GREMLIN Database
GSAB - Glutamate-1-semialdehyde 2,1-aminomutase 2
UniProt: P71084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (375)
Sequences: 20890 (12678)
Seq/√Len: 654.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_K82_E4.3591.00
226_N230_H3.8851.00
390_R422_D3.8321.00
45_Y53_K3.5161.00
332_M414_K3.1871.00
186_I224_Q3.0651.00
40_K47_W3.0531.00
100_M315_E3.0131.00
249_Y255_L2.8411.00
332_M410_E2.8231.00
321_G324_E2.7821.00
325_K329_L2.6491.00
409_T412_D2.5891.00
72_H319_E2.5871.00
343_T421_E2.5091.00
75_E79_K2.4991.00
100_M318_K2.3901.00
57_Y416_T2.3581.00
312_A315_E2.3091.00
72_H316_V2.2931.00
45_Y412_D2.2651.00
224_Q227_E2.2651.00
39_E49_V2.2201.00
336_G417_L2.2141.00
227_E231_N2.1901.00
70_H316_V2.1581.00
386_L426_H2.1181.00
390_R426_H2.1111.00
47_W53_K2.0901.00
72_H312_A2.0891.00
328_H410_E2.0671.00
386_L389_E2.0641.00
336_G414_K2.0341.00
100_M311_I2.0321.00
190_K231_N2.0011.00
136_K199_E1.9391.00
74_T78_K1.9161.00
415_D419_A1.9101.00
334_E338_L1.9021.00
97_F310_G1.9011.00
344_H421_E1.8631.00
110_K282_Q1.8521.00
331_A335_E1.8391.00
392_I419_A1.8151.00
386_L390_R1.8031.00
52_N391_G1.8021.00
48_D52_N1.7971.00
109_D282_Q1.7711.00
282_Q286_E1.7691.00
316_V320_K1.7631.00
92_K96_T1.7321.00
39_E83_N1.7301.00
204_L237_I1.7271.00
45_Y415_D1.7241.00
334_E352_R1.7181.00
336_G339_K1.7041.00
190_K194_E1.6731.00
189_Y225_V1.6601.00
348_I362_S1.6421.00
344_H425_K1.6361.00
99_K103_E1.6351.00
114_V276_G1.6141.00
77_I309_S1.6031.00
121_V264_A1.5921.00
273_L306_S1.5831.00
77_I81_A1.5771.00
104_A318_K1.5721.00
42_S71_P1.5621.00
96_T311_I1.5531.00
100_M103_E1.5511.00
187_D191_A1.5471.00
386_L423_A1.5351.00
334_E357_L1.5341.00
205_V225_V1.5271.00
249_Y327_D1.5041.00
329_L332_M1.5031.00
44_A412_D1.4961.00
203_V229_T1.4951.00
270_G275_I1.4931.00
238_Y253_Q1.4761.00
265_L277_A1.4711.00
193_L234_A1.4671.00
220_G223_E1.4631.00
79_K83_N1.4591.00
138_I200_I1.4541.00
53_K415_D1.4531.00
329_L413_I1.4481.00
131_Y284_I1.4241.00
190_K224_Q1.4181.00
265_L279_G1.4181.00
44_A407_A1.4131.00
421_E425_K1.4061.00
340_H421_E1.3971.00
249_Y254_D1.3911.00
123_T278_Y1.3881.00
226_N229_T1.3831.00
71_P75_E1.3821.00
325_K328_H1.3811.00
105_I279_G1.3811.00
137_I202_A1.3751.00
226_N236_V1.3741.00
387_M394_L1.3541.00
98_A113_F1.3531.00
111_V279_G1.3461.00
311_I315_E1.3451.00
191_A195_K1.3381.00
329_L410_E1.3371.00
250_G254_D1.3341.00
102_K111_V1.3291.00
324_E328_H1.3271.00
194_E232_A1.3251.00
312_A316_V1.3221.00
131_Y287_Q1.3141.00
390_R423_A1.3131.00
125_I137_I1.3121.00
336_G418_T1.3111.00
255_L353_L1.3111.00
140_F221_F1.3091.00
275_I307_I1.3051.00
136_K179_I1.2971.00
42_S69_A1.2951.00
332_M336_G1.2921.00
103_E318_K1.2861.00
48_D54_Y1.2841.00
75_E78_K1.2741.00
408_H413_I1.2681.00
178_V181_V1.2671.00
205_V222_L1.2651.00
340_H417_L1.2641.00
336_G421_E1.2601.00
124_T264_A1.2581.00
338_L341_A1.2481.00
262_L280_G1.2421.00
253_Q263_T1.2411.00
259_K281_K1.2411.00
121_V204_L1.2381.00
96_T315_E1.2361.00
128_A237_I1.2331.00
