EPSF - BACSU - GREMLIN Contacts

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EPSF - Putative glycosyltransferase EpsF

UniProt:	P71055	Sequences: MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYRNDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGFIALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRFLFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKNHAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELMRTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVWAETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	384 (350)
Sequences:	57219 (49069)
Seq/√Len:	2622.8

ECOLI - RFAG WCAL RFAB WCAI GLGA WBBK WCAC
BACSU - EPSF EPSD YPJH GLGA YTCC COTSA YQGM TUAC TUAH YKVP CGEB TAGE
HALSA - Q9HQQ0 Q9HSW1 Q9HS45 Q9HRP8 Q9HSV2 Q9HSV4 Q9HQT2 Q9HRP9
SULSO - Q97UM0 Q97ZD3 Q97VL4 Q97V80 Q97V61 Q980C8 Q97XT7 Q97UU3 Q97XT8 Q97XT9 Q97XT5 Q7LXI2 Q97XU2 Q7LXM9 Q97XT6 Q97XF6 Q97XT1 Q7LXF8 Q7LXF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
208_G	279_F	4.815	1.00
237_Q	264_L	3.694	1.00
247_C	251_E	3.303	1.00
149_A	173_H	3.294	1.00
282_F	298_A	3.206	1.00
206_I	239_V	3.064	1.00
93_H	374_Y	2.943	1.00
228_H	335_A	2.764	1.00
239_V	266_L	2.747	1.00
204_R	237_Q	2.747	1.00
224_K	253_E	2.704	1.00
209_H	219_H	2.607	1.00
7_R	37_Q	2.598	1.00
230_K	262_D	2.415	1.00
158_G	162_F	2.242	1.00
224_K	331_I	2.191	1.00
218_N	221_F	2.176	1.00
205_L	342_A	2.173	1.00
246_L	249_E	2.119	1.00
206_I	237_Q	2.094	1.00
309_D	314_K	2.087	1.00
253_E	257_Q	2.035	1.00
206_I	278_T	2.024	1.00
337_T	340_R	2.018	1.00
241_A	275_L	2.007	1.00
239_V	264_L	2.007	1.00
226_A	238_L	1.985	1.00
36_V	371_L	1.957	1.00
205_L	280_D	1.956	1.00
228_H	332_S	1.954	1.00
207_I	281_V	1.949	1.00
354_E	358_Q	1.856	1.00
317_A	323_T	1.838	1.00
255_R	260_L	1.819	1.00
318_G	321_L	1.810	1.00
344_A	347_P	1.808	1.00
218_N	287_L	1.789	1.00
356_L	360_G	1.781	1.00
340_R	347_P	1.772	1.00
227_A	257_Q	1.770	1.00
149_A	373_V	1.768	1.00
93_H	118_H	1.763	1.00
327_L	333_V	1.762	1.00
365_Q	369_A	1.760	1.00
39_D	62_F	1.758	1.00
39_D	86_N	1.756	1.00
324_R	337_T	1.754	1.00
155_E	158_G	1.753	1.00
282_F	303_L	1.744	1.00
309_D	327_L	1.732	1.00
173_H	376_I	1.732	1.00
178_G	363_A	1.724	1.00
34_S	368_G	1.721	1.00
340_R	344_A	1.703	1.00
222_L	238_L	1.693	1.00
117_C	147_A	1.685	1.00
158_G	174_L	1.661	1.00
155_E	315_V	1.655	1.00
210_V	272_I	1.650	1.00
152_A	172_V	1.646	1.00
226_A	236_F	1.618	1.00
339_A	343_A	1.607	1.00
243_D	247_C	1.604	1.00
222_L	283_V	1.587	1.00
371_L	375_N	1.581	1.00
324_R	340_R	1.531	1.00
9_L	41_L	1.528	1.00
155_E	174_L	1.517	1.00
330_P	333_V	1.516	1.00
30_K	364_Q	1.510	1.00
158_G	172_V	1.507	1.00
30_K	33_K	1.506	1.00
333_V	337_T	1.492	1.00
30_K	367_V	1.470	1.00
269_E	272_I	1.469	1.00
