YGAD - BACSU - GREMLIN Contacts

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YGAD - Putative multidrug export ATP-binding/permease protein YgaD

UniProt:	P71082	Sequences: MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVDDIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLFDHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTLDVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFAIEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPLTVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKADQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFYDVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIEAAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSALDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDYESQYKHLFTIQNLN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	580 (558)
Sequences:	52108 (36848)
Seq/√Len:	1559.9

ECOLI - MDLA MSBA CYDC CYDD MDLB YOJI YDDA ARAG PROV POTG
BACSU - YGAD YHEH YKNU YFIC SUNT CYDD YHEI YKNV YWJA BMRA YFIB CYDC YVRA OPUAA OPUCA OPUBA TAGH
HALSA - Q9HSQ7 Q9HMX3 BTUDA Q9HMW0
SULSO - Q97UJ9 Q97VF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
342_E	364_K	4.414	1.00
458_H	468_Y	4.281	1.00
545_K	557_I	4.193	1.00
366_N	369_E	4.187	1.00
369_E	545_K	4.125	1.00
345_N	360_D	4.048	1.00
453_K	458_H	3.965	1.00
433_R	445_L	3.920	1.00
430_E	434_E	3.894	1.00
344_Q	398_R	3.796	1.00
340_G	364_K	3.667	1.00
344_Q	400_L	3.615	1.00
458_H	462_M	3.530	1.00
560_H	570_Y	3.510	1.00
398_R	405_D	3.295	1.00
567_E	571_K	3.153	1.00
433_R	469_E	3.132	1.00
359_H	553_T	3.053	1.00
445_L	449_I	2.991	1.00
356_N	359_H	2.988	1.00
433_R	437_A	2.980	1.00
444_T	447_E	2.860	1.00
343_F	346_V	2.762	1.00
347_S	360_D	2.722	1.00
452_A	468_Y	2.713	1.00
556_E	566_Y	2.678	1.00
342_E	400_L	2.666	1.00
450_E	454_A	2.643	1.00
417_Q	498_P	2.605	1.00
385_V	501_I	2.585	1.00
385_V	533_V	2.530	1.00
559_T	562_E	2.507	1.00
449_I	458_H	2.474	1.00
349_Q	356_N	2.456	1.00
547_V	557_I	2.452	1.00
340_G	366_N	2.439	1.00
347_S	396_S	2.427	1.00
410_E	413_S	2.385	1.00
155_S	159_T	2.370	1.00
347_S	356_N	2.357	1.00
496_N	528_R	2.353	1.00
466_E	470_T	2.305	1.00
433_R	448_I	2.296	1.00
365_V	371_V	2.293	1.00
390_R	393_D	2.240	1.00
436_I	452_A	2.232	1.00
363_L	547_V	2.130	1.00
44_D	279_G	2.128	1.00
550_E	569_Q	2.126	1.00
556_E	568_S	2.116	1.00
522_D	542_H	2.110	1.00
440_K	447_E	2.104	1.00
419_G	497_P	2.093	1.00
340_G	367_R	2.092	1.00
370_T	543_A	2.079	1.00
556_E	567_E	2.062	1.00
449_I	453_K	2.059	1.00
447_E	496_N	1.990	1.00
196_A	233_H	1.975	1.00
393_D	407_R	1.971	1.00
457_A	460_F	1.968	1.00
349_Q	395_T	1.955	1.00
558_G	562_E	1.947	1.00
