GREMLIN Database
SP0M - Sporulation-control protein spo0M
UniProt: P71088 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (245)
Sequences: 644 (439)
Seq/√Len: 28.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_I191_L5.4321.00
36_T92_Q5.3281.00
45_A87_P4.9811.00
45_A86_Q3.5021.00
16_A46_Q3.4441.00
63_K68_H3.3841.00
155_N178_V3.3261.00
35_G95_F3.2651.00
23_E34_Q3.2381.00
40_K90_E3.2241.00
28_F31_E3.0611.00
49_R119_D2.9851.00
83_F91_H2.6170.99
106_T112_V2.6050.99
123_G126_K2.4780.99
140_I195_F2.4370.99
246_E250_E2.2190.98
9_A44_I2.2150.98
27_Y31_E2.1460.98
23_E36_T2.1350.98
9_A46_Q2.1090.97
62_V67_E2.0900.97
21_I38_H2.0880.97
9_A16_A2.0080.96
47_D84_T1.9550.96
141_E145_E1.9130.95
3_F7_L1.8620.95
137_H197_L1.8460.94
24_K31_E1.8090.94
39_V85_I1.8060.94
192_E209_D1.7990.93
247_E250_E1.7990.93
162_A172_V1.7910.93
124_I177_F1.7460.92
39_V93_F1.6850.91
103_T157_A1.6830.91
102_D168_R1.6580.90
116_T130_D1.6230.89
10_S46_Q1.6110.89
190_E209_D1.6050.89
207_E229_L1.5950.88
17_K40_K1.5910.88
29_P135_E1.5710.88
189_D221_E1.5600.87
26_A135_E1.5220.86
6_K93_F1.5050.85
103_T134_V1.4750.84
60_V158_D1.4560.83
24_K27_Y1.4520.83
57_T159_C1.4470.83
33_V187_M1.4430.83
234_F238_E1.4430.83
73_T76_S1.4410.83
39_V118_L1.4390.83
20_T114_V1.4330.82
34_Q96_T1.4290.82
4_F149_N1.3730.79
213_R217_G1.3660.79
55_L134_V1.3650.79
114_V171_F1.3630.79
188_L191_L1.3540.78
38_H90_E1.3300.77
240_E247_E1.3230.77
164_Y172_V1.3170.76
55_L99_L1.3130.76
176_E192_E1.3110.76
57_T112_V1.3110.76
172_V194_I1.3070.76
113_A210_R1.3070.76
193_L230_V1.3000.76
60_V67_E1.2990.75
20_T158_D1.2910.75
96_T106_T1.2810.74
147_I193_L1.2660.74
49_R126_K1.2650.74
59_Y159_C1.2590.73
59_Y171_F1.2560.73
51_I71_Y1.2360.72
62_V65_D1.2350.72
42_G120_I1.2290.71
86_Q89_E1.2260.71
82_S91_H1.2130.70
62_V174_E1.2080.70
212_A221_E1.2080.70
119_D217_G1.2040.70
134_V189_D1.1920.69
51_I82_S1.1850.68
85_I91_H1.1700.67
99_L132_I1.1560.66
160_E177_F1.1550.66
63_K66_E1.1510.66
48_I120_I1.1390.65
19_D89_E1.1240.64
202_L227_E1.1180.64
56_S115_V1.1080.63
35_G94_P1.1010.63
16_A39_V1.0970.62
144_L177_F1.0940.62
29_P138_P1.0840.61
144_L157_A1.0820.61
14_G19_D1.0790.61
198_D251_E1.0690.60
221_E226_G1.0620.60
4_F106_T1.0530.59
128_D174_E1.0480.59
227_E234_F1.0480.59
18_V100_P1.0460.59
228_Q231_R1.0450.59
52_D117_D1.0230.57
113_A129_H1.0180.57
212_A215_L1.0170.56
61_I70_K1.0060.56
27_Y99_L0.9910.54
188_L212_A0.9850.54
174_E209_D0.9790.54
193_L206_F0.9780.53
24_K33_V0.9740.53
26_A133_F0.9710.53
159_C170_P0.9640.52
127_S163_P0.9500.51
154_L157_A0.9480.51
77_F105_I0.9480.51
139_W202_L0.9380.50
206_F232_V0.9360.50
16_A42_G0.9330.50