221_F	287_L	1.463	1.00
216_V	288_Y	1.460	1.00
307_I	313_E	1.446	1.00
34_S	371_L	1.440	1.00
229_L	339_A	1.438	1.00
25_M	29_R	1.436	1.00
354_E	357_A	1.435	1.00
239_V	275_L	1.435	1.00
352_I	355_T	1.434	1.00
318_G	322_V	1.433	1.00
279_F	303_L	1.428	1.00
271_R	274_E	1.419	1.00
221_F	331_I	1.414	1.00
241_A	266_L	1.410	1.00
220_A	253_E	1.407	1.00
206_I	280_D	1.402	1.00
39_D	60_R	1.393	1.00
355_T	359_L	1.382	1.00
233_G	339_A	1.351	1.00
151_C	373_V	1.349	1.00
326_S	337_T	1.344	1.00
239_V	279_F	1.344	1.00
273_H	301_S	1.339	1.00
213_F	240_L	1.337	1.00
152_A	158_G	1.328	1.00
302_G	354_E	1.327	1.00
347_P	350_E	1.323	1.00
209_H	222_L	1.321	1.00
228_H	331_I	1.320	1.00
7_R	39_D	1.309	1.00
219_H	240_L	1.308	1.00
331_I	335_A	1.305	1.00
10_H	95_H	1.298	1.00
207_I	283_V	1.289	1.00
207_I	338_I	1.281	1.00
151_C	370_L	1.279	1.00
225_L	334_W	1.278	1.00
208_G	241_A	1.267	1.00
369_A	372_N	1.257	1.00
162_F	169_R	1.255	1.00
10_H	31_M	1.246	1.00
184_F	301_S	1.246	1.00
253_E	256_Q	1.241	1.00
365_Q	368_G	1.231	1.00
333_V	336_E	1.229	1.00
291_L	296_V	1.227	1.00
149_A	376_I	1.224	1.00
252_E	256_Q	1.214	1.00
155_E	159_R	1.209	1.00
287_L	329_E	1.193	1.00
355_T	358_Q	1.192	1.00
277_R	301_S	1.191	1.00
205_L	281_V	1.183	1.00
233_G	343_A	1.181	1.00
82_A	86_N	1.174	1.00
23_M	293_V	1.165	1.00
335_A	339_A	1.163	1.00
284_M	295_L	1.156	1.00
319_L	337_T	1.149	1.00
159_R	162_F	1.146	1.00
227_A	231_E	1.142	1.00
295_L	313_E	1.133	1.00
363_A	366_N	1.128	1.00
120_H	293_V	1.118	1.00
248_G	251_E	1.116	1.00
272_I	276_M	1.115	1.00
362_D	365_Q	1.111	1.00
206_I	279_F	1.109	1.00
251_E	255_R	1.108	1.00
94_A	114_V	1.108	1.00
311_I	314_K	1.105	1.00
183_L	273_H	1.104	1.00
286_S	289_E	1.099	1.00
220_A	224_K	1.098	1.00
347_P	351_F	1.097	1.00
326_S	334_W	1.095	1.00
308_S	326_S	1.092	1.00
152_A	161_L	1.091	1.00
106_A	110_A	1.088	1.00
366_N	369_A	1.088	1.00
239_V	278_T	1.088	1.00
345_G	348_K	1.085	1.00
153_C	157_A	1.084	1.00
248_G	252_E	1.081	1.00
221_F	224_K	1.073	1.00
285_P	334_W	1.070	1.00
357_A	360_G	1.067	1.00
30_K	34_S	1.067	1.00
153_C	177_N	1.067	1.00
276_M	301_S	1.065	1.00
205_L	236_F	1.064	1.00
284_M	294_V	1.064	1.00
307_I	325_L	1.062	1.00
221_F	308_S	1.061	1.00
221_F	329_E	1.054	1.00
204_R	235_R	1.046	1.00
208_G	275_L	1.037	1.00
341_A	351_F	1.029	1.00
282_F	294_V	1.026	1.00
207_I	226_A	1.020	1.00
10_H	28_Y	1.017	1.00
299_Q	305_C	1.015	1.00
220_A	287_L	1.015	1.00
205_L	235_R	1.014	1.00
312_T	315_V	1.011	1.00
212_R	216_V	1.011	1.00
273_H	277_R	1.009	1.00
32_D	35_K	1.009	1.00
266_L	275_L	1.005	1.00
295_L	307_I	1.003	1.00
292_P	313_E	1.003	1.00
94_A	117_C	1.003	1.00
173_H	373_V	1.000	1.00
230_K	233_G	0.993	1.00
322_V	356_L	0.991	1.00
220_A	249_E	0.991	1.00
336_E	340_R	0.991	1.00
