EPSG - BACSU - GREMLIN Contacts

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EPSG - Transmembrane protein EpsG

UniProt:	P71056	Sequences: MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLASLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNFITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAAVLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFLGMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERLRSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNALIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	367 (329)
Sequences:	1323 (1261)
Seq/√Len:	69.5

BACSU - EPSG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
92_G	186_L	4.352	1.00
130_G	136_S	4.159	1.00
54_Y	60_F	3.942	1.00
185_S	192_L	3.626	1.00
100_M	113_T	3.500	1.00
184_S	191_A	3.482	1.00
174_W	198_Y	3.476	1.00
169_I	198_Y	3.463	1.00
58_T	151_N	3.412	1.00
155_Q	312_Y	3.407	1.00
47_V	51_G	3.281	1.00
48_L	52_L	3.223	1.00
107_P	111_Y	3.166	1.00
162_L	194_M	3.125	1.00
173_N	176_R	2.988	1.00
168_Y	176_R	2.972	1.00
125_T	163_F	2.905	1.00
157_M	187_F	2.898	1.00
67_Y	100_M	2.893	1.00
161_V	180_I	2.770	1.00
51_G	112_F	2.742	1.00
121_F	164_W	2.676	1.00
136_S	322_P	2.674	1.00
92_G	187_F	2.671	1.00
196_P	199_F	2.647	1.00
181_V	185_S	2.555	1.00
124_K	164_W	2.537	1.00
177_Y	181_V	2.453	1.00
67_Y	104_T	2.436	1.00
98_W	101_N	2.429	1.00
90_D	154_R	2.426	1.00
140_F	149_S	2.358	1.00
93_F	97_L	2.331	1.00
47_V	116_V	2.299	1.00
96_L	114_V	2.243	1.00
169_I	177_Y	2.224	1.00
124_K	128_D	2.159	1.00
165_A	180_I	2.159	1.00
121_F	125_T	2.118	1.00
120_S	124_K	2.109	1.00
158_V	184_S	2.095	1.00
138_F	142_G	2.033	1.00
318_M	322_P	1.998	1.00
167_R	171_S	1.969	1.00
60_F	111_Y	1.968	1.00
67_Y	105_E	1.936	1.00
190_S	312_Y	1.841	1.00
162_L	184_S	1.840	1.00
191_A	312_Y	1.805	1.00
117_V	121_F	1.803	1.00
47_V	112_F	1.793	1.00
166_I	316_Y	1.792	1.00
206_W	209_A	1.764	1.00
71_G	101_N	1.721	1.00
122_I	149_S	1.718	1.00
57_G	151_N	1.704	1.00
115_A	118_T	1.643	0.99
97_L	110_M	1.623	0.99
160_A	164_W	1.620	0.99
118_T	149_S	1.614	0.99
56_V	151_N	1.588	0.99
55_R	60_F	1.560	0.99
126_L	136_S	1.559	0.99
148_A	152_G	1.558	0.99
128_D	167_R	1.550	0.99
168_Y	180_I	1.549	0.99
53_R	57_G	1.507	0.99
53_R	60_F	1.487	0.99
57_G	155_Q	1.481	0.99
181_V	195_I	1.460	0.99
149_S	152_G	1.439	0.98
108_Q	111_Y	1.433	0.98
90_D	189_S	1.433	0.98
118_T	157_M	1.427	0.98
64_T	107_P	1.412	0.98
88_A	91_P	1.408	0.98
91_P	186_L	1.405	0.98
43_L	47_V	1.402	0.98
66_L	97_L	1.400	0.98
185_S	189_S	1.392	0.98
