GREMLIN Database
EPSO - Putative pyruvyl transferase EpsO
UniProt: P71065 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (280)
Sequences: 364 (325)
Seq/√Len: 19.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y82_Q7.8331.00
29_Y47_T4.2151.00
46_G167_A4.2131.00
144_E295_Y3.9421.00
86_N98_R3.8661.00
272_H300_M3.6931.00
117_I151_A3.6231.00
182_Q262_E3.6051.00
272_H282_N3.5981.00
43_I269_L3.4101.00
286_D293_A3.3111.00
139_H161_Q3.0600.99
142_T151_A2.9870.99
43_I83_G2.9860.99
47_T82_Q2.8850.99
50_F166_M2.8160.99
141_M163_L2.8000.99
164_P299_W2.7960.99
95_Q99_E2.5750.98
81_C101_I2.4130.96
83_G269_L2.3560.96
282_N300_M2.3170.95
43_I85_G2.2050.94
87_F95_Q2.2020.94
33_P88_G2.1590.93
117_I147_S2.0680.92
188_R192_E2.0370.91
113_L166_M2.0090.90
89_D120_Q1.8820.87
294_N298_T1.8310.86
95_Q98_R1.7790.84
110_I135_H1.7570.83
286_D290_G1.7080.81
51_F61_R1.6780.80
268_R291_K1.6650.80
247_S272_H1.6430.79
144_E289_Y1.6170.77
115_Q164_P1.6120.77
141_M161_Q1.6000.77
37_N291_K1.5730.75
282_N306_T1.5600.75
103_Q134_K1.5370.74
149_A153_A1.5360.74
186_F258_F1.5270.73
51_F80_V1.5210.73
254_A257_F1.5100.72
89_D95_Q1.4830.71
80_V106_P1.4590.70
106_P135_H1.4500.69
88_G98_R1.4480.69
37_N84_G1.4460.69
98_R295_Y1.4460.69
85_G88_G1.4400.69
164_P192_E1.4390.69
47_T113_L1.4370.68
27_I44_M1.4150.67
78_I108_H1.4140.67
95_Q132_F1.3980.66
176_T259_S1.3970.66
140_I151_A1.3840.65
99_E124_N1.3820.65
50_F83_G1.3800.65
31_D82_Q1.3770.65
37_N268_R1.3760.65
284_V292_N1.3750.65
43_I50_F1.3670.64
50_F54_H1.3590.64
144_E269_L1.3330.62
43_I91_Y1.3250.62
148_Y160_I1.3160.61
48_E61_R1.3030.61
151_A160_I1.2990.60
37_N40_D1.2980.60
20_V27_I1.2970.60
271_G299_W1.2970.60
26_E77_L1.2890.60
43_I287_N1.2720.59
34_L113_L1.2570.58
263_S283_T1.2540.58
272_H280_K1.2540.58
35_Y126_K1.2490.57
280_K305_S1.2420.57
47_T166_M1.2230.56
88_G95_Q1.2160.55
36_G144_E1.2140.55
168_H276_S1.1930.54
37_N188_R1.1840.53
132_F292_N1.1740.53
29_Y113_L1.1720.52
168_H295_Y1.1680.52
26_E57_R1.1650.52
101_I146_A1.1590.52
284_V289_Y1.1570.51
98_R299_W1.1570.51
116_S186_F1.1440.51
103_Q260_R1.1440.51
272_H278_L1.1280.50
113_L151_A1.1260.49
86_N91_Y1.1250.49
275_S282_N1.1250.49
49_A283_T1.1170.49
80_V113_L1.1110.49
40_D85_G1.1090.48
227_N251_V1.1050.48
30_A123_D1.1050.48
74_D77_L1.1030.48
29_Y35_Y1.1010.48
88_G299_W1.0950.48
44_M254_A1.0940.47
293_A308_L1.0900.47
91_Y295_Y1.0730.46
85_G91_Y1.0510.45
42_F167_A1.0510.45
46_G85_G1.0450.44
91_Y98_R1.0420.44
32_Y41_L1.0380.44
47_T289_Y1.0310.43
84_G291_K1.0310.43
41_L250_I1.0300.43
40_D84_G1.0280.43
184_L261_Y1.0270.43
33_P41_L1.0240.43
102_V108_H1.0210.43
71_R116_S1.0210.43
18_L137_N1.0200.43
88_G119_F1.0090.42
289_Y295_Y1.0080.42
28_I60_K0.9990.41
31_D46_G0.9950.41
119_F278_L0.9860.41
89_D135_H0.9760.40
33_P47_T0.9760.40
40_D291_K0.9680.40
61_R267_S0.9660.39
153_A264_V0.9620.39
190_D299_W0.9590.39
41_L247_S0.9580.39
50_F287_N0.9540.39
144_E300_M0.9440.38
82_Q86_N0.9430.38
145_K149_A0.9430.38
143_R270_H0.9380.38
177_Q264_V0.9340.37