210_V	241_A	0.978	1.00
152_A	157_A	0.977	1.00
269_E	273_H	0.976	1.00
95_H	120_H	0.974	1.00
224_K	257_Q	0.974	1.00
26_N	29_R	0.972	1.00
210_V	276_M	0.971	1.00
223_L	254_A	0.971	1.00
368_G	372_N	0.969	1.00
254_A	265_F	0.966	1.00
28_Y	40_F	0.960	1.00
26_N	363_A	0.958	1.00
177_N	293_V	0.957	1.00
77_R	81_N	0.956	1.00
229_L	236_F	0.954	1.00
289_E	292_P	0.953	1.00
214_H	245_P	0.953	1.00
319_L	322_V	0.946	1.00
228_H	231_E	0.945	1.00
18_G	21_E	0.943	1.00
254_A	259_L	0.942	1.00
298_A	303_L	0.942	1.00
324_R	341_A	0.941	1.00
222_L	285_P	0.941	1.00
159_R	163_G	0.940	1.00
237_Q	262_D	0.940	1.00
153_C	290_G	0.938	1.00
366_N	370_L	0.936	1.00
324_R	351_F	0.934	1.00
181_L	362_D	0.933	1.00
229_L	338_I	0.930	1.00
168_E	171_R	0.929	1.00
178_G	366_N	0.922	1.00
184_F	273_H	0.921	1.00
160_F	163_G	0.920	1.00
345_G	349_R	0.914	1.00
344_A	348_K	0.909	1.00
307_I	317_A	0.908	1.00
23_M	120_H	0.907	1.00
221_F	334_W	0.904	1.00
116_V	151_C	0.903	1.00
295_L	305_C	0.902	1.00
353_K	356_L	0.899	1.00
209_H	240_L	0.893	1.00
276_M	303_L	0.886	1.00
318_G	356_L	0.884	1.00
299_Q	322_V	0.884	1.00
226_A	262_D	0.882	1.00
22_T	26_N	0.880	1.00
217_K	294_V	0.880	1.00
80_R	84_K	0.879	1.00
236_F	342_A	0.876	1.00
249_E	252_E	0.876	1.00
28_Y	32_D	0.875	1.00
147_A	150_L	0.872	1.00
220_A	246_L	0.872	1.00
8_V	36_V	0.869	1.00
114_V	147_A	0.868	1.00
356_L	359_L	0.866	1.00
217_K	289_E	0.864	1.00
225_L	335_A	0.863	1.00
306_I	326_S	0.861	1.00
229_L	335_A	0.858	1.00
348_K	351_F	0.856	1.00
80_R	109_L	0.851	1.00
281_V	341_A	0.848	1.00
229_L	342_A	0.846	1.00
180_D	183_L	0.846	1.00
243_D	268_T	0.843	1.00
173_H	369_A	0.840	1.00
306_I	337_T	0.839	1.00
317_A	325_L	0.838	1.00
227_A	230_K	0.837	1.00
209_H	285_P	0.834	1.00
310_S	313_E	0.829	1.00
368_G	371_L	0.828	1.00
175_L	373_V	0.826	1.00
284_M	313_E	0.823	1.00
105_L	109_L	0.821	1.00
224_K	227_A	0.820	1.00
304_P	341_A	0.819	1.00
208_G	276_M	0.819	1.00
252_E	255_R	0.817	1.00
160_F	164_Q	0.816	1.00
23_M	118_H	0.816	1.00
283_V	338_I	0.815	1.00
39_D	43_Y	0.814	1.00
362_D	366_N	0.811	1.00
156_D	159_R	0.810	1.00
162_F	172_V	0.809	1.00
324_R	347_P	0.804	1.00
114_V	117_C	0.804	1.00
295_L	316_D	0.801	1.00
24_V	95_H	0.801	1.00
274_E	277_R	0.799	1.00
151_C	175_L	0.799	1.00
281_V	338_I	0.797	1.00
217_K	286_S	0.796	1.00
249_E	253_E	0.794	1.00
275_L	278_T	0.792	1.00
332_S	336_E	0.790	1.00
254_A	263_V	0.783	1.00
26_N	180_D	0.783	1.00
274_E	278_T	0.781	1.00
209_H	282_F	0.781	1.00
254_A	257_Q	0.780	1.00
225_L	331_I	0.780	1.00
327_L	330_P	0.780	1.00
224_K	228_H	0.779	1.00
120_H	153_C	0.777	1.00
94_A	100_T	0.772	1.00
309_D	325_L	0.772	1.00
76_V	80_R	0.769	1.00
363_A	367_V	0.766	1.00
230_K	234_I	0.763	1.00
209_H	238_L	0.759	1.00
121_N	216_V	0.757	1.00
26_N	30_K	0.751	1.00
