GREMLIN Database
ADER - Transcriptional activator AdeR
UniProt: P71073 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (360)
Sequences: 5592 (4662)
Seq/√Len: 245.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
283_G295_S7.3631.00
369_A379_L6.2701.00
395_S401_D3.8361.00
358_N361_E3.8031.00
382_I386_T3.6421.00
404_N407_Q3.3491.00
352_D357_S3.0781.00
281_A302_V3.0491.00
376_A387_L2.9171.00
382_I387_L2.8621.00
369_A376_A2.8481.00
361_E365_R2.8381.00
368_E379_L2.7671.00
281_A299_A2.7031.00
406_N416_K2.6931.00
363_L394_I2.6761.00
284_G298_E2.6531.00
242_E300_L2.5991.00
365_R369_A2.5631.00
206_I299_A2.4971.00
384_V388_N2.4661.00
32_A45_I2.4591.00
352_D355_H2.4491.00
395_S402_L2.3131.00
400_I407_Q2.3031.00
208_R307_E2.2881.00
288_S291_F2.2501.00
204_V295_S2.2231.00
207_I280_I2.2051.00
365_R376_A2.2011.00
364_E368_E2.1881.00
362_T376_A2.1511.00
47_D51_K2.1391.00
375_T378_K2.1091.00
349_E418_R2.0491.00
175_K190_G2.0441.00
306_K317_F2.0131.00
29_E33_D2.0101.00
383_H386_T1.9821.00
400_I410_T1.9251.00
244_I296_Y1.9101.00
137_S140_D1.8881.00
318_S321_E1.8671.00
205_M282_F1.8641.00
392_K395_S1.8411.00
117_I125_G1.8301.00
370_D404_N1.8291.00
296_Y300_L1.8281.00
362_T387_L1.8221.00
286_Y298_E1.8221.00
373_V388_N1.7961.00
348_L394_I1.7761.00
392_K396_Q1.7691.00
174_W239_D1.7631.00
408_K412_Y1.7521.00
371_S408_K1.7431.00
35_I147_A1.7371.00
144_L148_A1.7341.00
374_N388_N1.7281.00
362_T394_I1.7221.00
365_R379_L1.6941.00
337_Q417_L1.6881.00
393_R396_Q1.6781.00
362_T390_R1.6751.00
367_I408_K1.6371.00
395_S403_K1.6341.00
409_F412_Y1.6121.00
374_N378_K1.6111.00
172_F191_F1.6101.00
286_Y295_S1.5501.00
394_I398_A1.5341.00
175_K180_H1.5221.00
293_S297_Q1.5211.00
348_L360_V1.5151.00
99_I102_K1.4961.00
369_A375_T1.4941.00
286_Y291_F1.4891.00
398_A407_Q1.4881.00
366_F371_S1.4731.00
208_R242_E1.4681.00
206_I300_L1.4471.00
302_V306_K1.4451.00
204_V299_A1.4411.00
350_Q354_D1.4341.00
204_V283_G1.4221.00
281_A303_L1.4221.00
295_S299_A1.4171.00
154_K157_K1.4131.00
291_F294_R1.4101.00
36_S56_S1.3891.00
344_S347_K1.3791.00
203_S249_P1.3661.00
208_R279_S1.3541.00
375_T379_L1.3531.00
374_N384_V1.3441.00
359_M394_I1.3291.00
365_R380_L1.3281.00
208_R303_L1.3131.00
114_A126_F1.3111.00
393_R397_I1.2991.00
368_E412_Y1.2921.00
283_G286_Y1.2891.00
371_S376_A1.2891.00
282_F318_S1.2851.00
367_I371_S1.2791.00
174_W178_T1.2771.00
385_N388_N1.2621.00
366_F373_V1.2581.00
27_R154_K1.2581.00
323_G326_Q1.2511.00
325_Y406_N1.2501.00
372_N387_L1.2401.00
359_M362_T1.2371.00
202_F292_V1.2361.00
391_L395_S1.2351.00
362_T382_I1.2311.00
284_G320_S1.2251.00
99_I103_Q1.2201.00
349_E360_V1.2151.00
281_A306_K1.2101.00
364_E418_R1.1991.00
346_S350_Q1.1991.00
359_M397_I1.1841.00
79_V82_K1.1781.00
373_V391_L1.1751.00
82_K86_D1.1531.00
164_K167_E1.1511.00
46_E128_W1.1481.00
389_Y393_R1.1451.00
412_Y416_K1.1421.00
372_N384_V1.1351.00