316_F	320_D	1.940	1.00
14_Y	96_D	1.930	1.00
449_I	462_M	1.922	1.00
514_E	536_R	1.920	1.00
10_F	100_K	1.915	1.00
44_D	277_T	1.903	1.00
12_K	15_K	1.891	1.00
365_V	531_F	1.890	1.00
436_I	448_I	1.877	1.00
62_T	66_I	1.873	1.00
343_F	363_L	1.842	1.00
104_H	323_Y	1.831	1.00
345_N	362_S	1.812	1.00
515_H	519_E	1.796	1.00
550_E	555_I	1.792	1.00
456_N	516_Y	1.775	1.00
371_V	545_K	1.748	1.00
451_A	455_A	1.743	1.00
371_V	547_V	1.738	1.00
555_I	569_Q	1.731	1.00
161_D	270_F	1.731	1.00
384_L	549_M	1.730	1.00
339_G	402_D	1.726	1.00
437_A	448_I	1.723	1.00
445_L	469_E	1.712	1.00
219_I	222_H	1.711	1.00
269_Y	273_N	1.704	1.00
369_E	544_D	1.680	1.00
370_T	532_V	1.680	1.00
547_V	554_I	1.678	1.00
450_E	453_K	1.674	1.00
454_A	523_K	1.670	1.00
437_A	445_L	1.655	1.00
372_A	543_A	1.650	1.00
341_V	531_F	1.628	1.00
443_A	494_L	1.606	1.00
373_L	547_V	1.598	1.00
107_K	323_Y	1.581	1.00
338_R	402_D	1.578	1.00
509_L	517_I	1.552	1.00
447_E	450_E	1.550	1.00
473_G	478_K	1.538	1.00
405_D	408_D	1.531	1.00
562_E	566_Y	1.526	1.00
452_A	461_I	1.524	1.00
63_I	67_M	1.523	1.00
340_G	402_D	1.522	1.00
459_E	462_M	1.521	1.00
158_L	165_T	1.521	1.00
128_D	314_R	1.512	1.00
66_I	70_L	1.510	1.00
569_Q	572_H	1.505	1.00
203_H	230_K	1.502	1.00
472_V	479_L	1.494	1.00
466_E	471_R	1.480	1.00
436_I	494_L	1.471	1.00
449_I	468_Y	1.464	1.00
199_Q	233_H	1.464	1.00
556_E	571_K	1.451	1.00
191_R	313_D	1.434	1.00
376_M	550_E	1.432	1.00
265_A	269_Y	1.429	1.00
192_E	237_K	1.425	1.00
373_L	384_L	1.421	1.00
366_N	545_K	1.413	1.00
358_L	361_V	1.411	1.00
40_K	283_A	1.404	1.00
446_E	449_I	1.403	1.00
346_V	394_V	1.396	1.00
429_S	471_R	1.393	1.00
389_P	420_M	1.389	1.00
343_F	388_I	1.382	1.00
158_L	162_V	1.375	1.00
541_T	561_D	1.371	1.00
104_H	108_L	1.365	1.00
196_A	237_K	1.361	1.00
561_D	565_D	1.361	1.00
348_F	383_T	1.356	1.00
196_A	199_Q	1.354	1.00
452_A	458_H	1.352	1.00
460_F	483_Q	1.345	1.00
348_F	387_L	1.340	1.00
523_K	526_K	1.338	1.00
445_L	448_I	1.331	1.00
360_D	553_T	1.320	1.00
347_S	359_H	1.310	1.00
387_L	399_L	1.305	1.00
339_G	367_R	1.292	1.00
534_A	539_T	1.286	1.00
519_E	523_K	1.283	1.00
59_S	63_I	1.277	1.00
404_T	408_D	1.274	1.00
13_P	96_D	1.268	1.00
454_A	493_F	1.268	1.00
337_I	402_D	1.265	1.00
185_R	188_K	1.259	1.00
348_F	392_Y	1.258	1.00
525_A	530_T	1.257	1.00
177_I	181_Y	1.256	1.00
24_I	78_V	1.256	1.00
270_F	275_P	1.253	1.00
372_A	540_I	1.251	1.00
464_F	470_T	1.248	1.00
569_Q	573_L	1.242	1.00
207_R	223_E	1.240	1.00
446_E	450_E	1.240	1.00
447_E	494_L	1.240	1.00
327_D	410_E	1.237	1.00
277_T	280_T	1.235	1.00
419_G	492_V	1.235	1.00
363_L	384_L	1.232	1.00
437_A	443_A	1.231	1.00
351_E	354_K	1.227	1.00
