GREMLIN Database
EPSK - Uncharacterized membrane protein EpsK
UniProt: P71060 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 505 (457)
Sequences: 17422 (14955)
Seq/√Len: 699.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
293_D296_G4.9231.00
221_K225_Q3.3961.00
102_S105_F3.1311.00
73_E76_K3.1081.00
149_R152_I3.0321.00
433_K437_G2.9531.00
339_A343_F2.9511.00
367_Q370_T2.8281.00
41_H261_A2.8001.00
320_G343_F2.6931.00
148_N287_S2.6681.00
369_K373_I2.5711.00
259_K337_T2.4131.00
244_D260_Y2.3951.00
323_A339_A2.3571.00
65_F146_Y2.3491.00
378_L411_K2.2171.00
324_G328_T2.2121.00
244_D386_A2.1861.00
323_A343_F2.1761.00
248_A252_L2.1531.00
390_S400_I2.1511.00
287_S291_K2.1501.00
344_I398_Y2.1461.00
448_V474_C2.1221.00
100_A125_L2.0891.00
253_G256_A2.0791.00
178_K181_Q2.0731.00
351_V409_I2.0721.00
64_F226_A2.0681.00
247_T390_S2.0681.00
299_N303_K2.0661.00
288_Y296_G2.0401.00
217_F221_K2.0391.00
232_V372_A2.0211.00
33_G36_A2.0121.00
318_L322_L1.9921.00
385_L403_A1.9881.00
341_L397_L1.9731.00
9_A151_Y1.9731.00
121_R125_L1.9601.00
445_A449_C1.9541.00
395_L402_L1.9481.00
79_A216_S1.9171.00
317_A446_W1.9101.00
374_V414_I1.9091.00
252_L256_A1.9011.00
344_I405_A1.8891.00
396_G399_G1.8861.00
247_T386_A1.8221.00
63_R67_V1.8061.00
99_L128_S1.7951.00
322_L325_P1.7951.00
76_K79_A1.7801.00
244_D404_G1.7521.00
294_M298_M1.7471.00
104_F121_R1.7381.00
445_A471_V1.7361.00
475_Y479_A1.7211.00
389_L403_A1.7181.00
392_P395_L1.7171.00
301_A361_I1.7071.00
312_L353_L1.7041.00
42_L249_N1.6981.00
386_A390_S1.6901.00
472_S476_A1.6731.00
434_G437_G1.6661.00
103_A125_L1.6631.00
30_K332_G1.6601.00
389_L395_L1.6561.00
325_P328_T1.6521.00
381_V410_L1.6421.00
318_L468_G1.6351.00
252_L397_L1.6251.00
344_I401_T1.6171.00
216_S219_T1.6161.00
313_A442_A1.6031.00
149_R204_L1.6001.00
399_G403_A1.5981.00
348_Y405_A1.5951.00
296_G299_N1.5931.00
236_G376_L1.5881.00
289_Y365_F1.5861.00
449_C471_V1.5811.00
310_L479_A1.5671.00
324_G339_A1.5571.00
351_V412_N1.5571.00
324_G343_F1.5561.00
247_T387_V1.5551.00
148_N284_I1.5521.00
316_A350_V1.5461.00
143_A147_A1.5441.00
327_L342_L1.5431.00
318_L445_A1.5421.00
341_L401_T1.5411.00
298_M302_N1.5341.00
285_M297_L1.5231.00
151_Y155_S1.5191.00
340_P398_Y1.5141.00
344_I402_L1.5071.00
322_L326_F1.5051.00
40_V44_Q1.5021.00
327_L338_I1.4981.00
403_A407_S1.4851.00
441_A478_F1.4851.00
319_L346_A1.4751.00
248_A400_I1.4681.00