100_M	110_M	1.389	0.98
114_V	157_M	1.378	0.98
149_S	156_Y	1.373	0.98
162_L	166_I	1.372	0.98
100_M	105_E	1.371	0.98
158_V	191_A	1.360	0.98
122_I	160_A	1.343	0.98
177_Y	197_V	1.343	0.98
168_Y	177_Y	1.340	0.98
53_R	56_V	1.337	0.98
146_Y	150_F	1.333	0.97
177_Y	194_M	1.333	0.97
162_L	177_Y	1.333	0.97
118_T	160_A	1.327	0.97
121_F	161_V	1.302	0.97
53_R	151_N	1.300	0.97
67_Y	106_D	1.297	0.97
178_F	198_Y	1.288	0.97
155_Q	311_I	1.287	0.97
194_M	312_Y	1.286	0.97
178_F	182_L	1.277	0.97
296_F	309_F	1.276	0.97
178_F	195_I	1.266	0.97
174_W	178_F	1.258	0.96
290_C	320_L	1.257	0.96
126_L	130_G	1.252	0.96
284_D	288_N	1.248	0.96
177_Y	198_Y	1.235	0.96
50_S	150_F	1.223	0.96
290_C	317_Q	1.220	0.96
125_T	164_W	1.219	0.96
111_Y	153_I	1.217	0.96
114_V	153_I	1.212	0.96
43_L	123_M	1.206	0.95
126_L	318_M	1.195	0.95
54_Y	108_Q	1.179	0.95
149_S	155_Q	1.177	0.95
91_P	189_S	1.165	0.95
152_G	155_Q	1.163	0.94
98_W	102_F	1.153	0.94
92_G	114_V	1.147	0.94
201_V	285_I	1.146	0.94
64_T	68_E	1.139	0.94
129_Y	167_R	1.134	0.94
64_T	111_Y	1.132	0.94
172_G	175_K	1.131	0.94
140_F	156_Y	1.127	0.93
123_M	127_A	1.119	0.93
158_V	312_Y	1.117	0.93
161_V	164_W	1.108	0.93
93_F	153_I	1.102	0.93
58_T	152_G	1.101	0.93
106_D	109_I	1.090	0.92
11_V	18_A	1.085	0.92
66_L	89_T	1.084	0.92
146_Y	151_N	1.083	0.92
53_R	153_I	1.083	0.92
130_G	133_F	1.077	0.92
57_G	146_Y	1.077	0.92
161_V	184_S	1.074	0.92
148_A	156_Y	1.073	0.92
116_V	120_S	1.056	0.91
152_G	311_I	1.052	0.91
148_A	155_Q	1.040	0.90
53_R	115_A	1.035	0.90
67_Y	97_L	1.035	0.90
169_I	196_P	1.033	0.90
167_R	177_Y	1.026	0.90
47_V	115_A	1.024	0.90
104_T	109_I	1.020	0.90
335_L	339_A	1.020	0.90
50_S	115_A	1.018	0.89
4_Y	56_V	1.018	0.89
281_P	284_D	1.017	0.89
167_R	198_Y	1.016	0.89
67_Y	71_G	1.015	0.89
350_L	355_D	1.014	0.89
165_A	177_Y	1.006	0.89
161_V	185_S	0.995	0.88
294_F	298_L	0.992	0.88
125_T	167_R	0.990	0.88
60_F	151_N	0.989	0.88
105_E	109_I	0.989	0.88
260_A	267_F	0.988	0.88
165_A	168_Y	0.988	0.88
165_A	184_S	0.981	0.88
177_Y	199_F	0.980	0.88
165_A	169_I	0.963	0.87
122_I	148_A	0.951	0.86
158_V	161_V	0.948	0.86
91_P	95_A	0.944	0.86
60_F	152_G	0.944	0.86
60_F	64_T	0.939	0.85
159_A	312_Y	0.935	0.85
193_I	309_F	0.921	0.84
12_F	15_S	0.921	0.84
46_L	137_V	0.918	0.84
39_I	137_V	0.914	0.84
169_I	174_W	0.913	0.84
227_F	281_P	0.910	0.83
190_S	194_M	0.904	0.83
162_L	191_A	0.899	0.83
50_S	145_H	0.898	0.83
130_G	322_P	0.897	0.82
125_T	319_I	0.892	0.82
127_A	133_F	0.886	0.82
189_S	239_S	0.883	0.81
122_I	140_F	0.882	0.81
46_L	49_V	0.878	0.81