360_V364_E1.1331.00
136_L140_D1.1251.00
118_W123_V1.1241.00
372_N375_T1.1231.00
76_P79_V1.1171.00
96_D99_I1.1151.00
266_Q270_K1.1151.00
227_T230_Q1.1131.00
369_A387_L1.1091.00
35_I39_L1.1081.00
205_M245_I1.1061.00
163_T167_E1.1051.00
112_R128_W1.1001.00
83_L86_D1.0951.00
125_G130_L1.0821.00
236_A245_I1.0821.00
373_V385_N1.0751.00
32_A43_I1.0741.00
406_N409_F1.0681.00
246_L292_V1.0651.00
380_L387_L1.0651.00
203_S285_I1.0591.00
163_T166_E1.0591.00
347_K397_I1.0561.00
203_S320_S1.0541.00
228_T231_V1.0471.00
222_Q226_E1.0381.00
263_L267_K1.0321.00
45_I127_I1.0301.00
391_L394_I1.0271.00
224_L227_T1.0211.00
34_H37_D1.0181.00
148_A152_K1.0061.00
370_D405_V1.0021.00
79_V83_L1.0001.00
343_Y347_K0.9991.00
282_F316_L0.9981.00
172_F190_G0.9861.00
27_R30_D0.9851.00
34_H38_V0.9851.00
191_F198_A0.9831.00
80_I84_W0.9821.00
81_N84_W0.9821.00
360_V415_I0.9811.00
321_E324_I0.9721.00
206_I303_L0.9701.00
57_T61_C0.9681.00
350_Q353_R0.9641.00
264_S267_K0.9601.00
384_V392_K0.9591.00
328_L413_L0.9501.00
299_A302_V0.9481.00
165_N169_S0.9461.00
42_P130_L0.9441.00
354_D357_S0.9441.00
132_I135_T0.9381.00
389_Y396_Q0.9371.00
381_N389_Y0.9351.00
407_Q410_T0.9321.00
188_A191_F0.9301.00
395_S399_E0.9261.00
173_F246_L0.9251.00
281_A298_E0.9231.00
204_V246_L0.9231.00
402_L407_Q0.9201.00
28_L151_V0.9181.00
340_H344_S0.9161.00
325_Y416_K0.9161.00
143_T147_A0.9161.00
286_Y294_R0.9151.00
197_A200_S0.9151.00
145_Q148_A0.9141.00
362_T380_L0.9071.00
365_R368_E0.9051.00
30_D34_H0.8991.00
322_L326_Q0.8961.00
409_F416_K0.8901.00
364_E416_K0.8901.00
144_L147_A0.8891.00
279_S307_E0.8881.00
405_V412_Y0.8871.00
368_E406_N0.8851.00
344_S410_T0.8851.00
298_E339_G0.8821.00
398_A411_I0.8801.00
366_F391_L0.8801.00
326_Q343_Y0.8791.00
409_F413_L0.8781.00
98_P101_V0.8760.99
294_R298_E0.8760.99
363_L367_I0.8740.99
342_N350_Q0.8710.99
204_V296_Y0.8710.99
196_M202_F0.8700.99
43_I129_A0.8700.99
47_D53_L0.8700.99
362_T389_Y0.8680.99
206_I281_A0.8670.99
141_L145_Q0.8640.99
96_D100_R0.8600.99
402_L408_K0.8600.99
324_I413_L0.8590.99
405_V408_K0.8540.99
141_L147_A0.8520.99
83_L88_T0.8500.99
39_L42_P0.8480.99
289_I292_V0.8470.99
117_I151_V0.8440.99
225_Q229_Q0.8420.99
302_V322_L0.8400.99
191_F194_L0.8370.99
210_N279_S0.8370.99
244_I300_L0.8370.99
206_I244_I0.8360.99
43_I127_I0.8360.99
32_A54_A0.8350.99
225_Q228_T0.8300.99
206_I242_E0.8260.99
223_Y226_E0.8260.99
370_D408_K0.8260.99
360_V418_R0.8190.99
32_A36_S0.8150.99
403_K408_K0.8140.99
83_L87_G0.8130.99
41_C140_D0.8110.99
81_N85_K0.8090.99
342_N346_S0.8080.99
372_N388_N0.8040.99
342_N414_D0.8040.99
52_L56_S0.8020.99
94_K97_Q0.8010.99
39_L143_T0.8000.99
110_S114_A0.7930.99
145_Q149_K0.7920.99
40_R43_I0.7900.99
114_A117_I0.7900.99
46_E112_R0.7870.99
78_K87_G0.7850.99
264_S268_Q0.7850.99
36_S42_P0.7840.99
353_R357_S0.7840.99
352_D356_Q0.7830.99
367_I412_Y0.7820.99
95_T100_R0.7810.99