69_A74_T1.2301.00
182_P188_S1.2201.00
70_H320_K1.2171.00
110_K286_E1.2151.00
40_K83_N1.2121.00
187_D190_K1.2101.00
38_M46_F1.2061.00
203_V225_V1.2051.00
66_T316_V1.2051.00
76_A312_A1.2051.00
315_E319_E1.2031.00
74_T82_E1.2021.00
269_I275_I1.1921.00
74_T81_A1.1851.00
412_D415_D1.1831.00
220_G256_L1.1781.00
256_L353_L1.1731.00
114_V278_Y1.1681.00
173_S177_E1.1681.00
327_D331_A1.1611.00
223_E227_E1.1611.00
275_I310_G1.1561.00
190_K228_L1.1541.00
77_I305_A1.1531.00
418_T422_D1.1361.00
182_P185_D1.1331.00
235_L284_I1.1261.00
154_A204_L1.1221.00
113_F307_I1.1211.00
338_L342_E1.1171.00
184_N218_K1.1171.00
223_E257_Q1.1031.00
269_I277_A1.0931.00
390_R419_A1.0921.00
387_M419_A1.0911.00
251_G265_L1.0901.00
78_K81_A1.0881.00
186_I228_L1.0851.00
37_A49_V1.0821.00
387_M423_A1.0801.00
262_L278_Y1.0771.00
238_Y258_V1.0751.00
39_E92_K1.0731.00
44_A55_I1.0651.00
316_V319_E1.0651.00
173_S176_N1.0611.00
415_D418_T1.0591.00
392_I416_T1.0561.00
45_Y55_I1.0411.00
410_E414_K1.0351.00
42_S53_K1.0271.00
72_H315_E1.0261.00
335_E339_K1.0251.00
414_K418_T1.0211.00
188_S191_A1.0081.00
120_A264_A1.0041.00
134_R233_G1.0031.00
39_E47_W0.9981.00
108_M279_G0.9931.00
39_E51_G0.9931.00
190_K227_E0.9911.00
229_T234_A0.9901.00
118_T151_V0.9871.00
42_S47_W0.9851.00
385_K389_E0.9841.00
387_M392_I0.9841.00
127_V278_Y0.9801.00
271_G313_C0.9731.00
97_F311_I0.9711.00
219_E223_E0.9661.00
227_E230_H0.9641.00
100_M104_A0.9611.00
382_T386_L0.9611.00
248_M254_D0.9571.00
104_A250_G0.9561.00
135_T199_E0.9531.00
202_A237_I0.9501.00
125_I154_A0.9471.00
190_K232_A0.9431.00
324_E327_D0.9391.00
75_E82_E0.9391.00
216_E353_L0.9281.00
245_F317_L0.9281.00
197_G232_A0.9221.00
72_H75_E0.9211.00
411_Q414_K0.9181.00
222_L256_L0.9181.00
55_I412_D0.9181.00
207_P238_Y0.9171.00
341_A347_T0.9171.00
348_I360_Y0.9161.00
140_F217_P0.9151.00
141_A182_P0.9141.00
65_I268_I0.9071.00
66_T313_C0.9071.00
323_Y326_L0.9021.00
37_A95_V0.9021.00
317_L323_Y0.9021.00
192_A195_K0.9001.00
220_G224_Q0.8981.00
127_V280_G0.8971.00
339_K343_T0.8961.00
181_V192_A0.8941.00
79_K308_L0.8881.00
124_T237_I0.8841.00
308_L312_A0.8841.00
107_A263_T0.8841.00
325_K410_E0.8811.00
330_G334_E0.8811.00
139_K204_L0.8801.00
172_K175_A0.8791.00
73_I309_S0.8771.00
193_L200_I0.8771.00
225_V236_V0.8761.00
317_L322_V0.8751.00
131_Y235_L0.8711.00
104_A314_L0.8691.00
335_E338_L0.8681.00
66_T73_I0.8651.00
55_I415_D0.8641.00
136_K194_E0.8601.00
79_K82_E0.8551.00
255_L327_D0.8461.00
44_A409_T0.8451.00
230_H259_K0.8391.00
228_L232_A0.8381.00
96_T100_M0.8351.00
49_V92_K0.8351.00
128_A202_A0.8341.00
57_Y408_H0.8321.00
136_K200_I0.8321.00
64_I271_G0.8311.00
136_K196_W0.8311.00
93_H308_L0.8281.00
250_G323_Y0.8251.00
84_G87_Y0.8241.00
118_T148_S0.8241.00
243_T356_A0.8221.00
349_T360_Y0.8181.00
323_Y327_D0.8171.00
339_K421_E0.8151.00
322_V326_L0.8121.00
381_S385_K0.8051.00
72_H76_A0.8031.00
343_T425_K0.8021.00
208_I353_L0.8021.00
355_G408_H0.7941.00
128_A235_L0.7901.00
408_H416_T0.7891.00
106_P253_Q0.7861.00
