GREMLIN Database
EPSJ - Uncharacterized glycosyltransferase EpsJ
UniProt: P71059 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (285)
Sequences: 11281 (10129)
Seq/√Len: 600.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_R172_E3.8201.00
14_V91_G3.4321.00
15_E45_R2.9751.00
39_N64_H2.9331.00
11_M46_S2.9191.00
20_E212_R2.8461.00
76_T80_A2.7801.00
79_K177_L2.7441.00
102_R206_E2.6641.00
189_P193_S2.5681.00
68_G72_S2.4261.00
29_T101_Q2.3131.00
47_G64_H2.2961.00
112_L202_K2.2581.00
51_E64_H2.2461.00
45_R48_E2.2031.00
19_E23_D2.1741.00
96_S210_I2.1621.00
6_S83_G2.1491.00
47_G51_E2.1441.00
72_S180_E2.1211.00
63_I80_A2.1001.00
37_L50_A2.0831.00
5_V104_T2.0661.00
19_E52_D2.0631.00
87_G100_F2.0531.00
13_N43_P2.0251.00
47_G62_V1.9671.00
106_E202_K1.9341.00
120_Y210_I1.9321.00
95_V99_M1.9301.00
65_Q68_G1.9241.00
34_E61_R1.9191.00
8_I77_G1.9111.00
23_D53_Y1.8981.00
20_E94_Y1.8741.00
113_D167_R1.8641.00
85_Y107_A1.8171.00
38_V77_G1.8111.00
63_I76_T1.7791.00
30_L104_T1.7391.00
11_M37_L1.7311.00
9_V35_I1.7311.00
70_L218_L1.7091.00
9_V21_C1.7071.00
89_V95_V1.6951.00
106_E204_L1.6931.00
65_Q76_T1.6871.00
5_V100_F1.6631.00
4_L84_T1.6471.00
94_Y210_I1.6461.00
103_L165_L1.6161.00
6_S34_E1.6061.00
103_L117_C1.6051.00
9_V25_L1.6041.00
87_G99_M1.6001.00
87_G165_L1.5921.00
76_T79_K1.5731.00
34_E83_G1.5661.00
169_E173_R1.5561.00
5_V165_L1.5531.00
81_A168_R1.5171.00
122_Q210_I1.5131.00
98_A102_R1.5121.00
74_R90_D1.4971.00
12_Y67_N1.4861.00
15_E49_I1.4771.00
25_L89_V1.4761.00
179_D189_P1.4721.00
101_Q105_E1.4681.00
22_I53_Y1.4601.00
19_E53_Y1.4581.00
35_I60_I1.4531.00
61_R80_A1.4511.00
94_Y212_R1.4421.00
41_G65_Q1.4361.00
65_Q72_S1.4281.00
170_L194_A1.4211.00
23_D27_R1.4151.00
99_M103_L1.4131.00
4_L32_D1.4031.00
117_C208_L1.3871.00
86_I168_R1.3631.00
70_L186_E1.3471.00
21_C89_V1.3391.00
39_N47_G1.3321.00
50_A62_V1.3251.00
11_M14_V1.3161.00
39_N42_T1.3161.00
33_I100_F1.3081.00
87_G95_V1.2961.00
85_Y165_L1.2891.00
106_E110_N1.2891.00
19_E49_I1.2861.00
171_F190_F1.2821.00
78_I86_I1.2801.00
52_D56_R1.2791.00
120_Y207_G1.2761.00
84_T167_R1.2721.00
94_Y122_Q1.2691.00
26_L60_I1.2651.00
214_N217_S1.2651.00
107_A165_L1.2521.00
107_A115_V1.2421.00
104_T108_E1.2331.00
30_L33_I1.2331.00
14_V17_F1.2221.00
38_V73_A1.2211.00
74_R88_F1.2211.00
34_E82_R1.2151.00
103_L115_V1.2151.00
119_F162_W1.2151.00
114_I201_V1.2011.00
98_A101_Q1.1941.00
61_R82_R1.1931.00
40_D67_N1.1841.00
13_N42_T1.1761.00
78_I88_F1.1741.00
48_E51_E1.1721.00
27_R97_S1.1671.00
106_E109_Q1.1561.00
71_S186_E1.1531.00
99_M208_L1.1481.00
22_I37_L1.1331.00
70_L74_R1.1261.00
173_R197_E1.1251.00
51_E54_A1.1251.00
51_E62_V1.1181.00
72_S76_T1.1151.00
164_Y191_N1.1131.00
99_M117_C1.1091.00
102_R105_E1.1031.00
11_M50_A1.1011.00
68_G73_A1.0821.00
22_I35_I1.0771.00
110_N202_K1.0741.00
170_L198_A1.0731.00
54_A62_V1.0701.00
78_I171_F1.0661.00
118_G203_M1.0661.00
114_I194_A1.0501.00
6_S36_I1.0371.00
166_Y191_N1.0371.00
174_A197_E1.0331.00
78_I81_A1.0321.00