142_L	146_N	0.750	1.00
156_D	160_F	0.750	1.00
227_A	259_L	0.750	1.00
187_N	277_R	0.749	1.00
352_I	356_L	0.748	1.00
176_P	369_A	0.746	1.00
372_N	376_I	0.744	1.00
12_L	24_V	0.743	1.00
23_M	177_N	0.742	1.00
215_E	220_A	0.740	1.00
210_V	282_F	0.738	1.00
175_L	370_L	0.738	1.00
116_V	149_A	0.736	1.00
308_S	328_S	0.733	1.00
10_H	38_F	0.730	1.00
34_S	364_Q	0.730	1.00
364_Q	368_G	0.728	1.00
77_R	80_R	0.727	1.00
319_L	324_R	0.726	1.00
215_E	246_L	0.725	1.00
213_F	247_C	0.725	1.00
22_T	25_M	0.724	1.00
113_P	148_T	0.724	1.00
91_A	374_Y	0.724	1.00
215_E	287_L	0.721	1.00
269_E	275_L	0.720	1.00
321_L	352_I	0.720	1.00
336_E	339_A	0.720	1.00
29_R	57_L	0.720	1.00
211_A	219_H	0.719	1.00
233_G	236_F	0.719	1.00
176_P	315_V	0.719	1.00
370_L	374_Y	0.718	1.00
372_N	375_N	0.717	1.00
107_A	114_V	0.716	1.00
18_G	212_R	0.714	1.00
202_A	205_L	0.712	1.00
153_C	293_V	0.711	1.00
12_L	20_A	0.708	1.00
306_I	341_A	0.707	1.00
292_P	295_L	0.706	1.00
340_R	343_A	0.705	1.00
93_H	370_L	0.701	1.00
219_H	246_L	0.698	1.00
284_M	292_P	0.696	1.00
207_I	236_F	0.695	1.00
116_V	374_Y	0.690	1.00
95_H	118_H	0.687	1.00
37_Q	60_R	0.685	1.00
296_V	361_Y	0.684	1.00
346_R	350_E	0.678	1.00
314_K	325_L	0.678	1.00
341_A	348_K	0.676	1.00
107_A	110_A	0.675	1.00
332_S	335_A	0.673	1.00
132_D	135_Q	0.672	1.00
246_L	250_I	0.671	1.00
34_S	367_V	0.671	1.00
308_S	334_W	0.669	1.00
131_K	134_L	0.665	1.00
173_H	176_P	0.664	1.00
373_V	376_I	0.663	1.00
211_A	217_K	0.662	1.00
180_D	184_F	0.661	1.00
108_R	146_N	0.660	1.00
74_T	78_N	0.660	1.00
242_G	267_G	0.659	1.00
235_R	262_D	0.659	1.00
175_L	369_A	0.656	1.00
229_L	234_I	0.654	1.00
176_P	361_Y	0.653	1.00
81_N	85_E	0.652	1.00
32_D	38_F	0.652	1.00
280_D	348_K	0.650	1.00
23_M	370_L	0.649	1.00
251_E	265_F	0.648	1.00
33_K	364_Q	0.646	1.00
22_T	269_E	0.645	1.00
291_L	361_Y	0.642	1.00
181_L	300_A	0.642	1.00
32_D	58_G	0.640	1.00
91_A	116_V	0.640	1.00
109_L	112_V	0.639	1.00
27_L	370_L	0.637	1.00
205_L	345_G	0.637	1.00
317_A	322_V	0.628	1.00
94_A	103_I	0.628	1.00
207_I	342_A	0.628	1.00
225_L	338_I	0.628	1.00
138_V	142_L	0.627	1.00
205_L	208_G	0.624	1.00
275_L	279_F	0.624	1.00
218_N	329_E	0.624	1.00
226_A	229_L	0.623	1.00
55_L	58_G	0.622	1.00
92_V	107_A	0.622	1.00
223_L	263_V	0.622	1.00
353_K	357_A	0.617	1.00
120_H	177_N	0.616	1.00
304_P	348_K	0.615	1.00
283_V	334_W	0.615	1.00
133_R	136_L	0.614	1.00
110_A	113_P	0.614	1.00
208_G	282_F	0.614	1.00
96_T	99_Q	0.613	1.00
14_G	21_E	0.613	1.00
326_S	333_V	0.611	1.00
36_V	375_N	0.610	1.00
213_F	219_H	0.609	1.00
222_L	226_A	0.604	1.00
29_R	33_K	0.603	1.00
154_G	157_A	0.601	1.00
282_F	305_C	0.600	1.00
92_V	112_V	0.600	1.00
206_I	275_L	0.599	1.00
281_V	306_I	0.599	1.00
310_S	314_K	0.597	1.00
10_H	93_H	0.596	1.00
