GREMLIN Database
EPSM - Putative acetyltransferase EpsM
UniProt: P71063 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (176)
Sequences: 5482 (4410)
Seq/√Len: 332.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_G180_W3.6501.00
126_H144_Y3.6311.00
122_R140_Q3.1131.00
106_G125_A3.0531.00
104_V122_R3.0171.00
125_A143_D2.9581.00
124_G143_D2.6791.00
127_C145_V2.6131.00
154_S167_T2.5741.00
143_D161_E2.4901.00
107_E125_A2.4351.00
142_S161_E2.3921.00
114_G132_G2.3781.00
144_Y162_G2.3721.00
135_A139_N2.3621.00
102_S120_D2.3581.00
105_I109_T2.2641.00
165_V169_A2.1661.00
158_S176_I2.0921.00
109_T127_C2.0871.00
140_Q158_S2.0711.00
161_E179_A2.0371.00
160_Q179_A1.8661.00
100_S103_A1.8581.00
76_K80_E1.8291.00
127_C161_E1.7951.00
145_V163_A1.7791.00
27_R48_G1.7601.00
138_D156_A1.7461.00
96_S114_G1.7431.00
100_S119_A1.7311.00
115_A129_I1.6671.00
94_H113_A1.6621.00
132_G150_R1.6491.00
120_D138_D1.6221.00
117_I121_A1.6081.00
91_T109_T1.5991.00
129_I133_A1.5251.00
109_T125_A1.4471.00
145_V161_E1.4451.00
69_V75_R1.4051.00
108_G126_H1.3921.00
109_T143_D1.3691.00
135_A141_I1.3641.00
131_T149_P1.3391.00
118_Q136_E1.3351.00
80_E84_L1.3071.00
99_V103_A1.3031.00
160_Q176_I1.2991.00
142_S158_S1.2801.00
128_I146_H1.2731.00
127_C143_D1.2671.00
111_I115_A1.2561.00
156_A174_Q1.2551.00
78_L81_R1.2451.00
163_A181_S1.2361.00
118_Q137_H1.2351.00
134_V152_T1.2291.00
79_A126_H1.2271.00
20_I92_L1.2111.00
145_V179_A1.2051.00
130_N146_H1.1971.00
141_I145_V1.1911.00
148_S164_H1.1701.00
16_I28_L1.1681.00
139_N153_L1.1651.00
172_I175_I1.1651.00
76_K162_G1.1601.00
159_V163_A1.1571.00
83_G107_E1.1501.00
106_G109_T1.1251.00
54_T70_G1.1191.00
133_A147_L1.0991.00
153_L159_V1.0881.00
109_T123_I1.0871.00
20_I30_A1.0631.00
76_K161_E1.0521.00
166_G172_I1.0461.00
98_I114_G1.0431.00
79_A83_G1.0421.00
98_I116_I1.0331.00
76_K144_Y1.0331.00
167_T170_S1.0311.00
53_V56_L1.0281.00
152_T168_G1.0141.00
14_K120_D1.0081.00
105_I111_I0.9981.00
137_H155_G0.9971.00
14_K138_D0.9951.00
121_A139_N0.9951.00
141_I147_L0.9931.00
152_T167_T0.9741.00
121_A135_A0.9711.00
19_L41_G0.9591.00
77_Q81_R0.9471.00
177_I181_S0.9451.00
6_I68_A0.9421.00
78_L82_L0.9341.00
106_G124_G0.9151.00
165_V171_V0.9001.00
81_R85_G0.8911.00
163_A179_A0.8911.00
82_L85_G0.8891.00
44_E47_T0.8871.00
89_F126_H0.8781.00
159_V165_V0.8711.00
21_N101_K0.8701.00
123_I127_C0.8691.00
147_L165_V0.8631.00
103_A117_I0.8571.00
13_G31_V0.8571.00
63_V84_L0.8491.00
110_V128_I0.8401.00
93_I110_V0.8401.00
93_I97_A0.8321.00
34_D37_K0.8211.00
132_G152_T0.8191.00
111_I117_I0.8161.00
19_L92_L0.8021.00
67_I79_A0.8001.00
112_M128_I0.7991.00
102_S119_A0.7961.00
133_A151_A0.7941.00
127_C141_I0.7931.00
105_I123_I0.7901.00
142_S160_Q0.7861.00
123_I129_I0.7801.00
151_A169_A0.7791.00
94_H98_I0.7731.00
147_L151_A0.7721.00
17_R28_L0.7721.00
172_I184_G0.7711.00
106_G143_D0.7691.00
20_I32_L0.7681.00
145_V159_V0.7651.00
116_I131_T0.7641.00
39_F42_G0.7621.00
160_Q181_S0.7601.00
