GREMLIN Database
EPSI - Putative pyruvyl transferase EpsI
UniProt: P71058 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (299)
Sequences: 333 (297)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_H103_I7.7701.00
107_N119_R4.6161.00
61_A192_V4.1201.00
169_D302_G3.9571.00
279_M306_L3.8981.00
279_M289_C3.7191.00
206_G269_E3.4831.00
138_A176_M3.3970.99
58_I276_L3.1100.99
44_L62_S3.0960.99
116_E120_R3.0210.99
167_A176_M2.9520.99
58_I104_G2.9430.98
189_P305_W2.8740.98
62_S103_I2.6660.97
166_M188_Q2.6540.97
293_R300_M2.5950.97
102_I122_I2.5180.96
134_L191_M2.4480.95
48_P109_G2.4400.95
323_V327_V2.3800.94
138_A172_T2.3700.94
289_C306_L2.2090.92
104_G276_L2.1700.91
164_L186_L2.1630.91
58_I106_G2.1300.90
65_F191_M2.1100.90
44_L134_L2.0580.89
212_R216_E2.0210.88
231_L238_I1.9080.84
120_R149_E1.8920.84
108_M116_E1.8590.83
50_H151_K1.7810.80
131_V160_H1.7760.80
110_D116_E1.7620.79
275_R298_K1.7520.79
169_D296_D1.7180.77
261_L264_K1.7050.77
52_N298_K1.6960.76
166_M186_L1.6950.76
289_C312_M1.6650.75
313_K329_E1.6540.74
315_I322_R1.6160.73
301_E304_Q1.6110.72
107_N112_Y1.6040.72
65_F104_G1.5960.72
116_E119_R1.5510.69
106_G109_G1.5330.69
124_K159_A1.5110.67
112_Y302_G1.4960.67
187_K305_W1.4730.65
66_L101_F1.4650.65
165_L176_M1.4630.65
42_I101_F1.4600.65
210_C265_L1.4450.64
110_D141_S1.4390.63
159_A282_C1.4350.63
101_F127_H1.4310.63
52_N275_R1.4230.63
109_G119_R1.4170.62
58_I112_Y1.4030.61
52_N55_D1.4000.61
26_L29_A1.3960.61
73_F254_R1.3670.59
137_T301_E1.3600.59
48_P62_S1.3600.59
58_I65_F1.3570.59
49_S134_L1.3530.59
62_S134_L1.3460.58
130_R162_G1.3440.58
174_Q178_Q1.3420.58
291_V299_V1.3410.58
173_Y185_I1.3390.58
178_Q271_V1.3350.58
135_P216_E1.3340.57
193_L283_A1.3320.57
48_P59_A1.3310.57
137_T292_I1.3050.56
119_R302_G1.3020.56
116_E157_Y1.2910.55
300_M314_L1.2900.55
51_D169_D1.2890.55
59_A261_L1.2510.53
33_V162_G1.2460.52
127_H160_H1.2460.52
58_I294_S1.2380.52
124_K267_S1.2370.52
212_R298_K1.2350.52
105_G298_K1.2300.51
52_N212_R1.2290.51
55_D106_G1.2230.51
103_I107_N1.2140.50
61_A285_T1.2050.50
254_R279_M1.1930.49
193_L302_G1.1880.49
100_V126_F1.1870.49
65_F294_S1.1700.48
52_N105_G1.1640.47
137_T210_C1.1590.47
287_T311_F1.1530.47
128_D155_K1.1510.47
55_D105_G1.1490.46
44_L101_F1.1480.46
46_L103_I1.1450.46
296_D302_G1.1180.45
207_V269_E1.1130.44
77_E254_R1.1110.44
46_L293_R1.1090.44
168_R277_H1.1030.44
61_A106_G1.1010.44
235_F238_I1.0980.43
