GREMLIN Database
EPSF - Putative glycosyltransferase EpsF
UniProt: P71055 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (350)
Sequences: 57219 (49069)
Seq/√Len: 2622.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_G279_F4.8151.00
237_Q264_L3.6941.00
247_C251_E3.3031.00
149_A173_H3.2941.00
282_F298_A3.2061.00
206_I239_V3.0641.00
93_H374_Y2.9431.00
228_H335_A2.7641.00
239_V266_L2.7471.00
204_R237_Q2.7471.00
224_K253_E2.7041.00
209_H219_H2.6071.00
7_R37_Q2.5981.00
230_K262_D2.4151.00
158_G162_F2.2421.00
224_K331_I2.1911.00
218_N221_F2.1761.00
205_L342_A2.1731.00
246_L249_E2.1191.00
206_I237_Q2.0941.00
309_D314_K2.0871.00
253_E257_Q2.0351.00
206_I278_T2.0241.00
337_T340_R2.0181.00
241_A275_L2.0071.00
239_V264_L2.0071.00
226_A238_L1.9851.00
36_V371_L1.9571.00
205_L280_D1.9561.00
228_H332_S1.9541.00
207_I281_V1.9491.00
354_E358_Q1.8561.00
317_A323_T1.8381.00
255_R260_L1.8191.00
318_G321_L1.8101.00
344_A347_P1.8081.00
218_N287_L1.7891.00
356_L360_G1.7811.00
340_R347_P1.7721.00
227_A257_Q1.7701.00
149_A373_V1.7681.00
93_H118_H1.7631.00
327_L333_V1.7621.00
365_Q369_A1.7601.00
39_D62_F1.7581.00
39_D86_N1.7561.00
324_R337_T1.7541.00
155_E158_G1.7531.00
282_F303_L1.7441.00
309_D327_L1.7321.00
173_H376_I1.7321.00
178_G363_A1.7241.00
34_S368_G1.7211.00
340_R344_A1.7031.00
222_L238_L1.6931.00
117_C147_A1.6851.00
158_G174_L1.6611.00
155_E315_V1.6551.00
210_V272_I1.6501.00
152_A172_V1.6461.00
226_A236_F1.6181.00
339_A343_A1.6071.00
243_D247_C1.6041.00
222_L283_V1.5871.00
371_L375_N1.5811.00
324_R340_R1.5311.00
9_L41_L1.5281.00
155_E174_L1.5171.00
330_P333_V1.5161.00
30_K364_Q1.5101.00
158_G172_V1.5071.00
30_K33_K1.5061.00
333_V337_T1.4921.00
30_K367_V1.4701.00
269_E272_I1.4691.00
221_F287_L1.4631.00
216_V288_Y1.4601.00
307_I313_E1.4461.00
34_S371_L1.4401.00
229_L339_A1.4381.00
25_M29_R1.4361.00
354_E357_A1.4351.00
239_V275_L1.4351.00
352_I355_T1.4341.00
318_G322_V1.4331.00
279_F303_L1.4281.00
271_R274_E1.4191.00
221_F331_I1.4141.00
241_A266_L1.4101.00
220_A253_E1.4071.00
206_I280_D1.4021.00
39_D60_R1.3931.00
355_T359_L1.3821.00
233_G339_A1.3511.00
151_C373_V1.3491.00
326_S337_T1.3441.00
239_V279_F1.3441.00
273_H301_S1.3391.00
213_F240_L1.3371.00
152_A158_G1.3281.00
302_G354_E1.3271.00
347_P350_E1.3231.00
209_H222_L1.3211.00
228_H331_I1.3201.00
7_R39_D1.3091.00
219_H240_L1.3081.00
331_I335_A1.3051.00
10_H95_H1.2981.00
207_I283_V1.2891.00
207_I338_I1.2811.00
151_C370_L1.2791.00
225_L334_W1.2781.00
208_G241_A1.2671.00
369_A372_N1.2571.00
162_F169_R1.2551.00
10_H31_M1.2461.00
184_F301_S1.2461.00
253_E256_Q1.2411.00
365_Q368_G1.2311.00
333_V336_E1.2291.00
291_L296_V1.2271.00
149_A376_I1.2241.00
252_E256_Q1.2141.00
155_E159_R1.2091.00
287_L329_E1.1931.00
355_T358_Q1.1921.00
277_R301_S1.1911.00
205_L281_V1.1831.00
233_G343_A1.1811.00
82_A86_N1.1741.00
23_M293_V1.1651.00
335_A339_A1.1631.00
284_M295_L1.1561.00
319_L337_T1.1491.00
159_R162_F1.1461.00
227_A231_E1.1421.00
295_L313_E1.1331.00
363_A366_N1.1281.00
120_H293_V1.1181.00
248_G251_E1.1161.00
272_I276_M1.1151.00
362_D365_Q1.1111.00
206_I279_F1.1091.00
251_E255_R1.1081.00
94_A114_V1.1081.00
311_I314_K1.1051.00
183_L273_H1.1041.00
286_S289_E1.0991.00
220_A224_K1.0981.00
347_P351_F1.0971.00
326_S334_W1.0951.00
308_S326_S1.0921.00
152_A161_L1.0911.00
106_A110_A1.0881.00
366_N369_A1.0881.00
239_V278_T1.0881.00
345_G348_K1.0851.00
153_C157_A1.0841.00
248_G252_E1.0811.00
