830.99
43_I95_V2.3270.99
46_G56_L2.2240.99
39_I95_V2.0370.98
42_F59_A1.9930.98
53_V57_M1.9520.97
66_E74_P1.8010.96
42_F63_V1.7740.96
15_A18_E1.7210.95
38_Y63_V1.5380.91
21_K41_C1.4930.89
59_A62_H1.4880.89
36_A77_L1.4850.89
8_Q12_L1.4730.89
28_V49_D1.4710.89
18_E21_K1.4610.88
58_E62_H1.4610.88
32_Y36_A1.4520.88
14_F41_C1.4310.87
13_I17_G1.4040.86
6_V10_K1.3090.82
32_Y76_M1.3060.82
17_G38_Y1.2990.81
16_A91_K1.2970.81
21_K42_F1.2810.80
81_Q94_T1.2800.80
21_K38_Y1.2700.80
19_L41_C1.2600.79
51_K59_A1.2330.78
72_G75_E1.2140.77
55_E59_A1.1930.75
59_A63_V1.1750.74
66_E75_E1.1000.69
13_I40_T1.0950.69
53_V96_H1.0920.69
57_M60_G1.0890.68
15_A21_K1.0860.68
51_K55_E1.0410.65
52_G55_E1.0310.64
39_I44_M0.9740.60
10_K85_T0.9710.59
18_E41_C0.9680.59
9_E18_E0.9480.58
46_G49_D0.9410.57
53_V56_L0.9370.57
56_L60_G0.9270.56
4_T55_E0.9250.56
64_L99_I0.9120.55
64_L69_V0.9110.55
85_T90_V0.9080.54
35_A99_I0.8810.52
24_K38_Y0.8770.52
46_G51_K0.8690.51
44_M82_V0.8530.50
79_S94_T0.8400.49
6_V90_V0.8340.48
33_P72_G0.7920.45
17_G21_K0.7910.45
72_G77_L0.7750.43
21_K25_A0.7590.42
71_E87_P0.7570.42
22_Q41_C0.7500.41
21_K65_T0.7490.41
29_L62_H0.7460.41
42_F46_G0.7440.41
85_T91_K0.7440.41
42_F60_G0.7340.40
10_K44_M0.7220.39
9_E79_S0.7190.39
6_V97_Q0.7130.38
38_Y61_R0.7130.38
14_F19_L0.7100.38
24_K67_K0.7060.38
58_E61_R0.6960.37
6_V75_E0.6940.37
5_P14_F0.6890.36
33_P91_K0.6890.36
36_A90_V0.6880.36
35_A39_I0.6870.36
18_E40_T0.6830.36
79_S97_Q0.6820.36
26_R45_E0.6790.36
43_I54_A0.6740.35
72_G91_K0.6730.35
47_A82_V0.6730.35
58_E78_D0.6640.35
44_M84_A0.6640.35
72_G76_M0.6620.34
77_L80_I0.6580.34
68_D91_K0.6560.34
47_A93_V0.6560.34
70_M87_P0.6460.33
36_A40_T0.6450.33
56_L91_K0.6450.33
54_A71_E0.6430.33
88_D91_K0.6400.33
2_K43_I0.6380.33
5_P40_T0.6300.32
2_K73_V0.6210.31
3_L7_E0.6180.31
2_K6_V0.6180.31
71_E74_P0.6110.31
57_M96_H0.6090.30
89_G92_L0.6040.30
48_R88_D0.6030.30
12_L32_Y0.5950.30
88_D96_H0.5930.29
61_R97_Q0.5840.29
23_R31_N0.5810.29
35_A68_D0.5800.28
4_T19_L0.5730.28
25_A38_Y0.5720.28
65_T99_I0.5710.28
69_V83_E0.5680.28
23_R45_E0.5670.28
4_T91_K0.5660.28
29_L97_Q0.5650.27
45_E60_G0.5650.27
17_G22_Q0.5620.27
28_V64_L0.5620.27
29_L65_T0.5570.27
24_K28_V0.5540.27
12_L71_E0.5540.27
66_E94_T0.5520.27
1_M7_E0.5360.26
45_E49_D0.5320.25
45_E88_D0.5320.25
2_K8_Q0.5310.25
13_I18_E0.5290.25
77_L82_V0.5280.25
11_L19_L0.5210.25
38_Y42_F0.5170.24
7_E13_I0.5140.24
74_P99_I0.5120.24
49_D81_Q0.5110.24
12_L90_V0.5080.24
26_R50_G0.5070.24
12_L15_A0.5060.24
28_V51_K0.5030.24
33_P46_G0.5020.24
46_G65_T0.5010.23
35_A76_M0.5000.23
2_K28_V0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gy7A 3 1 100 0.034 Contact Map
2fvhA 2 0.9429 100 0.035 Contact Map
4ac7A 3 0.9524 100 0.042 Contact Map
4furA 3 0.9524 100 0.044 Contact Map
3qgaA 3 1 100 0.046 Contact Map
1e9yA 5 0.9905 100 0.049 Contact Map
1xw8A 2 0.9524 27.8 0.936 Contact Map
2xu2A 4 0.981 19 0.941 Contact Map
4d2uA 3 0.8381 17 0.942 Contact Map
1v6tA 4 0.981 14.9 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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