115_I145_Q0.7780.99
203_S283_G0.7760.99
79_V87_G0.7740.99
77_E81_N0.7720.99
327_Y340_H0.7700.99
344_S414_D0.7670.99
42_P46_E0.7670.99
366_F395_S0.7670.99
57_T60_D0.7660.99
320_S343_Y0.7640.99
302_V319_F0.7600.99
401_D404_N0.7580.99
286_Y292_V0.7530.98
319_F326_Q0.7520.98
38_V42_P0.7510.98
114_A128_W0.7500.98
28_L53_L0.7480.98
179_G293_S0.7450.98
174_W237_T0.7450.98
323_G340_H0.7440.98
395_S398_A0.7430.98
349_E352_D0.7430.98
50_H126_F0.7410.98
187_M190_G0.7400.98
381_N386_T0.7400.98
364_E415_I0.7400.98
53_L56_S0.7360.98
206_I296_Y0.7350.98
44_T50_H0.7340.98
45_I117_I0.7320.98
324_I409_F0.7310.98
263_L266_Q0.7300.98
80_I86_D0.7260.98
344_S400_I0.7200.98
384_V412_Y0.7170.98
135_T139_E0.7150.98
108_G113_V0.7140.98
334_K337_Q0.7140.98
36_S44_T0.7130.98
201_E285_I0.7120.98
95_T98_P0.7110.98
41_C129_A0.7100.98
371_S405_V0.7100.98
323_G410_T0.7090.98
342_N347_K0.7080.98
139_E143_T0.7040.98
355_H393_R0.7030.98
80_I83_L0.6950.97
149_K152_K0.6930.97
205_M280_I0.6930.97
167_E171_E0.6920.97
283_G299_A0.6920.97
281_A319_F0.6900.97
373_V383_H0.6900.97
126_F129_A0.6890.97
45_I151_V0.6880.97
219_Q223_Y0.6870.97
112_R117_I0.6850.97
146_M149_K0.6850.97
395_S400_I0.6850.97
115_I119_K0.6840.97
223_Y227_T0.6810.97
267_K271_E0.6810.97
340_H346_S0.6800.97
161_R164_K0.6790.97
56_S59_S0.6780.97
333_E336_K0.6780.97
410_T415_I0.6780.97
340_H414_D0.6770.97
173_F178_T0.6770.97
43_I46_E0.6760.97
44_T52_L0.6760.97
366_F376_A0.6750.97
100_R103_Q0.6730.97
170_Q174_W0.6730.97
284_G343_Y0.6700.97
76_P80_I0.6690.97
280_I316_L0.6680.97
381_N384_V0.6670.97
297_Q301_S0.6660.97
189_D193_K0.6650.97
186_D189_D0.6650.97
50_H55_Y0.6620.97
143_T153_N0.6610.97
359_M390_R0.6610.97
368_E416_K0.6590.96
141_L148_A0.6580.96
126_F130_L0.6580.96
172_F194_L0.6570.96
341_Y417_L0.6560.96
267_K270_K0.6550.96
44_T55_Y0.6540.96
146_M153_N0.6530.96
123_V126_F0.6530.96
42_P56_S0.6520.96
376_A382_I0.6490.96
226_E230_Q0.6470.96
160_I164_K0.6410.96
121_K125_G0.6390.96
352_D360_V0.6380.96
47_D50_H0.6370.96
95_T102_K0.6370.96
324_I410_T0.6350.96
229_Q232_Y0.6340.96
358_N393_R0.6310.95
373_V387_L0.6310.95
198_A289_I0.6300.95
36_S41_C0.6280.95
116_S126_F0.6280.95
274_K277_D0.6280.95
141_L144_L0.6260.95
97_Q101_V0.6250.95
385_N409_F0.6250.95
294_R297_Q0.6240.95
400_I411_I0.6230.95
31_V154_K0.6230.95
223_Y228_T0.6230.95
46_E52_L0.6210.95
79_V86_D0.6190.95
406_N410_T0.6180.95
94_K99_I0.6180.95
339_G342_N0.6160.95
182_H186_D0.6160.95
151_V155_L0.6160.95
112_R116_S0.6160.95
78_K82_K0.6140.95
334_K338_A0.6140.95
328_L409_F0.6120.95
31_V36_S0.6110.95
87_G96_D0.6100.95
159_Q162_K0.6070.94
117_I120_N0.6070.94
106_E109_L0.6060.94
76_P82_K0.6050.94
371_S388_N0.6050.94
52_L55_Y0.6040.94
45_I54_A0.6010.94
338_A342_N0.6010.94
348_L397_I0.6010.94
177_L296_Y0.5990.94
402_L411_I0.5950.94
373_V384_V0.5930.94
35_I43_I0.5910.94
383_H389_Y0.5900.94
43_I112_R0.5880.93