297_L361_I1.4571.00
43_T127_G1.4501.00
248_A257_S1.4341.00
61_V84_Y1.4331.00
29_V262_A1.4261.00
384_V388_T1.4231.00
164_R189_G1.4221.00
267_P345_H1.4141.00
340_P343_F1.4091.00
446_W450_K1.4031.00
295_E299_N1.3931.00
112_V119_D1.3891.00
81_I143_A1.3761.00
288_Y300_Y1.3721.00
181_Q185_A1.3681.00
382_N386_A1.3641.00
15_L19_F1.3571.00
373_I377_L1.3551.00
247_T251_M1.3431.00
167_S185_A1.3371.00
25_T265_Q1.3321.00
382_N404_G1.3281.00
123_S183_Q1.3251.00
22_V26_P1.3091.00
263_I338_I1.3071.00
26_P30_K1.3061.00
67_V366_N1.3031.00
256_A397_L1.3021.00
451_A454_F1.3021.00
296_G300_Y1.2991.00
333_P336_S1.2961.00
229_W372_A1.2891.00
263_I341_L1.2871.00
420_V423_I1.2861.00
253_G257_S1.2761.00
281_F304_A1.2721.00
163_I192_I1.2631.00
302_N306_R1.2631.00
236_G379_G1.2621.00
367_Q423_I1.2591.00
78_N82_S1.2571.00
34_V259_K1.2421.00
347_G405_A1.2351.00
60_V226_A1.2351.00
16_L158_A1.2311.00
444_F478_F1.2281.00
348_Y401_T1.2271.00
468_G472_S1.2261.00
388_T391_G1.2251.00
103_A107_D1.2201.00
100_A104_F1.2171.00
386_A404_G1.2161.00
83_N220_S1.2141.00
325_P453_Q1.2121.00
301_A358_L1.2111.00
243_I383_V1.2081.00
451_A455_I1.1981.00
104_F125_L1.1931.00
242_Q245_L1.1891.00
395_L399_G1.1851.00
442_A446_W1.1821.00
416_T420_V1.1801.00
34_V258_G1.1791.00
248_A260_Y1.1771.00
387_V391_G1.1721.00
101_G104_F1.1711.00
177_P181_Q1.1701.00
228_A232_V1.1651.00
289_Y297_L1.1651.00
381_V385_L1.1621.00
418_L421_S1.1621.00
132_I135_F1.1581.00
382_N407_S1.1581.00
309_G313_A1.1531.00
337_T340_P1.1501.00
41_H258_G1.1461.00
319_L342_L1.1441.00
166_L170_L1.1421.00
327_L339_A1.1421.00
84_Y223_L1.1391.00
103_A121_R1.1371.00
13_A154_S1.1361.00
29_V331_L1.1301.00
37_F41_H1.1261.00
398_Y401_T1.1181.00
17_S161_M1.1161.00
376_L380_A1.1151.00
285_M364_A1.1141.00
341_L398_Y1.1071.00
90_L94_L1.1061.00
316_A320_G1.1051.00
282_A286_T1.1021.00
222_E366_N1.1011.00
24_M165_V1.1001.00
236_G372_A1.0971.00
314_L442_A1.0971.00
418_L422_R1.0961.00
150_L280_L1.0961.00
65_F77_A1.0931.00
101_G105_F1.0921.00
66_S146_Y1.0891.00
229_W369_K1.0891.00
133_L191_V1.0881.00
42_L257_S1.0881.00
447_T451_A1.0871.00
96_L100_A1.0861.00
64_F67_V1.0851.00
373_I376_L1.0831.00
239_L379_G1.0831.00
259_K338_I1.0821.00
354_A412_N1.0821.00
39_F254_A1.0821.00
129_V132_I1.0801.00
240_F382_N1.0741.00
156_I196_L1.0691.00
251_M390_S1.0671.00
294_M365_F1.0671.00
198_F202_K1.0601.00
25_T331_L1.0601.00
19_F23_W1.0571.00
226_A368_Q1.0561.00