332_M335_E0.7861.00
422_D426_H0.7771.00
93_H311_I0.7761.00
102_K108_M0.7731.00
101_L279_G0.7721.00
273_L305_A0.7711.00
229_T236_V0.7681.00
130_A295_Y0.7681.00
84_G88_G0.7681.00
55_I416_T0.7661.00
133_G199_E0.7651.00
253_Q258_V0.7631.00
336_G413_I0.7631.00
181_V185_D0.7631.00
177_E180_T0.7621.00
188_S192_A0.7571.00
356_A403_F0.7571.00
402_W420_V0.7551.00
251_G263_T0.7551.00
111_V277_A0.7541.00
351_N360_Y0.7531.00
224_Q228_L0.7521.00
174_I188_S0.7511.00
328_H332_M0.7491.00
350_V357_L0.7481.00
233_G283_E0.7481.00
245_F314_L0.7481.00
192_A196_W0.7481.00
196_W199_E0.7471.00
207_P222_L0.7441.00
91_T94_E0.7421.00
245_F265_L0.7391.00
43_G407_A0.7391.00
329_L355_G0.7371.00
328_H331_A0.7341.00
340_H344_H0.7331.00
172_K176_N0.7321.00
226_N258_V0.7291.00
97_F307_I0.7291.00
193_L228_L0.7281.00
90_P95_V0.7251.00
250_G318_K0.7221.00
283_E286_E0.7221.00
203_V234_A0.7211.00
76_A309_S0.7201.00
200_I234_A0.7201.00
383_F420_V0.7201.00
339_K342_E0.7191.00
93_H307_I0.7171.00
205_V236_V0.7131.00
245_F250_G0.7121.00
223_E256_L0.7121.00
128_A262_L0.7121.00
384_F396_P0.7101.00
382_T385_K0.7101.00
361_F383_F0.7091.00
62_G403_F0.7081.00
247_F255_L0.7081.00
172_K178_V0.7081.00
114_V120_A0.7071.00
352_R357_L0.7051.00
93_H96_T0.7051.00
174_I177_E0.7051.00
210_G242_I0.7031.00
55_I392_I0.7031.00
253_Q260_P0.7021.00
57_Y392_I0.7021.00
289_A295_Y0.7011.00
124_T262_L0.7001.00
73_I271_G0.6991.00
298_G301_A0.6991.00
95_V99_K0.6971.00
183_F217_P0.6941.00
125_I204_L0.6921.00
94_E98_A0.6881.00
44_A405_T0.6851.00
179_I348_I0.6811.00
121_V151_V0.6801.00
208_I247_F0.6801.00
127_V288_V0.6781.00
93_H97_F0.6761.00
411_Q415_D0.6751.00
115_N119_E0.6701.00
326_L330_G0.6681.00
265_L269_I0.6661.00
189_Y203_V0.6661.00
281_K284_I0.6661.00
116_S119_E0.6641.00
81_A305_A0.6621.00
344_H424_F0.6581.00
361_F424_F0.6581.00
245_F269_I0.6571.00
236_V258_V0.6551.00
383_F423_A0.6551.00
59_A403_F0.6551.00
38_M41_A0.6541.00
216_E352_R0.6541.00
416_T419_A0.6531.00
100_M314_L0.6531.00
219_E256_L0.6531.00
332_M413_I0.6531.00
126_R296_Q0.6511.00
46_F393_N0.6491.00
80_A83_N0.6461.00
37_A90_P0.6461.00
387_M420_V0.6441.00
325_K409_T0.6421.00
83_N92_K0.6421.00
127_V262_L0.6411.00
105_I263_T0.6411.00
346_I362_S0.6401.00
52_N389_E0.6371.00
230_H236_V0.6361.00
80_A93_H0.6351.00
331_A334_E0.6351.00
38_M84_G0.6351.00
241_V264_A0.6341.00
104_A251_G0.6341.00
59_A405_T0.6331.00
44_A408_H0.6331.00
330_G352_R0.6321.00
237_I262_L0.6311.00
284_I287_Q0.6311.00
108_M263_T0.6311.00
392_I415_D0.6301.00
385_K388_L0.6291.00
408_H412_D0.6291.00
58_L395_A0.6291.00
185_D188_S0.6291.00
76_A79_K0.6291.00
85_V273_L0.6291.00
350_V359_V0.6241.00
219_E353_L0.6211.00
209_V215_V0.6211.00
131_Y283_E0.6201.00
83_N93_H0.6191.00
53_K419_A0.6161.00
228_L231_N0.6161.00
419_A423_A0.6161.00
69_A81_A0.6151.00
280_G285_M0.6141.00
222_L238_Y0.6141.00
266_G276_G0.6141.00
191_A194_E0.6131.00
106_P254_D0.6091.00
193_L232_A0.6091.00
186_I190_K0.6081.00
326_L406_T0.6071.00
66_T322_V0.6061.00
58_L393_N0.6061.00
