EPSK - BACSU - GREMLIN Contacts

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EPSK - Uncharacterized membrane protein EpsK

UniProt:	P71060	Sequences: MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQNVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGSAFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQMLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFRTSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGTVASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPSFSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGPAHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCKAIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	505 (457)
Sequences:	17422 (14955)
Seq/√Len:	699.6

ECOLI - MURJ WZXC WZXE RFBX YGHQ MDTK DINF YEEO
BACSU - EPSK YTGP TUAB SP5B YABM YKVU YOEA YPNP NORM YISQ
HALSA - Q9HRT3 Q9HQQ5 Q9HSW2 Q9HRF2 Q9HN79 Q9HMS7 Q9HRF7
SULSO - Q7LXE2 Q97XT3 Q97XG2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
293_D	296_G	4.923	1.00
221_K	225_Q	3.396	1.00
102_S	105_F	3.131	1.00
73_E	76_K	3.108	1.00
149_R	152_I	3.032	1.00
433_K	437_G	2.953	1.00
339_A	343_F	2.951	1.00
367_Q	370_T	2.828	1.00
41_H	261_A	2.800	1.00
320_G	343_F	2.693	1.00
148_N	287_S	2.668	1.00
369_K	373_I	2.571	1.00
259_K	337_T	2.413	1.00
244_D	260_Y	2.395	1.00
323_A	339_A	2.357	1.00
65_F	146_Y	2.349	1.00
378_L	411_K	2.217	1.00
324_G	328_T	2.212	1.00
244_D	386_A	2.186	1.00
323_A	343_F	2.176	1.00
248_A	252_L	2.153	1.00
390_S	400_I	2.151	1.00
287_S	291_K	2.150	1.00
344_I	398_Y	2.146	1.00
448_V	474_C	2.122	1.00
100_A	125_L	2.089	1.00
253_G	256_A	2.079	1.00
178_K	181_Q	2.073	1.00
351_V	409_I	2.072	1.00
64_F	226_A	2.068	1.00
247_T	390_S	2.068	1.00
299_N	303_K	2.066	1.00
288_Y	296_G	2.040	1.00
217_F	221_K	2.039	1.00
232_V	372_A	2.021	1.00
33_G	36_A	2.012	1.00
318_L	322_L	1.992	1.00
385_L	403_A	1.988	1.00
341_L	397_L	1.973	1.00
9_A	151_Y	1.973	1.00
121_R	125_L	1.960	1.00
445_A	449_C	1.954	1.00
395_L	402_L	1.948	1.00
79_A	216_S	1.917	1.00
317_A	446_W	1.910	1.00
374_V	414_I	1.909	1.00
252_L	256_A	1.901	1.00
344_I	405_A	1.889	1.00
396_G	399_G	1.886	1.00
247_T	386_A	1.822	1.00
63_R	67_V	1.806	1.00
99_L	128_S	1.795	1.00
322_L	325_P	1.795	1.00
76_K	79_A	1.780	1.00
244_D	404_G	1.752	1.00
294_M	298_M	1.747	1.00
104_F	121_R	1.738	1.00
445_A	471_V	1.736	1.00
475_Y	479_A	1.721	1.00
389_L	403_A	1.718	1.00
392_P	395_L	1.717	1.00
301_A	361_I	1.707	1.00
312_L	353_L	1.704	1.00
42_L	249_N	1.698	1.00