388_I	531_F	1.225	1.00
344_Q	362_S	1.224	1.00
99_A	103_D	1.221	1.00
376_M	569_Q	1.212	1.00
356_N	395_T	1.205	1.00
199_Q	230_K	1.204	1.00
104_H	319_I	1.194	1.00
340_G	403_G	1.189	1.00
338_R	367_R	1.182	1.00
460_F	464_F	1.167	1.00
36_P	287_Y	1.161	1.00
449_I	452_A	1.160	1.00
223_E	438_I	1.155	1.00
232_G	236_D	1.152	1.00
457_A	461_I	1.151	1.00
33_L	152_I	1.149	1.00
432_I	487_I	1.147	1.00
371_V	531_F	1.146	1.00
367_R	498_P	1.146	1.00
463_S	483_Q	1.144	1.00
462_M	467_G	1.142	1.00
361_V	384_L	1.141	1.00
452_A	457_A	1.139	1.00
171_L	259_A	1.139	1.00
343_F	399_L	1.138	1.00
225_A	229_E	1.137	1.00
37_L	41_Y	1.137	1.00
485_Q	507_S	1.130	1.00
116_T	120_E	1.129	1.00
189_L	240_R	1.128	1.00
394_V	406_I	1.125	1.00
221_D	225_A	1.123	1.00
103_D	107_K	1.120	1.00
96_D	100_K	1.120	1.00
377_S	513_S	1.117	1.00
473_G	476_G	1.116	1.00
157_M	284_F	1.110	1.00
413_S	416_N	1.105	1.00
15_K	19_F	1.104	1.00
101_L	318_F	1.103	1.00
459_E	463_S	1.103	1.00
27_V	78_V	1.102	1.00
560_H	564_M	1.102	1.00
164_L	284_F	1.100	1.00
411_A	415_R	1.096	1.00
455_A	490_A	1.093	1.00
440_K	443_A	1.093	1.00
570_Y	573_L	1.092	1.00
215_R	220_E	1.091	1.00
370_T	530_T	1.089	1.00
546_I	560_H	1.084	1.00
114_A	392_Y	1.083	1.00
104_H	107_K	1.081	1.00
451_A	493_F	1.080	1.00
41_Y	45_D	1.078	1.00
365_V	529_T	1.077	1.00
210_G	426_F	1.077	1.00
266_C	270_F	1.074	1.00
343_F	384_L	1.071	1.00
532_V	543_A	1.070	1.00
120_E	198_A	1.070	1.00
312_M	316_F	1.070	1.00
404_T	409_Y	1.065	1.00
203_H	226_Q	1.063	1.00
456_N	519_E	1.062	1.00
548_V	569_Q	1.061	1.00
223_E	226_Q	1.061	1.00
40_K	44_D	1.061	1.00
17_Q	88_W	1.060	1.00
479_L	487_I	1.059	1.00
88_W	92_K	1.054	1.00
181_Y	185_R	1.053	1.00
444_T	494_L	1.049	1.00
425_T	488_S	1.046	1.00
117_R	120_E	1.045	1.00
456_N	513_S	1.044	1.00
341_V	388_I	1.037	1.00
235_L	239_I	1.036	1.00
387_L	394_V	1.036	1.00
401_I	414_L	1.031	1.00
399_L	406_I	1.027	1.00
345_N	396_S	1.022	1.00
229_E	233_H	1.020	1.00
268_G	272_I	1.017	1.00
421_V	492_V	1.015	1.00
192_E	196_A	1.007	1.00
21_T	86_A	1.007	1.00
516_Y	519_E	1.005	1.00
240_R	243_N	1.003	1.00
450_E	496_N	1.002	1.00
222_H	226_Q	0.999	1.00
356_N	396_S	0.997	1.00
151_L	155_S	0.996	1.00
9_Q	12_K	0.994	1.00
350_Y	357_I	0.993	1.00
456_N	523_K	0.991	1.00
95_Y	99_A	0.991	1.00
227_F	231_N	0.990	1.00
434_E	437_A	0.984	1.00
456_N	520_A	0.983	1.00
162_V	166_L	0.983	1.00
163_K	275_P	0.982	1.00
512_E	516_Y	0.979	1.00
534_A	540_I	0.977	1.00
166_L	170_V	0.975	1.00
226_Q	230_K	0.972	1.00
40_K	280_T	0.970	1.00
24_I	81_Y	0.970	1.00
448_I	468_Y	0.969	1.00
500_L	528_R	0.967	1.00
390_R	411_A	0.964	1.00
38_L	64_M	0.962	1.00
191_R	195_Q	0.961	1.00
443_A	447_E	0.959	1.00
