EPSO - BACSU - GREMLIN Contacts

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EPSO - Putative pyruvyl transferase EpsO

UniProt:	P71065	Sequences: MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIMKGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIVQTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHIQLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRRTIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSSLLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	322 (280)
Sequences:	364 (325)
Seq/√Len:	19.4

BACSU - EPSO EPSI GS30

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_Y	82_Q	7.833	1.00
29_Y	47_T	4.215	1.00
46_G	167_A	4.213	1.00
144_E	295_Y	3.942	1.00
86_N	98_R	3.866	1.00
272_H	300_M	3.693	1.00
117_I	151_A	3.623	1.00
182_Q	262_E	3.605	1.00
272_H	282_N	3.598	1.00
43_I	269_L	3.410	1.00
286_D	293_A	3.311	1.00
139_H	161_Q	3.060	0.99
142_T	151_A	2.987	0.99
43_I	83_G	2.986	0.99
47_T	82_Q	2.885	0.99
50_F	166_M	2.816	0.99
141_M	163_L	2.800	0.99
164_P	299_W	2.796	0.99
95_Q	99_E	2.575	0.98
81_C	101_I	2.413	0.96
83_G	269_L	2.356	0.96
282_N	300_M	2.317	0.95
43_I	85_G	2.205	0.94
87_F	95_Q	2.202	0.94
33_P	88_G	2.159	0.93
117_I	147_S	2.068	0.92
188_R	192_E	2.037	0.91
113_L	166_M	2.009	0.90
89_D	120_Q	1.882	0.87
294_N	298_T	1.831	0.86
95_Q	98_R	1.779	0.84
110_I	135_H	1.757	0.83
286_D	290_G	1.708	0.81
51_F	61_R	1.678	0.80
268_R	291_K	1.665	0.80
247_S	272_H	1.643	0.79
144_E	289_Y	1.617	0.77
115_Q	164_P	1.612	0.77
141_M	161_Q	1.600	0.77
37_N	291_K	1.573	0.75
282_N	306_T	1.560	0.75
103_Q	134_K	1.537	0.74
149_A	153_A	1.536	0.74
186_F	258_F	1.527	0.73
51_F	80_V	1.521	0.73
254_A	257_F	1.510	0.72
89_D	95_Q	1.483	0.71
80_V	106_P	1.459	0.70
106_P	135_H	1.450	0.69
88_G	98_R	1.448	0.69
37_N	84_G	1.446	0.69
98_R	295_Y	1.446	0.69
85_G	88_G	1.440	0.69
164_P	192_E	1.439	0.69
47_T	113_L	1.437	0.68
27_I	44_M	1.415	0.67
78_I	108_H	1.414	0.67
95_Q	132_F	1.398	0.66
176_T	259_S	1.397	0.66
140_I	151_A	1.384	0.65
99_E	124_N	1.382	0.65
50_F	83_G	1.380	0.65
31_D	82_Q	1.377	0.65
37_N	268_R	1.376	0.65
284_V	292_N	1.375	0.65
43_I	50_F	1.367	0.64
50_F	54_H	1.359	0.64
144_E	269_L	1.333	0.62
43_I	91_Y	1.325	0.62
148_Y	160_I	1.316	0.61
48_E	61_R	1.303	0.61
151_A	160_I	1.299	0.60
37_N	40_D	1.298	0.60
20_V	27_I	1.297	0.60
271_G	299_W	1.297	0.60
26_E	77_L	1.289	0.60
43_I	287_N	1.272	0.59
34_L	113_L	1.257	0.58
263_S	283_T	1.254	0.58
272_H	280_K	1.254	0.58
35_Y	126_K	1.249	0.57
280_K	305_S	1.242	0.57
47_T	166_M	1.223	0.56
88_G	95_Q	1.216	0.55
36_G	144_E	1.214	0.55
168_H	276_S	1.193	0.54
37_N	188_R	1.184	0.53
132_F	292_N	1.174	0.53
29_Y	113_L	1.172	0.52
168_H	295_Y	1.168	0.52
26_E	57_R	1.165	0.52