386_A	390_S	1.690	1.00
472_S	476_A	1.673	1.00
434_G	437_G	1.666	1.00
103_A	125_L	1.663	1.00
30_K	332_G	1.660	1.00
389_L	395_L	1.656	1.00
325_P	328_T	1.652	1.00
381_V	410_L	1.642	1.00
318_L	468_G	1.635	1.00
252_L	397_L	1.625	1.00
344_I	401_T	1.617	1.00
216_S	219_T	1.616	1.00
313_A	442_A	1.603	1.00
149_R	204_L	1.600	1.00
399_G	403_A	1.598	1.00
348_Y	405_A	1.595	1.00
296_G	299_N	1.593	1.00
236_G	376_L	1.588	1.00
289_Y	365_F	1.586	1.00
449_C	471_V	1.581	1.00
310_L	479_A	1.567	1.00
324_G	339_A	1.557	1.00
351_V	412_N	1.557	1.00
324_G	343_F	1.556	1.00
247_T	387_V	1.555	1.00
148_N	284_I	1.552	1.00
316_A	350_V	1.546	1.00
143_A	147_A	1.544	1.00
327_L	342_L	1.543	1.00
318_L	445_A	1.542	1.00
341_L	401_T	1.541	1.00
298_M	302_N	1.534	1.00
285_M	297_L	1.523	1.00
151_Y	155_S	1.519	1.00
340_P	398_Y	1.514	1.00
344_I	402_L	1.507	1.00
322_L	326_F	1.505	1.00
40_V	44_Q	1.502	1.00
327_L	338_I	1.498	1.00
403_A	407_S	1.485	1.00
441_A	478_F	1.485	1.00
319_L	346_A	1.475	1.00
248_A	400_I	1.468	1.00
297_L	361_I	1.457	1.00
43_T	127_G	1.450	1.00
248_A	257_S	1.434	1.00
61_V	84_Y	1.433	1.00
29_V	262_A	1.426	1.00
384_V	388_T	1.423	1.00
164_R	189_G	1.422	1.00
267_P	345_H	1.414	1.00
340_P	343_F	1.409	1.00
446_W	450_K	1.403	1.00
295_E	299_N	1.393	1.00
112_V	119_D	1.389	1.00
81_I	143_A	1.376	1.00
288_Y	300_Y	1.372	1.00
181_Q	185_A	1.368	1.00
382_N	386_A	1.364	1.00
15_L	19_F	1.357	1.00
373_I	377_L	1.355	1.00
247_T	251_M	1.343	1.00
167_S	185_A	1.337	1.00
25_T	265_Q	1.332	1.00
382_N	404_G	1.328	1.00
123_S	183_Q	1.325	1.00
22_V	26_P	1.309	1.00
263_I	338_I	1.307	1.00
26_P	30_K	1.306	1.00
67_V	366_N	1.303	1.00
256_A	397_L	1.302	1.00
451_A	454_F	1.302	1.00
296_G	300_Y	1.299	1.00
333_P	336_S	1.296	1.00
229_W	372_A	1.289	1.00
263_I	341_L	1.287	1.00
420_V	423_I	1.286	1.00
253_G	257_S	1.276	1.00
281_F	304_A	1.272	1.00
163_I	192_I	1.263	1.00
302_N	306_R	1.263	1.00
236_G	379_G	1.262	1.00
367_Q	423_I	1.259	1.00
78_N	82_S	1.257	1.00
34_V	259_K	1.242	1.00
347_G	405_A	1.235	1.00
60_V	226_A	1.235	1.00
16_L	158_A	1.231	1.00
444_F	478_F	1.228	1.00
348_Y	401_T	1.227	1.00
468_G	472_S	1.226	1.00
388_T	391_G	1.225	1.00
103_A	107_D	1.220	1.00
100_A	104_F	1.217	1.00
386_A	404_G	1.216	1.00
83_N	220_S	1.214	1.00
325_P	453_Q	1.212	1.00
301_A	358_L	1.211	1.00
243_I	383_V	1.208	1.00
451_A	455_I	1.198	1.00
104_F	125_L	1.193	1.00
242_Q	245_L	1.189	1.00
395_L	399_G	1.185	1.00
442_A	446_W	1.182	1.00
416_T	420_V	1.180	1.00
34_V	258_G	1.179	1.00
248_A	260_Y	1.177	1.00