562_E	565_D	0.959	1.00
379_G	549_M	0.957	1.00
219_I	223_E	0.957	1.00
131_Q	311_S	0.954	1.00
114_A	386_S	0.953	1.00
63_I	66_I	0.952	1.00
344_Q	364_K	0.947	1.00
228_N	232_G	0.946	1.00
328_K	331_A	0.945	1.00
360_D	396_S	0.944	1.00
160_L	280_T	0.944	1.00
398_R	407_R	0.942	1.00
433_R	449_I	0.940	1.00
309_I	313_D	0.939	1.00
342_E	403_G	0.939	1.00
112_F	116_T	0.938	1.00
178_S	251_V	0.937	1.00
413_S	417_Q	0.935	1.00
267_A	281_M	0.934	1.00
451_A	494_L	0.933	1.00
498_P	528_R	0.933	1.00
568_S	571_K	0.932	1.00
461_I	468_Y	0.932	1.00
222_H	225_A	0.931	1.00
19_F	23_L	0.929	1.00
361_V	554_I	0.927	1.00
185_R	244_W	0.927	1.00
233_H	237_K	0.925	1.00
454_A	524_L	0.925	1.00
24_I	85_F	0.924	1.00
453_K	462_M	0.922	1.00
111_R	324_E	0.915	1.00
214_I	223_E	0.915	1.00
346_V	387_L	0.911	1.00
232_G	235_L	0.908	1.00
369_E	557_I	0.906	1.00
109_S	324_E	0.904	1.00
14_Y	92_K	0.904	1.00
189_L	237_K	0.903	1.00
370_T	522_D	0.903	1.00
342_E	362_S	0.900	1.00
101_L	125_V	0.899	1.00
167_I	266_C	0.897	1.00
193_R	238_A	0.895	1.00
492_V	500_L	0.894	1.00
16_K	20_V	0.894	1.00
176_G	180_K	0.894	1.00
224_Q	228_N	0.892	1.00
349_Q	357_I	0.891	1.00
372_A	546_I	0.889	1.00
230_K	233_H	0.887	1.00
372_A	534_A	0.885	1.00
466_E	469_E	0.885	1.00
389_P	418_V	0.882	1.00
394_V	407_R	0.876	1.00
409_Y	414_L	0.876	1.00
412_R	416_N	0.875	1.00
163_K	270_F	0.874	1.00
549_M	554_I	0.874	1.00
157_M	165_T	0.874	1.00
370_T	525_A	0.872	1.00
226_Q	229_E	0.871	1.00
351_E	355_E	0.869	1.00
431_T	434_E	0.868	1.00
554_I	557_I	0.868	1.00
377_S	486_R	0.864	1.00
124_R	317_E	0.863	1.00
389_P	501_I	0.863	1.00
472_V	478_K	0.862	1.00
382_S	386_S	0.862	1.00
328_K	408_D	0.859	1.00
70_L	74_L	0.858	1.00
327_D	411_A	0.858	1.00
154_I	165_T	0.857	1.00
185_R	189_L	0.856	1.00
401_I	499_L	0.856	1.00
192_E	240_R	0.855	1.00
111_R	115_N	0.854	1.00
504_E	535_H	0.854	1.00
188_K	192_E	0.852	1.00
473_G	477_V	0.851	1.00
60_L	63_I	0.850	1.00
270_F	273_N	0.848	1.00
448_I	494_L	0.847	1.00
225_A	228_N	0.842	1.00
212_P	386_S	0.841	1.00
221_D	224_Q	0.839	1.00
433_R	468_Y	0.839	1.00
367_R	402_D	0.837	1.00
41_Y	64_M	0.836	1.00
159_T	162_V	0.835	1.00
421_V	489_I	0.834	1.00
400_L	403_G	0.834	1.00
37_L	156_I	0.833	1.00
237_K	240_R	0.833	1.00
418_V	499_L	0.832	1.00
454_A	458_H	0.831	1.00
394_V	399_L	0.830	1.00
108_L	321_E	0.828	1.00
332_I	404_T	0.828	1.00
100_K	104_H	0.824	1.00
31_I	78_V	0.822	1.00
180_K	184_G	0.821	1.00
156_I	160_L	0.821	1.00
462_M	468_Y	0.819	1.00
336_Q	402_D	0.819	1.00
460_F	463_S	0.814	1.00
428_F	435_N	0.811	1.00
14_Y	17_Q	0.809	1.00
349_Q	352_K	0.808	1.00
330_N	334_A	0.806	1.00
239_I	243_N	0.805	1.00
457_A	463_S	0.804	1.00
