EPSH - BACSU - GREMLIN Contacts

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EPSH - Putative glycosyltransferase EpsH

UniProt:	P71057	Sequences: METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSADASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCEQMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSWNKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSIVQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSRRLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQRVIEYKMRNRG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (280)
Sequences:	9738 (8859)
Seq/√Len:	529.4

ECOLI - YIBD WCAA WCAE GTRB ARNC WBBL PGAC YAIP
BACSU - EPSH EPSJ GGAA GGAB CGED YFNE EPSE CSBB TUAG SPSA YWDF YKCC YKOT TAGF YDAM
HALSA - Q9HQP4 Q9HQP8 Q9HSC8 Q9HQP3 Q9HQQ6 Q9HR08 Q9HNK3
SULSO - Q7LXF7 Q97TZ0 Q7LXG6 Q97TY0 Q97X05 Q97WK7 Q97YG5 Q97YN4 Q97W52

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
166_R	170_E	3.863	1.00
15_T	92_S	3.257	1.00
40_N	65_H	3.138	1.00
12_V	47_S	3.087	1.00
21_T	212_R	3.080	1.00
16_E	46_A	2.974	1.00
80_E	175_S	2.725	1.00
103_Q	206_T	2.719	1.00
77_K	81_A	2.711	1.00
189_F	193_R	2.554	1.00
30_T	102_E	2.529	1.00
69_Q	73_A	2.487	1.00
48_P	65_H	2.369	1.00
24_E	54_Y	2.238	1.00
20_R	24_E	2.208	1.00
20_R	53_E	2.184	1.00
38_I	51_A	2.180	1.00
14_N	44_A	2.142	1.00
64_I	81_A	2.112	1.00
97_E	210_H	2.109	1.00
7_S	84_G	2.109	1.00
52_E	65_H	2.095	1.00
66_Q	69_Q	2.091	1.00
6_V	105_L	2.068	1.00
46_A	49_D	2.047	1.00
73_A	178_L	2.036	1.00
96_I	100_Y	2.023	1.00
48_P	52_E	2.007	1.00
88_A	101_C	1.992	1.00
107_T	202_S	1.956	1.00
35_E	62_K	1.944	1.00
10_V	26_L	1.939	1.00
48_P	63_V	1.929	1.00
21_T	95_W	1.914	1.00
112_T	202_S	1.898	1.00
9_L	78_G	1.868	1.00
31_M	105_L	1.859	1.00
10_V	36_I	1.822	1.00
12_V	38_I	1.816	1.00
64_I	77_K	1.816	1.00
6_V	101_C	1.772	1.00
10_V	22_C	1.771	1.00
107_T	204_V	1.766	1.00
86_F	108_A	1.745	1.00
90_I	96_I	1.741	1.00
71_L	218_I	1.729	1.00
39_V	78_G	1.726	1.00
23_L	54_Y	1.685	1.00
7_S	35_E	1.677	1.00
95_W	210_H	1.663	1.00
66_Q	73_A	1.654	1.00
6_V	163_L	1.651	1.00
5_A	85_E	1.630	1.00
20_R	54_Y	1.624	1.00
167_S	171_A	1.620	1.00
102_E	106_R	1.613	1.00
35_E	84_G	1.612	1.00
88_A	100_Y	1.603	1.00
104_M	163_L	1.585	1.00
88_A	163_L	1.582	1.00
77_K	80_E	1.577	1.00
82_A	166_R	1.570	1.00
26_L	90_I	1.533	1.00
66_Q	77_K	1.519	1.00
51_A	63_V	1.511	1.00
75_R	91_D	1.504	1.00
99_D	103_Q	1.504	1.00
40_N	48_P	1.490	1.00
42_G	66_Q	1.467	1.00
36_I	61_F	1.459	1.00
13_Y	68_N	1.456	1.00
113_D	165_R	1.449	1.00
34_I	101_C	1.447	1.00
16_E	50_I	1.425	1.00
79_I	87_I	1.417	1.00
62_K	81_A	1.405	1.00
100_Y	104_M	1.401	1.00
168_M	194_A	1.399	1.00
120_A	210_H	1.385	1.00
5_A	33_N	1.376	1.00