85_G269_L0.9340.37
86_N188_R0.9330.37
164_P190_D0.9320.37
59_R73_L0.9270.37
46_G278_L0.9270.37
280_K300_M0.9230.37
193_A267_S0.9210.37
155_F275_S0.9180.37
79_I105_Y0.9170.36
148_Y296_F0.9160.36
98_R110_I0.9150.36
91_Y297_H0.9070.36
110_I118_Y0.9070.36
125_L150_T0.9040.36
88_G115_Q0.9000.35
91_Y173_V0.8970.35
53_E104_T0.8960.35
32_Y247_S0.8930.35
42_F284_V0.8900.35
36_G273_I0.8860.35
276_S303_V0.8830.34
41_L282_N0.8830.34
50_F147_S0.8810.34
150_T154_Y0.8790.34
83_G91_Y0.8770.34
39_G84_G0.8750.34
286_D308_L0.8740.34
35_Y164_P0.8730.34
269_L287_N0.8720.34
88_G164_P0.8670.34
184_L289_Y0.8670.34
101_I110_I0.8630.33
157_T308_L0.8610.33
192_E299_W0.8560.33
165_D270_H0.8560.33
95_Q299_W0.8540.33
30_A81_C0.8530.33
131_I135_H0.8490.33
162_L298_T0.8470.32
116_S258_F0.8460.32
166_M289_Y0.8450.32
115_Q287_N0.8430.32
84_G268_R0.8410.32
274_L278_L0.8390.32
52_K145_K0.8380.32
46_G295_Y0.8320.32
43_I289_Y0.8320.32
273_I302_G0.8290.31
22_P28_I0.8250.31
85_G98_R0.8230.31
286_D289_Y0.8230.31
182_Q280_K0.8230.31
188_R291_K0.8170.31
110_I131_I0.8160.31
46_G163_L0.8160.31
46_G83_G0.8140.31
247_S278_L0.8140.31
214_A306_T0.8120.31
78_I160_I0.8100.30
98_R132_F0.8100.30
27_I80_V0.8090.30
28_I123_D0.8060.30
155_F168_H0.7990.30
110_I263_S0.7990.30
25_S183_K0.7980.30
242_I246_Y0.7960.30
153_A157_T0.7930.30
144_E276_S0.7900.29
58_V161_Q0.7860.29
125_L154_Y0.7840.29
87_F286_D0.7820.29
111_V304_P0.7800.29
112_I140_I0.7770.29
152_Q252_Q0.7680.28
189_T197_L0.7660.28
35_Y299_W0.7640.28
39_G270_H0.7620.28
78_I296_F0.7600.28
176_T191_H0.7580.28
109_K137_N0.7570.28
38_V274_L0.7550.28
51_F102_V0.7520.27
33_P114_P0.7520.27
102_V135_H0.7460.27
295_Y299_W0.7440.27
40_D268_R0.7420.27
24_Q284_V0.7420.27
116_S146_A0.7390.27
117_I273_I0.7380.27
40_D43_I0.7380.27
61_R111_V0.7370.27
42_F46_G0.7360.27
113_L275_S0.7330.26
164_P271_G0.7320.26
107_N130_E0.7310.26
91_Y271_G0.7300.26
272_H299_W0.7300.26
210_T214_A0.7280.26
65_D213_S0.7270.26
119_F170_L0.7240.26
116_S285_I0.7220.26
34_L287_N0.7210.26
208_W229_L0.7210.26
119_F128_T0.7210.26
43_I144_E0.7200.26
31_D286_D0.7170.26
117_I140_I0.7150.26
75_P225_T0.7130.25
185_R267_S0.7120.25
159_H252_Q0.7090.25
162_L299_W0.7080.25
116_S183_K0.7070.25
174_I183_K0.7070.25
143_R165_D0.7060.25
131_I242_I0.6990.25
33_P306_T0.6980.25
83_G287_N0.6970.25
164_P188_R0.6970.25
60_K247_S0.6960.25
29_Y80_V0.6900.24
55_G152_Q0.6880.24
52_K76_N0.6870.24
43_I46_G0.6850.24
276_S282_N0.6810.24
91_Y192_E0.6810.24
109_K139_H0.6780.24
53_E224_Q0.6750.24
95_Q272_H0.6740.24
43_I88_G0.6740.24
118_Y289_Y0.6740.24
272_H295_Y0.6720.23
293_A297_H0.6710.23
84_G270_H0.6710.23
81_C239_I0.6680.23
270_H291_K0.6670.23
46_G169_Q0.6660.23
115_Q299_W0.6620.23
114_P165_D0.6610.23
44_M80_V0.6600.23
150_T275_S0.6590.23
252_Q273_I0.6580.23
180_S301_E0.6560.23
303_V306_T0.6560.23
134_K275_S0.6550.23
112_I310_Q0.6540.23
140_I147_S0.6530.23
90_L288_S0.6510.23
40_D188_R0.6500.23
256_R279_Q0.6490.22
152_Q285_I0.6490.22
89_D164_P0.6470.22