35_I143_T0.5880.93
46_E51_K0.5850.93
42_P54_A0.5840.93
115_I148_A0.5840.93
35_I38_V0.5830.93
283_G302_V0.5830.93
323_G343_Y0.5820.93
298_E319_F0.5820.93
305_T325_Y0.5810.93
413_L416_K0.5810.93
84_W87_G0.5800.93
42_P45_I0.5780.93
296_Y303_L0.5780.93
326_Q336_K0.5760.93
169_S194_L0.5750.93
108_G198_A0.5740.93
222_Q225_Q0.5730.93
109_L398_A0.5730.93
362_T386_T0.5720.93
50_H54_A0.5710.92
115_I144_L0.5710.92
161_R165_N0.5710.92
96_D102_K0.5700.92
52_L58_H0.5690.92
405_V409_F0.5690.92
383_H388_N0.5680.92
102_K107_V0.5680.92
112_R124_L0.5630.92
205_M247_T0.5630.92
146_M176_M0.5630.92
27_R42_P0.5630.92
50_H53_L0.5620.92
164_K168_R0.5620.92
297_Q350_Q0.5620.92
279_S314_K0.5620.92
172_F176_M0.5600.92
117_I127_I0.5590.92
147_A151_V0.5580.92
215_E320_S0.5570.92
167_E170_Q0.5570.92
145_Q153_N0.5560.91
151_V154_K0.5550.91
143_T146_M0.5550.91
50_H60_D0.5540.91
203_S234_L0.5520.91
210_N307_E0.5520.91
341_Y346_S0.5510.91
39_L140_D0.5510.91
150_A153_N0.5500.91
93_L96_D0.5500.91
110_S119_K0.5490.91
377_S387_L0.5490.91
371_S384_V0.5490.91
384_V387_L0.5490.91
200_S248_S0.5480.91
85_K88_T0.5480.91
363_L411_I0.5460.91
331_L334_K0.5450.91
148_A153_N0.5450.91
155_L158_L0.5440.91
213_L216_K0.5410.90
239_D244_I0.5410.90
224_L228_T0.5410.90
152_K156_L0.5400.90
188_A199_P0.5400.90
367_I394_I0.5390.90
127_I322_L0.5380.90
305_T326_Q0.5370.90
301_S332_N0.5350.90
189_D192_H0.5340.90
84_W88_T0.5330.90
305_T309_F0.5330.90
205_M262_A0.5320.90
100_R141_L0.5320.90
266_Q274_K0.5310.89
125_G128_W0.5300.89
46_E50_H0.5300.89
208_R241_N0.5300.89
328_L417_L0.5290.89
156_L159_Q0.5290.89
111_N131_E0.5290.89
171_E408_K0.5280.89
132_I136_L0.5270.89
110_S130_L0.5260.89
142_L385_N0.5260.89
265_T272_R0.5260.89
322_L325_Y0.5250.89
119_K125_G0.5240.89
142_L146_M0.5240.89
28_L32_A0.5230.89
303_L322_L0.5220.89
95_T101_V0.5200.89
340_H343_Y0.5190.88
268_Q271_E0.5180.88
231_V252_D0.5180.88
129_A144_L0.5170.88
27_R43_I0.5170.88
366_F370_D0.5150.88
133_Q140_D0.5150.88
139_E142_L0.5130.88
372_N385_N0.5130.88
176_M187_M0.5130.88
78_K102_K0.5120.88
100_R274_K0.5110.88
118_W145_Q0.5110.88
408_K415_I0.5080.87
287_N291_F0.5080.87
28_L155_L0.5070.87
384_V389_Y0.5070.87
265_T269_L0.5070.87
301_S304_K0.5070.87
382_I390_R0.5060.87
400_I404_N0.5060.87
214_T224_L0.5040.87
302_V317_F0.5040.87
176_M198_A0.5020.87
36_S46_E0.5020.87
112_R115_I0.5010.87
176_M231_V0.5000.87
131_E140_D0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onqA 5 0.5972 100 0.473 Contact Map
2gx5A 2 0.3744 98.5 0.858 Contact Map
4eu0A 1 0.6161 97.3 0.894 Contact Map
2w1rA 2 0.2773 96.6 0.904 Contact Map
3e0yA 2 0.3412 96.4 0.906 Contact Map
3p01A 2 0.346 96.2 0.908 Contact Map
1mc0A 4 0.3697 96 0.909 Contact Map
3vv4A 2 0.3318 95.9 0.91 Contact Map
3ci6A 2 0.3483 95.8 0.91 Contact Map
2lb5A 1 0.3294 95.8 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.