387_V	391_G	1.172	1.00
101_G	104_F	1.171	1.00
177_P	181_Q	1.170	1.00
228_A	232_V	1.165	1.00
289_Y	297_L	1.165	1.00
381_V	385_L	1.162	1.00
418_L	421_S	1.162	1.00
132_I	135_F	1.158	1.00
382_N	407_S	1.158	1.00
309_G	313_A	1.153	1.00
337_T	340_P	1.150	1.00
41_H	258_G	1.146	1.00
319_L	342_L	1.144	1.00
166_L	170_L	1.142	1.00
327_L	339_A	1.142	1.00
84_Y	223_L	1.139	1.00
103_A	121_R	1.137	1.00
13_A	154_S	1.136	1.00
29_V	331_L	1.130	1.00
37_F	41_H	1.126	1.00
398_Y	401_T	1.118	1.00
17_S	161_M	1.116	1.00
376_L	380_A	1.115	1.00
285_M	364_A	1.114	1.00
341_L	398_Y	1.107	1.00
90_L	94_L	1.106	1.00
316_A	320_G	1.105	1.00
282_A	286_T	1.102	1.00
222_E	366_N	1.101	1.00
24_M	165_V	1.100	1.00
236_G	372_A	1.097	1.00
314_L	442_A	1.097	1.00
418_L	422_R	1.096	1.00
150_L	280_L	1.096	1.00
65_F	77_A	1.093	1.00
101_G	105_F	1.092	1.00
66_S	146_Y	1.089	1.00
229_W	369_K	1.089	1.00
133_L	191_V	1.088	1.00
42_L	257_S	1.088	1.00
447_T	451_A	1.087	1.00
96_L	100_A	1.086	1.00
64_F	67_V	1.085	1.00
373_I	376_L	1.083	1.00
239_L	379_G	1.083	1.00
259_K	338_I	1.082	1.00
354_A	412_N	1.082	1.00
39_F	254_A	1.082	1.00
129_V	132_I	1.080	1.00
240_F	382_N	1.074	1.00
156_I	196_L	1.069	1.00
251_M	390_S	1.067	1.00
294_M	365_F	1.067	1.00
198_F	202_K	1.060	1.00
25_T	331_L	1.060	1.00
19_F	23_W	1.057	1.00
226_A	368_Q	1.056	1.00
156_I	197_S	1.055	1.00
107_D	120_V	1.053	1.00
385_L	389_L	1.052	1.00
453_Q	467_T	1.050	1.00
79_A	83_N	1.049	1.00
133_L	194_S	1.047	1.00
244_D	382_N	1.043	1.00
389_L	392_P	1.042	1.00
317_A	442_A	1.040	1.00
54_T	58_S	1.035	1.00
33_G	334_S	1.034	1.00
255_S	259_K	1.031	1.00
195_V	199_Y	1.029	1.00
441_A	445_A	1.029	1.00
263_I	345_H	1.029	1.00
295_E	298_M	1.028	1.00
60_V	227_G	1.028	1.00
262_A	331_L	1.027	1.00
450_K	454_F	1.025	1.00
36_A	39_F	1.025	1.00
167_S	171_L	1.025	1.00
129_V	187_L	1.025	1.00
348_Y	351_V	1.022	1.00
7_F	280_L	1.021	1.00
26_P	331_L	1.019	1.00
326_F	330_W	1.016	1.00
104_F	108_R	1.016	1.00
288_Y	293_D	1.012	1.00
27_F	31_T	1.011	1.00
40_V	182_I	1.010	1.00
62_V	142_A	1.010	1.00
86_A	90_L	1.009	1.00
96_L	99_L	1.004	1.00
184_L	187_L	1.002	1.00
380_A	384_V	1.002	1.00
87_A	220_S	1.000	1.00
152_I	200_F	0.997	1.00
20_L	165_V	0.996	1.00
184_L	188_A	0.995	1.00
60_V	223_L	0.994	1.00
336_S	339_A	0.990	1.00
10_N	280_L	0.988	1.00
140_F	198_F	0.987	1.00
258_G	262_A	0.976	1.00
248_A	397_L	0.972	1.00
323_A	342_L	0.971	1.00
103_A	128_S	0.965	1.00
345_H	401_T	0.963	1.00
405_A	408_L	0.961	1.00
10_N	154_S	0.954	1.00