64_A290_V1.0980.43
99_M129_Y1.0960.43
109_G116_E1.0760.42
48_P191_M1.0670.42
112_Y119_R1.0630.41
106_G294_S1.0620.41
279_M287_T1.0610.41
279_M285_T1.0550.41
57_A192_V1.0510.41
134_L292_I1.0500.41
61_A302_G1.0500.41
167_A180_F1.0490.40
214_D305_W1.0470.40
56_H257_E1.0460.40
122_I171_T1.0430.40
177_K259_E1.0340.40
208_Y296_D1.0310.39
306_L312_M1.0250.39
106_G293_R1.0080.38
111_L245_I1.0070.38
137_T265_L1.0060.38
46_L61_A1.0060.38
323_V328_N0.9960.37
135_P190_D0.9950.37
134_L176_M0.9930.37
216_E274_D0.9910.37
106_G112_Y0.9910.37
238_I241_F0.9900.37
175_F179_H0.9790.37
24_Y28_A0.9690.36
105_G275_R0.9660.36
133_Q163_L0.9630.36
278_G305_W0.9620.36
139_H169_D0.9620.36
104_G294_S0.9610.36
54_G277_H0.9590.35
54_G168_R0.9590.35
170_E174_Q0.9570.35
55_D298_K0.9550.35
203_E270_A0.9530.35
140_F285_T0.9530.35
44_L176_M0.9520.35
106_G137_T0.9490.35
109_G140_F0.9490.35
128_D177_K0.9480.35
291_V296_D0.9480.35
135_P212_R0.9400.34
208_Y268_A0.9390.34
157_Y299_V0.9320.34
101_F134_L0.9290.34
119_R157_Y0.9290.34
249_V253_T0.9280.34
281_F285_T0.9270.34
99_M185_I0.9260.34
162_G323_V0.9240.33
212_R275_R0.9240.33
47_L56_H0.9230.33
66_L123_I0.9210.33
58_I212_R0.9210.33
42_I186_L0.9190.33
35_A42_I0.9170.33
299_V303_Y0.9160.33
136_A189_P0.9090.33
206_G287_T0.9070.33
165_L257_E0.9060.33
102_I119_R0.9040.32
131_V156_I0.9010.32
138_A165_L0.8990.32
110_D120_R0.8980.32
293_R297_H0.8950.32
187_K304_Q0.8910.32
135_P214_D0.8910.32
46_L119_R0.8900.32
62_S191_M0.8890.32
180_F193_L0.8880.32
61_A104_G0.8880.32
104_G112_Y0.8860.31
95_H98_D0.8860.31
62_S296_D0.8850.31
217_S274_D0.8830.31
112_Y278_G0.8820.31
102_I123_I0.8800.31
106_G119_R0.8750.31
165_L205_E0.8650.30
120_R153_A0.8500.30
134_L290_V0.8490.30
110_D160_H0.8450.29
106_G276_L0.8440.29
24_Y27_G0.8440.29
315_I318_P0.8400.29
280_I299_V0.8400.29
47_L77_E0.8360.29
140_F195_L0.8350.29
47_L153_A0.8350.29
55_D58_I0.8290.29
207_V270_A0.8280.29
287_T306_L0.8270.29
56_H289_C0.8260.28
42_I70_Y0.8210.28
105_G212_R0.8210.28
75_I84_Y0.8200.28
214_D274_D0.8190.28
282_C310_P0.8190.28
280_I302_G0.8180.28
229_A233_E0.8170.28
50_H90_L0.8150.28
57_A291_V0.8120.28
24_Y149_E0.8120.28
137_T160_H0.8100.28
212_R274_D0.8100.28
51_D280_I0.8090.28
120_R156_I0.8080.28
68_Q125_T0.8080.28
140_F180_F0.8050.27
189_P216_E0.8050.27
324_T327_V0.8050.27
48_P56_H0.8040.27
173_Y199_K0.8040.27
58_I109_G0.8040.27
182_E213_E0.8010.27
107_N302_G0.7950.27