42_G45_W0.7581.00
15_V41_G0.7531.00
117_I129_I0.7500.99
61_P70_G0.7490.99
163_A178_G0.7480.99
121_A136_E0.7450.99
146_H164_H0.7440.99
74_V78_L0.7430.99
161_E180_W0.7420.99
124_G161_E0.7420.99
141_I159_V0.7390.99
103_A121_A0.7350.99
162_G179_A0.7340.99
118_Q134_V0.7280.99
149_P167_T0.7260.99
45_W50_P0.7220.99
108_G125_A0.7220.99
154_S173_P0.7190.99
142_S179_A0.7180.99
153_L157_V0.7180.99
73_S77_Q0.7160.99
98_I113_A0.7110.99
9_D31_V0.7080.99
148_S154_S0.7070.99
74_V77_Q0.6990.99
115_A133_A0.6970.99
150_R168_G0.6960.99
145_V160_Q0.6950.99
80_E83_G0.6940.99
12_H15_V0.6910.99
81_R84_L0.6910.99
79_A144_Y0.6900.99
24_S28_L0.6850.99
35_K38_T0.6810.99
124_G140_Q0.6740.99
82_L87_D0.6700.99
66_L110_V0.6690.99
178_G181_S0.6690.99
45_W64_L0.6650.99
118_Q121_A0.6640.99
166_G173_P0.6630.99
17_R31_V0.6620.99
97_A111_I0.6620.99
18_E100_S0.6460.98
52_A56_L0.6450.98
112_M118_Q0.6430.98
15_V19_L0.6420.98
175_I182_I0.6410.98
94_H97_A0.6370.98
20_I26_T0.6370.98
138_D155_G0.6360.98
160_Q178_G0.6350.98
109_T124_G0.6320.98
117_I123_I0.6320.98
127_C142_S0.6320.98
12_H16_I0.6310.98
147_L153_L0.6280.98
36_F39_F0.6250.98
7_V68_A0.6250.98
72_N75_R0.6160.98
170_S173_P0.6160.98
91_T125_A0.6160.98
169_A183_V0.6100.98
131_T136_E0.6090.98
15_V118_Q0.6090.98
55_E58_R0.6070.98
130_N149_P0.6040.98
177_I183_V0.6000.98
156_A173_P0.5990.98
97_A117_I0.5950.97
22_A94_H0.5920.97
12_H48_G0.5890.97
34_D54_T0.5870.97
173_P184_G0.5850.97
19_L23_R0.5850.97
126_H143_D0.5810.97
20_I23_R0.5800.97
115_A130_N0.5790.97
100_S118_Q0.5760.97
154_S170_S0.5750.97
58_R61_P0.5720.97
142_S145_V0.5710.97
124_G142_S0.5690.97
110_V113_A0.5650.96
73_S76_K0.5640.96
175_I178_G0.5640.96
116_I134_V0.5630.96
45_W48_G0.5630.96
57_R60_I0.5620.96
130_N133_A0.5610.96
42_G50_P0.5600.96
114_G150_R0.5540.96
154_S172_I0.5520.96
93_I111_I0.5510.96
11_G15_V0.5510.96
79_A92_L0.5490.96
171_V177_I0.5470.96
6_I31_V0.5450.96
46_Y49_P0.5450.96
119_A137_H0.5430.96
26_T90_I0.5410.96
38_T43_K0.5390.95
83_G86_K0.5370.95
91_T105_I0.5370.95
26_T46_Y0.5360.95
14_K49_P0.5340.95
42_G47_T0.5320.95
104_V120_D0.5320.95
157_V175_I0.5300.95
173_P182_I0.5290.95
154_S166_G0.5290.95
134_V149_P0.5260.95
179_A182_I0.5240.95
160_Q163_A0.5220.95
33_D37_K0.5220.95
52_A58_R0.5210.95
62_D65_F0.5200.94
62_D87_D0.5190.94
18_E22_A0.5180.94
13_G17_R0.5130.94
22_A95_P0.5120.94
63_V66_L0.5110.94
134_V150_R0.5040.94
164_H182_I0.5030.93
124_G127_C0.5010.93
67_I75_R0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m9cA 3 0.9537 100 0.27 Contact Map
4m98A 3 0.9352 100 0.275 Contact Map
3bfpA 3 0.8333 100 0.282 Contact Map
4ea9A 3 0.9259 100 0.284 Contact Map
3pmoA 3 0.9815 100 0.434 Contact Map
4e79A 3 0.9861 100 0.446 Contact Map
2iu8A 3 0.9861 100 0.466 Contact Map
4ihfA 4 0.9815 100 0.475 Contact Map
4g3qA 3 0.9769 100 0.481 Contact Map
3r8yA 3 0.8889 100 0.489 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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