GREMLIN Database
EPSL - Uncharacterized sugar transferase EpsL
UniProt: P71062 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 202 (180)
Sequences: 8711 (6222)
Seq/√Len: 463.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R9_L3.9361.00
43_V51_P3.4931.00
43_V53_T3.4081.00
41_K53_T3.3311.00
156_W160_N3.2871.00
29_V80_T2.8511.00
26_T89_I2.6901.00
83_L87_L2.4681.00
125_R159_D2.4631.00
33_K79_K2.3201.00
149_K152_E2.1311.00
98_V133_I2.0791.00
136_W140_N2.0761.00
168_K172_L1.9521.00
46_G131_P1.9271.00
55_Y97_N1.9191.00
136_W156_W1.8521.00
31_R36_S1.8341.00
27_I38_V1.8261.00
51_P113_M1.8201.00
41_K55_Y1.8081.00
31_R38_V1.8041.00
16_L96_L1.7781.00
13_I99_L1.7761.00
37_P62_D1.7481.00
59_T84_I1.7471.00
26_T57_F1.7241.00
12_A16_L1.7221.00
125_R128_E1.6821.00
7_F11_A1.6791.00
111_L115_Y1.6771.00
175_R179_V1.6761.00
141_G145_I1.6671.00
106_V134_T1.6391.00
88_S142_R1.5931.00
26_T84_I1.5891.00
63_E67_K1.5791.00
8_D104_S1.5571.00
96_L100_K1.5171.00
129_V158_V1.5101.00
86_K180_S1.5071.00
23_I57_F1.4891.00
39_F55_Y1.4791.00
45_P51_P1.4691.00
61_T67_K1.4621.00
146_S149_K1.4341.00
15_L19_T1.3761.00
30_V34_I1.3711.00
17_C20_S1.3551.00
47_L130_K1.3531.00
172_L176_K1.3351.00
25_F29_V1.3331.00
157_Y166_D1.3051.00
9_L13_I1.2871.00
140_N172_L1.2831.00
113_M117_P1.2751.00
11_A105_L1.2361.00
156_W165_L1.2301.00
97_N102_D1.2221.00
135_G150_K1.2191.00
106_V170_L1.2131.00
37_P58_R1.2111.00
12_A99_L1.2051.00
28_A32_L1.2041.00
136_W169_I1.1911.00
21_V24_L1.1861.00
135_G138_Q1.1741.00
4_K166_D1.1731.00
45_P116_L1.1521.00
136_W165_L1.1421.00
61_T64_R1.1311.00
84_I87_L1.1241.00
19_T23_I1.1001.00
12_A17_C1.0891.00
11_A15_L1.0751.00
111_L119_Y1.0731.00
137_A150_K1.0721.00
30_V33_K1.0571.00
15_L105_L1.0481.00
31_R34_I1.0421.00
105_L170_L1.0351.00
164_F168_K1.0331.00
112_L115_Y1.0311.00
115_Y119_Y1.0271.00
80_T84_I1.0271.00
9_L12_A1.0201.00
33_K80_T1.0141.00
126_R154_D1.0121.00
16_L20_S1.0091.00
120_T123_Q1.0091.00
61_T75_V1.0081.00
134_T173_T1.0081.00
111_L116_L0.9991.00
138_Q154_D0.9861.00
42_Q54_L0.9841.00
162_S165_L0.9781.00
15_L95_L0.9631.00
29_V33_K0.9621.00
111_L147_W0.9421.00
49_G127_H0.9361.00
136_W153_L0.9271.00
20_S23_I0.9261.00
171_C175_R0.9261.00
63_E66_S0.9241.00
55_Y100_K0.9231.00
49_G124_A0.9221.00
111_L150_K0.9221.00
140_N153_L0.9211.00
170_L174_V0.9201.00
7_F163_F0.9181.00
143_N150_K0.9141.00
40_F65_D0.9121.00
26_T29_V0.9041.00
73_D82_R0.8991.00
45_P113_M0.8941.00
19_T22_I0.8911.00
52_F103_L0.8821.00
160_N165_L0.8801.00
88_S143_N0.8761.00
177_V182_G0.8671.00
20_S24_L0.8661.00
139_I172_L0.8631.00
163_F167_L0.8621.00
13_I17_C0.8611.00
55_Y96_L0.8571.00
165_L168_K0.8551.00
21_V25_F0.8511.00
95_L105_L0.8431.00
27_I30_V0.8401.00
77_L82_R0.8361.00
9_L99_L0.8351.00
175_R181_E0.8341.00
24_L28_A0.8331.00
48_H128_E0.8311.00
36_S62_D0.8301.00
4_K8_D0.8291.00
96_L102_D0.8261.00
116_L119_Y0.8201.00
4_K104_S0.8181.00
116_L127_H0.8121.00
176_K181_E0.8071.00
23_I39_F0.7951.00