201_P271_V0.7940.27
123_I160_H0.7820.26
61_A188_Q0.7800.26
279_M302_G0.7770.26
140_F153_A0.7760.26
169_D271_V0.7760.26
132_V310_P0.7760.26
319_E326_A0.7730.26
110_D143_T0.7730.26
181_Q185_I0.7710.26
169_D266_Q0.7700.26
207_V310_P0.7680.26
44_L112_Y0.7590.25
25_W28_A0.7580.25
191_M296_D0.7530.25
182_E314_L0.7510.25
52_N214_D0.7510.25
281_F311_F0.7490.25
56_H254_R0.7490.25
269_E288_P0.7480.25
67_E170_E0.7480.25
293_R296_D0.7450.25
176_M185_I0.7430.25
58_I214_D0.7410.24
216_E298_K0.7410.24
56_H112_Y0.7410.24
105_G168_R0.7410.24
105_G277_H0.7410.24
53_L260_A0.7410.24
258_L262_W0.7380.24
53_L281_F0.7380.24
168_R298_K0.7350.24
277_H298_K0.7350.24
177_K292_I0.7340.24
239_K243_T0.7320.24
142_D201_P0.7320.24
281_F291_V0.7300.24
254_R289_C0.7300.24
175_F282_C0.7250.24
65_F302_G0.7240.24
214_D298_K0.7220.24
135_P274_D0.7190.24
169_D283_A0.7170.23
193_L196_D0.7150.23
67_E97_E0.7120.23
106_G212_R0.7090.23
254_R285_T0.7080.23
115_E284_L0.7070.23
104_G109_G0.7050.23
102_I175_F0.7010.23
104_G306_L0.7000.23
257_E261_L0.6990.23
222_E272_V0.6990.23
45_T102_I0.6980.23
81_K155_K0.6970.23
119_R131_V0.6960.23
270_A290_V0.6930.22
322_R326_A0.6920.22
124_K161_P0.6910.22
92_R272_V0.6890.22
213_E221_E0.6890.22
39_Q291_V0.6880.22
59_A101_F0.6870.22
209_M299_V0.6850.22
58_I62_S0.6840.22
204_R287_T0.6810.22
35_A41_K0.6810.22
112_Y276_L0.6780.22
150_L179_H0.6730.22
254_R306_L0.6730.22
40_K98_D0.6730.22
168_R190_D0.6720.22
190_D277_H0.6720.22
138_A158_N0.6660.21
271_V282_C0.6630.21
143_T167_A0.6630.21
44_L49_S0.6630.21
112_Y212_R0.6630.21
89_S134_L0.6620.21
58_I61_A0.6600.21
162_G199_K0.6590.21
59_A254_R0.6580.21
178_Q182_E0.6580.21
43_I75_I0.6550.21
275_R282_C0.6550.21
55_D275_R0.6550.21
227_V232_C0.6550.21
58_I216_E0.6530.21
325_A330_L0.6470.21
46_L294_S0.6450.20
48_P135_P0.6440.20
150_L180_F0.6440.20
190_D278_G0.6400.20
44_L47_L0.6390.20
117_W316_E0.6380.20
273_T291_V0.6350.20
165_L232_C0.6350.20
133_Q316_E0.6340.20
65_F267_S0.6320.20
227_V235_F0.6300.20
47_L57_A0.6280.20
215_Q271_V0.6280.20
132_V247_R0.6280.20
163_L308_D0.6280.20
100_V161_P0.6270.20
271_V290_V0.6270.20
94_R225_N0.6260.20
174_Q177_K0.6250.20
92_R137_T0.6230.20
131_V270_A0.6230.20
65_F194_Y0.6230.20
52_N58_I0.6220.20
326_A330_L0.6150.19
83_I111_L0.6110.19
325_A329_E0.6100.19
62_S76_V0.6100.19
169_D276_L0.6080.19
153_A157_Y0.6080.19
24_Y30_D0.6070.19
150_L175_F0.6070.19
224_R283_A0.6060.19