233_N	371_P	0.953	1.00
336_S	340_P	0.953	1.00
67_V	222_E	0.950	1.00
388_T	392_P	0.950	1.00
180_W	183_Q	0.949	1.00
57_L	84_Y	0.947	1.00
26_P	29_V	0.944	1.00
263_I	342_L	0.943	1.00
224_F	227_G	0.938	1.00
314_L	475_Y	0.937	1.00
321_G	446_W	0.934	1.00
28_I	182_I	0.933	1.00
386_A	389_L	0.931	1.00
7_F	277_V	0.928	1.00
185_A	189_G	0.928	1.00
171_L	177_P	0.925	1.00
85_L	140_F	0.922	1.00
363_T	371_P	0.921	1.00
125_L	129_V	0.920	1.00
219_T	222_E	0.918	1.00
284_I	287_S	0.915	1.00
98_P	102_S	0.910	1.00
468_G	471_V	0.908	1.00
320_G	323_A	0.906	1.00
126_I	187_L	0.906	1.00
100_A	103_A	0.906	1.00
82_S	86_A	0.905	1.00
11_L	276_T	0.903	1.00
96_L	132_I	0.899	1.00
14_F	18_V	0.899	1.00
113_P	119_D	0.897	1.00
325_P	467_T	0.896	1.00
65_F	147_A	0.896	1.00
322_L	467_T	0.896	1.00
168_V	185_A	0.895	1.00
77_A	147_A	0.892	1.00
410_L	414_I	0.887	1.00
314_L	317_A	0.884	1.00
107_D	121_R	0.881	1.00
432_L	436_I	0.879	1.00
450_K	453_Q	0.875	1.00
128_S	132_I	0.873	1.00
34_V	334_S	0.872	1.00
105_F	109_V	0.870	1.00
303_K	306_R	0.869	1.00
5_I	151_Y	0.869	1.00
402_L	405_A	0.868	1.00
402_L	406_I	0.861	1.00
372_A	376_L	0.859	1.00
26_P	330_W	0.859	1.00
92_S	135_F	0.859	1.00
320_G	324_G	0.859	1.00
465_I	469_V	0.859	1.00
463_S	467_T	0.858	1.00
35_E	254_A	0.857	1.00
224_F	228_A	0.857	1.00
122_L	180_W	0.855	1.00
34_V	335_F	0.855	1.00
284_I	288_Y	0.852	1.00
63_R	366_N	0.851	1.00
306_R	310_L	0.850	1.00
6_N	148_N	0.850	1.00
93_L	97_L	0.849	1.00
225_Q	369_K	0.847	1.00
215_L	220_S	0.844	1.00
260_Y	345_H	0.844	1.00
75_E	79_A	0.844	1.00
199_Y	203_K	0.843	1.00
229_W	368_Q	0.842	1.00
249_N	257_S	0.840	1.00
327_L	331_L	0.837	1.00
8_S	12_T	0.836	1.00
122_L	125_L	0.836	1.00
436_I	440_S	0.835	1.00
320_G	347_G	0.834	1.00
267_P	349_L	0.834	1.00
434_G	438_P	0.833	1.00
103_A	106_I	0.833	1.00
175_F	178_K	0.832	1.00
329_I	461_W	0.830	1.00
170_L	174_C	0.829	1.00
218_R	221_K	0.826	1.00
162_L	166_L	0.823	1.00
452_I	470_T	0.822	1.00
230_S	368_Q	0.822	1.00
261_A	265_Q	0.820	1.00
442_A	445_A	0.818	1.00
329_I	464_L	0.817	1.00
377_L	414_I	0.816	1.00
460_S	463_S	0.816	1.00
317_A	321_G	0.815	1.00
33_G	335_F	0.812	1.00
441_A	479_A	0.809	1.00
32_L	36_A	0.809	1.00
362_W	371_P	0.809	1.00
130_L	190_A	0.806	1.00
189_G	193_A	0.804	1.00
160_Q	164_R	0.802	1.00
119_D	122_L	0.802	1.00
308_N	353_L	0.801	1.00
385_L	406_I	0.801	1.00
280_L	283_P	0.798	1.00
56_A	227_G	0.798	1.00
371_P	375_T	0.798	1.00
348_Y	404_G	0.798	1.00
167_S	188_A	0.797	1.00
358_L	416_T	0.795	1.00
