EPSL - BACSU - GREMLIN Contacts

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EPSL - Uncharacterized sugar transferase EpsL

UniProt:	P71062	Sequences: MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVRPGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGDLSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDNWSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	202 (180)
Sequences:	8711 (6222)
Seq/√Len:	463.8

ECOLI - WCAJ
BACSU - EPSL TUAA
HALSA - Q9HSZ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_R	9_L	3.936	1.00
43_V	51_P	3.493	1.00
43_V	53_T	3.408	1.00
41_K	53_T	3.331	1.00
156_W	160_N	3.287	1.00
29_V	80_T	2.851	1.00
26_T	89_I	2.690	1.00
83_L	87_L	2.468	1.00
125_R	159_D	2.463	1.00
33_K	79_K	2.320	1.00
149_K	152_E	2.131	1.00
98_V	133_I	2.079	1.00
136_W	140_N	2.076	1.00
168_K	172_L	1.952	1.00
46_G	131_P	1.927	1.00
55_Y	97_N	1.919	1.00
136_W	156_W	1.852	1.00
31_R	36_S	1.834	1.00
27_I	38_V	1.826	1.00
51_P	113_M	1.820	1.00
41_K	55_Y	1.808	1.00
31_R	38_V	1.804	1.00
16_L	96_L	1.778	1.00
13_I	99_L	1.776	1.00
37_P	62_D	1.748	1.00
59_T	84_I	1.747	1.00
26_T	57_F	1.724	1.00
12_A	16_L	1.722	1.00
125_R	128_E	1.682	1.00
7_F	11_A	1.679	1.00
111_L	115_Y	1.677	1.00
175_R	179_V	1.676	1.00
141_G	145_I	1.667	1.00
106_V	134_T	1.639	1.00
88_S	142_R	1.593	1.00
26_T	84_I	1.589	1.00
63_E	67_K	1.579	1.00
8_D	104_S	1.557	1.00
96_L	100_K	1.517	1.00
129_V	158_V	1.510	1.00
86_K	180_S	1.507	1.00
23_I	57_F	1.489	1.00
39_F	55_Y	1.479	1.00
45_P	51_P	1.469	1.00
61_T	67_K	1.462	1.00
146_S	149_K	1.434	1.00
15_L	19_T	1.376	1.00
30_V	34_I	1.371	1.00
17_C	20_S	1.355	1.00
47_L	130_K	1.353	1.00
172_L	176_K	1.335	1.00
25_F	29_V	1.333	1.00
157_Y	166_D	1.305	1.00
9_L	13_I	1.287	1.00
140_N	172_L	1.283	1.00
113_M	117_P	1.275	1.00
11_A	105_L	1.236	1.00
156_W	165_L	1.230	1.00
97_N	102_D	1.222	1.00
135_G	150_K	1.219	1.00
106_V	170_L	1.213	1.00
37_P	58_R	1.211	1.00
12_A	99_L	1.205	1.00
28_A	32_L	1.204	1.00
136_W	169_I	1.191	1.00
21_V	24_L	1.186	1.00
135_G	138_Q	1.174	1.00
4_K	166_D	1.173	1.00
45_P	116_L	1.152	1.00
136_W	165_L	1.142	1.00
61_T	64_R	1.131	1.00
84_I	87_L	1.124	1.00
19_T	23_I	1.100	1.00
12_A	17_C	1.089	1.00
11_A	15_L	1.075	1.00
111_L	119_Y	1.073	1.00
137_A	150_K	1.072	1.00
30_V	33_K	1.057	1.00
15_L	105_L	1.048	1.00
31_R	34_I	1.042	1.00
105_L	170_L	1.035	1.00
164_F	168_K	1.033	1.00