156_I	159_T	0.804	1.00
213_V	217_F	0.803	1.00
500_L	525_A	0.802	1.00
131_Q	307_Q	0.801	1.00
21_T	89_T	0.800	1.00
334_A	409_Y	0.800	1.00
200_V	234_F	0.799	1.00
128_D	311_S	0.798	1.00
341_V	401_I	0.796	1.00
550_E	553_T	0.795	1.00
416_N	495_K	0.790	1.00
347_S	395_T	0.787	1.00
334_A	337_I	0.786	1.00
45_D	60_L	0.785	1.00
31_I	74_L	0.783	1.00
45_D	48_Q	0.783	1.00
271_V	276_L	0.781	1.00
506_T	517_I	0.780	1.00
37_L	40_K	0.779	1.00
38_L	71_F	0.778	1.00
336_Q	498_P	0.777	1.00
332_I	408_D	0.777	1.00
536_R	539_T	0.776	1.00
427_L	484_K	0.773	1.00
437_A	442_D	0.770	1.00
147_M	151_L	0.769	1.00
514_E	518_Q	0.768	1.00
170_V	173_P	0.768	1.00
427_L	487_I	0.768	1.00
424_D	484_K	0.768	1.00
135_F	308_S	0.767	1.00
486_R	513_S	0.766	1.00
436_I	487_I	0.765	1.00
210_G	213_V	0.764	1.00
104_H	322_P	0.764	1.00
456_N	459_E	0.760	1.00
160_L	283_A	0.759	1.00
77_P	81_Y	0.758	1.00
464_F	479_L	0.757	1.00
455_A	486_R	0.755	1.00
80_Y	84_Y	0.755	1.00
101_L	315_V	0.755	1.00
406_I	414_L	0.755	1.00
325_L	393_D	0.754	1.00
146_D	297_R	0.754	1.00
25_G	145_L	0.754	1.00
158_L	169_I	0.753	1.00
315_V	319_I	0.752	1.00
30_S	34_A	0.752	1.00
409_Y	413_S	0.752	1.00
17_Q	92_K	0.752	1.00
472_V	476_G	0.751	1.00
334_A	413_S	0.748	1.00
153_V	290_R	0.748	1.00
120_E	124_R	0.748	1.00
211_M	215_R	0.747	1.00
38_L	67_M	0.745	1.00
41_Y	44_D	0.744	1.00
8_M	11_V	0.744	1.00
436_I	468_Y	0.743	1.00
163_K	166_L	0.743	1.00
457_A	487_I	0.742	1.00
271_V	281_M	0.740	1.00
233_H	236_D	0.739	1.00
161_D	276_L	0.738	1.00
44_D	48_Q	0.738	1.00
440_K	496_N	0.736	1.00
437_A	441_P	0.735	1.00
481_G	486_R	0.735	1.00
8_M	12_K	0.734	1.00
454_A	520_A	0.733	1.00
236_D	240_R	0.733	1.00
66_I	69_A	0.732	1.00
64_M	67_M	0.732	1.00
152_I	155_S	0.728	1.00
44_D	47_I	0.726	1.00
43_V	282_V	0.725	1.00
100_K	103_D	0.725	1.00
196_A	230_K	0.725	1.00
497_P	528_R	0.725	1.00
60_L	64_M	0.725	1.00
489_I	502_L	0.724	1.00
374_V	548_V	0.723	1.00
440_K	495_K	0.722	1.00
161_D	165_T	0.722	1.00
355_E	359_H	0.721	1.00
254_T	258_L	0.720	1.00
28_K	79_E	0.720	1.00
270_F	274_G	0.720	1.00
414_L	418_V	0.719	1.00
189_L	192_E	0.719	1.00
192_E	195_Q	0.719	1.00
333_K	413_S	0.718	1.00
349_Q	355_E	0.717	1.00
67_M	70_L	0.716	1.00
65_A	69_A	0.715	1.00
94_L	133_K	0.714	1.00
177_I	180_K	0.712	1.00
370_T	542_H	0.711	1.00
100_K	319_I	0.710	1.00
17_Q	85_F	0.709	1.00
566_Y	569_Q	0.709	1.00
62_T	65_A	0.708	1.00
266_C	269_Y	0.708	1.00
121_V	318_F	0.708	1.00
341_V	499_L	0.708	1.00
279_G	283_A	0.707	1.00
518_Q	539_T	0.706	1.00
545_K	559_T	0.706	1.00
359_H	551_N	0.706	1.00
352_K	355_E	0.700	1.00
556_E	563_L	0.700	1.00
339_G	529_T	0.700	1.00
564_M	571_K	0.699	1.00
31_I	71_F	0.698	1.00