90_L	93_L	0.793	1.00
343_F	347_G	0.793	1.00
105_F	108_R	0.792	1.00
54_T	88_S	0.789	1.00
244_D	264_I	0.789	1.00
417_P	421_S	0.789	1.00
80_Y	84_Y	0.788	1.00
288_Y	291_K	0.788	1.00
338_I	341_L	0.787	1.00
94_L	98_P	0.786	1.00
286_T	290_S	0.786	1.00
385_L	388_T	0.785	1.00
443_V	447_T	0.784	1.00
31_T	172_F	0.780	1.00
245_L	257_S	0.779	1.00
282_A	364_A	0.777	1.00
258_G	261_A	0.776	1.00
383_V	387_V	0.775	1.00
144_P	201_F	0.774	1.00
9_A	13_A	0.774	1.00
320_G	346_A	0.773	1.00
225_Q	228_A	0.773	1.00
45_N	245_L	0.770	1.00
374_V	378_L	0.770	1.00
43_T	123_S	0.767	1.00
461_W	468_G	0.766	1.00
44_Q	48_N	0.766	1.00
464_L	468_G	0.765	1.00
61_V	65_F	0.764	1.00
314_L	445_A	0.764	1.00
438_P	442_A	0.762	1.00
297_L	365_F	0.760	1.00
76_K	219_T	0.760	1.00
103_A	124_I	0.760	1.00
136_L	194_S	0.754	1.00
7_F	11_L	0.750	1.00
235_I	239_L	0.750	1.00
182_I	186_A	0.748	1.00
260_Y	264_I	0.746	1.00
266_F	331_L	0.743	1.00
89_V	93_L	0.743	1.00
141_G	145_F	0.742	1.00
48_N	51_S	0.741	1.00
25_T	29_V	0.740	1.00
133_L	187_L	0.737	1.00
126_I	184_L	0.737	1.00
38_G	258_G	0.736	1.00
370_T	373_I	0.736	1.00
328_T	336_S	0.733	1.00
40_V	179_I	0.732	1.00
37_F	262_A	0.732	1.00
20_L	24_M	0.730	1.00
381_V	384_V	0.729	1.00
202_K	205_I	0.728	1.00
264_I	268_L	0.727	1.00
12_T	16_L	0.727	1.00
449_C	467_T	0.727	1.00
398_Y	402_L	0.725	1.00
62_V	146_Y	0.724	1.00
471_V	475_Y	0.722	1.00
236_G	375_T	0.721	1.00
274_A	278_A	0.720	1.00
34_V	255_S	0.719	1.00
419_Y	423_I	0.715	1.00
318_L	471_V	0.714	1.00
386_A	400_I	0.713	1.00
308_N	357_P	0.713	1.00
137_M	194_S	0.712	1.00
347_G	350_V	0.711	1.00
164_R	168_V	0.710	1.00
474_C	478_F	0.707	1.00
187_L	190_A	0.706	1.00
97_L	101_G	0.705	1.00
61_V	80_Y	0.705	1.00
304_A	357_P	0.704	1.00
28_I	168_V	0.703	1.00
63_R	368_Q	0.701	1.00
83_N	215_L	0.699	1.00
27_F	169_L	0.697	1.00
37_F	258_G	0.697	1.00
223_L	227_G	0.696	1.00
409_I	413_A	0.695	1.00
265_Q	269_L	0.695	1.00
262_A	265_Q	0.693	1.00
226_A	230_S	0.692	1.00
347_G	351_V	0.688	1.00
335_F	338_I	0.688	1.00
310_L	314_L	0.687	1.00
238_L	242_Q	0.687	1.00
42_L	45_N	0.685	1.00
358_L	412_N	0.684	1.00
300_Y	304_A	0.683	1.00
6_N	280_L	0.681	1.00
282_A	360_Y	0.680	1.00
126_I	183_Q	0.680	1.00
246_L	250_L	0.679	1.00
74_R	78_N	0.678	1.00
60_V	64_F	0.675	1.00
225_Q	229_W	0.674	1.00
328_T	339_A	0.674	1.00
51_S	54_T	0.674	1.00
315_P	318_L	0.671	1.00
243_I	247_T	0.671	1.00
200_F	204_L	0.670	1.00
277_V	281_F	0.670	1.00
454_F	457_K	0.670	1.00
258_G	335_F	0.669	1.00
360_Y	364_A	0.669	1.00
