GREMLIN Database
EPSG - Transmembrane protein EpsG
UniProt: P71056 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 367 (329)
Sequences: 1323 (1261)
Seq/√Len: 69.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_G186_L4.3521.00
130_G136_S4.1591.00
54_Y60_F3.9421.00
185_S192_L3.6261.00
100_M113_T3.5001.00
184_S191_A3.4821.00
174_W198_Y3.4761.00
169_I198_Y3.4631.00
58_T151_N3.4121.00
155_Q312_Y3.4071.00
47_V51_G3.2811.00
48_L52_L3.2231.00
107_P111_Y3.1661.00
162_L194_M3.1251.00
173_N176_R2.9881.00
168_Y176_R2.9721.00
125_T163_F2.9051.00
157_M187_F2.8981.00
67_Y100_M2.8931.00
161_V180_I2.7701.00
51_G112_F2.7421.00
121_F164_W2.6761.00
136_S322_P2.6741.00
92_G187_F2.6711.00
196_P199_F2.6471.00
181_V185_S2.5551.00
124_K164_W2.5371.00
177_Y181_V2.4531.00
67_Y104_T2.4361.00
98_W101_N2.4291.00
90_D154_R2.4261.00
140_F149_S2.3581.00
93_F97_L2.3311.00
47_V116_V2.2991.00
96_L114_V2.2431.00
169_I177_Y2.2241.00
124_K128_D2.1591.00
165_A180_I2.1591.00
121_F125_T2.1181.00
120_S124_K2.1091.00
158_V184_S2.0951.00
138_F142_G2.0331.00
318_M322_P1.9981.00
167_R171_S1.9691.00
60_F111_Y1.9681.00
67_Y105_E1.9361.00
190_S312_Y1.8411.00
162_L184_S1.8401.00
191_A312_Y1.8051.00
117_V121_F1.8031.00
47_V112_F1.7931.00
166_I316_Y1.7921.00
206_W209_A1.7641.00
71_G101_N1.7211.00
122_I149_S1.7181.00
57_G151_N1.7041.00
115_A118_T1.6430.99
97_L110_M1.6230.99
160_A164_W1.6200.99
118_T149_S1.6140.99
56_V151_N1.5880.99
55_R60_F1.5600.99
126_L136_S1.5590.99
148_A152_G1.5580.99
128_D167_R1.5500.99
168_Y180_I1.5490.99
53_R57_G1.5070.99
53_R60_F1.4870.99
57_G155_Q1.4810.99
181_V195_I1.4600.99
149_S152_G1.4390.98
108_Q111_Y1.4330.98
90_D189_S1.4330.98
118_T157_M1.4270.98
64_T107_P1.4120.98
88_A91_P1.4080.98
91_P186_L1.4050.98
43_L47_V1.4020.98
66_L97_L1.4000.98
185_S189_S1.3920.98
100_M110_M1.3890.98
114_V157_M1.3780.98
149_S156_Y1.3730.98
162_L166_I1.3720.98
100_M105_E1.3710.98
158_V191_A1.3600.98
122_I160_A1.3430.98
177_Y197_V1.3430.98
168_Y177_Y1.3400.98
53_R56_V1.3370.98
146_Y150_F1.3330.97
177_Y194_M1.3330.97
162_L177_Y1.3330.97
118_T160_A1.3270.97
121_F161_V1.3020.97
53_R151_N1.3000.97
67_Y106_D1.2970.97
178_F198_Y1.2880.97
155_Q311_I1.2870.97
194_M312_Y1.2860.97
178_F182_L1.2770.97
296_F309_F1.2760.97
178_F195_I1.2660.97
174_W178_F1.2580.96
290_C320_L1.2570.96
126_L130_G1.2520.96
284_D288_N1.2480.96
177_Y198_Y1.2350.96
50_S150_F1.2230.96
290_C317_Q1.2200.96
125_T164_W1.2190.96
111_Y153_I1.2170.96
114_V153_I1.2120.96
43_L123_M1.2060.95
126_L318_M1.1950.95
54_Y108_Q1.1790.95
149_S155_Q1.1770.95
91_P189_S1.1650.95
152_G155_Q1.1630.94
98_W102_F1.1530.94
92_G114_V1.1470.94