50_F169_Q0.6460.22
183_K263_S0.6430.22
152_Q281_E0.6380.22
114_P190_D0.6370.22
27_I47_T0.6370.22
107_N152_Q0.6350.22
184_L288_S0.6340.22
249_Y306_T0.6330.22
113_L283_T0.6330.22
119_F155_F0.6320.22
48_E172_P0.6310.22
269_L295_Y0.6310.22
32_Y186_F0.6290.22
30_A79_I0.6290.22
141_M309_I0.6270.21
85_G116_S0.6150.21
247_S282_N0.6150.21
81_C98_R0.6140.21
185_R301_E0.6130.21
138_L227_N0.6120.21
280_K284_V0.6120.21
39_G143_R0.6100.21
23_K147_S0.6100.21
157_T160_I0.6100.21
43_I47_T0.6100.21
43_I268_R0.6090.21
151_A200_H0.6060.21
214_A304_P0.6050.21
89_D124_N0.6050.21
112_I138_L0.6050.21
99_E128_T0.6040.21
90_L190_D0.6030.20
191_H279_Q0.6000.20
153_A199_E0.6000.20
180_S280_K0.6000.20
33_P91_Y0.5970.20
108_H135_H0.5970.20
101_I183_K0.5960.20
300_M306_T0.5940.20
294_N297_H0.5920.20
179_P263_S0.5920.20
25_S76_N0.5920.20
89_D115_Q0.5880.20
46_G207_D0.5880.20
89_D99_E0.5840.20
140_I153_A0.5840.20
113_L285_I0.5830.20
98_R190_D0.5830.20
85_G299_W0.5810.20
146_A294_N0.5790.19
82_Q115_Q0.5770.19
102_V311_H0.5770.19
225_T230_N0.5760.19
53_E145_K0.5730.19
33_P82_Q0.5720.19
144_E259_S0.5720.19
33_P44_M0.5700.19
254_A258_F0.5700.19
168_H171_F0.5700.19
224_Q249_Y0.5680.19
48_E208_W0.5670.19
273_I295_Y0.5660.19
144_E264_V0.5650.19
40_D270_H0.5630.19
188_R268_R0.5630.19
18_L49_A0.5610.19
31_D98_R0.5600.19
41_L258_F0.5570.19
51_F246_Y0.5560.19
17_L56_I0.5540.19
44_M95_Q0.5540.19
268_R275_S0.5540.19
29_Y262_E0.5540.19
56_I247_S0.5530.18
29_Y68_P0.5530.18
292_N296_F0.5520.18
101_I230_N0.5520.18
45_K170_L0.5510.18
140_I238_P0.5500.18
58_V119_F0.5490.18
44_M51_F0.5480.18
142_T155_F0.5450.18
72_K123_D0.5420.18
147_S268_R0.5410.18
67_F104_T0.5380.18
122_K173_V0.5370.18
146_A275_S0.5360.18
124_N128_T0.5360.18
59_R141_M0.5350.18
262_E281_E0.5330.18
102_V128_T0.5320.18
85_G287_N0.5320.18
273_I292_N0.5310.18
37_N270_H0.5310.18
48_E51_F0.5290.18
39_G165_D0.5280.18
103_Q136_A0.5280.18
282_N295_Y0.5260.17
114_P192_E0.5240.17
140_I181_N0.5230.17
118_Y144_E0.5220.17
126_K130_E0.5220.17
92_P99_E0.5210.17
121_N210_T0.5180.17
43_I291_K0.5150.17
135_H258_F0.5140.17
38_V251_V0.5140.17
176_T256_R0.5130.17
32_Y128_T0.5120.17
198_Q265_E0.5120.17
180_S281_E0.5120.17
254_A272_H0.5120.17
81_C102_V0.5100.17
41_L271_G0.5100.17
115_Q286_D0.5100.17
143_R291_K0.5100.17
137_N226_L0.5090.17
84_G143_R0.5090.17
98_R115_Q0.5080.17
87_F243_W0.5070.17
90_L181_N0.5050.17
290_G295_Y0.5050.17
31_D229_L0.5030.17
164_P298_T0.5020.17
151_A272_H0.5010.17
142_T299_W0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gt1A 1 0.8758 79.4 0.951 Contact Map
3rhzA 4 0.8137 76.5 0.952 Contact Map
3l7iA 4 0.9193 72.1 0.954 Contact Map
3tovA 1 0.882 57.8 0.958 Contact Map
4w6qA 4 0.8075 44.3 0.961 Contact Map
3vz6A 1 0.3851 40.4 0.962 Contact Map
3aekB 2 0.823 39.1 0.962 Contact Map
3ot5A 2 0.9006 29.7 0.965 Contact Map
2xciA 3 0.8323 25.9 0.966 Contact Map
2x6qA 1 0.9037 22.2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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