156_I197_S1.0551.00
107_D120_V1.0531.00
385_L389_L1.0521.00
453_Q467_T1.0501.00
79_A83_N1.0491.00
133_L194_S1.0471.00
244_D382_N1.0431.00
389_L392_P1.0421.00
317_A442_A1.0401.00
54_T58_S1.0351.00
33_G334_S1.0341.00
255_S259_K1.0311.00
195_V199_Y1.0291.00
441_A445_A1.0291.00
263_I345_H1.0291.00
295_E298_M1.0281.00
60_V227_G1.0281.00
262_A331_L1.0271.00
450_K454_F1.0251.00
36_A39_F1.0251.00
167_S171_L1.0251.00
129_V187_L1.0251.00
348_Y351_V1.0221.00
7_F280_L1.0211.00
26_P331_L1.0191.00
326_F330_W1.0161.00
104_F108_R1.0161.00
288_Y293_D1.0121.00
27_F31_T1.0111.00
40_V182_I1.0101.00
62_V142_A1.0101.00
86_A90_L1.0091.00
96_L99_L1.0041.00
184_L187_L1.0021.00
380_A384_V1.0021.00
87_A220_S1.0001.00
152_I200_F0.9971.00
20_L165_V0.9961.00
184_L188_A0.9951.00
60_V223_L0.9941.00
336_S339_A0.9901.00
10_N280_L0.9881.00
140_F198_F0.9871.00
258_G262_A0.9761.00
248_A397_L0.9721.00
323_A342_L0.9711.00
103_A128_S0.9651.00
345_H401_T0.9631.00
405_A408_L0.9611.00
10_N154_S0.9541.00
233_N371_P0.9531.00
336_S340_P0.9531.00
67_V222_E0.9501.00
388_T392_P0.9501.00
180_W183_Q0.9491.00
57_L84_Y0.9471.00
26_P29_V0.9441.00
263_I342_L0.9431.00
224_F227_G0.9381.00
314_L475_Y0.9371.00
321_G446_W0.9341.00
28_I182_I0.9331.00
386_A389_L0.9311.00
7_F277_V0.9281.00
185_A189_G0.9281.00
171_L177_P0.9251.00
85_L140_F0.9221.00
363_T371_P0.9211.00
125_L129_V0.9201.00
219_T222_E0.9181.00
284_I287_S0.9151.00
98_P102_S0.9101.00
468_G471_V0.9081.00
320_G323_A0.9061.00
126_I187_L0.9061.00
100_A103_A0.9061.00
82_S86_A0.9051.00
11_L276_T0.9031.00
96_L132_I0.8991.00
14_F18_V0.8991.00
113_P119_D0.8971.00
325_P467_T0.8961.00
65_F147_A0.8961.00
322_L467_T0.8961.00
168_V185_A0.8951.00
77_A147_A0.8921.00
410_L414_I0.8871.00
314_L317_A0.8841.00
107_D121_R0.8811.00
432_L436_I0.8791.00
450_K453_Q0.8751.00
128_S132_I0.8731.00
34_V334_S0.8721.00
105_F109_V0.8701.00
303_K306_R0.8691.00
5_I151_Y0.8691.00
402_L405_A0.8681.00
402_L406_I0.8611.00
372_A376_L0.8591.00
26_P330_W0.8591.00
92_S135_F0.8591.00
320_G324_G0.8591.00
465_I469_V0.8591.00
463_S467_T0.8581.00
35_E254_A0.8571.00
224_F228_A0.8571.00
122_L180_W0.8551.00
34_V335_F0.8551.00
284_I288_Y0.8521.00
63_R366_N0.8511.00
306_R310_L0.8501.00
6_N148_N0.8501.00
93_L97_L0.8491.00
225_Q369_K0.8471.00
215_L220_S0.8441.00
260_Y345_H0.8441.00
75_E79_A0.8441.00
199_Y203_K0.8431.00
229_W368_Q0.8421.00
249_N257_S0.8401.00
327_L331_L0.8371.00