201_V285_I1.1460.94
64_T68_E1.1390.94
129_Y167_R1.1340.94
64_T111_Y1.1320.94
172_G175_K1.1310.94
140_F156_Y1.1270.93
123_M127_A1.1190.93
158_V312_Y1.1170.93
161_V164_W1.1080.93
93_F153_I1.1020.93
58_T152_G1.1010.93
106_D109_I1.0900.92
11_V18_A1.0850.92
66_L89_T1.0840.92
146_Y151_N1.0830.92
53_R153_I1.0830.92
130_G133_F1.0770.92
57_G146_Y1.0770.92
161_V184_S1.0740.92
148_A156_Y1.0730.92
116_V120_S1.0560.91
152_G311_I1.0520.91
148_A155_Q1.0400.90
53_R115_A1.0350.90
67_Y97_L1.0350.90
169_I196_P1.0330.90
167_R177_Y1.0260.90
47_V115_A1.0240.90
104_T109_I1.0200.90
335_L339_A1.0200.90
50_S115_A1.0180.89
4_Y56_V1.0180.89
281_P284_D1.0170.89
167_R198_Y1.0160.89
67_Y71_G1.0150.89
350_L355_D1.0140.89
165_A177_Y1.0060.89
161_V185_S0.9950.88
294_F298_L0.9920.88
125_T167_R0.9900.88
60_F151_N0.9890.88
105_E109_I0.9890.88
260_A267_F0.9880.88
165_A168_Y0.9880.88
165_A184_S0.9810.88
177_Y199_F0.9800.88
165_A169_I0.9630.87
122_I148_A0.9510.86
158_V161_V0.9480.86
91_P95_A0.9440.86
60_F152_G0.9440.86
60_F64_T0.9390.85
159_A312_Y0.9350.85
193_I309_F0.9210.84
12_F15_S0.9210.84
46_L137_V0.9180.84
39_I137_V0.9140.84
169_I174_W0.9130.84
227_F281_P0.9100.83
190_S194_M0.9040.83
162_L191_A0.8990.83
50_S145_H0.8980.83
130_G322_P0.8970.82
125_T319_I0.8920.82
127_A133_F0.8860.82
189_S239_S0.8830.81
122_I140_F0.8820.81
46_L49_V0.8780.81
121_F124_K0.8780.81
54_Y57_G0.8740.81
67_Y101_N0.8710.81
92_G157_M0.8680.80
92_G192_L0.8660.80
218_L283_I0.8640.80
191_A271_C0.8580.80
46_L147_Y0.8580.80
104_T107_P0.8570.80
222_F283_I0.8540.79
196_P346_L0.8540.79
67_Y306_F0.8530.79
47_V119_Y0.8500.79
258_K262_L0.8460.79
96_L110_M0.8450.79
67_Y109_I0.8440.78
36_K127_A0.8440.78
51_G115_A0.8420.78
60_F107_P0.8300.77
288_N291_L0.8290.77
192_L208_P0.8220.77
246_W295_L0.8220.77
58_T90_D0.8190.76
148_A311_I0.8170.76
155_Q190_S0.8170.76
183_V282_Q0.8140.76
182_L186_L0.8120.76
100_M117_V0.8090.75
97_L100_M0.8020.75
161_V187_F0.7930.74
347_Y351_L0.7930.74
199_F349_Y0.7910.74
196_P202_R0.7890.74
237_N240_Y0.7890.74
39_I123_M0.7870.73
350_L354_V0.7830.73
273_K276_L0.7820.73
7_N45_S0.7790.73
155_Q191_A0.7720.72
7_N49_V0.7690.72
57_G152_G0.7680.72
93_F118_T0.7670.72
111_Y190_S0.7670.72
152_G156_Y0.7660.71
50_S149_S0.7640.71
161_V167_R0.7600.71
64_T93_F0.7580.71
54_Y64_T0.7560.70
157_M160_A0.7550.70
172_G198_Y0.7540.70
68_E96_L0.7440.69
215_A342_V0.7410.69
126_L321_V0.7400.69
343_C346_L0.7390.69
113_T117_V0.7380.69
92_G97_L0.7370.68
260_A336_I0.7340.68
298_L302_K0.7310.68
293_G317_Q0.7280.68
92_G161_V0.7200.67
289_L316_Y0.7200.67
174_W177_Y0.7150.66
161_V183_V0.7130.66
128_D171_S0.7100.66
50_S146_Y0.7090.65
89_T239_S0.7030.65
