GREMLIN Database
EPSH - Putative glycosyltransferase EpsH
UniProt: P71057 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (280)
Sequences: 9738 (8859)
Seq/√Len: 529.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_R170_E3.8631.00
15_T92_S3.2571.00
40_N65_H3.1381.00
12_V47_S3.0871.00
21_T212_R3.0801.00
16_E46_A2.9741.00
80_E175_S2.7251.00
103_Q206_T2.7191.00
77_K81_A2.7111.00
189_F193_R2.5541.00
30_T102_E2.5291.00
69_Q73_A2.4871.00
48_P65_H2.3691.00
24_E54_Y2.2381.00
20_R24_E2.2081.00
20_R53_E2.1841.00
38_I51_A2.1801.00
14_N44_A2.1421.00
64_I81_A2.1121.00
97_E210_H2.1091.00
7_S84_G2.1091.00
52_E65_H2.0951.00
66_Q69_Q2.0911.00
6_V105_L2.0681.00
46_A49_D2.0471.00
73_A178_L2.0361.00
96_I100_Y2.0231.00
48_P52_E2.0071.00
88_A101_C1.9921.00
107_T202_S1.9561.00
35_E62_K1.9441.00
10_V26_L1.9391.00
48_P63_V1.9291.00
21_T95_W1.9141.00
112_T202_S1.8981.00
9_L78_G1.8681.00
31_M105_L1.8591.00
10_V36_I1.8221.00
12_V38_I1.8161.00
64_I77_K1.8161.00
6_V101_C1.7721.00
10_V22_C1.7711.00
107_T204_V1.7661.00
86_F108_A1.7451.00
90_I96_I1.7411.00
71_L218_I1.7291.00
39_V78_G1.7261.00
23_L54_Y1.6851.00
7_S35_E1.6771.00
95_W210_H1.6631.00
66_Q73_A1.6541.00
6_V163_L1.6511.00
5_A85_E1.6301.00
20_R54_Y1.6241.00
167_S171_A1.6201.00
102_E106_R1.6131.00
35_E84_G1.6121.00
88_A100_Y1.6031.00
104_M163_L1.5851.00
88_A163_L1.5821.00
77_K80_E1.5771.00
82_A166_R1.5701.00
26_L90_I1.5331.00
66_Q77_K1.5191.00
51_A63_V1.5111.00
75_R91_D1.5041.00
99_D103_Q1.5041.00
40_N48_P1.4901.00
42_G66_Q1.4671.00
36_I61_F1.4591.00
13_Y68_N1.4561.00
113_D165_R1.4491.00
34_I101_C1.4471.00
16_E50_I1.4251.00
79_I87_I1.4171.00
62_K81_A1.4051.00
100_Y104_M1.4011.00
168_M194_A1.3991.00
120_A210_H1.3851.00
5_A33_N1.3761.00
177_P189_F1.3681.00
22_C90_I1.3651.00
169_I190_F1.3561.00
71_L186_E1.3381.00
104_M117_C1.3371.00
62_K83_R1.3261.00
31_M34_I1.3261.00
113_D200_S1.3241.00
122_E210_H1.3171.00
87_I166_R1.3161.00
20_R50_I1.2981.00
75_R89_F1.2941.00
95_W212_R1.2891.00
39_V74_V1.2851.00
23_L36_I1.2821.00
88_A96_I1.2801.00
86_F163_L1.2741.00
177_P181_E1.2681.00
14_N43_S1.2591.00
40_N43_S1.2571.00
108_A163_L1.2511.00
27_R61_F1.2321.00
24_E28_N1.2201.00
41_D68_N1.2171.00
99_D102_E1.2131.00
164_Y191_S1.2071.00
35_E83_R1.1961.00
53_E57_M1.1871.00
52_E55_A1.1771.00
12_V15_T1.1671.00
15_T18_Y1.1661.00
168_M199_R1.1541.00
79_I82_A1.1531.00
52_E63_V1.1521.00
117_C208_L1.1431.00
23_L38_I1.1411.00
105_L109_G1.1411.00
50_I54_Y1.1401.00
85_E165_R1.1381.00
119_Y160_W1.1351.00
12_V51_A1.1301.00
28_N98_P1.1251.00
106_R110_D1.1151.00
71_L75_R1.1111.00
11_A92_S1.1091.00
71_L159_S1.1071.00
69_Q74_V1.1051.00
100_Y208_L1.0941.00
72_G186_E1.0931.00
171_A197_F1.0931.00
55_A63_V1.0911.00
5_A83_R1.0851.00
103_Q106_R1.0851.00
23_L27_R1.0821.00
85_E109_G1.0781.00
7_S37_I1.0781.00
100_Y117_C1.0761.00
6_V88_A1.0731.00
73_A77_K1.0651.00
79_I89_F1.0591.00
55_A61_F1.0461.00
162_K191_S1.0461.00
49_D52_E1.0261.00