177_P	189_F	1.368	1.00
22_C	90_I	1.365	1.00
169_I	190_F	1.356	1.00
71_L	186_E	1.338	1.00
104_M	117_C	1.337	1.00
62_K	83_R	1.326	1.00
31_M	34_I	1.326	1.00
113_D	200_S	1.324	1.00
122_E	210_H	1.317	1.00
87_I	166_R	1.316	1.00
20_R	50_I	1.298	1.00
75_R	89_F	1.294	1.00
95_W	212_R	1.289	1.00
39_V	74_V	1.285	1.00
23_L	36_I	1.282	1.00
88_A	96_I	1.280	1.00
86_F	163_L	1.274	1.00
177_P	181_E	1.268	1.00
14_N	43_S	1.259	1.00
40_N	43_S	1.257	1.00
108_A	163_L	1.251	1.00
27_R	61_F	1.232	1.00
24_E	28_N	1.220	1.00
41_D	68_N	1.217	1.00
99_D	102_E	1.213	1.00
164_Y	191_S	1.207	1.00
35_E	83_R	1.196	1.00
53_E	57_M	1.187	1.00
52_E	55_A	1.177	1.00
12_V	15_T	1.167	1.00
15_T	18_Y	1.166	1.00
168_M	199_R	1.154	1.00
79_I	82_A	1.153	1.00
52_E	63_V	1.152	1.00
117_C	208_L	1.143	1.00
23_L	38_I	1.141	1.00
105_L	109_G	1.141	1.00
50_I	54_Y	1.140	1.00
85_E	165_R	1.138	1.00
119_Y	160_W	1.135	1.00
12_V	51_A	1.130	1.00
28_N	98_P	1.125	1.00
106_R	110_D	1.115	1.00
71_L	75_R	1.111	1.00
11_A	92_S	1.109	1.00
71_L	159_S	1.107	1.00
69_Q	74_V	1.105	1.00
100_Y	208_L	1.094	1.00
72_G	186_E	1.093	1.00
171_A	197_F	1.093	1.00
55_A	63_V	1.091	1.00
5_A	83_R	1.085	1.00
103_Q	106_R	1.085	1.00
23_L	27_R	1.082	1.00
85_E	109_G	1.078	1.00
7_S	37_I	1.078	1.00
100_Y	117_C	1.076	1.00
6_V	88_A	1.073	1.00
73_A	77_K	1.065	1.00
79_I	89_F	1.059	1.00
55_A	61_F	1.046	1.00
162_K	191_S	1.046	1.00
49_D	52_E	1.026	1.00
107_T	110_D	1.022	1.00
44_A	47_S	1.022	1.00
108_A	115_V	1.017	1.00
48_P	51_A	1.017	1.00
27_R	54_Y	1.016	1.00
95_W	122_E	1.016	1.00
72_G	76_N	1.011	1.00
53_E	56_K	1.003	1.00
41_D	70_G	1.000	1.00
75_R	186_E	0.999	1.00
103_Q	208_L	0.990	1.00
90_I	209_Y	0.980	1.00
167_S	170_E	0.980	1.00
82_A	87_I	0.975	1.00
159_S	176_F	0.974	1.00
79_I	169_I	0.972	1.00
120_A	207_P	0.970	1.00
26_L	96_I	0.966	1.00
12_V	19_I	0.963	1.00
18_Y	212_R	0.959	1.00
41_D	74_V	0.957	1.00
190_F	194_A	0.956	1.00
8_L	34_I	0.952	1.00
49_D	53_E	0.947	1.00
7_S	82_A	0.946	1.00
12_V	92_S	0.940	1.00
8_L	26_L	0.935	1.00
14_N	47_S	0.931	1.00
104_M	108_A	0.916	1.00
11_A	74_V	0.916	1.00
103_Q	204_V	0.915	1.00
31_M	101_C	0.913	1.00
172_H	175_S	0.906	1.00
27_R	58_D	0.905	1.00
214_H	217_S	0.896	1.00
15_T	214_H	0.894	1.00
172_H	197_F	0.890	1.00
22_C	25_S	0.885	1.00
74_V	77_K	0.884	1.00
217_S	220_Q	0.882	1.00
118_N	203_Y	0.876	1.00
168_M	198_A	0.871	1.00
87_I	169_I	0.869	1.00
42_G	68_N	0.858	1.00
5_A	84_G	0.858	1.00
23_L	61_F	0.855	1.00
97_E	100_Y	0.849	1.00
58_D	61_F	0.840	1.00
122_E	212_R	0.838	1.00
35_E	82_A	0.834	1.00
25_S	96_I	0.833	1.00
71_L	74_V	0.831	1.00
196_F	240_F	0.831	1.00
26_L	36_I	0.830	1.00
164_Y	194_A	0.830	1.00
8_L	101_C	0.819	1.00
19_I	51_A	0.810	1.00
116_I	162_K	0.799	1.00
16_E	45_D	0.799	1.00