112_L	115_Y	1.031	1.00
115_Y	119_Y	1.027	1.00
80_T	84_I	1.027	1.00
9_L	12_A	1.020	1.00
33_K	80_T	1.014	1.00
126_R	154_D	1.012	1.00
16_L	20_S	1.009	1.00
120_T	123_Q	1.009	1.00
61_T	75_V	1.008	1.00
134_T	173_T	1.008	1.00
111_L	116_L	0.999	1.00
138_Q	154_D	0.986	1.00
42_Q	54_L	0.984	1.00
162_S	165_L	0.978	1.00
15_L	95_L	0.963	1.00
29_V	33_K	0.962	1.00
111_L	147_W	0.942	1.00
49_G	127_H	0.936	1.00
136_W	153_L	0.927	1.00
20_S	23_I	0.926	1.00
171_C	175_R	0.926	1.00
63_E	66_S	0.924	1.00
55_Y	100_K	0.923	1.00
49_G	124_A	0.922	1.00
111_L	150_K	0.922	1.00
140_N	153_L	0.921	1.00
170_L	174_V	0.920	1.00
7_F	163_F	0.918	1.00
143_N	150_K	0.914	1.00
40_F	65_D	0.912	1.00
26_T	29_V	0.904	1.00
73_D	82_R	0.899	1.00
45_P	113_M	0.894	1.00
19_T	22_I	0.891	1.00
52_F	103_L	0.882	1.00
160_N	165_L	0.880	1.00
88_S	143_N	0.876	1.00
177_V	182_G	0.867	1.00
20_S	24_L	0.866	1.00
139_I	172_L	0.863	1.00
163_F	167_L	0.862	1.00
13_I	17_C	0.861	1.00
55_Y	96_L	0.857	1.00
165_L	168_K	0.855	1.00
21_V	25_F	0.851	1.00
95_L	105_L	0.843	1.00
27_I	30_V	0.840	1.00
77_L	82_R	0.836	1.00
9_L	99_L	0.835	1.00
175_R	181_E	0.834	1.00
24_L	28_A	0.833	1.00
48_H	128_E	0.831	1.00
36_S	62_D	0.830	1.00
4_K	8_D	0.829	1.00
96_L	102_D	0.826	1.00
116_L	119_Y	0.820	1.00
4_K	104_S	0.818	1.00
116_L	127_H	0.812	1.00
176_K	181_E	0.807	1.00
23_I	39_F	0.795	1.00
18_C	21_V	0.795	1.00
98_V	105_L	0.792	1.00
33_K	78_T	0.787	1.00
23_I	92_L	0.776	1.00
31_R	37_P	0.772	1.00
148_E	152_E	0.772	1.00
155_V	158_V	0.769	1.00
119_Y	147_W	0.769	1.00
79_K	83_L	0.760	1.00
4_K	161_W	0.759	1.00
122_K	152_E	0.757	1.00
68_G	114_D	0.752	1.00
29_V	32_L	0.749	1.00
126_R	155_V	0.740	1.00
16_L	99_L	0.737	1.00
172_L	175_R	0.737	1.00
10_T	14_F	0.735	1.00
146_S	150_K	0.734	1.00
22_I	26_T	0.724	1.00
54_L	94_Q	0.724	1.00
144_A	182_G	0.723	1.00
79_K	82_R	0.720	1.00
125_R	155_V	0.718	1.00
80_T	83_L	0.718	1.00
161_W	165_L	0.717	1.00
34_I	80_T	0.715	1.00
111_L	151_F	0.715	1.00
108_P	129_V	0.714	1.00
126_R	150_K	0.713	1.00
5_R	130_K	0.709	1.00
124_A	127_H	0.708	1.00
120_T	124_A	0.705	1.00
167_L	171_C	0.705	1.00
123_Q	151_F	0.701	1.00
112_L	119_Y	0.700	1.00
116_L	123_Q	0.695	1.00
30_V	57_F	0.687	1.00
45_P	112_L	0.684	1.00
92_L	95_L	0.682	1.00
112_L	147_W	0.681	1.00
30_V	58_R	0.676	1.00
30_V	38_V	0.675	1.00
136_W	160_N	0.674	1.00
64_R	70_L	0.671	1.00
34_I	58_R	0.670	1.00