18_C21_V0.7951.00
98_V105_L0.7921.00
33_K78_T0.7871.00
23_I92_L0.7761.00
31_R37_P0.7721.00
148_E152_E0.7721.00
155_V158_V0.7691.00
119_Y147_W0.7691.00
79_K83_L0.7601.00
4_K161_W0.7591.00
122_K152_E0.7571.00
68_G114_D0.7521.00
29_V32_L0.7491.00
126_R155_V0.7401.00
16_L99_L0.7371.00
172_L175_R0.7371.00
10_T14_F0.7351.00
146_S150_K0.7341.00
22_I26_T0.7241.00
54_L94_Q0.7241.00
144_A182_G0.7231.00
79_K82_R0.7201.00
125_R155_V0.7181.00
80_T83_L0.7181.00
161_W165_L0.7171.00
34_I80_T0.7151.00
111_L151_F0.7151.00
108_P129_V0.7141.00
126_R150_K0.7131.00
5_R130_K0.7091.00
124_A127_H0.7081.00
120_T124_A0.7051.00
167_L171_C0.7051.00
123_Q151_F0.7011.00
112_L119_Y0.7001.00
116_L123_Q0.6951.00
30_V57_F0.6871.00
45_P112_L0.6841.00
92_L95_L0.6821.00
112_L147_W0.6811.00
30_V58_R0.6761.00
30_V38_V0.6751.00
136_W160_N0.6741.00
64_R70_L0.6711.00
34_I58_R0.6701.00
3_L6_L0.6681.00
41_K54_L0.6671.00
175_R178_L0.6641.00
123_Q147_W0.6601.00
88_S182_G0.6571.00
38_V57_F0.6561.00
170_L177_V0.6491.00
177_V180_S0.6481.00
19_T95_L0.6451.00
67_K70_L0.6441.00
72_P75_V0.6431.00
27_I31_R0.6411.00
135_G154_D0.6381.00
137_A141_G0.6361.00
7_F167_L0.6340.99
88_S150_K0.6330.99
114_D119_Y0.6330.99
43_V113_M0.6290.99
56_K91_E0.6280.99
149_K153_L0.6270.99
145_I153_L0.6230.99
111_L123_Q0.6220.99
16_L23_I0.6190.99
144_A147_W0.6180.99
6_L9_L0.6170.99
65_D69_N0.6110.99
145_I150_K0.6100.99
40_F112_L0.6090.99
6_L10_T0.6060.99
60_M77_L0.6050.99
47_L129_V0.6040.99
128_E159_D0.6040.99
11_A14_F0.6000.99
23_I26_T0.5950.99
136_W172_L0.5940.99
45_P127_H0.5930.99
19_T26_T0.5910.99
115_Y118_L0.5880.99
147_W150_K0.5860.99
135_G151_F0.5830.99
83_L89_I0.5820.99
12_A19_T0.5760.99
139_I176_K0.5760.99
152_E156_W0.5730.99
31_R35_G0.5710.99
141_G144_A0.5680.99
114_D118_L0.5680.99
17_C21_V0.5670.99
35_G58_R0.5660.99
24_L27_I0.5640.99
106_V161_W0.5630.99
65_D68_G0.5610.99
122_K125_R0.5480.99
28_A31_R0.5470.99
140_N156_W0.5470.99
9_L16_L0.5430.98
5_R12_A0.5430.98
73_D76_R0.5420.98
12_A105_L0.5380.98
30_V80_T0.5370.98
123_Q127_H0.5370.98
4_K157_Y0.5350.98
27_I57_F0.5300.98
23_I96_L0.5290.98
115_Y137_A0.5290.98
164_F171_C0.5250.98
82_R86_K0.5240.98
111_L127_H0.5230.98
108_P131_P0.5220.98
9_L14_F0.5210.98
32_L35_G0.5180.98
115_Y147_W0.5120.98
138_Q141_G0.5120.98
84_I94_Q0.5110.98
66_S69_N0.5090.98
11_A170_L0.5080.98
88_S141_G0.5070.98
137_A140_N0.5060.98
91_E109_R0.5060.98
9_L104_S0.5050.98
11_A95_L0.5010.97
60_M76_R0.5010.97
111_L126_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2clyA 1 0.0941 8.8 0.964 Contact Map
4k84A 1 0.4059 6.1 0.967 Contact Map
4pw8A 4 0.4455 4.8 0.968 Contact Map
4ezcA 3 0.297 4.8 0.968 Contact Map
2k44A 1 0.1337 4.3 0.969 Contact Map
3o2uA 1 0.7178 3.3 0.971 Contact Map
3wguG 1 0.1683 3 0.972 Contact Map
1q55A 2 0 2.7 0.972 Contact Map
3fewX 1 0.2822 2.5 0.973 Contact Map
4w8pB 1 0.104 2.3 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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