EPSM - BACSU - GREMLIN Contacts

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EPSM - Putative acetyltransferase EpsM

UniProt:	P71063	Sequences: MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKEWYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKSAVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQEGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	216 (176)
Sequences:	5482 (4410)
Seq/√Len:	332.4

ECOLI - THGA MAA LPXD WCAF CAIE PAAY WCAB YRDA WBBJ
BACSU - EPSM DAPH MAA YTOA CYSE
HALSA - Q9HQ06
SULSO - Q980E1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_G	180_W	3.650	1.00
126_H	144_Y	3.631	1.00
122_R	140_Q	3.113	1.00
106_G	125_A	3.053	1.00
104_V	122_R	3.017	1.00
125_A	143_D	2.958	1.00
124_G	143_D	2.679	1.00
127_C	145_V	2.613	1.00
154_S	167_T	2.574	1.00
143_D	161_E	2.490	1.00
107_E	125_A	2.435	1.00
142_S	161_E	2.392	1.00
114_G	132_G	2.378	1.00
144_Y	162_G	2.372	1.00
135_A	139_N	2.362	1.00
102_S	120_D	2.358	1.00
105_I	109_T	2.264	1.00
165_V	169_A	2.166	1.00
158_S	176_I	2.092	1.00
109_T	127_C	2.087	1.00
140_Q	158_S	2.071	1.00
161_E	179_A	2.037	1.00
160_Q	179_A	1.866	1.00
100_S	103_A	1.858	1.00
76_K	80_E	1.829	1.00
127_C	161_E	1.795	1.00
145_V	163_A	1.779	1.00
27_R	48_G	1.760	1.00
138_D	156_A	1.746	1.00
96_S	114_G	1.743	1.00
100_S	119_A	1.731	1.00
115_A	129_I	1.667	1.00
94_H	113_A	1.662	1.00
132_G	150_R	1.649	1.00
120_D	138_D	1.622	1.00
117_I	121_A	1.608	1.00
91_T	109_T	1.599	1.00
129_I	133_A	1.525	1.00
109_T	125_A	1.447	1.00
145_V	161_E	1.445	1.00
69_V	75_R	1.405	1.00
108_G	126_H	1.392	1.00
109_T	143_D	1.369	1.00
135_A	141_I	1.364	1.00
131_T	149_P	1.339	1.00
118_Q	136_E	1.335	1.00
80_E	84_L	1.307	1.00
99_V	103_A	1.303	1.00
160_Q	176_I	1.299	1.00
142_S	158_S	1.280	1.00
128_I	146_H	1.273	1.00
127_C	143_D	1.267	1.00
111_I	115_A	1.256	1.00
156_A	174_Q	1.255	1.00
78_L	81_R	1.245	1.00
163_A	181_S	1.236	1.00
118_Q	137_H	1.235	1.00
134_V	152_T	1.229	1.00
79_A	126_H	1.227	1.00
20_I	92_L	1.211	1.00
145_V	179_A	1.205	1.00
130_N	146_H	1.197	1.00
141_I	145_V	1.191	1.00
148_S	164_H	1.170	1.00
16_I	28_L	1.168	1.00
139_N	153_L	1.165	1.00
172_I	175_I	1.165	1.00
76_K	162_G	1.160	1.00
159_V	163_A	1.157	1.00
83_G	107_E	1.150	1.00
106_G	109_T	1.125	1.00
54_T	70_G	1.119	1.00
133_A	147_L	1.099	1.00
153_L	159_V	1.088	1.00
109_T	123_I	1.087	1.00
20_I	30_A	1.063	1.00