184_G	188_K	0.697	1.00
333_K	410_E	0.697	1.00
135_F	305_L	0.696	1.00
58_T	62_T	0.696	1.00
568_S	573_L	0.696	1.00
103_D	224_Q	0.693	1.00
105_I	113_Y	0.693	1.00
394_V	405_D	0.692	1.00
400_L	405_D	0.691	1.00
368_G	527_D	0.691	1.00
432_I	461_I	0.690	1.00
520_A	523_K	0.689	1.00
350_Y	383_T	0.689	1.00
109_S	325_L	0.688	1.00
313_D	317_E	0.687	1.00
452_A	455_A	0.686	1.00
37_L	160_L	0.686	1.00
545_K	562_E	0.685	1.00
23_L	27_V	0.685	1.00
485_Q	508_A	0.685	1.00
450_E	524_L	0.684	1.00
29_F	148_L	0.682	1.00
500_L	530_T	0.680	1.00
331_A	334_A	0.677	1.00
117_R	202_G	0.675	1.00
165_T	284_F	0.675	1.00
394_V	398_R	0.674	1.00
465_P	470_T	0.674	1.00
74_L	78_V	0.674	1.00
447_E	451_A	0.673	1.00
437_A	440_K	0.673	1.00
267_A	271_V	0.672	1.00
368_G	529_T	0.670	1.00
519_E	522_D	0.670	1.00
27_V	74_L	0.669	1.00
59_S	62_T	0.669	1.00
153_V	291_M	0.669	1.00
155_S	158_L	0.669	1.00
429_S	473_G	0.668	1.00
20_V	85_F	0.667	1.00
386_S	392_Y	0.665	1.00
451_A	490_A	0.665	1.00
110_L	114_A	0.663	1.00
9_Q	100_K	0.663	1.00
108_L	323_Y	0.660	1.00
481_G	508_A	0.657	1.00
25_G	82_R	0.655	1.00
377_S	504_E	0.655	1.00
153_V	287_Y	0.654	1.00
242_T	246_A	0.653	1.00
371_V	557_I	0.649	1.00
387_L	392_Y	0.649	1.00
556_E	569_Q	0.649	1.00
308_S	311_S	0.649	1.00
12_K	16_K	0.648	1.00
430_E	471_R	0.648	1.00
198_A	314_R	0.648	1.00
401_I	406_I	0.646	1.00
293_N	297_R	0.646	1.00
561_D	564_M	0.645	1.00
518_Q	534_A	0.643	1.00
143_I	147_M	0.643	1.00
92_K	95_Y	0.640	1.00
514_E	539_T	0.639	1.00
337_I	417_Q	0.635	1.00
16_K	19_F	0.635	1.00
480_S	483_Q	0.634	1.00
540_I	543_A	0.634	1.00
168_S	288_I	0.633	1.00
506_T	514_E	0.632	1.00
101_L	319_I	0.630	1.00
567_E	572_H	0.630	1.00
190_T	241_H	0.629	1.00
517_I	520_A	0.627	1.00
365_V	369_E	0.626	1.00
84_Y	88_W	0.624	1.00
361_V	549_M	0.622	1.00
385_V	531_F	0.622	1.00
332_I	335_D	0.622	1.00
499_L	529_T	0.622	1.00
196_A	234_F	0.622	1.00
163_K	266_C	0.621	1.00
338_R	529_T	0.620	1.00
94_L	98_R	0.618	1.00
97_I	129_V	0.617	1.00
489_I	517_I	0.615	1.00
150_I	154_I	0.614	1.00
556_E	564_M	0.612	1.00
246_A	250_A	0.611	1.00
457_A	468_Y	0.610	1.00
431_T	469_E	0.608	1.00
373_L	531_F	0.607	1.00
501_I	531_F	0.605	1.00
161_D	164_L	0.605	1.00
363_L	554_I	0.604	1.00
429_S	478_K	0.603	1.00
164_L	270_F	0.603	1.00
236_D	239_I	0.603	1.00
112_F	121_V	0.602	1.00
445_L	452_A	0.602	1.00
445_L	468_Y	0.602	1.00
240_R	244_W	0.601	1.00
514_E	538_S	0.600	1.00
189_L	241_H	0.600	1.00
194_S	197_L	0.600	1.00
181_Y	184_G	0.599	1.00
134_D	304_T	0.598	1.00
33_L	36_P	0.598	1.00
358_L	549_M	0.597	1.00
325_L	390_R	0.597	1.00
385_V	420_M	0.597	1.00
104_H	321_E	0.596	1.00
541_T	560_H	0.596	1.00