107_T110_D1.0221.00
44_A47_S1.0221.00
108_A115_V1.0171.00
48_P51_A1.0171.00
27_R54_Y1.0161.00
95_W122_E1.0161.00
72_G76_N1.0111.00
53_E56_K1.0031.00
41_D70_G1.0001.00
75_R186_E0.9991.00
103_Q208_L0.9901.00
90_I209_Y0.9801.00
167_S170_E0.9801.00
82_A87_I0.9751.00
159_S176_F0.9741.00
79_I169_I0.9721.00
120_A207_P0.9701.00
26_L96_I0.9661.00
12_V19_I0.9631.00
18_Y212_R0.9591.00
41_D74_V0.9571.00
190_F194_A0.9561.00
8_L34_I0.9521.00
49_D53_E0.9471.00
7_S82_A0.9461.00
12_V92_S0.9401.00
8_L26_L0.9351.00
14_N47_S0.9311.00
104_M108_A0.9161.00
11_A74_V0.9161.00
103_Q204_V0.9151.00
31_M101_C0.9131.00
172_H175_S0.9061.00
27_R58_D0.9051.00
214_H217_S0.8961.00
15_T214_H0.8941.00
172_H197_F0.8901.00
22_C25_S0.8851.00
74_V77_K0.8841.00
217_S220_Q0.8821.00
118_N203_Y0.8761.00
168_M198_A0.8711.00
87_I169_I0.8691.00
42_G68_N0.8581.00
5_A84_G0.8581.00
23_L61_F0.8551.00
97_E100_Y0.8491.00
58_D61_F0.8401.00
122_E212_R0.8381.00
35_E82_A0.8341.00
25_S96_I0.8331.00
71_L74_V0.8311.00
196_F240_F0.8311.00
26_L36_I0.8301.00
164_Y194_A0.8301.00
8_L101_C0.8191.00
19_I51_A0.8101.00
116_I162_K0.7991.00
16_E45_D0.7991.00
12_V40_N0.7981.00
41_D69_Q0.7941.00
232_A236_T0.7931.00
76_N176_F0.7901.00
113_D199_R0.7881.00
105_L108_A0.7881.00
231_L235_E0.7801.00
104_M115_V0.7771.00
69_Q77_K0.7761.00
79_I175_S0.7731.00
185_V188_Q0.7721.00
111_E200_S0.7681.00
46_A50_I0.7661.00
225_K229_S0.7641.00
37_I81_A0.7601.00
30_T99_D0.7551.00
96_I101_C0.7541.00
143_K146_Y0.7501.00
142_P145_H0.7501.00
240_F244_N0.7471.00
103_Q107_T0.7461.00
69_Q178_L0.7451.00
86_F165_R0.7431.00
143_K147_I0.7431.00
168_M172_H0.7401.00
89_F176_F0.7401.00
112_T200_S0.7381.00
27_R36_I0.7361.00
76_N175_S0.7341.00
172_H194_A0.7331.00
24_E27_R0.7311.00
114_L194_A0.7311.00
165_R168_M0.7261.00
194_A198_A0.7261.00
4_P31_M0.7241.00
22_C26_L0.7231.00
189_F236_T0.7221.00
97_E208_L0.7221.00
236_T240_F0.7211.00
85_E167_S0.7211.00
177_P236_T0.7211.00
4_P109_G0.7191.00
164_Y169_I0.7181.00
19_I47_S0.7141.00
39_V77_K0.7131.00
213_I220_Q0.7121.00
132_S136_Q0.7111.00
25_S95_W0.7101.00
232_A235_E0.7081.00
4_P85_E0.7071.00
38_I61_F0.7051.00
112_T115_V0.7031.00
119_Y161_N0.6991.00
123_F127_G0.6931.00
111_E165_R0.6911.00
37_I78_G0.6881.00
71_L91_D0.6881.00
6_V31_M0.6871.00
177_P193_R0.6871.00
24_E57_M0.6851.00
30_T98_P0.6821.00
22_C94_D0.6781.00
171_A199_R0.6741.00
19_I92_S0.6721.00
160_W209_Y0.6721.00
23_L51_A0.6721.00
74_V78_G0.6721.00
178_L181_E0.6701.00
16_E47_S0.6681.00
15_T71_L0.6671.00
145_H149_A0.6651.00
22_C96_I0.6651.00
5_A105_L0.6651.00
168_M197_F0.6651.00
32_D60_R0.6621.00
99_D208_L0.6611.00
228_E232_A0.6581.00
22_C95_W0.6551.00
114_L198_A0.6541.00
18_Y214_H0.6541.00
108_A112_T0.6541.00
10_V92_S0.6511.00
27_R57_M0.6501.00
27_R60_R0.6471.00
11_A75_R0.6451.00
132_S135_A0.6451.00
198_A201_V0.6441.00
124_E127_G0.6431.00
170_E175_S0.6411.00
43_S47_S0.6401.00
37_I62_K0.6391.00
260_L264_I0.6391.00
86_F109_G0.6391.00