101_I	146_A	1.159	0.52
284_V	289_Y	1.157	0.51
98_R	299_W	1.157	0.51
116_S	186_F	1.144	0.51
103_Q	260_R	1.144	0.51
272_H	278_L	1.128	0.50
113_L	151_A	1.126	0.49
86_N	91_Y	1.125	0.49
275_S	282_N	1.125	0.49
49_A	283_T	1.117	0.49
80_V	113_L	1.111	0.49
40_D	85_G	1.109	0.48
227_N	251_V	1.105	0.48
30_A	123_D	1.105	0.48
74_D	77_L	1.103	0.48
29_Y	35_Y	1.101	0.48
88_G	299_W	1.095	0.48
44_M	254_A	1.094	0.47
293_A	308_L	1.090	0.47
91_Y	295_Y	1.073	0.46
85_G	91_Y	1.051	0.45
42_F	167_A	1.051	0.45
46_G	85_G	1.045	0.44
91_Y	98_R	1.042	0.44
32_Y	41_L	1.038	0.44
47_T	289_Y	1.031	0.43
84_G	291_K	1.031	0.43
41_L	250_I	1.030	0.43
40_D	84_G	1.028	0.43
184_L	261_Y	1.027	0.43
33_P	41_L	1.024	0.43
102_V	108_H	1.021	0.43
71_R	116_S	1.021	0.43
18_L	137_N	1.020	0.43
88_G	119_F	1.009	0.42
289_Y	295_Y	1.008	0.42
28_I	60_K	0.999	0.41
31_D	46_G	0.995	0.41
119_F	278_L	0.986	0.41
89_D	135_H	0.976	0.40
33_P	47_T	0.976	0.40
40_D	291_K	0.968	0.40
61_R	267_S	0.966	0.39
153_A	264_V	0.962	0.39
190_D	299_W	0.959	0.39
41_L	247_S	0.958	0.39
50_F	287_N	0.954	0.39
144_E	300_M	0.944	0.38
82_Q	86_N	0.943	0.38
145_K	149_A	0.943	0.38
143_R	270_H	0.938	0.38
177_Q	264_V	0.934	0.37
85_G	269_L	0.934	0.37
86_N	188_R	0.933	0.37
164_P	190_D	0.932	0.37
59_R	73_L	0.927	0.37
46_G	278_L	0.927	0.37
280_K	300_M	0.923	0.37
193_A	267_S	0.921	0.37
155_F	275_S	0.918	0.37
79_I	105_Y	0.917	0.36
148_Y	296_F	0.916	0.36
98_R	110_I	0.915	0.36
91_Y	297_H	0.907	0.36
110_I	118_Y	0.907	0.36
125_L	150_T	0.904	0.36
88_G	115_Q	0.900	0.35
91_Y	173_V	0.897	0.35
53_E	104_T	0.896	0.35
32_Y	247_S	0.893	0.35
42_F	284_V	0.890	0.35
36_G	273_I	0.886	0.35
276_S	303_V	0.883	0.34
41_L	282_N	0.883	0.34
50_F	147_S	0.881	0.34
150_T	154_Y	0.879	0.34
83_G	91_Y	0.877	0.34
39_G	84_G	0.875	0.34
286_D	308_L	0.874	0.34
35_Y	164_P	0.873	0.34
269_L	287_N	0.872	0.34
88_G	164_P	0.867	0.34
184_L	289_Y	0.867	0.34
101_I	110_I	0.863	0.33
157_T	308_L	0.861	0.33
192_E	299_W	0.856	0.33
165_D	270_H	0.856	0.33
95_Q	299_W	0.854	0.33
30_A	81_C	0.853	0.33
131_I	135_H	0.849	0.33
162_L	298_T	0.847	0.32
116_S	258_F	0.846	0.32
166_M	289_Y	0.845	0.32
115_Q	287_N	0.843	0.32
84_G	268_R	0.841	0.32
274_L	278_L	0.839	0.32
52_K	145_K	0.838	0.32
46_G	295_Y	0.832	0.32
43_I	289_Y	0.832	0.32
273_I	302_G	0.829	0.31
22_P	28_I	0.825	0.31
85_G	98_R	0.823	0.31
286_D	289_Y	0.823	0.31
182_Q	280_K	0.823	0.31
188_R	291_K	0.817	0.31
110_I	131_I	0.816	0.31
46_G	163_L	0.816	0.31
46_G	83_G	0.814	0.31
247_S	278_L	0.814	0.31
214_A	306_T	0.812	0.31
78_I	160_I	0.810	0.30
98_R	132_F	0.810	0.30
27_I	80_V	0.809	0.30
28_I	123_D	0.806	0.30
155_F	168_H	0.799	0.30
110_I	263_S	0.799	0.30
25_S	183_K	0.798	0.30
242_I	246_Y	0.796	0.30