187_L	191_V	0.668	1.00
377_L	380_A	0.665	1.00
218_R	222_E	0.665	1.00
86_A	210_F	0.663	1.00
267_P	270_L	0.662	1.00
165_V	169_L	0.662	1.00
186_A	190_A	0.661	1.00
167_S	170_L	0.659	1.00
416_T	419_Y	0.659	1.00
401_T	405_A	0.658	1.00
368_Q	371_P	0.657	1.00
240_F	379_G	0.657	1.00
82_S	85_L	0.655	1.00
360_Y	363_T	0.655	1.00
265_Q	268_L	0.654	1.00
288_Y	297_L	0.652	1.00
65_F	81_I	0.650	1.00
74_R	77_A	0.649	1.00
67_V	290_S	0.649	1.00
262_A	335_F	0.649	1.00
449_C	453_Q	0.642	1.00
348_Y	408_L	0.641	1.00
86_A	89_V	0.641	1.00
467_T	471_V	0.639	1.00
160_Q	193_A	0.638	1.00
245_L	261_A	0.637	1.00
233_N	375_T	0.635	1.00
104_F	107_D	0.635	1.00
242_Q	268_L	0.632	1.00
300_Y	303_K	0.631	1.00
62_V	66_S	0.631	1.00
242_Q	246_L	0.629	1.00
251_M	387_V	0.625	1.00
323_A	346_A	0.623	1.00
196_L	200_F	0.623	1.00
16_L	20_L	0.622	1.00
86_A	215_L	0.619	1.00
342_L	346_A	0.617	1.00
40_V	183_Q	0.614	1.00
265_Q	331_L	0.614	1.00
63_R	364_A	0.613	1.00
381_V	407_S	0.613	1.00
47_I	131_F	0.610	1.00
87_A	91_I	0.610	1.00
92_S	96_L	0.608	1.00
220_S	224_F	0.608	1.00
100_A	128_S	0.606	1.00
46_V	50_F	0.606	1.00
284_I	300_Y	0.606	1.00
96_L	128_S	0.604	1.00
13_A	158_A	0.602	1.00
10_N	150_L	0.602	1.00
122_L	126_I	0.601	1.00
109_V	250_L	0.601	1.00
35_E	39_F	0.599	1.00
10_N	14_F	0.598	1.00
125_L	128_S	0.597	1.00
145_F	153_T	0.597	1.00
230_S	363_T	0.597	1.00
413_A	417_P	0.597	1.00
306_R	434_G	0.596	1.00
99_L	124_I	0.596	1.00
28_I	37_F	0.595	1.00
32_L	179_I	0.595	1.00
344_I	347_G	0.593	1.00
25_T	37_F	0.591	1.00
355_F	412_N	0.590	1.00
79_A	82_S	0.588	1.00
152_I	155_S	0.587	1.00
405_A	409_I	0.587	1.00
461_W	465_I	0.586	1.00
452_I	455_I	0.586	1.00
36_A	179_I	0.586	1.00
58_S	142_A	0.585	1.00
445_A	474_C	0.584	1.00
309_G	350_V	0.582	1.00
197_S	201_F	0.581	1.00
21_S	26_P	0.579	1.00
178_K	185_A	0.577	1.00
332_G	335_F	0.577	1.00
180_W	184_L	0.574	1.00
414_I	418_L	0.573	1.00
391_G	396_G	0.572	1.00
150_L	154_S	0.571	1.00
233_N	372_A	0.571	1.00
352_S	356_M	0.571	1.00
361_I	420_V	0.570	1.00
321_G	449_C	0.569	1.00
11_L	15_L	0.569	1.00
75_E	78_N	0.566	1.00
453_Q	463_S	0.564	1.00
382_N	385_L	0.564	1.00
144_P	152_I	0.563	1.00
95_L	99_L	0.563	1.00
275_G	279_S	0.562	1.00
422_R	425_G	0.562	1.00
155_S	159_V	0.562	1.00
469_V	472_S	0.562	1.00
452_I	456_V	0.561	1.00
262_A	338_I	0.559	1.00
79_A	219_T	0.559	1.00
433_K	436_I	0.559	1.00
16_L	162_L	0.558	1.00
247_T	383_V	0.556	1.00
252_L	390_S	0.555	1.00
370_T	374_V	0.555	1.00
42_L	245_L	0.554	1.00
163_I	166_L	0.554	1.00