8_S12_T0.8361.00
122_L125_L0.8361.00
436_I440_S0.8351.00
320_G347_G0.8341.00
267_P349_L0.8341.00
434_G438_P0.8331.00
103_A106_I0.8331.00
175_F178_K0.8321.00
329_I461_W0.8301.00
170_L174_C0.8291.00
218_R221_K0.8261.00
162_L166_L0.8231.00
452_I470_T0.8221.00
230_S368_Q0.8221.00
261_A265_Q0.8201.00
442_A445_A0.8181.00
329_I464_L0.8171.00
377_L414_I0.8161.00
460_S463_S0.8161.00
317_A321_G0.8151.00
33_G335_F0.8121.00
441_A479_A0.8091.00
32_L36_A0.8091.00
362_W371_P0.8091.00
130_L190_A0.8061.00
189_G193_A0.8041.00
160_Q164_R0.8021.00
119_D122_L0.8021.00
308_N353_L0.8011.00
385_L406_I0.8011.00
280_L283_P0.7981.00
56_A227_G0.7981.00
371_P375_T0.7981.00
348_Y404_G0.7981.00
167_S188_A0.7971.00
358_L416_T0.7951.00
90_L93_L0.7931.00
343_F347_G0.7931.00
105_F108_R0.7921.00
54_T88_S0.7891.00
244_D264_I0.7891.00
417_P421_S0.7891.00
80_Y84_Y0.7881.00
288_Y291_K0.7881.00
338_I341_L0.7871.00
94_L98_P0.7861.00
286_T290_S0.7861.00
385_L388_T0.7851.00
443_V447_T0.7841.00
31_T172_F0.7801.00
245_L257_S0.7791.00
282_A364_A0.7771.00
258_G261_A0.7761.00
383_V387_V0.7751.00
144_P201_F0.7741.00
9_A13_A0.7741.00
320_G346_A0.7731.00
225_Q228_A0.7731.00
45_N245_L0.7701.00
374_V378_L0.7701.00
43_T123_S0.7671.00
461_W468_G0.7661.00
44_Q48_N0.7661.00
464_L468_G0.7651.00
61_V65_F0.7641.00
314_L445_A0.7641.00
438_P442_A0.7621.00
297_L365_F0.7601.00
76_K219_T0.7601.00
103_A124_I0.7601.00
136_L194_S0.7541.00
7_F11_L0.7501.00
235_I239_L0.7501.00
182_I186_A0.7481.00
260_Y264_I0.7461.00
266_F331_L0.7431.00
89_V93_L0.7431.00
141_G145_F0.7421.00
48_N51_S0.7411.00
25_T29_V0.7401.00
133_L187_L0.7371.00
126_I184_L0.7371.00
38_G258_G0.7361.00
370_T373_I0.7361.00
328_T336_S0.7331.00
40_V179_I0.7321.00
37_F262_A0.7321.00
20_L24_M0.7301.00
381_V384_V0.7291.00
202_K205_I0.7281.00
264_I268_L0.7271.00
12_T16_L0.7271.00
449_C467_T0.7271.00
398_Y402_L0.7251.00
62_V146_Y0.7241.00
471_V475_Y0.7221.00
236_G375_T0.7211.00
274_A278_A0.7201.00
34_V255_S0.7191.00
419_Y423_I0.7151.00
318_L471_V0.7141.00
386_A400_I0.7131.00
308_N357_P0.7131.00
137_M194_S0.7121.00
347_G350_V0.7111.00
164_R168_V0.7101.00
474_C478_F0.7071.00
187_L190_A0.7061.00
97_L101_G0.7051.00
61_V80_Y0.7051.00
304_A357_P0.7041.00
28_I168_V0.7031.00
63_R368_Q0.7011.00
83_N215_L0.6991.00
27_F169_L0.6971.00
37_F258_G0.6971.00
223_L227_G0.6961.00
409_I413_A0.6951.00
265_Q269_L0.6951.00
262_A265_Q0.6931.00