121_F	124_K	0.878	0.81
54_Y	57_G	0.874	0.81
67_Y	101_N	0.871	0.81
92_G	157_M	0.868	0.80
92_G	192_L	0.866	0.80
218_L	283_I	0.864	0.80
191_A	271_C	0.858	0.80
46_L	147_Y	0.858	0.80
104_T	107_P	0.857	0.80
222_F	283_I	0.854	0.79
196_P	346_L	0.854	0.79
67_Y	306_F	0.853	0.79
47_V	119_Y	0.850	0.79
258_K	262_L	0.846	0.79
96_L	110_M	0.845	0.79
67_Y	109_I	0.844	0.78
36_K	127_A	0.844	0.78
51_G	115_A	0.842	0.78
60_F	107_P	0.830	0.77
288_N	291_L	0.829	0.77
192_L	208_P	0.822	0.77
246_W	295_L	0.822	0.77
58_T	90_D	0.819	0.76
148_A	311_I	0.817	0.76
155_Q	190_S	0.817	0.76
183_V	282_Q	0.814	0.76
182_L	186_L	0.812	0.76
100_M	117_V	0.809	0.75
97_L	100_M	0.802	0.75
161_V	187_F	0.793	0.74
347_Y	351_L	0.793	0.74
199_F	349_Y	0.791	0.74
196_P	202_R	0.789	0.74
237_N	240_Y	0.789	0.74
39_I	123_M	0.787	0.73
350_L	354_V	0.783	0.73
273_K	276_L	0.782	0.73
7_N	45_S	0.779	0.73
155_Q	191_A	0.772	0.72
7_N	49_V	0.769	0.72
57_G	152_G	0.768	0.72
93_F	118_T	0.767	0.72
111_Y	190_S	0.767	0.72
152_G	156_Y	0.766	0.71
50_S	149_S	0.764	0.71
161_V	167_R	0.760	0.71
64_T	93_F	0.758	0.71
54_Y	64_T	0.756	0.70
157_M	160_A	0.755	0.70
172_G	198_Y	0.754	0.70
68_E	96_L	0.744	0.69
215_A	342_V	0.741	0.69
126_L	321_V	0.740	0.69
343_C	346_L	0.739	0.69
113_T	117_V	0.738	0.69
92_G	97_L	0.737	0.68
260_A	336_I	0.734	0.68
298_L	302_K	0.731	0.68
293_G	317_Q	0.728	0.68
92_G	161_V	0.720	0.67
289_L	316_Y	0.720	0.67
174_W	177_Y	0.715	0.66
161_V	183_V	0.713	0.66
128_D	171_S	0.710	0.66
50_S	146_Y	0.709	0.65
89_T	239_S	0.703	0.65
121_F	160_A	0.703	0.65
57_G	312_Y	0.703	0.65
143_T	148_A	0.703	0.65
53_R	136_S	0.702	0.65
133_F	137_V	0.700	0.64
159_A	307_A	0.699	0.64
114_V	118_T	0.699	0.64
90_D	239_S	0.698	0.64
121_F	157_M	0.698	0.64
172_G	177_Y	0.694	0.64
51_G	110_M	0.693	0.64
229_S	292_L	0.692	0.64
107_P	137_V	0.690	0.63
53_R	322_P	0.690	0.63
60_F	322_P	0.689	0.63
267_F	315_L	0.688	0.63
303_D	306_F	0.684	0.63
117_V	157_M	0.683	0.63
54_Y	151_N	0.683	0.63
151_N	356_S	0.682	0.62
108_Q	112_F	0.679	0.62
282_Q	286_V	0.678	0.62
35_N	235_L	0.676	0.62
11_V	36_K	0.673	0.61
127_A	260_A	0.672	0.61
53_R	290_C	0.671	0.61
118_T	152_G	0.669	0.61
57_G	149_S	0.668	0.61
141_L	200_I	0.668	0.61
100_M	107_P	0.668	0.61
177_Y	185_S	0.668	0.61
53_R	111_Y	0.666	0.61
138_F	341_V	0.665	0.61
67_Y	192_L	0.665	0.61
196_P	313_F	0.661	0.60
101_N	104_T	0.659	0.60
161_V	177_Y	0.658	0.60
151_N	305_I	0.654	0.59
120_S	228_I	0.653	0.59
93_F	288_N	0.653	0.59
129_Y	286_V	0.652	0.59
272_Y	276_L	0.647	0.58
96_L	292_L	0.647	0.58