145_L	149_T	0.596	1.00
346_V	397_G	0.594	1.00
109_S	112_F	0.594	1.00
449_I	461_I	0.593	1.00
28_K	78_V	0.592	1.00
195_Q	199_Q	0.591	1.00
128_D	194_S	0.591	1.00
123_S	201_Q	0.591	1.00
134_D	138_T	0.590	1.00
203_H	223_E	0.590	1.00
101_L	129_V	0.590	1.00
331_A	413_S	0.589	1.00
419_G	495_K	0.589	1.00
182_F	248_T	0.589	1.00
346_V	399_L	0.589	1.00
364_K	557_I	0.587	1.00
124_R	128_D	0.586	1.00
557_I	562_E	0.586	1.00
355_E	551_N	0.585	1.00
556_E	572_H	0.584	1.00
448_I	452_A	0.584	1.00
38_L	41_Y	0.583	1.00
268_G	271_V	0.582	1.00
437_A	452_A	0.582	1.00
560_H	563_L	0.582	1.00
132_T	312_M	0.581	1.00
432_I	472_V	0.581	1.00
276_L	280_T	0.580	1.00
34_A	71_F	0.580	1.00
456_N	517_I	0.580	1.00
511_L	514_E	0.579	1.00
555_I	567_E	0.579	1.00
411_A	414_L	0.579	1.00
159_T	163_K	0.578	1.00
47_I	50_G	0.578	1.00
366_N	371_V	0.578	1.00
349_Q	354_K	0.576	1.00
510_D	513_S	0.574	1.00
566_Y	571_K	0.574	1.00
90_A	137_I	0.574	1.00
203_H	207_R	0.573	1.00
115_N	351_E	0.573	1.00
94_L	129_V	0.573	1.00
519_E	542_H	0.573	1.00
76_P	80_Y	0.573	1.00
95_Y	231_N	0.573	1.00
509_L	513_S	0.572	1.00
19_F	22_V	0.571	1.00
142_N	297_R	0.571	1.00
489_I	493_F	0.571	1.00
258_L	262_I	0.571	1.00
87_Q	91_S	0.571	1.00
548_V	556_E	0.570	1.00
173_P	177_I	0.569	1.00
193_R	241_H	0.569	1.00
276_L	281_M	0.569	1.00
102_F	106_Q	0.568	1.00
40_K	279_G	0.568	1.00
349_Q	396_S	0.568	1.00
269_Y	272_I	0.567	1.00
352_K	356_N	0.567	1.00
422_L	425_T	0.566	1.00
194_S	310_A	0.566	1.00
327_D	331_A	0.565	1.00
67_M	71_F	0.565	1.00
29_F	33_L	0.565	1.00
331_A	410_E	0.564	1.00
328_K	410_E	0.563	1.00
373_L	549_M	0.562	1.00
123_S	198_A	0.562	1.00
13_P	100_K	0.561	1.00
73_I	77_P	0.561	1.00
551_N	555_I	0.560	1.00
87_Q	138_T	0.559	1.00
176_G	179_V	0.558	1.00
129_V	315_V	0.557	1.00
546_I	559_T	0.557	1.00
518_Q	532_V	0.557	1.00
374_V	540_I	0.557	1.00
14_Y	93_V	0.556	1.00
348_F	357_I	0.556	1.00
361_V	547_V	0.556	1.00
421_V	502_L	0.556	1.00
46_I	60_L	0.556	1.00
118_T	122_I	0.555	1.00
502_L	505_A	0.555	1.00
146_D	150_I	0.554	1.00
455_A	493_F	0.554	1.00
267_A	270_F	0.552	1.00
467_G	470_T	0.552	1.00
192_E	233_H	0.552	1.00
32_P	75_R	0.552	1.00
505_A	532_V	0.552	1.00
123_S	197_L	0.552	1.00
346_V	362_S	0.550	1.00
91_S	94_L	0.549	1.00
423_Q	481_G	0.548	1.00
199_Q	202_G	0.547	1.00
174_L	177_I	0.546	1.00
435_N	487_I	0.546	1.00
343_F	361_V	0.545	1.00
347_S	358_L	0.545	1.00
437_A	494_L	0.545	1.00
373_L	533_V	0.545	1.00
386_S	420_M	0.545	1.00
461_I	464_F	0.544	1.00
453_K	459_E	0.544	1.00
130_E	133_K	0.544	1.00
424_D	475_R	0.544	1.00
253_N	296_R	0.543	1.00
311_S	314_R	0.543	1.00
257_D	261_L	0.543	1.00
493_F	520_A	0.542	1.00
229_E	232_G	0.542	1.00