226_A230_S0.6921.00
347_G351_V0.6881.00
335_F338_I0.6881.00
310_L314_L0.6871.00
238_L242_Q0.6871.00
42_L45_N0.6851.00
358_L412_N0.6841.00
300_Y304_A0.6831.00
6_N280_L0.6811.00
282_A360_Y0.6801.00
126_I183_Q0.6801.00
246_L250_L0.6791.00
74_R78_N0.6781.00
60_V64_F0.6751.00
225_Q229_W0.6741.00
328_T339_A0.6741.00
51_S54_T0.6741.00
315_P318_L0.6711.00
243_I247_T0.6711.00
200_F204_L0.6701.00
277_V281_F0.6701.00
454_F457_K0.6701.00
258_G335_F0.6691.00
360_Y364_A0.6691.00
187_L191_V0.6681.00
377_L380_A0.6651.00
218_R222_E0.6651.00
86_A210_F0.6631.00
267_P270_L0.6621.00
165_V169_L0.6621.00
186_A190_A0.6611.00
167_S170_L0.6591.00
416_T419_Y0.6591.00
401_T405_A0.6581.00
368_Q371_P0.6571.00
240_F379_G0.6571.00
82_S85_L0.6551.00
360_Y363_T0.6551.00
265_Q268_L0.6541.00
288_Y297_L0.6521.00
65_F81_I0.6501.00
74_R77_A0.6491.00
67_V290_S0.6491.00
262_A335_F0.6491.00
449_C453_Q0.6421.00
348_Y408_L0.6411.00
86_A89_V0.6411.00
467_T471_V0.6391.00
160_Q193_A0.6381.00
245_L261_A0.6371.00
233_N375_T0.6351.00
104_F107_D0.6351.00
242_Q268_L0.6321.00
300_Y303_K0.6311.00
62_V66_S0.6311.00
242_Q246_L0.6291.00
251_M387_V0.6251.00
323_A346_A0.6231.00
196_L200_F0.6231.00
16_L20_L0.6221.00
86_A215_L0.6191.00
342_L346_A0.6171.00
40_V183_Q0.6141.00
265_Q331_L0.6141.00
63_R364_A0.6131.00
381_V407_S0.6131.00
47_I131_F0.6101.00
87_A91_I0.6101.00
92_S96_L0.6081.00
220_S224_F0.6081.00
100_A128_S0.6061.00
46_V50_F0.6061.00
284_I300_Y0.6061.00
96_L128_S0.6041.00
13_A158_A0.6021.00
10_N150_L0.6021.00
122_L126_I0.6011.00
109_V250_L0.6011.00
35_E39_F0.5991.00
10_N14_F0.5981.00
125_L128_S0.5971.00
145_F153_T0.5971.00
230_S363_T0.5971.00
413_A417_P0.5971.00
306_R434_G0.5961.00
99_L124_I0.5961.00
28_I37_F0.5951.00
32_L179_I0.5951.00
344_I347_G0.5931.00
25_T37_F0.5911.00
355_F412_N0.5901.00
79_A82_S0.5881.00
152_I155_S0.5871.00
405_A409_I0.5871.00
461_W465_I0.5861.00
452_I455_I0.5861.00
36_A179_I0.5861.00
58_S142_A0.5851.00
445_A474_C0.5841.00
309_G350_V0.5821.00
197_S201_F0.5811.00
21_S26_P0.5791.00
178_K185_A0.5771.00
332_G335_F0.5771.00
180_W184_L0.5741.00
414_I418_L0.5731.00
391_G396_G0.5721.00
150_L154_S0.5711.00
233_N372_A0.5711.00
352_S356_M0.5711.00
361_I420_V0.5701.00
321_G449_C0.5691.00
11_L15_L0.5691.00
75_E78_N0.5661.00
453_Q463_S0.5641.00
382_N385_L0.5641.00
144_P152_I0.5631.00
95_L99_L0.5631.00
275_G279_S0.5621.00
422_R425_G0.5621.00
155_S159_V0.5621.00
469_V472_S0.5621.00