76_K	161_E	1.052	1.00
166_G	172_I	1.046	1.00
98_I	114_G	1.043	1.00
79_A	83_G	1.042	1.00
98_I	116_I	1.033	1.00
76_K	144_Y	1.033	1.00
167_T	170_S	1.031	1.00
53_V	56_L	1.028	1.00
152_T	168_G	1.014	1.00
14_K	120_D	1.008	1.00
105_I	111_I	0.998	1.00
137_H	155_G	0.997	1.00
14_K	138_D	0.995	1.00
121_A	139_N	0.995	1.00
141_I	147_L	0.993	1.00
152_T	167_T	0.974	1.00
121_A	135_A	0.971	1.00
19_L	41_G	0.959	1.00
77_Q	81_R	0.947	1.00
177_I	181_S	0.945	1.00
6_I	68_A	0.942	1.00
78_L	82_L	0.934	1.00
106_G	124_G	0.915	1.00
165_V	171_V	0.900	1.00
81_R	85_G	0.891	1.00
163_A	179_A	0.891	1.00
82_L	85_G	0.889	1.00
44_E	47_T	0.887	1.00
89_F	126_H	0.878	1.00
159_V	165_V	0.871	1.00
21_N	101_K	0.870	1.00
123_I	127_C	0.869	1.00
147_L	165_V	0.863	1.00
103_A	117_I	0.857	1.00
13_G	31_V	0.857	1.00
63_V	84_L	0.849	1.00
110_V	128_I	0.840	1.00
93_I	110_V	0.840	1.00
93_I	97_A	0.832	1.00
34_D	37_K	0.821	1.00
132_G	152_T	0.819	1.00
111_I	117_I	0.816	1.00
19_L	92_L	0.802	1.00
67_I	79_A	0.800	1.00
112_M	128_I	0.799	1.00
102_S	119_A	0.796	1.00
133_A	151_A	0.794	1.00
127_C	141_I	0.793	1.00
105_I	123_I	0.790	1.00
142_S	160_Q	0.786	1.00
123_I	129_I	0.780	1.00
151_A	169_A	0.779	1.00
94_H	98_I	0.773	1.00
147_L	151_A	0.772	1.00
17_R	28_L	0.772	1.00
172_I	184_G	0.771	1.00
106_G	143_D	0.769	1.00
20_I	32_L	0.768	1.00
145_V	159_V	0.765	1.00
116_I	131_T	0.764	1.00
39_F	42_G	0.762	1.00
160_Q	181_S	0.760	1.00
42_G	45_W	0.758	1.00
15_V	41_G	0.753	1.00
117_I	129_I	0.750	0.99
61_P	70_G	0.749	0.99
163_A	178_G	0.748	0.99
121_A	136_E	0.745	0.99
146_H	164_H	0.744	0.99
74_V	78_L	0.743	0.99
161_E	180_W	0.742	0.99
124_G	161_E	0.742	0.99
141_I	159_V	0.739	0.99
103_A	121_A	0.735	0.99
162_G	179_A	0.734	0.99
118_Q	134_V	0.728	0.99
149_P	167_T	0.726	0.99
45_W	50_P	0.722	0.99
108_G	125_A	0.722	0.99
154_S	173_P	0.719	0.99
142_S	179_A	0.718	0.99
153_L	157_V	0.718	0.99
73_S	77_Q	0.716	0.99
98_I	113_A	0.711	0.99
9_D	31_V	0.708	0.99
148_S	154_S	0.707	0.99
74_V	77_Q	0.699	0.99
115_A	133_A	0.697	0.99
150_R	168_G	0.696	0.99
145_V	160_Q	0.695	0.99
80_E	83_G	0.694	0.99
12_H	15_V	0.691	0.99
81_R	84_L	0.691	0.99
79_A	144_Y	0.690	0.99
24_S	28_L	0.685	0.99
35_K	38_T	0.681	0.99
124_G	140_Q	0.674	0.99
82_L	87_D	0.670	0.99
66_L	110_V	0.669	0.99
178_G	181_S	0.669	0.99
45_W	64_L	0.665	0.99
118_Q	121_A	0.664	0.99
166_G	173_P	0.663	0.99
17_R	31_V	0.662	0.99
97_A	111_I	0.662	0.99