153_A	157_T	0.793	0.30
144_E	276_S	0.790	0.29
58_V	161_Q	0.786	0.29
125_L	154_Y	0.784	0.29
87_F	286_D	0.782	0.29
111_V	304_P	0.780	0.29
112_I	140_I	0.777	0.29
152_Q	252_Q	0.768	0.28
189_T	197_L	0.766	0.28
35_Y	299_W	0.764	0.28
39_G	270_H	0.762	0.28
78_I	296_F	0.760	0.28
176_T	191_H	0.758	0.28
109_K	137_N	0.757	0.28
38_V	274_L	0.755	0.28
51_F	102_V	0.752	0.27
33_P	114_P	0.752	0.27
102_V	135_H	0.746	0.27
295_Y	299_W	0.744	0.27
40_D	268_R	0.742	0.27
24_Q	284_V	0.742	0.27
116_S	146_A	0.739	0.27
117_I	273_I	0.738	0.27
40_D	43_I	0.738	0.27
61_R	111_V	0.737	0.27
42_F	46_G	0.736	0.27
113_L	275_S	0.733	0.26
164_P	271_G	0.732	0.26
107_N	130_E	0.731	0.26
91_Y	271_G	0.730	0.26
272_H	299_W	0.730	0.26
210_T	214_A	0.728	0.26
65_D	213_S	0.727	0.26
119_F	170_L	0.724	0.26
116_S	285_I	0.722	0.26
34_L	287_N	0.721	0.26
208_W	229_L	0.721	0.26
119_F	128_T	0.721	0.26
43_I	144_E	0.720	0.26
31_D	286_D	0.717	0.26
117_I	140_I	0.715	0.26
75_P	225_T	0.713	0.25
185_R	267_S	0.712	0.25
159_H	252_Q	0.709	0.25
162_L	299_W	0.708	0.25
116_S	183_K	0.707	0.25
174_I	183_K	0.707	0.25
143_R	165_D	0.706	0.25
131_I	242_I	0.699	0.25
33_P	306_T	0.698	0.25
83_G	287_N	0.697	0.25
164_P	188_R	0.697	0.25
60_K	247_S	0.696	0.25
29_Y	80_V	0.690	0.24
55_G	152_Q	0.688	0.24
52_K	76_N	0.687	0.24
43_I	46_G	0.685	0.24
276_S	282_N	0.681	0.24
91_Y	192_E	0.681	0.24
109_K	139_H	0.678	0.24
53_E	224_Q	0.675	0.24
95_Q	272_H	0.674	0.24
43_I	88_G	0.674	0.24
118_Y	289_Y	0.674	0.24
272_H	295_Y	0.672	0.23
293_A	297_H	0.671	0.23
84_G	270_H	0.671	0.23
81_C	239_I	0.668	0.23
270_H	291_K	0.667	0.23
46_G	169_Q	0.666	0.23
115_Q	299_W	0.662	0.23
114_P	165_D	0.661	0.23
44_M	80_V	0.660	0.23
150_T	275_S	0.659	0.23
252_Q	273_I	0.658	0.23
180_S	301_E	0.656	0.23
303_V	306_T	0.656	0.23
134_K	275_S	0.655	0.23
112_I	310_Q	0.654	0.23
140_I	147_S	0.653	0.23
90_L	288_S	0.651	0.23
40_D	188_R	0.650	0.23
256_R	279_Q	0.649	0.22
152_Q	285_I	0.649	0.22
89_D	164_P	0.647	0.22
50_F	169_Q	0.646	0.22
183_K	263_S	0.643	0.22
152_Q	281_E	0.638	0.22
114_P	190_D	0.637	0.22
27_I	47_T	0.637	0.22
107_N	152_Q	0.635	0.22
184_L	288_S	0.634	0.22
249_Y	306_T	0.633	0.22
113_L	283_T	0.633	0.22
119_F	155_F	0.632	0.22
48_E	172_P	0.631	0.22
269_L	295_Y	0.631	0.22
32_Y	186_F	0.629	0.22
30_A	79_I	0.629	0.22
141_M	309_I	0.627	0.21
85_G	116_S	0.615	0.21
247_S	282_N	0.615	0.21
81_C	98_R	0.614	0.21
185_R	301_E	0.613	0.21
138_L	227_N	0.612	0.21
280_K	284_V	0.612	0.21
39_G	143_R	0.610	0.21
23_K	147_S	0.610	0.21
157_T	160_I	0.610	0.21
43_I	47_T	0.610	0.21
43_I	268_R	0.609	0.21
151_A	200_H	0.606	0.21
214_A	304_P	0.605	0.21
89_D	124_N	0.605	0.21
112_I	138_L	0.605	0.21
99_E	128_T	0.604	0.21