452_I456_V0.5611.00
262_A338_I0.5591.00
79_A219_T0.5591.00
433_K436_I0.5591.00
16_L162_L0.5581.00
247_T383_V0.5561.00
252_L390_S0.5551.00
370_T374_V0.5551.00
42_L245_L0.5541.00
163_I166_L0.5541.00
375_T379_G0.5521.00
13_A16_L0.5521.00
133_L136_L0.5521.00
374_V377_L0.5521.00
317_A320_G0.5511.00
161_M165_V0.5491.00
475_Y478_F0.5481.00
444_F447_T0.5481.00
245_L264_I0.5471.00
182_I185_A0.5471.00
107_D124_I0.5461.00
322_L471_V0.5461.00
80_Y219_T0.5441.00
32_L38_G0.5441.00
35_E38_G0.5411.00
321_G442_A0.5411.00
126_I130_L0.5401.00
193_A196_L0.5401.00
21_S25_T0.5391.00
328_T331_L0.5381.00
313_A350_V0.5371.00
64_F222_E0.5361.00
274_A356_M0.5361.00
404_G407_S0.5361.00
4_T8_S0.5361.00
94_L97_L0.5351.00
244_D247_T0.5341.00
92_S128_S0.5341.00
124_I128_S0.5341.00
439_L442_A0.5331.00
305_V358_L0.5331.00
316_A346_A0.5331.00
81_I140_F0.5311.00
222_E226_A0.5291.00
161_M164_R0.5291.00
283_P287_S0.5291.00
390_S399_G0.5281.00
49_Y238_L0.5281.00
420_V424_T0.5281.00
158_A162_L0.5271.00
325_P463_S0.5271.00
134_T190_A0.5271.00
164_R185_A0.5271.00
16_L19_F0.5251.00
66_S286_T0.5241.00
80_Y223_L0.5241.00
466_A469_V0.5231.00
351_V405_A0.5231.00
437_G441_A0.5221.00
359_F371_P0.5211.00
408_L412_N0.5211.00
156_I193_A0.5211.00
376_L379_G0.5211.00
93_L132_I0.5201.00
359_F363_T0.5201.00
297_L301_A0.5201.00
233_N237_V0.5201.00
463_S466_A0.5201.00
378_L407_S0.5191.00
367_Q371_P0.5181.00
20_L23_W0.5181.00
294_M297_L0.5181.00
276_T279_S0.5171.00
142_A146_Y0.5171.00
388_T395_L0.5161.00
170_L175_F0.5151.00
83_N219_T0.5140.99
408_L411_K0.5130.99
389_L399_G0.5120.99
62_V283_P0.5090.99
243_I382_N0.5080.99
321_G324_G0.5080.99
102_S106_I0.5080.99
367_Q422_R0.5080.99
147_A204_L0.5070.99
112_V120_V0.5070.99
159_V162_L0.5050.99
83_N86_A0.5040.99
126_I180_W0.5040.99
314_L318_L0.5040.99
24_M168_V0.5030.99
431_F434_G0.5020.99
207_W210_F0.5010.99
252_L396_G0.5000.99
447_T450_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8455 100 0.336 Contact Map
3w4tA 1 0.8396 100 0.35 Contact Map
4humA 1 0.8614 100 0.353 Contact Map
3mktA 1 0.8574 100 0.36 Contact Map
2cfqA 1 0.7703 43.2 0.945 Contact Map
1pw4A 1 0.7822 29 0.95 Contact Map
3wdoA 1 0.7802 27.1 0.951 Contact Map
4m64A 1 0.7941 16.9 0.955 Contact Map
4w6vA 1 0.3624 9.7 0.96 Contact Map
4xnjA 1 0.3921 7.4 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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