3_L	6_L	0.668	1.00
41_K	54_L	0.667	1.00
175_R	178_L	0.664	1.00
123_Q	147_W	0.660	1.00
88_S	182_G	0.657	1.00
38_V	57_F	0.656	1.00
170_L	177_V	0.649	1.00
177_V	180_S	0.648	1.00
19_T	95_L	0.645	1.00
67_K	70_L	0.644	1.00
72_P	75_V	0.643	1.00
27_I	31_R	0.641	1.00
135_G	154_D	0.638	1.00
137_A	141_G	0.636	1.00
7_F	167_L	0.634	0.99
88_S	150_K	0.633	0.99
114_D	119_Y	0.633	0.99
43_V	113_M	0.629	0.99
56_K	91_E	0.628	0.99
149_K	153_L	0.627	0.99
145_I	153_L	0.623	0.99
111_L	123_Q	0.622	0.99
16_L	23_I	0.619	0.99
144_A	147_W	0.618	0.99
6_L	9_L	0.617	0.99
65_D	69_N	0.611	0.99
145_I	150_K	0.610	0.99
40_F	112_L	0.609	0.99
6_L	10_T	0.606	0.99
60_M	77_L	0.605	0.99
47_L	129_V	0.604	0.99
128_E	159_D	0.604	0.99
11_A	14_F	0.600	0.99
23_I	26_T	0.595	0.99
136_W	172_L	0.594	0.99
45_P	127_H	0.593	0.99
19_T	26_T	0.591	0.99
115_Y	118_L	0.588	0.99
147_W	150_K	0.586	0.99
135_G	151_F	0.583	0.99
83_L	89_I	0.582	0.99
12_A	19_T	0.576	0.99
139_I	176_K	0.576	0.99
152_E	156_W	0.573	0.99
31_R	35_G	0.571	0.99
141_G	144_A	0.568	0.99
114_D	118_L	0.568	0.99
17_C	21_V	0.567	0.99
35_G	58_R	0.566	0.99
24_L	27_I	0.564	0.99
106_V	161_W	0.563	0.99
65_D	68_G	0.561	0.99
122_K	125_R	0.548	0.99
28_A	31_R	0.547	0.99
140_N	156_W	0.547	0.99
9_L	16_L	0.543	0.98
5_R	12_A	0.543	0.98
73_D	76_R	0.542	0.98
12_A	105_L	0.538	0.98
30_V	80_T	0.537	0.98
123_Q	127_H	0.537	0.98
4_K	157_Y	0.535	0.98
27_I	57_F	0.530	0.98
23_I	96_L	0.529	0.98
115_Y	137_A	0.529	0.98
164_F	171_C	0.525	0.98
82_R	86_K	0.524	0.98
111_L	127_H	0.523	0.98
108_P	131_P	0.522	0.98
9_L	14_F	0.521	0.98
32_L	35_G	0.518	0.98
115_Y	147_W	0.512	0.98
138_Q	141_G	0.512	0.98
84_I	94_Q	0.511	0.98
66_S	69_N	0.509	0.98
11_A	170_L	0.508	0.98
88_S	141_G	0.507	0.98
137_A	140_N	0.506	0.98
91_E	109_R	0.506	0.98
9_L	104_S	0.505	0.98
11_A	95_L	0.501	0.97
60_M	76_R	0.501	0.97
111_L	126_R	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2clyA	1	0.0941	8.8	0.964	Contact Map
4k84A	1	0.4059	6.1	0.967	Contact Map
4pw8A	4	0.4455	4.8	0.968	Contact Map
4ezcA	3	0.297	4.8	0.968	Contact Map
2k44A	1	0.1337	4.3	0.969	Contact Map
3o2uA	1	0.7178	3.3	0.971	Contact Map
3wguG	1	0.1683	3	0.972	Contact Map
1q55A	2	0	2.7	0.972	Contact Map
3fewX	1	0.2822	2.5	0.973	Contact Map
4w8pB	1	0.104	2.3	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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