18_E	100_S	0.646	0.98
52_A	56_L	0.645	0.98
112_M	118_Q	0.643	0.98
15_V	19_L	0.642	0.98
175_I	182_I	0.641	0.98
94_H	97_A	0.637	0.98
20_I	26_T	0.637	0.98
138_D	155_G	0.636	0.98
160_Q	178_G	0.635	0.98
109_T	124_G	0.632	0.98
117_I	123_I	0.632	0.98
127_C	142_S	0.632	0.98
12_H	16_I	0.631	0.98
147_L	153_L	0.628	0.98
36_F	39_F	0.625	0.98
7_V	68_A	0.625	0.98
72_N	75_R	0.616	0.98
170_S	173_P	0.616	0.98
91_T	125_A	0.616	0.98
169_A	183_V	0.610	0.98
131_T	136_E	0.609	0.98
15_V	118_Q	0.609	0.98
55_E	58_R	0.607	0.98
130_N	149_P	0.604	0.98
177_I	183_V	0.600	0.98
156_A	173_P	0.599	0.98
97_A	117_I	0.595	0.97
22_A	94_H	0.592	0.97
12_H	48_G	0.589	0.97
34_D	54_T	0.587	0.97
173_P	184_G	0.585	0.97
19_L	23_R	0.585	0.97
126_H	143_D	0.581	0.97
20_I	23_R	0.580	0.97
115_A	130_N	0.579	0.97
100_S	118_Q	0.576	0.97
154_S	170_S	0.575	0.97
58_R	61_P	0.572	0.97
142_S	145_V	0.571	0.97
124_G	142_S	0.569	0.97
110_V	113_A	0.565	0.96
73_S	76_K	0.564	0.96
175_I	178_G	0.564	0.96
116_I	134_V	0.563	0.96
45_W	48_G	0.563	0.96
57_R	60_I	0.562	0.96
130_N	133_A	0.561	0.96
42_G	50_P	0.560	0.96
114_G	150_R	0.554	0.96
154_S	172_I	0.552	0.96
93_I	111_I	0.551	0.96
11_G	15_V	0.551	0.96
79_A	92_L	0.549	0.96
171_V	177_I	0.547	0.96
6_I	31_V	0.545	0.96
46_Y	49_P	0.545	0.96
119_A	137_H	0.543	0.96
26_T	90_I	0.541	0.96
38_T	43_K	0.539	0.95
83_G	86_K	0.537	0.95
91_T	105_I	0.537	0.95
26_T	46_Y	0.536	0.95
14_K	49_P	0.534	0.95
42_G	47_T	0.532	0.95
104_V	120_D	0.532	0.95
157_V	175_I	0.530	0.95
173_P	182_I	0.529	0.95
154_S	166_G	0.529	0.95
134_V	149_P	0.526	0.95
179_A	182_I	0.524	0.95
160_Q	163_A	0.522	0.95
33_D	37_K	0.522	0.95
52_A	58_R	0.521	0.95
62_D	65_F	0.520	0.94
62_D	87_D	0.519	0.94
18_E	22_A	0.518	0.94
13_G	17_R	0.513	0.94
22_A	95_P	0.512	0.94
63_V	66_L	0.511	0.94
134_V	150_R	0.504	0.94
164_H	182_I	0.503	0.93
124_G	127_C	0.501	0.93
67_I	75_R	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m9cA	3	0.9537	100	0.27	Contact Map
4m98A	3	0.9352	100	0.275	Contact Map
3bfpA	3	0.8333	100	0.282	Contact Map
4ea9A	3	0.9259	100	0.284	Contact Map
3pmoA	3	0.9815	100	0.434	Contact Map
4e79A	3	0.9861	100	0.446	Contact Map
2iu8A	3	0.9861	100	0.466	Contact Map
4ihfA	4	0.9815	100	0.475	Contact Map
4g3qA	3	0.9769	100	0.481	Contact Map
3r8yA	3	0.8889	100	0.489	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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