231_R234_F0.9240.49
31_E89_E0.9220.49
159_C171_F0.9210.49
29_P140_I0.9210.49
146_A176_E0.9110.48
40_K47_D0.9090.48
47_D82_S0.9080.48
79_V144_L0.9070.48
48_I145_E0.9060.48
156_E207_E0.9050.48
54_Q73_T0.9030.48
115_V127_S0.9020.48
153_R178_V0.8980.47
100_P171_F0.8970.47
16_A44_I0.8930.47
37_V43_K0.8930.47
62_V66_E0.8870.46
46_Q120_I0.8860.46
223_Y226_G0.8840.46
174_E207_E0.8830.46
166_Q203_E0.8800.46
40_K201_G0.8770.46
55_L169_L0.8720.45
222_M231_R0.8700.45
33_V138_P0.8580.44
59_Y170_P0.8580.44
140_I197_L0.8580.44
180_T193_L0.8550.44
28_F141_E0.8530.44
134_V206_F0.8520.44
38_H92_Q0.8510.44
160_E207_E0.8500.44
103_T114_V0.8500.44
28_F134_V0.8490.44
175_F217_G0.8490.44
34_Q99_L0.8480.44
209_D214_G0.8460.43
144_L196_L0.8400.43
122_G148_E0.8380.43
17_K180_T0.8360.43
110_V159_C0.8360.43
51_I115_V0.8330.42
32_E96_T0.8280.42
45_A92_Q0.8250.42
49_R123_G0.8220.42
214_G217_G0.8170.41
177_F186_Q0.8170.41
52_D78_R0.8130.41
110_V154_L0.8120.41
195_F204_I0.8110.41
45_A78_R0.8040.40
204_I232_V0.8030.40
179_P212_A0.8030.40
7_L206_F0.8010.40
143_V202_L0.7980.40
25_D168_R0.7970.40
164_Y167_R0.7950.40
236_Q239_L0.7910.39
22_L39_V0.7850.39
129_H183_Y0.7830.39
19_D190_E0.7790.38
5_K207_E0.7750.38
189_D226_G0.7720.38
45_A84_T0.7690.38
120_I152_F0.7690.38
19_D130_D0.7640.37
5_K25_D0.7630.37
118_L186_Q0.7620.37
103_T112_V0.7620.37
4_F93_F0.7570.37
16_A53_L0.7570.37
198_D201_G0.7510.36
44_I75_H0.7490.36
189_D211_R0.7460.36
77_F97_F0.7440.36
25_D81_G0.7410.36
57_T177_F0.7390.36
21_I36_T0.7370.35
175_F193_L0.7360.35
43_K87_P0.7350.35
64_D93_F0.7280.35
181_S206_F0.7260.35
107_V147_I0.7220.34
167_R248_V0.7180.34
212_A217_G0.7170.34
29_P137_H0.7140.34
78_R111_E0.7130.34
204_I225_D0.7080.33
70_K191_L0.7080.33
81_G123_G0.7060.33
155_N203_E0.7020.33
44_I120_I0.7020.33
225_D233_R0.6970.33
145_E149_N0.6970.33
46_Q85_I0.6950.33
43_K231_R0.6920.32
27_Y33_V0.6920.32
229_L232_V0.6890.32
164_Y194_I0.6870.32
5_K13_I0.6850.32
79_V162_A0.6850.32
39_V181_S0.6840.32
245_L249_L0.6840.32
158_D172_V0.6810.32
79_V149_N0.6800.32
30_G173_Q0.6800.32
176_E209_D0.6780.31
42_G118_L0.6770.31
113_A136_A0.6750.31
98_T201_G0.6730.31
152_F188_L0.6730.31
189_D210_R0.6730.31
213_R220_E0.6640.30
64_D67_E0.6640.30
113_A197_L0.6630.30
48_I88_G0.6620.30
43_K88_G0.6600.30
51_I79_V0.6590.30
111_E145_E0.6590.30
57_T106_T0.6590.30
74_I152_F0.6580.30
120_I222_M0.6580.30
3_F112_V0.6570.30
154_L175_F0.6560.30
112_V155_N0.6550.30
58_R129_H0.6540.30
59_Y164_Y0.6500.30
4_F22_L0.6490.29
157_A204_I0.6480.29
33_V155_N0.6480.29
99_L106_T0.6450.29
213_R216_R0.6420.29
20_T53_L0.6410.29
163_P167_R0.6390.29
95_F204_I0.6350.29