5_A109_G0.6371.00
5_A31_M0.6361.00
27_R34_I0.6351.00
14_N45_D0.6351.00
277_R281_K0.6341.00
76_N79_I0.6321.00
78_G82_A0.6311.00
51_A55_A0.6311.00
66_Q74_V0.6301.00
19_I50_I0.6261.00
234_Y238_A0.6261.00
239_A243_E0.6261.00
204_V208_L0.6261.00
15_T22_C0.6251.00
16_E19_I0.6251.00
145_H148_K0.6251.00
104_M204_V0.6251.00
229_S232_A0.6251.00
34_I60_R0.6231.00
159_S162_K0.6221.00
8_L88_A0.6211.00
159_S191_S0.6201.00
42_G65_H0.6181.00
115_V118_N0.6181.00
10_V90_I0.6171.00
76_N178_L0.6161.00
219_V222_Y0.6151.00
16_E49_D0.6131.00
88_A161_N0.6131.00
52_E56_K0.6121.00
76_N190_F0.6091.00
42_G74_V0.6081.00
72_G181_E0.6021.00
138_Y141_Q0.6001.00
86_F105_L0.6001.00
169_I194_A0.5991.00
157_G161_N0.5961.00
26_L34_I0.5951.00
96_I209_Y0.5951.00
29_Q102_E0.5930.99
71_L89_F0.5920.99
233_L237_N0.5910.99
214_H220_Q0.5900.99
11_A41_D0.5890.99
18_Y22_C0.5880.99
234_Y237_N0.5860.99
204_V207_P0.5860.99
157_G188_Q0.5850.99
37_I82_A0.5820.99
10_V38_I0.5820.99
236_T239_A0.5810.99
118_N207_P0.5790.99
217_S221_R0.5790.99
193_R236_T0.5790.99
88_A104_M0.5790.99
9_L89_F0.5760.99
55_A58_D0.5750.99
51_A65_H0.5740.99
47_S50_I0.5720.99
48_P55_A0.5680.99
22_C92_S0.5680.99
50_I53_E0.5660.99
39_V81_A0.5650.99
54_Y58_D0.5640.99
121_A213_I0.5600.99
75_R159_S0.5600.99
229_S233_L0.5540.99
41_D91_D0.5520.99
97_E120_A0.5490.99
175_S178_L0.5480.99
157_G191_S0.5470.99
172_H190_F0.5470.99
191_S195_H0.5460.99
188_Q192_F0.5440.99
89_F169_I0.5430.99
146_Y151_F0.5430.99
10_V23_L0.5420.99
238_A242_Q0.5400.99
16_E92_S0.5390.99
91_D186_E0.5380.99
280_E283_R0.5380.99
6_V108_A0.5370.99
158_F161_N0.5360.99
149_A152_E0.5340.99
45_D50_I0.5330.99
42_G67_E0.5330.99
280_E284_N0.5330.99
175_S190_F0.5320.99
30_T34_I0.5320.99
108_A165_R0.5300.99
159_S186_E0.5290.99
71_L184_H0.5280.99
64_I78_G0.5280.99
6_V104_M0.5270.99
175_S193_R0.5270.99
42_G69_Q0.5250.99
239_A242_Q0.5250.99
242_Q245_N0.5250.99
135_A138_Y0.5210.99
137_T140_D0.5200.99
105_L163_L0.5200.99
19_I38_I0.5190.99
156_R160_W0.5170.99
265_C268_N0.5170.99
147_I152_E0.5150.99
34_I83_R0.5140.99
15_T47_S0.5130.99
90_I100_Y0.5130.99
13_Y41_D0.5120.99
134_I138_Y0.5110.99
149_A153_G0.5110.99
123_F126_T0.5100.98
214_H219_V0.5100.98
101_C163_L0.5080.98
75_R176_F0.5080.98
51_A61_F0.5070.98
74_V91_D0.5070.98
168_M171_A0.5070.98
177_P190_F0.5060.98
111_E114_L0.5020.98
23_L50_I0.5020.98
150_L153_G0.5010.98
99_D206_T0.5010.98
157_G185_V0.5000.98
157_G162_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.5291 100 0.357 Contact Map
3l7iA 4 0.064 100 0.38 Contact Map
1qg8A 1 0.6453 100 0.4 Contact Map
2z86A 2 0.7355 100 0.401 Contact Map
2d7iA 1 0.939 100 0.426 Contact Map
1xhbA 1 0.8983 100 0.429 Contact Map
5ajoA 1 0.9128 100 0.45 Contact Map
4fixA 3 0.9564 100 0.485 Contact Map
2nxvA 4 0.6657 100 0.509 Contact Map
3ckjA 2 0.7645 100 0.511 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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