375_T	379_G	0.552	1.00
13_A	16_L	0.552	1.00
133_L	136_L	0.552	1.00
374_V	377_L	0.552	1.00
317_A	320_G	0.551	1.00
161_M	165_V	0.549	1.00
475_Y	478_F	0.548	1.00
444_F	447_T	0.548	1.00
245_L	264_I	0.547	1.00
182_I	185_A	0.547	1.00
107_D	124_I	0.546	1.00
322_L	471_V	0.546	1.00
80_Y	219_T	0.544	1.00
32_L	38_G	0.544	1.00
35_E	38_G	0.541	1.00
321_G	442_A	0.541	1.00
126_I	130_L	0.540	1.00
193_A	196_L	0.540	1.00
21_S	25_T	0.539	1.00
328_T	331_L	0.538	1.00
313_A	350_V	0.537	1.00
64_F	222_E	0.536	1.00
274_A	356_M	0.536	1.00
404_G	407_S	0.536	1.00
4_T	8_S	0.536	1.00
94_L	97_L	0.535	1.00
244_D	247_T	0.534	1.00
92_S	128_S	0.534	1.00
124_I	128_S	0.534	1.00
439_L	442_A	0.533	1.00
305_V	358_L	0.533	1.00
316_A	346_A	0.533	1.00
81_I	140_F	0.531	1.00
222_E	226_A	0.529	1.00
161_M	164_R	0.529	1.00
283_P	287_S	0.529	1.00
390_S	399_G	0.528	1.00
49_Y	238_L	0.528	1.00
420_V	424_T	0.528	1.00
158_A	162_L	0.527	1.00
325_P	463_S	0.527	1.00
134_T	190_A	0.527	1.00
164_R	185_A	0.527	1.00
16_L	19_F	0.525	1.00
66_S	286_T	0.524	1.00
80_Y	223_L	0.524	1.00
466_A	469_V	0.523	1.00
351_V	405_A	0.523	1.00
437_G	441_A	0.522	1.00
359_F	371_P	0.521	1.00
408_L	412_N	0.521	1.00
156_I	193_A	0.521	1.00
376_L	379_G	0.521	1.00
93_L	132_I	0.520	1.00
359_F	363_T	0.520	1.00
297_L	301_A	0.520	1.00
233_N	237_V	0.520	1.00
463_S	466_A	0.520	1.00
378_L	407_S	0.519	1.00
367_Q	371_P	0.518	1.00
20_L	23_W	0.518	1.00
294_M	297_L	0.518	1.00
276_T	279_S	0.517	1.00
142_A	146_Y	0.517	1.00
388_T	395_L	0.516	1.00
170_L	175_F	0.515	1.00
83_N	219_T	0.514	0.99
408_L	411_K	0.513	0.99
389_L	399_G	0.512	0.99
62_V	283_P	0.509	0.99
243_I	382_N	0.508	0.99
321_G	324_G	0.508	0.99
102_S	106_I	0.508	0.99
367_Q	422_R	0.508	0.99
147_A	204_L	0.507	0.99
112_V	120_V	0.507	0.99
159_V	162_L	0.505	0.99
83_N	86_A	0.504	0.99
126_I	180_W	0.504	0.99
314_L	318_L	0.504	0.99
24_M	168_V	0.503	0.99
431_F	434_G	0.502	0.99
207_W	210_F	0.501	0.99
252_L	396_G	0.500	0.99
447_T	450_K	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lz6A	1	0.8455	100	0.336	Contact Map
3w4tA	1	0.8396	100	0.35	Contact Map
4humA	1	0.8614	100	0.353	Contact Map
3mktA	1	0.8574	100	0.36	Contact Map
2cfqA	1	0.7703	43.2	0.945	Contact Map
1pw4A	1	0.7822	29	0.95	Contact Map
3wdoA	1	0.7802	27.1	0.951	Contact Map
4m64A	1	0.7941	16.9	0.955	Contact Map
4w6vA	1	0.3624	9.7	0.96	Contact Map
4xnjA	1	0.3921	7.4	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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