121_F160_A0.7030.65
57_G312_Y0.7030.65
143_T148_A0.7030.65
53_R136_S0.7020.65
133_F137_V0.7000.64
159_A307_A0.6990.64
114_V118_T0.6990.64
90_D239_S0.6980.64
121_F157_M0.6980.64
172_G177_Y0.6940.64
51_G110_M0.6930.64
229_S292_L0.6920.64
107_P137_V0.6900.63
53_R322_P0.6900.63
60_F322_P0.6890.63
267_F315_L0.6880.63
303_D306_F0.6840.63
117_V157_M0.6830.63
54_Y151_N0.6830.63
151_N356_S0.6820.62
108_Q112_F0.6790.62
282_Q286_V0.6780.62
35_N235_L0.6760.62
11_V36_K0.6730.61
127_A260_A0.6720.61
53_R290_C0.6710.61
118_T152_G0.6690.61
57_G149_S0.6680.61
141_L200_I0.6680.61
100_M107_P0.6680.61
177_Y185_S0.6680.61
53_R111_Y0.6660.61
138_F341_V0.6650.61
67_Y192_L0.6650.61
196_P313_F0.6610.60
101_N104_T0.6590.60
161_V177_Y0.6580.60
151_N305_I0.6540.59
120_S228_I0.6530.59
93_F288_N0.6530.59
129_Y286_V0.6520.59
272_Y276_L0.6470.58
96_L292_L0.6470.58
158_V190_S0.6400.58
100_M109_I0.6400.58
126_L133_F0.6390.57
175_K202_R0.6370.57
39_I43_L0.6370.57
212_G329_D0.6370.57
211_F215_A0.6360.57
161_V174_W0.6360.57
16_W301_T0.6320.57
91_P215_A0.6310.57
155_Q159_A0.6300.56
57_G311_I0.6300.56
113_T330_E0.6250.56
333_N336_I0.6250.56
226_K229_S0.6240.56
157_M161_V0.6230.56
54_Y111_Y0.6210.55
280_W327_I0.6210.55
32_Y36_K0.6210.55
172_G202_R0.6190.55
151_N155_Q0.6180.55
86_K330_E0.6180.55
93_F114_V0.6180.55
13_I40_W0.6170.55
11_V33_R0.6170.55
280_W283_I0.6170.55
262_L317_Q0.6150.55
337_Y341_V0.6150.55
93_F157_M0.6140.55
11_V141_L0.6140.55
91_P190_S0.6140.55
197_V292_L0.6130.54
183_V281_P0.6130.54
325_V329_D0.6130.54
56_V240_Y0.6130.54
111_Y150_F0.6120.54
56_V60_F0.6110.54
60_F106_D0.6100.54
106_D112_F0.6090.54
149_S312_Y0.6050.53
122_I126_L0.6050.53
107_P153_I0.6050.53
58_T114_V0.6050.53
165_A186_L0.6040.53
38_L42_P0.6030.53
54_Y155_Q0.6020.53
87_T91_P0.6020.53
147_Y151_N0.6010.53
99_L173_N0.6000.53
151_N240_Y0.6000.53
217_F295_L0.6000.53
266_L270_F0.5990.53
110_M114_V0.5990.53
162_L324_F0.5950.52
111_Y115_A0.5950.52
145_H298_L0.5930.52
335_L349_Y0.5920.52
293_G314_G0.5910.52
118_T122_I0.5910.52
249_T310_N0.5900.52
60_F108_Q0.5900.52
313_F324_F0.5890.51
171_S176_R0.5890.51
100_M104_T0.5880.51
169_I172_G0.5870.51
201_V288_N0.5870.51
173_N215_A0.5860.51
143_T151_N0.5850.51
116_V119_Y0.5850.51
153_I156_Y0.5840.51
60_F115_A0.5840.51
70_A101_N0.5830.51
89_T94_T0.5830.51
5_A10_I0.5820.51
150_F312_Y0.5820.51
159_A245_K0.5810.51
9_G333_N0.5800.50
172_G197_V0.5800.50
122_I311_I0.5790.50
155_Q188_H0.5780.50
223_L350_L0.5780.50
96_L187_F0.5770.50
139_L321_V0.5770.50
145_H322_P0.5770.50
118_T151_N0.5770.50
262_L290_C0.5750.50
137_V175_K0.5750.50
283_I287_V0.5740.50
234_V342_V0.5730.50