123_S127_R1.0311.00
48_E52_D1.0271.00
43_P46_S1.0231.00
4_L82_R1.0181.00
70_L161_V1.0171.00
111_Q200_R1.0031.00
161_V178_F1.0031.00
22_I26_L1.0001.00
5_V87_G0.9991.00
4_L83_G0.9941.00
81_A86_I0.9941.00
217_S220_E0.9871.00
105_E109_Q0.9871.00
170_L199_E0.9861.00
26_L53_Y0.9861.00
11_M18_I0.9841.00
102_R208_L0.9831.00
7_I33_I0.9671.00
106_E115_V0.9651.00
25_L95_V0.9631.00
74_R186_E0.9631.00
169_E172_E0.9611.00
40_D73_A0.9571.00
40_D69_G0.9561.00
89_V209_Y0.9541.00
6_S81_A0.9541.00
10_P91_G0.9491.00
11_M91_G0.9471.00
84_T108_E0.9431.00
71_S75_N0.9281.00
49_I53_Y0.9241.00
113_D199_E0.9191.00
47_G50_A0.9181.00
7_I25_L0.9161.00
190_F194_A0.9091.00
23_D26_L0.9071.00
96_S120_Y0.9041.00
17_F212_R0.9031.00
10_P73_A0.9001.00
54_A60_I0.9001.00
52_D55_K0.8971.00
102_R204_L0.8941.00
7_I100_F0.8931.00
107_A112_L0.8901.00
30_L100_F0.8881.00
113_D200_R0.8761.00
103_L107_A0.8731.00
14_V214_N0.8711.00
24_S95_V0.8701.00
3_P84_T0.8651.00
96_S99_M0.8641.00
174_A177_L0.8631.00
21_C24_S0.8601.00
70_L73_A0.8591.00
68_G76_T0.8571.00
26_L57_D0.8561.00
22_I60_I0.8541.00
73_A76_T0.8511.00
113_D198_A0.8511.00
122_Q212_R0.8491.00
78_I177_L0.8481.00
18_I50_A0.8321.00
29_T98_A0.8221.00
40_D68_G0.8221.00
116_G164_Y0.8181.00
122_Q126_R0.8161.00
174_A194_A0.8141.00
166_Y194_A0.8061.00
3_P108_E0.8011.00
235_Y239_I0.8001.00
45_R49_I0.7981.00
88_F178_F0.7971.00
161_V164_Y0.7941.00
123_S126_R0.7941.00
167_R170_L0.7931.00
11_M39_N0.7871.00
75_N178_F0.7861.00
237_A240_A0.7831.00
26_L59_R0.7811.00
41_G67_N0.7711.00
102_R106_E0.7701.00
13_N46_S0.7701.00
121_K213_E0.7601.00
162_W209_Y0.7591.00
23_D56_R0.7581.00
196_R241_F0.7561.00
233_K236_Q0.7561.00
112_L200_R0.7531.00
33_I59_R0.7521.00
37_L60_I0.7521.00
3_P30_L0.7521.00
111_Q167_R0.7521.00
213_E220_E0.7511.00
233_K237_A0.7471.00
96_S208_L0.7461.00
170_L174_A0.7451.00
75_N177_L0.7441.00
166_Y171_F0.7431.00
141_T144_E0.7411.00
57_D60_I0.7361.00
68_G180_E0.7361.00
104_T107_A0.7341.00
194_A198_A0.7321.00
29_T97_S0.7271.00
73_A77_G0.7241.00
185_A188_S0.7241.00
36_I80_A0.7211.00
17_F214_N0.7201.00
84_T169_E0.7191.00
112_L115_V0.7131.00
21_C94_Y0.7131.00
25_L35_I0.7131.00
153_H156_R0.7121.00
3_P32_D0.7071.00
21_C25_L0.7011.00
115_V165_L0.7011.00
26_L35_I0.6961.00
198_A201_V0.6951.00
240_A244_H0.6911.00
18_I46_S0.6881.00
118_G205_D0.6851.00
86_I171_F0.6851.00
104_T165_L0.6821.00
36_I81_A0.6821.00
241_F245_Y0.6821.00
70_L90_D0.6821.00
179_D237_A0.6801.00
116_G203_M0.6781.00
36_I77_G0.6761.00
229_E233_K0.6701.00
21_C93_D0.6691.00
118_G207_G0.6681.00
36_I61_R0.6671.00
4_L104_T0.6661.00
10_P74_R0.6651.00
5_V107_A0.6631.00
95_V100_F0.6621.00
15_E44_D0.6611.00
123_S129_Y0.6601.00
237_A241_F0.6601.00
230_H233_K0.6591.00
232_Q236_Q0.6591.00
240_A243_N0.6581.00
24_S94_Y0.6571.00
15_E18_I0.6561.00
8_I88_F0.6541.00
5_V30_L0.6541.00
19_E56_R0.6511.00
106_E112_L0.6511.00
239_I243_N0.6491.00
4_L108_E0.6481.00
34_E81_A0.6481.00
18_I49_I0.6471.00
75_N180_E0.6431.00
33_I82_R0.6421.00