328_K	332_I	0.542	1.00
531_F	547_V	0.540	1.00
48_Q	51_G	0.540	1.00
197_L	201_Q	0.539	1.00
119_G	202_G	0.539	1.00
97_I	132_T	0.538	1.00
329_P	333_K	0.538	1.00
27_V	31_I	0.537	1.00
162_V	165_T	0.536	1.00
330_N	408_D	0.536	1.00
120_E	314_R	0.536	1.00
337_I	367_R	0.536	1.00
401_I	409_Y	0.535	1.00
440_K	494_L	0.534	1.00
366_N	529_T	0.534	1.00
365_V	370_T	0.533	1.00
402_D	498_P	0.533	1.00
518_Q	542_H	0.532	1.00
352_K	395_T	0.531	1.00
382_S	385_V	0.531	1.00
410_E	414_L	0.530	1.00
193_R	197_L	0.530	1.00
199_Q	203_H	0.529	1.00
213_V	216_S	0.529	1.00
123_S	127_N	0.528	1.00
513_S	516_Y	0.528	1.00
14_Y	89_T	0.527	1.00
37_L	283_A	0.527	1.00
506_T	509_L	0.526	1.00
330_N	333_K	0.526	1.00
83_Q	87_Q	0.526	1.00
458_H	461_I	0.526	1.00
81_Y	85_F	0.525	1.00
29_F	32_P	0.525	1.00
189_L	244_W	0.525	1.00
493_F	524_L	0.525	1.00
520_A	524_L	0.524	1.00
455_A	489_I	0.524	1.00
452_A	490_A	0.524	1.00
486_R	509_L	0.522	1.00
84_Y	87_Q	0.522	1.00
234_F	238_A	0.522	1.00
124_R	314_R	0.520	1.00
548_V	555_I	0.520	1.00
34_A	37_L	0.519	1.00
110_L	391_F	0.519	1.00
511_L	538_S	0.518	1.00
178_S	255_I	0.517	1.00
329_P	332_I	0.517	1.00
427_L	472_V	0.517	1.00
106_Q	109_S	0.516	1.00
45_D	49_G	0.515	1.00
35_L	39_L	0.514	1.00
524_L	528_R	0.513	1.00
516_Y	520_A	0.513	1.00
337_I	401_I	0.513	1.00
383_T	392_Y	0.512	1.00
359_H	362_S	0.512	1.00
550_E	572_H	0.512	1.00
174_L	178_S	0.511	1.00
13_P	16_K	0.511	1.00
337_I	340_G	0.511	1.00
356_N	360_D	0.510	1.00
146_D	298_L	0.509	1.00
557_I	566_Y	0.509	1.00
272_I	275_P	0.508	1.00
91_S	95_Y	0.508	1.00
214_I	220_E	0.508	1.00
453_K	468_Y	0.507	1.00
157_M	168_S	0.507	1.00
330_N	410_E	0.507	1.00
207_R	214_I	0.506	1.00
37_L	287_Y	0.506	1.00
156_I	287_Y	0.506	1.00
146_D	149_T	0.506	1.00
149_T	153_V	0.506	1.00
339_G	498_P	0.506	1.00
262_I	266_C	0.505	1.00
482_G	510_D	0.505	1.00
365_V	547_V	0.505	1.00
525_A	528_R	0.505	1.00
532_V	540_I	0.504	1.00
116_T	321_E	0.504	1.00
332_I	336_Q	0.503	1.00
332_I	410_E	0.503	1.00
22_V	25_G	0.503	1.00
377_S	509_L	0.503	1.00
141_M	144_W	0.502	1.00
280_T	283_A	0.501	1.00
388_I	501_I	0.501	1.00
17_Q	20_V	0.500	1.00
522_D	525_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ry2A	2	0.9655	100	0.049	Contact Map
4a82A	2	0.9948	100	0.077	Contact Map
4q4hB	1	0.9845	100	0.118	Contact Map
4f4cA	1	0.9707	100	0.12	Contact Map
3b60A	2	0.9845	100	0.125	Contact Map
3b5xA	2	0.9845	100	0.126	Contact Map
4q4hA	1	0.9845	100	0.13	Contact Map
3zdqA	2	0.9707	100	0.134	Contact Map
4mrsA	2	0.9948	100	0.137	Contact Map
4q9hA	1	0.9966	100	0.143	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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