191_L196_L0.6350.29
32_E132_I0.6300.28
245_L248_V0.6290.28
48_I200_D0.6280.28
83_F89_E0.6260.28
43_K133_F0.6230.28
220_E224_N0.6230.28
112_V177_F0.6220.28
191_L249_L0.6210.28
240_E252_I0.6200.28
214_G218_W0.6200.28
171_F203_E0.6190.28
59_Y72_A0.6190.28
80_T85_I0.6190.28
144_L183_Y0.6180.28
164_Y205_I0.6170.27
93_F97_F0.6160.27
155_N190_E0.6160.27
65_D96_T0.6130.27
85_I111_E0.6100.27
208_V211_R0.6100.27
222_M226_G0.6090.27
239_L251_E0.6070.27
5_K43_K0.6060.27
229_L234_F0.6050.27
16_A112_V0.6050.27
53_L114_V0.6020.27
76_S150_L0.6000.26
46_Q112_V0.5980.26
207_E220_E0.5970.26
181_S240_E0.5970.26
179_P188_L0.5960.26
19_D37_V0.5950.26
3_F162_A0.5930.26
93_F248_V0.5920.26
73_T143_V0.5920.26
97_F136_A0.5850.26
105_I202_L0.5830.25
18_V97_F0.5770.25
28_F249_L0.5770.25
138_P229_L0.5760.25
102_D196_L0.5680.25
220_E223_Y0.5660.24
3_F170_P0.5660.24
27_Y114_V0.5650.24
13_I209_D0.5650.24
114_V136_A0.5650.24
17_K142_N0.5650.24
18_V125_D0.5630.24
101_L199_E0.5620.24
115_V249_L0.5620.24
8_A58_R0.5580.24
11_A101_L0.5550.24
106_T207_E0.5550.24
34_Q120_I0.5530.24
137_H140_I0.5520.24
239_L249_L0.5520.24
35_G195_F0.5520.24
25_D247_E0.5510.24
37_V189_D0.5510.24
26_A141_E0.5500.24
35_G77_F0.5500.24
226_G231_R0.5500.24
189_D230_V0.5500.24
57_T113_A0.5490.24
61_I164_Y0.5480.23
11_A142_N0.5470.23
53_L155_N0.5460.23
112_V159_C0.5450.23
39_V187_M0.5440.23
48_I225_D0.5400.23
53_L199_E0.5400.23
6_K214_G0.5370.23
102_D204_I0.5370.23
53_L95_F0.5320.23
29_P101_L0.5290.22
61_I65_D0.5280.22
73_T87_P0.5280.22
158_D192_E0.5260.22
101_L204_I0.5250.22
122_G186_Q0.5250.22
119_D152_F0.5230.22
235_S240_E0.5220.22
9_A69_R0.5210.22
166_Q179_P0.5210.22
248_V252_I0.5200.22
53_L132_I0.5180.22
112_V141_E0.5170.22
124_I138_P0.5170.22
161_Q200_D0.5160.22
13_I188_L0.5140.22
203_E231_R0.5140.22
75_H217_G0.5120.22
34_Q64_D0.5120.22
148_E251_E0.5110.21
51_I163_P0.5110.21
185_R195_F0.5110.21
41_G136_A0.5100.21
22_L144_L0.5100.21
144_L175_F0.5100.21
54_Q252_I0.5080.21
15_A120_I0.5080.21
188_L226_G0.5080.21
63_K191_L0.5070.21
59_Y172_V0.5060.21
45_A82_S0.5050.21
43_K181_S0.5030.21
46_Q126_K0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r7xA 1 0.5078 99.3 0.836 Contact Map
4ll1A 2 0.8101 99.1 0.848 Contact Map
4geiA 1 0.4767 98.7 0.869 Contact Map
2fauA 1 0.8333 98.5 0.879 Contact Map
4r7vA 1 0.5078 98.2 0.887 Contact Map
1sujA 1 0.8682 96.6 0.916 Contact Map
1g4mA 1 0.8682 96.2 0.92 Contact Map
3uguA 1 0.845 96.1 0.92 Contact Map
2r51A 2 0.5194 95.3 0.925 Contact Map
4zwjA 1 0.5039 91.5 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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