4_L30_L0.6411.00
124_S127_R0.6411.00
204_L207_G0.6401.00
110_N200_R0.6391.00
170_L197_E0.6381.00
75_N78_I0.6371.00
42_T46_S0.6321.00
85_Y167_R0.6311.00
18_I91_G0.6291.00
22_I50_A0.6291.00
14_V70_L0.6261.00
41_G66_A0.6231.00
10_P40_D0.6221.00
50_A54_A0.6221.00
189_P237_A0.6211.00
234_Q238_K0.6211.00
15_E48_E0.6201.00
258_Y261_R0.6201.00
26_L33_I0.6191.00
95_V209_Y0.6171.00
9_V91_G0.6161.00
46_S49_I0.6131.00
113_D116_G0.6131.00
214_N218_L0.6121.00
38_V76_T0.6111.00
179_D193_S0.6111.00
177_L193_S0.6091.00
4_L33_I0.6081.00
53_Y57_D0.6081.00
49_I52_D0.6081.00
230_H234_Q0.6071.00
214_N220_E0.6071.00
87_G117_C0.6071.00
9_V89_V0.6041.00
115_V204_L0.6021.00
25_L37_L0.6001.00
70_L88_F0.5981.00
7_I87_G0.5931.00
77_G90_D0.5901.00
51_E55_K0.5861.00
70_L184_F0.5851.00
28_Q101_Q0.5851.00
238_K242_Y0.5841.00
159_W188_S0.5831.00
116_G159_W0.5821.00
160_Y188_S0.5811.00
277_S281_I0.5791.00
12_Y40_D0.5791.00
126_R129_Y0.5781.00
20_E23_D0.5771.00
161_V191_N0.5741.00
90_D186_E0.5741.00
85_Y108_E0.5711.00
214_N219_T0.5691.00
3_P83_G0.5691.00
8_I38_V0.5681.00
85_Y104_T0.5671.00
256_N259_I0.5651.00
65_Q73_A0.5631.00
9_V37_L0.5631.00
21_C91_G0.5611.00
114_I164_Y0.5591.00
155_T200_R0.5591.00
15_E46_S0.5591.00
32_D59_R0.5560.99
265_P269_A0.5550.99
189_P192_L0.5530.99
53_Y56_R0.5520.99
21_C95_V0.5520.99
87_G103_L0.5510.99
204_L208_L0.5510.99
154_E157_F0.5490.99
98_A206_E0.5470.99
172_E177_L0.5450.99
124_S215_P0.5450.99
135_E138_R0.5430.99
255_L259_I0.5420.99
173_R199_E0.5420.99
103_L204_L0.5420.99
242_Y245_Y0.5400.99
223_Y227_M0.5400.99
87_G163_R0.5390.99
28_Q100_F0.5380.99
13_N44_D0.5370.99
75_N79_K0.5370.99
274_S278_P0.5370.99
235_Y238_K0.5360.99
114_I198_A0.5350.99
29_T33_I0.5350.99
8_I168_R0.5330.99
239_I242_Y0.5330.99
159_W164_Y0.5320.99
119_F163_R0.5320.99
75_N193_S0.5310.99
8_I86_I0.5300.99
98_A208_L0.5300.99
17_F21_C0.5300.99
166_Y190_F0.5280.99
226_A230_H0.5280.99
174_A190_F0.5270.99
9_V22_I0.5260.99
89_V99_M0.5260.99
54_A57_D0.5240.99
47_G54_A0.5230.99
236_Q240_A0.5230.99
38_V63_I0.5220.99
146_T149_L0.5210.99
41_G68_G0.5210.99
191_N195_F0.5210.99
14_V21_C0.5200.99
219_T222_P0.5200.99
280_D284_K0.5170.99
61_R64_H0.5170.99
69_G73_A0.5170.99
28_Q95_V0.5160.99
105_E108_E0.5150.99
266_M270_N0.5130.99
161_V186_E0.5110.99
45_R52_D0.5110.99
74_R178_F0.5060.99
284_K287_Q0.5050.99
10_P90_D0.5050.99
14_V90_D0.5050.99
171_F177_L0.5030.99
46_S50_A0.5030.99
113_D170_L0.5010.99
30_L101_Q0.5000.99
88_F171_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.5407 100 0.311 Contact Map
3l7iA 4 0.0785 100 0.324 Contact Map
2z86A 2 0.7326 100 0.363 Contact Map
1qg8A 1 0.6424 100 0.373 Contact Map
1xhbA 1 0.9244 100 0.41 Contact Map
2d7iA 1 0.9709 100 0.413 Contact Map
5ajoA 1 0.9738 100 0.428 Contact Map
4fixA 3 0.9564 100 0.444 Contact Map
2nxvA 4 0.6628 100 0.482 Contact Map
3ckjA 2 0.7442 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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