158_V	190_S	0.640	0.58
100_M	109_I	0.640	0.58
126_L	133_F	0.639	0.57
175_K	202_R	0.637	0.57
39_I	43_L	0.637	0.57
212_G	329_D	0.637	0.57
211_F	215_A	0.636	0.57
161_V	174_W	0.636	0.57
16_W	301_T	0.632	0.57
91_P	215_A	0.631	0.57
155_Q	159_A	0.630	0.56
57_G	311_I	0.630	0.56
113_T	330_E	0.625	0.56
333_N	336_I	0.625	0.56
226_K	229_S	0.624	0.56
157_M	161_V	0.623	0.56
54_Y	111_Y	0.621	0.55
280_W	327_I	0.621	0.55
32_Y	36_K	0.621	0.55
172_G	202_R	0.619	0.55
151_N	155_Q	0.618	0.55
86_K	330_E	0.618	0.55
93_F	114_V	0.618	0.55
13_I	40_W	0.617	0.55
11_V	33_R	0.617	0.55
280_W	283_I	0.617	0.55
262_L	317_Q	0.615	0.55
337_Y	341_V	0.615	0.55
93_F	157_M	0.614	0.55
11_V	141_L	0.614	0.55
91_P	190_S	0.614	0.55
197_V	292_L	0.613	0.54
183_V	281_P	0.613	0.54
325_V	329_D	0.613	0.54
56_V	240_Y	0.613	0.54
111_Y	150_F	0.612	0.54
56_V	60_F	0.611	0.54
60_F	106_D	0.610	0.54
106_D	112_F	0.609	0.54
149_S	312_Y	0.605	0.53
122_I	126_L	0.605	0.53
107_P	153_I	0.605	0.53
58_T	114_V	0.605	0.53
165_A	186_L	0.604	0.53
38_L	42_P	0.603	0.53
54_Y	155_Q	0.602	0.53
87_T	91_P	0.602	0.53
147_Y	151_N	0.601	0.53
99_L	173_N	0.600	0.53
151_N	240_Y	0.600	0.53
217_F	295_L	0.600	0.53
266_L	270_F	0.599	0.53
110_M	114_V	0.599	0.53
162_L	324_F	0.595	0.52
111_Y	115_A	0.595	0.52
145_H	298_L	0.593	0.52
335_L	349_Y	0.592	0.52
293_G	314_G	0.591	0.52
118_T	122_I	0.591	0.52
249_T	310_N	0.590	0.52
60_F	108_Q	0.590	0.52
313_F	324_F	0.589	0.51
171_S	176_R	0.589	0.51
100_M	104_T	0.588	0.51
169_I	172_G	0.587	0.51
201_V	288_N	0.587	0.51
173_N	215_A	0.586	0.51
143_T	151_N	0.585	0.51
116_V	119_Y	0.585	0.51
153_I	156_Y	0.584	0.51
60_F	115_A	0.584	0.51
70_A	101_N	0.583	0.51
89_T	94_T	0.583	0.51
5_A	10_I	0.582	0.51
150_F	312_Y	0.582	0.51
159_A	245_K	0.581	0.51
9_G	333_N	0.580	0.50
172_G	197_V	0.580	0.50
122_I	311_I	0.579	0.50
155_Q	188_H	0.578	0.50
223_L	350_L	0.578	0.50
96_L	187_F	0.577	0.50
139_L	321_V	0.577	0.50
145_H	322_P	0.577	0.50
118_T	151_N	0.577	0.50
262_L	290_C	0.575	0.50
137_V	175_K	0.575	0.50
283_I	287_V	0.574	0.50
234_V	342_V	0.573	0.50
115_A	149_S	0.572	0.49
96_L	157_M	0.572	0.49
51_G	108_Q	0.571	0.49
217_F	298_L	0.570	0.49
227_F	341_V	0.569	0.49
170_I	203_R	0.569	0.49
245_K	253_G	0.568	0.49
38_L	44_A	0.567	0.49
100_M	103_I	0.567	0.49
162_L	181_V	0.565	0.49
55_R	61_Q	0.565	0.49
196_P	292_L	0.565	0.49
84_T	116_V	0.563	0.48
174_W	199_F	0.561	0.48
122_I	342_V	0.561	0.48
185_S	195_I	0.557	0.48
7_N	14_W	0.557	0.48
155_Q	313_F	0.557	0.48
270_F	315_L	0.556	0.48
312_Y	325_V	0.556	0.48