90_L	190_D	0.603	0.20
191_H	279_Q	0.600	0.20
153_A	199_E	0.600	0.20
180_S	280_K	0.600	0.20
33_P	91_Y	0.597	0.20
108_H	135_H	0.597	0.20
101_I	183_K	0.596	0.20
300_M	306_T	0.594	0.20
294_N	297_H	0.592	0.20
179_P	263_S	0.592	0.20
25_S	76_N	0.592	0.20
89_D	115_Q	0.588	0.20
46_G	207_D	0.588	0.20
89_D	99_E	0.584	0.20
140_I	153_A	0.584	0.20
113_L	285_I	0.583	0.20
98_R	190_D	0.583	0.20
85_G	299_W	0.581	0.20
146_A	294_N	0.579	0.19
82_Q	115_Q	0.577	0.19
102_V	311_H	0.577	0.19
225_T	230_N	0.576	0.19
53_E	145_K	0.573	0.19
33_P	82_Q	0.572	0.19
144_E	259_S	0.572	0.19
33_P	44_M	0.570	0.19
254_A	258_F	0.570	0.19
168_H	171_F	0.570	0.19
224_Q	249_Y	0.568	0.19
48_E	208_W	0.567	0.19
273_I	295_Y	0.566	0.19
144_E	264_V	0.565	0.19
40_D	270_H	0.563	0.19
188_R	268_R	0.563	0.19
18_L	49_A	0.561	0.19
31_D	98_R	0.560	0.19
41_L	258_F	0.557	0.19
51_F	246_Y	0.556	0.19
17_L	56_I	0.554	0.19
44_M	95_Q	0.554	0.19
268_R	275_S	0.554	0.19
29_Y	262_E	0.554	0.19
56_I	247_S	0.553	0.18
29_Y	68_P	0.553	0.18
292_N	296_F	0.552	0.18
101_I	230_N	0.552	0.18
45_K	170_L	0.551	0.18
140_I	238_P	0.550	0.18
58_V	119_F	0.549	0.18
44_M	51_F	0.548	0.18
142_T	155_F	0.545	0.18
72_K	123_D	0.542	0.18
147_S	268_R	0.541	0.18
67_F	104_T	0.538	0.18
122_K	173_V	0.537	0.18
146_A	275_S	0.536	0.18
124_N	128_T	0.536	0.18
59_R	141_M	0.535	0.18
262_E	281_E	0.533	0.18
102_V	128_T	0.532	0.18
85_G	287_N	0.532	0.18
273_I	292_N	0.531	0.18
37_N	270_H	0.531	0.18
48_E	51_F	0.529	0.18
39_G	165_D	0.528	0.18
103_Q	136_A	0.528	0.18
282_N	295_Y	0.526	0.17
114_P	192_E	0.524	0.17
140_I	181_N	0.523	0.17
118_Y	144_E	0.522	0.17
126_K	130_E	0.522	0.17
92_P	99_E	0.521	0.17
121_N	210_T	0.518	0.17
43_I	291_K	0.515	0.17
135_H	258_F	0.514	0.17
38_V	251_V	0.514	0.17
176_T	256_R	0.513	0.17
32_Y	128_T	0.512	0.17
198_Q	265_E	0.512	0.17
180_S	281_E	0.512	0.17
254_A	272_H	0.512	0.17
81_C	102_V	0.510	0.17
41_L	271_G	0.510	0.17
115_Q	286_D	0.510	0.17
143_R	291_K	0.510	0.17
137_N	226_L	0.509	0.17
84_G	143_R	0.509	0.17
98_R	115_Q	0.508	0.17
87_F	243_W	0.507	0.17
90_L	181_N	0.505	0.17
290_G	295_Y	0.505	0.17
31_D	229_L	0.503	0.17
164_P	298_T	0.502	0.17
151_A	272_H	0.501	0.17
142_T	299_W	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gt1A	1	0.8758	79.4	0.951	Contact Map
3rhzA	4	0.8137	76.5	0.952	Contact Map
3l7iA	4	0.9193	72.1	0.954	Contact Map
3tovA	1	0.882	57.8	0.958	Contact Map
4w6qA	4	0.8075	44.3	0.961	Contact Map
3vz6A	1	0.3851	40.4	0.962	Contact Map
3aekB	2	0.823	39.1	0.962	Contact Map
3ot5A	2	0.9006	29.7	0.965	Contact Map
2xciA	3	0.8323	25.9	0.966	Contact Map
2x6qA	1	0.9037	22.2	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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