115_A149_S0.5720.49
96_L157_M0.5720.49
51_G108_Q0.5710.49
217_F298_L0.5700.49
227_F341_V0.5690.49
170_I203_R0.5690.49
245_K253_G0.5680.49
38_L44_A0.5670.49
100_M103_I0.5670.49
162_L181_V0.5650.49
55_R61_Q0.5650.49
196_P292_L0.5650.49
84_T116_V0.5630.48
174_W199_F0.5610.48
122_I342_V0.5610.48
185_S195_I0.5570.48
7_N14_W0.5570.48
155_Q313_F0.5570.48
270_F315_L0.5560.48
312_Y325_V0.5560.48
49_V300_A0.5560.48
125_T129_Y0.5560.48
305_I311_I0.5540.47
151_N156_Y0.5530.47
295_L332_S0.5530.47
40_W43_L0.5530.47
54_Y312_Y0.5530.47
124_K161_V0.5520.47
152_G190_S0.5510.47
11_V15_S0.5510.47
55_R64_T0.5500.47
165_A181_V0.5500.47
104_T231_F0.5490.47
266_L339_A0.5470.46
169_I194_M0.5460.46
110_M355_D0.5460.46
135_L242_H0.5460.46
200_I270_F0.5450.46
59_D308_R0.5450.46
235_L240_Y0.5400.46
153_I289_L0.5400.46
344_Y350_L0.5400.46
145_H156_Y0.5380.45
60_F149_S0.5380.45
45_S324_F0.5360.45
54_Y107_P0.5360.45
342_V346_L0.5350.45
210_I214_S0.5330.45
276_L281_P0.5330.45
194_M309_F0.5310.45
297_G307_A0.5300.44
204_K346_L0.5300.44
179_L183_V0.5300.44
144_F148_A0.5290.44
204_K284_D0.5290.44
146_Y149_S0.5290.44
57_G118_T0.5280.44
130_G323_Y0.5280.44
179_L199_F0.5280.44
152_G303_D0.5270.44
172_G242_H0.5260.44
338_I342_V0.5260.44
206_W288_N0.5260.44
11_V46_L0.5250.44
107_P146_Y0.5240.44
48_L219_G0.5240.44
149_S153_I0.5240.44
17_F225_Q0.5230.44
255_N265_P0.5230.44
217_F220_M0.5220.43
56_V152_G0.5220.43
293_G300_A0.5220.43
266_L336_I0.5210.43
59_D63_Y0.5210.43
13_I231_F0.5210.43
109_I113_T0.5200.43
270_F273_K0.5200.43
111_Y155_Q0.5180.43
108_Q146_Y0.5180.43
31_G48_L0.5160.43
129_Y170_I0.5160.43
120_S123_M0.5150.43
111_Y151_N0.5130.42
290_C293_G0.5120.42
151_N190_S0.5110.42
118_T155_Q0.5110.42
103_I342_V0.5100.42
212_G235_L0.5100.42
12_F45_S0.5090.42
90_D265_P0.5070.42
297_G303_D0.5070.42
197_V289_L0.5050.41
292_L342_V0.5050.41
167_R170_I0.5050.41
183_V186_L0.5040.41
191_A319_I0.5040.41
312_Y316_Y0.5040.41
331_K338_I0.5040.41
164_W167_R0.5030.41
147_Y152_G0.5030.41
112_F115_A0.5020.41
12_F261_V0.5020.41
41_I267_F0.5010.41
6_V153_I0.5010.41
4_Y8_M0.5010.41
122_I147_Y0.5000.41
167_R172_G0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rceA 1 0.7738 10.1 0.956 Contact Map
2z73A 2 0.733 2.3 0.967 Contact Map
2l2tA 2 0.1199 1.1 0.973 Contact Map
3wajA 1 0.7793 1 0.973 Contact Map
2jwaA 2 0.1199 0.9 0.974 Contact Map
1v54I 1 0.1962 0.7 0.976 Contact Map
1wazA 1 0.1253 0.7 0.976 Contact Map
2k3cA 1 0.0845 0.7 0.976 Contact Map
2rddB 1 0.0954 0.7 0.976 Contact Map
2ks1B 1 0.1199 0.6 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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