272_I	275_L	0.596	1.00
360_G	365_Q	0.595	1.00
114_V	148_T	0.595	1.00
234_I	343_A	0.594	1.00
285_P	308_S	0.593	1.00
35_K	371_L	0.592	1.00
254_A	260_L	0.592	1.00
152_A	174_L	0.591	1.00
367_V	371_L	0.590	1.00
229_L	233_G	0.588	1.00
118_H	370_L	0.587	1.00
157_A	160_F	0.586	1.00
130_W	133_R	0.585	1.00
9_L	39_D	0.584	1.00
156_D	314_K	0.584	1.00
276_M	294_V	0.583	1.00
158_G	169_R	0.583	1.00
118_H	151_C	0.583	1.00
218_N	285_P	0.581	1.00
28_Y	38_F	0.581	1.00
230_K	236_F	0.578	1.00
32_D	36_V	0.577	1.00
130_W	134_L	0.572	1.00
298_A	305_C	0.571	1.00
119_S	157_A	0.568	1.00
241_A	272_I	0.566	1.00
221_F	225_L	0.563	1.00
208_G	239_V	0.563	1.00
346_R	349_R	0.560	1.00
296_V	316_D	0.558	1.00
309_D	328_S	0.557	1.00
180_D	363_A	0.557	1.00
20_A	96_T	0.556	1.00
218_N	308_S	0.556	1.00
227_A	256_Q	0.554	1.00
123_S	126_T	0.550	1.00
238_L	263_V	0.549	1.00
176_P	366_N	0.549	1.00
223_L	250_I	0.549	1.00
292_P	296_V	0.548	1.00
182_E	185_A	0.547	1.00
208_G	303_L	0.545	1.00
157_A	290_G	0.544	1.00
205_L	348_K	0.544	1.00
225_L	229_L	0.543	1.00
286_S	292_P	0.543	1.00
220_A	250_I	0.543	1.00
26_N	293_V	0.541	1.00
322_V	353_K	0.540	1.00
23_M	95_H	0.540	1.00
286_S	294_V	0.539	1.00
155_E	176_P	0.539	1.00
306_I	338_I	0.537	1.00
107_A	148_T	0.536	1.00
185_A	277_R	0.536	1.00
141_R	145_A	0.536	1.00
9_L	92_V	0.536	1.00
185_A	188_G	0.534	1.00
269_E	274_E	0.533	1.00
122_T	125_K	0.531	1.00
215_E	249_E	0.531	1.00
212_R	217_K	0.530	1.00
78_N	81_N	0.529	1.00
294_V	298_A	0.528	1.00
35_K	38_F	0.528	1.00
12_L	15_M	0.528	1.00
132_D	136_L	0.527	1.00
84_K	110_A	0.527	1.00
63_Y	66_S	0.527	1.00
129_N	132_D	0.526	1.00
57_L	60_R	0.526	1.00
30_K	363_A	0.525	1.00
320_G	340_R	0.525	1.00
10_H	374_Y	0.524	1.00
176_P	291_L	0.524	1.00
241_A	279_F	0.523	1.00
7_R	90_S	0.522	1.00
149_A	171_R	0.521	1.00
280_D	345_G	0.521	1.00
28_Y	59_G	0.519	1.00
369_A	373_V	0.516	1.00
203_D	206_I	0.516	1.00
149_A	153_C	0.516	1.00
233_G	342_A	0.516	1.00
205_L	237_Q	0.515	1.00
142_L	145_A	0.514	1.00
225_L	283_V	0.511	1.00
91_A	94_A	0.511	1.00
23_M	27_L	0.510	1.00
250_I	265_F	0.509	1.00
213_F	242_G	0.509	1.00
204_R	278_T	0.507	1.00
230_K	261_S	0.505	1.00
82_A	85_E	0.504	1.00
156_D	315_V	0.501	1.00
29_R	32_D	0.501	1.00
276_M	282_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c48A	2	0.9688	100	0.171	Contact Map
2r60A	1	0.9714	100	0.171	Contact Map
1rzuA	1	0.9583	100	0.204	Contact Map
3froA	3	0.974	100	0.206	Contact Map
2qzsA	1	0.9531	100	0.213	Contact Map
4n9wA	1	0.8984	100	0.213	Contact Map
3okpA	1	0.9453	100	0.216	Contact Map
2iw1A	1	0.9271	100	0.228	Contact Map
2x6qA	1	0.9349	100	0.231	Contact Map
2jjmA	4	0.9115	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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