176_M224_R0.6060.19
112_Y216_E0.6040.19
111_L295_F0.6040.19
235_F244_T0.6020.19
259_E280_I0.5960.19
42_I62_S0.5960.19
65_F106_G0.5950.19
149_E152_R0.5920.18
171_T282_C0.5910.18
54_G105_G0.5910.18
48_P103_I0.5890.18
185_I292_I0.5890.18
98_D274_D0.5870.18
54_G298_K0.5860.18
297_H305_W0.5860.18
132_V151_K0.5860.18
246_G282_C0.5850.18
184_T259_E0.5840.18
27_G30_D0.5820.18
192_V306_L0.5810.18
297_H314_L0.5780.18
216_E273_T0.5770.18
313_K326_A0.5760.18
53_L257_E0.5760.18
66_L76_V0.5750.18
124_K128_D0.5740.18
165_L178_Q0.5730.18
138_A280_I0.5730.18
174_Q181_Q0.5720.18
126_F157_Y0.5710.18
199_K223_Q0.5700.18
56_H265_L0.5680.18
190_D274_D0.5650.18
276_L302_G0.5650.18
172_T277_H0.5650.18
168_R172_T0.5650.18
153_A180_F0.5590.17
216_E280_I0.5580.17
241_F261_L0.5540.17
52_N277_H0.5520.17
52_N168_R0.5520.17
195_L284_L0.5510.17
116_E305_W0.5500.17
109_G112_Y0.5490.17
297_H302_G0.5460.17
190_D216_E0.5450.17
215_Q286_G0.5450.17
123_I153_A0.5450.17
101_F132_V0.5430.17
46_L107_N0.5410.17
170_E226_R0.5410.17
300_M316_E0.5410.17
109_G189_P0.5410.17
257_E284_L0.5400.17
124_K156_I0.5390.17
106_G279_M0.5360.17
283_A309_I0.5360.17
75_I112_Y0.5360.17
235_F282_C0.5350.17
181_Q231_L0.5340.16
144_K307_K0.5310.16
168_R275_R0.5310.16
209_M307_K0.5300.16
40_K97_E0.5300.16
173_Y226_R0.5290.16
57_A189_P0.5280.16
108_M293_R0.5280.16
55_D212_R0.5280.16
207_V213_E0.5260.16
276_L294_S0.5260.16
111_L297_H0.5250.16
123_I215_Q0.5220.16
54_G190_D0.5210.16
57_A305_W0.5200.16
208_Y271_V0.5180.16
58_I275_R0.5180.16
56_H278_G0.5170.16
54_G104_G0.5170.16
261_L279_M0.5170.16
85_K156_I0.5160.16
106_G305_W0.5150.16
247_R251_R0.5140.16
191_M297_H0.5130.16
217_S299_V0.5120.16
136_A280_I0.5100.16
29_A279_M0.5090.16
58_I298_K0.5070.16
47_L210_C0.5050.16
274_D289_C0.5040.16
57_A61_A0.5040.16
111_L214_D0.5030.15
172_T275_R0.5020.15
180_F282_C0.5010.15
63_K66_L0.5010.15
139_H144_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gt1A 1 0.7709 95.7 0.936 Contact Map
3tovA 1 0.7709 93.6 0.943 Contact Map
3rhzA 4 0.8352 86.9 0.951 Contact Map
3l7iA 4 0.9302 82.1 0.954 Contact Map
1pswA 1 0.7682 81.1 0.955 Contact Map
3okpA 1 0.8715 62.5 0.961 Contact Map
4x7rA 1 0.9358 53.3 0.963 Contact Map
2x0dA 2 0.8771 48.4 0.964 Contact Map
2jjmA 4 0.8073 47.2 0.964 Contact Map
3froA 3 0.933 45.4 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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