12_V	40_N	0.798	1.00
41_D	69_Q	0.794	1.00
232_A	236_T	0.793	1.00
76_N	176_F	0.790	1.00
113_D	199_R	0.788	1.00
105_L	108_A	0.788	1.00
231_L	235_E	0.780	1.00
104_M	115_V	0.777	1.00
69_Q	77_K	0.776	1.00
79_I	175_S	0.773	1.00
185_V	188_Q	0.772	1.00
111_E	200_S	0.768	1.00
46_A	50_I	0.766	1.00
225_K	229_S	0.764	1.00
37_I	81_A	0.760	1.00
30_T	99_D	0.755	1.00
96_I	101_C	0.754	1.00
143_K	146_Y	0.750	1.00
142_P	145_H	0.750	1.00
240_F	244_N	0.747	1.00
103_Q	107_T	0.746	1.00
69_Q	178_L	0.745	1.00
86_F	165_R	0.743	1.00
143_K	147_I	0.743	1.00
168_M	172_H	0.740	1.00
89_F	176_F	0.740	1.00
112_T	200_S	0.738	1.00
27_R	36_I	0.736	1.00
76_N	175_S	0.734	1.00
172_H	194_A	0.733	1.00
24_E	27_R	0.731	1.00
114_L	194_A	0.731	1.00
165_R	168_M	0.726	1.00
194_A	198_A	0.726	1.00
4_P	31_M	0.724	1.00
22_C	26_L	0.723	1.00
189_F	236_T	0.722	1.00
97_E	208_L	0.722	1.00
236_T	240_F	0.721	1.00
85_E	167_S	0.721	1.00
177_P	236_T	0.721	1.00
4_P	109_G	0.719	1.00
164_Y	169_I	0.718	1.00
19_I	47_S	0.714	1.00
39_V	77_K	0.713	1.00
213_I	220_Q	0.712	1.00
132_S	136_Q	0.711	1.00
25_S	95_W	0.710	1.00
232_A	235_E	0.708	1.00
4_P	85_E	0.707	1.00
38_I	61_F	0.705	1.00
112_T	115_V	0.703	1.00
119_Y	161_N	0.699	1.00
123_F	127_G	0.693	1.00
111_E	165_R	0.691	1.00
37_I	78_G	0.688	1.00
71_L	91_D	0.688	1.00
6_V	31_M	0.687	1.00
177_P	193_R	0.687	1.00
24_E	57_M	0.685	1.00
30_T	98_P	0.682	1.00
22_C	94_D	0.678	1.00
171_A	199_R	0.674	1.00
19_I	92_S	0.672	1.00
160_W	209_Y	0.672	1.00
23_L	51_A	0.672	1.00
74_V	78_G	0.672	1.00
178_L	181_E	0.670	1.00
16_E	47_S	0.668	1.00
15_T	71_L	0.667	1.00
145_H	149_A	0.665	1.00
22_C	96_I	0.665	1.00
5_A	105_L	0.665	1.00
168_M	197_F	0.665	1.00
32_D	60_R	0.662	1.00
99_D	208_L	0.661	1.00
228_E	232_A	0.658	1.00
22_C	95_W	0.655	1.00
114_L	198_A	0.654	1.00
18_Y	214_H	0.654	1.00
108_A	112_T	0.654	1.00
10_V	92_S	0.651	1.00
27_R	57_M	0.650	1.00
27_R	60_R	0.647	1.00
11_A	75_R	0.645	1.00
132_S	135_A	0.645	1.00
198_A	201_V	0.644	1.00
124_E	127_G	0.643	1.00
170_E	175_S	0.641	1.00
43_S	47_S	0.640	1.00
37_I	62_K	0.639	1.00
260_L	264_I	0.639	1.00
86_F	109_G	0.639	1.00
5_A	109_G	0.637	1.00
5_A	31_M	0.636	1.00
27_R	34_I	0.635	1.00
14_N	45_D	0.635	1.00
277_R	281_K	0.634	1.00
76_N	79_I	0.632	1.00
78_G	82_A	0.631	1.00
51_A	55_A	0.631	1.00
66_Q	74_V	0.630	1.00
19_I	50_I	0.626	1.00
234_Y	238_A	0.626	1.00
239_A	243_E	0.626	1.00
204_V	208_L	0.626	1.00
15_T	22_C	0.625	1.00
16_E	19_I	0.625	1.00
145_H	148_K	0.625	1.00
104_M	204_V	0.625	1.00
229_S	232_A	0.625	1.00
34_I	60_R	0.623	1.00
159_S	162_K	0.622	1.00
8_L	88_A	0.621	1.00
159_S	191_S	0.620	1.00
42_G	65_H	0.618	1.00
115_V	118_N	0.618	1.00
10_V	90_I	0.617	1.00
76_N	178_L	0.616	1.00
219_V	222_Y	0.615	1.00
16_E	49_D	0.613	1.00