49_V	300_A	0.556	0.48
125_T	129_Y	0.556	0.48
305_I	311_I	0.554	0.47
151_N	156_Y	0.553	0.47
295_L	332_S	0.553	0.47
40_W	43_L	0.553	0.47
54_Y	312_Y	0.553	0.47
124_K	161_V	0.552	0.47
152_G	190_S	0.551	0.47
11_V	15_S	0.551	0.47
55_R	64_T	0.550	0.47
165_A	181_V	0.550	0.47
104_T	231_F	0.549	0.47
266_L	339_A	0.547	0.46
169_I	194_M	0.546	0.46
110_M	355_D	0.546	0.46
135_L	242_H	0.546	0.46
200_I	270_F	0.545	0.46
59_D	308_R	0.545	0.46
235_L	240_Y	0.540	0.46
153_I	289_L	0.540	0.46
344_Y	350_L	0.540	0.46
145_H	156_Y	0.538	0.45
60_F	149_S	0.538	0.45
45_S	324_F	0.536	0.45
54_Y	107_P	0.536	0.45
342_V	346_L	0.535	0.45
210_I	214_S	0.533	0.45
276_L	281_P	0.533	0.45
194_M	309_F	0.531	0.45
297_G	307_A	0.530	0.44
204_K	346_L	0.530	0.44
179_L	183_V	0.530	0.44
144_F	148_A	0.529	0.44
204_K	284_D	0.529	0.44
146_Y	149_S	0.529	0.44
57_G	118_T	0.528	0.44
130_G	323_Y	0.528	0.44
179_L	199_F	0.528	0.44
152_G	303_D	0.527	0.44
172_G	242_H	0.526	0.44
338_I	342_V	0.526	0.44
206_W	288_N	0.526	0.44
11_V	46_L	0.525	0.44
107_P	146_Y	0.524	0.44
48_L	219_G	0.524	0.44
149_S	153_I	0.524	0.44
17_F	225_Q	0.523	0.44
255_N	265_P	0.523	0.44
217_F	220_M	0.522	0.43
56_V	152_G	0.522	0.43
293_G	300_A	0.522	0.43
266_L	336_I	0.521	0.43
59_D	63_Y	0.521	0.43
13_I	231_F	0.521	0.43
109_I	113_T	0.520	0.43
270_F	273_K	0.520	0.43
111_Y	155_Q	0.518	0.43
108_Q	146_Y	0.518	0.43
31_G	48_L	0.516	0.43
129_Y	170_I	0.516	0.43
120_S	123_M	0.515	0.43
111_Y	151_N	0.513	0.42
290_C	293_G	0.512	0.42
151_N	190_S	0.511	0.42
118_T	155_Q	0.511	0.42
103_I	342_V	0.510	0.42
212_G	235_L	0.510	0.42
12_F	45_S	0.509	0.42
90_D	265_P	0.507	0.42
297_G	303_D	0.507	0.42
197_V	289_L	0.505	0.41
292_L	342_V	0.505	0.41
167_R	170_I	0.505	0.41
183_V	186_L	0.504	0.41
191_A	319_I	0.504	0.41
312_Y	316_Y	0.504	0.41
331_K	338_I	0.504	0.41
164_W	167_R	0.503	0.41
147_Y	152_G	0.503	0.41
112_F	115_A	0.502	0.41
12_F	261_V	0.502	0.41
41_I	267_F	0.501	0.41
6_V	153_I	0.501	0.41
4_Y	8_M	0.501	0.41
122_I	147_Y	0.500	0.41
167_R	172_G	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rceA	1	0.7738	10.1	0.956	Contact Map
2z73A	2	0.733	2.3	0.967	Contact Map
2l2tA	2	0.1199	1.1	0.973	Contact Map
3wajA	1	0.7793	1	0.973	Contact Map
2jwaA	2	0.1199	0.9	0.974	Contact Map
1v54I	1	0.1962	0.7	0.976	Contact Map
1wazA	1	0.1253	0.7	0.976	Contact Map
2k3cA	1	0.0845	0.7	0.976	Contact Map
2rddB	1	0.0954	0.7	0.976	Contact Map
2ks1B	1	0.1199	0.6	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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