217_P220_G0.6051.00
380_F396_P0.6051.00
175_A178_V0.6041.00
179_I192_A0.6021.00
139_K180_T0.6011.00
41_A46_F0.6011.00
105_I251_G0.6011.00
333_L417_L0.6011.00
209_V212_F0.6001.00
117_G241_V0.5981.00
329_L408_H0.5961.00
326_L355_G0.5951.00
383_F387_M0.5951.00
402_W416_T0.5941.00
123_T296_Q0.5941.00
129_R149_D0.5931.00
84_G89_T0.5931.00
417_L421_E0.5921.00
107_A253_Q0.5921.00
359_V420_V0.5911.00
104_A249_Y0.5911.00
362_S365_K0.5911.00
76_A315_E0.5901.00
138_I192_A0.5891.00
173_S178_V0.5891.00
210_G356_A0.5881.00
86_L89_T0.5881.00
71_P82_E0.5881.00
138_I189_Y0.5871.00
336_G340_H0.5851.00
333_L413_I0.5831.00
107_A259_K0.5831.00
65_I406_T0.5831.00
134_R199_E0.5821.00
134_R234_A0.5811.00
176_N179_I0.5781.00
419_A422_D0.5781.00
125_I150_L0.5781.00
96_T99_K0.5771.00
189_Y224_Q0.5771.00
207_P243_T0.5761.00
333_L357_L0.5761.00
144_Y147_H0.5761.00
102_K109_D0.5761.00
379_T382_T0.5751.00
361_F379_T0.5741.00
423_A426_H0.5721.00
194_E231_N0.5701.00
309_S312_A0.5701.00
329_L409_T0.5691.00
347_T424_F0.5681.00
178_V185_D0.5661.00
327_D330_G0.5611.00
81_A309_S0.5601.00
341_A350_V0.5591.00
97_F113_F0.5581.00
154_A178_V0.5571.00
262_L284_I0.5571.00
42_S45_Y0.5571.00
187_D224_Q0.5561.00
97_F275_I0.5551.00
230_H283_E0.5551.00
351_N358_T0.5551.00
223_E226_N0.5541.00
186_I189_Y0.5511.00
140_F205_V0.5501.00
181_V188_S0.5471.00
286_E289_A0.5451.00
360_Y400_E0.5431.00
378_E382_T0.5421.00
245_F251_G0.5411.00
420_V424_F0.5411.00
181_V184_N0.5411.00
189_Y228_L0.5401.00
36_V39_E0.5391.00
37_A92_K0.5391.00
194_E199_E0.5381.00
55_I408_H0.5381.00
332_M417_L0.5381.00
65_I317_L0.5381.00
392_I423_A0.5351.00
208_I356_A0.5351.00
142_G212_F0.5341.00
172_K181_V0.5331.00
320_K325_K0.5320.99
250_G317_L0.5320.99
114_V119_E0.5320.99
413_I417_L0.5310.99
340_H418_T0.5300.99
359_V402_W0.5290.99
79_K312_A0.5290.99
73_I313_C0.5280.99
384_F388_L0.5270.99
414_K417_L0.5260.99
77_I273_L0.5250.99
158_G162_L0.5230.99
39_E42_S0.5220.99
416_T420_V0.5170.99
132_T201_A0.5170.99
263_T279_G0.5150.99
217_P222_L0.5150.99
395_A398_K0.5140.99
260_P263_T0.5130.99
346_I379_T0.5110.99
303_N306_S0.5110.99
105_I265_L0.5110.99
186_I225_V0.5100.99
378_E381_S0.5100.99
395_A399_Y0.5090.99
314_L318_K0.5080.99
235_L262_L0.5080.99
347_T359_V0.5070.99
205_V238_Y0.5060.99
413_I416_T0.5060.99
193_L196_W0.5060.99
40_K53_K0.5050.99
341_A424_F0.5040.99
242_I356_A0.5030.99
73_I312_A0.5030.99
223_E258_V0.5030.99
219_E257_Q0.5010.99
388_L393_N0.5010.99
110_K285_M0.5000.99
225_V234_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2epjA 2 0.972 100 0.359 Contact Map
4e77A 2 0.9441 100 0.382 Contact Map
2ykyA 4 0.951 100 0.392 Contact Map
4atqA 7 0.9534 100 0.392 Contact Map
4ao9A 2 0.9487 100 0.395 Contact Map
4a0gA 2 0.9627 100 0.4 Contact Map
4uoxA 3 0.951 100 0.404 Contact Map
3oksA 2 0.9487 100 0.407 Contact Map
4ffcA 4 0.951 100 0.409 Contact Map
4e3qA 3 0.9767 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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