88_A	161_N	0.613	1.00
52_E	56_K	0.612	1.00
76_N	190_F	0.609	1.00
42_G	74_V	0.608	1.00
72_G	181_E	0.602	1.00
138_Y	141_Q	0.600	1.00
86_F	105_L	0.600	1.00
169_I	194_A	0.599	1.00
157_G	161_N	0.596	1.00
26_L	34_I	0.595	1.00
96_I	209_Y	0.595	1.00
29_Q	102_E	0.593	0.99
71_L	89_F	0.592	0.99
233_L	237_N	0.591	0.99
214_H	220_Q	0.590	0.99
11_A	41_D	0.589	0.99
18_Y	22_C	0.588	0.99
234_Y	237_N	0.586	0.99
204_V	207_P	0.586	0.99
157_G	188_Q	0.585	0.99
37_I	82_A	0.582	0.99
10_V	38_I	0.582	0.99
236_T	239_A	0.581	0.99
118_N	207_P	0.579	0.99
217_S	221_R	0.579	0.99
193_R	236_T	0.579	0.99
88_A	104_M	0.579	0.99
9_L	89_F	0.576	0.99
55_A	58_D	0.575	0.99
51_A	65_H	0.574	0.99
47_S	50_I	0.572	0.99
48_P	55_A	0.568	0.99
22_C	92_S	0.568	0.99
50_I	53_E	0.566	0.99
39_V	81_A	0.565	0.99
54_Y	58_D	0.564	0.99
121_A	213_I	0.560	0.99
75_R	159_S	0.560	0.99
229_S	233_L	0.554	0.99
41_D	91_D	0.552	0.99
97_E	120_A	0.549	0.99
175_S	178_L	0.548	0.99
157_G	191_S	0.547	0.99
172_H	190_F	0.547	0.99
191_S	195_H	0.546	0.99
188_Q	192_F	0.544	0.99
89_F	169_I	0.543	0.99
146_Y	151_F	0.543	0.99
10_V	23_L	0.542	0.99
238_A	242_Q	0.540	0.99
16_E	92_S	0.539	0.99
91_D	186_E	0.538	0.99
280_E	283_R	0.538	0.99
6_V	108_A	0.537	0.99
158_F	161_N	0.536	0.99
149_A	152_E	0.534	0.99
45_D	50_I	0.533	0.99
42_G	67_E	0.533	0.99
280_E	284_N	0.533	0.99
175_S	190_F	0.532	0.99
30_T	34_I	0.532	0.99
108_A	165_R	0.530	0.99
159_S	186_E	0.529	0.99
71_L	184_H	0.528	0.99
64_I	78_G	0.528	0.99
6_V	104_M	0.527	0.99
175_S	193_R	0.527	0.99
42_G	69_Q	0.525	0.99
239_A	242_Q	0.525	0.99
242_Q	245_N	0.525	0.99
135_A	138_Y	0.521	0.99
137_T	140_D	0.520	0.99
105_L	163_L	0.520	0.99
19_I	38_I	0.519	0.99
156_R	160_W	0.517	0.99
265_C	268_N	0.517	0.99
147_I	152_E	0.515	0.99
34_I	83_R	0.514	0.99
15_T	47_S	0.513	0.99
90_I	100_Y	0.513	0.99
13_Y	41_D	0.512	0.99
134_I	138_Y	0.511	0.99
149_A	153_G	0.511	0.99
123_F	126_T	0.510	0.98
214_H	219_V	0.510	0.98
101_C	163_L	0.508	0.98
75_R	176_F	0.508	0.98
51_A	61_F	0.507	0.98
74_V	91_D	0.507	0.98
168_M	171_A	0.507	0.98
177_P	190_F	0.506	0.98
111_E	114_L	0.502	0.98
23_L	50_I	0.502	0.98
150_L	153_G	0.501	0.98
99_D	206_T	0.501	0.98
157_G	185_V	0.500	0.98
157_G	162_K	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bcvA	2	0.5291	100	0.357	Contact Map
3l7iA	4	0.064	100	0.38	Contact Map
1qg8A	1	0.6453	100	0.4	Contact Map
2z86A	2	0.7355	100	0.401	Contact Map
2d7iA	1	0.939	100	0.426	Contact Map
1xhbA	1	0.8983	100	0.429	Contact Map
5ajoA	1	0.9128	100	0.45	Contact Map
4fixA	3	0.9564	100	0.485	Contact Map
2nxvA	4	0.6657	100	0.509	Contact Map
3ckjA	2	0.7645	100	0.511	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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