221_F224_K1.0731.00
285_P334_W1.0701.00
357_A360_G1.0671.00
30_K34_S1.0671.00
153_C177_N1.0671.00
276_M301_S1.0651.00
205_L236_F1.0641.00
284_M294_V1.0641.00
307_I325_L1.0621.00
221_F308_S1.0611.00
221_F329_E1.0541.00
204_R235_R1.0461.00
208_G275_L1.0371.00
341_A351_F1.0291.00
282_F294_V1.0261.00
207_I226_A1.0201.00
10_H28_Y1.0171.00
299_Q305_C1.0151.00
220_A287_L1.0151.00
205_L235_R1.0141.00
312_T315_V1.0111.00
212_R216_V1.0111.00
273_H277_R1.0091.00
32_D35_K1.0091.00
266_L275_L1.0051.00
295_L307_I1.0031.00
292_P313_E1.0031.00
94_A117_C1.0031.00
173_H373_V1.0001.00
230_K233_G0.9931.00
322_V356_L0.9911.00
220_A249_E0.9911.00
336_E340_R0.9911.00
210_V241_A0.9781.00
152_A157_A0.9771.00
269_E273_H0.9761.00
95_H120_H0.9741.00
224_K257_Q0.9741.00
26_N29_R0.9721.00
210_V276_M0.9711.00
223_L254_A0.9711.00
368_G372_N0.9691.00
254_A265_F0.9661.00
28_Y40_F0.9601.00
26_N363_A0.9581.00
177_N293_V0.9571.00
77_R81_N0.9561.00
229_L236_F0.9541.00
289_E292_P0.9531.00
214_H245_P0.9531.00
319_L322_V0.9461.00
228_H231_E0.9451.00
18_G21_E0.9431.00
254_A259_L0.9421.00
298_A303_L0.9421.00
324_R341_A0.9411.00
222_L285_P0.9411.00
159_R163_G0.9401.00
237_Q262_D0.9401.00
153_C290_G0.9381.00
366_N370_L0.9361.00
324_R351_F0.9341.00
181_L362_D0.9331.00
229_L338_I0.9301.00
168_E171_R0.9291.00
178_G366_N0.9221.00
184_F273_H0.9211.00
160_F163_G0.9201.00
345_G349_R0.9141.00
344_A348_K0.9091.00
307_I317_A0.9081.00
23_M120_H0.9071.00
221_F334_W0.9041.00
116_V151_C0.9031.00
295_L305_C0.9021.00
353_K356_L0.8991.00
209_H240_L0.8931.00
276_M303_L0.8861.00
318_G356_L0.8841.00
299_Q322_V0.8841.00
226_A262_D0.8821.00
22_T26_N0.8801.00
217_K294_V0.8801.00
80_R84_K0.8791.00
236_F342_A0.8761.00
249_E252_E0.8761.00
28_Y32_D0.8751.00
147_A150_L0.8721.00
220_A246_L0.8721.00
8_V36_V0.8691.00
114_V147_A0.8681.00
356_L359_L0.8661.00
217_K289_E0.8641.00
225_L335_A0.8631.00
306_I326_S0.8611.00
229_L335_A0.8581.00
348_K351_F0.8561.00
80_R109_L0.8511.00
281_V341_A0.8481.00
229_L342_A0.8461.00
180_D183_L0.8461.00
243_D268_T0.8431.00
173_H369_A0.8401.00
306_I337_T0.8391.00
317_A325_L0.8381.00
227_A230_K0.8371.00
209_H285_P0.8341.00
310_S313_E0.8291.00
368_G371_L0.8281.00
175_L373_V0.8261.00
284_M313_E0.8231.00
105_L109_L0.8211.00
224_K227_A0.8201.00
304_P341_A0.8191.00
208_G276_M0.8191.00
252_E255_R0.8171.00
160_F164_Q0.8161.00
23_M118_H0.8161.00
283_V338_I0.8151.00
39_D43_Y0.8141.00
362_D366_N0.8111.00
156_D159_R0.8101.00
162_F172_V0.8091.00
324_R347_P0.8041.00
114_V117_C0.8041.00
295_L316_D0.8011.00
24_V95_H0.8011.00
274_E277_R0.7991.00
151_C175_L0.7991.00
281_V338_I0.7971.00
217_K286_S0.7961.00
249_E253_E0.7941.00
275_L278_T0.7921.00
332_S336_E0.7901.00
254_A263_V0.7831.00
26_N180_D0.7831.00
274_E278_T0.7811.00
209_H282_F0.7811.00
254_A257_Q0.7801.00
225_L331_I0.7801.00
327_L330_P0.7801.00
224_K228_H0.7791.00
120_H153_C0.7771.00
94_A100_T0.7721.00
309_D325_L0.7721.00
76_V80_R0.7691.00
363_A367_V0.7661.00
230_K234_I0.7631.00
209_H238_L0.7591.00
121_N216_V0.7571.00
26_N30_K0.7511.00
142_L146_N0.7501.00
156_D160_F0.7501.00
227_A259_L0.7501.00
187_N277_R0.7491.00
352_I356_L0.7481.00
176_P369_A0.7461.00
372_N376_I0.7441.00
12_L24_V0.7431.00
23_M177_N0.7421.00
215_E220_A0.7401.00
210_V282_F0.7381.00
175_L370_L0.7381.00
116_V149_A0.7361.00
308_S328_S0.7331.00
10_H38_F0.7301.00
34_S364_Q0.7301.00
364_Q368_G0.7281.00
77_R80_R0.7271.00
319_L324_R0.7261.00
215_E246_L0.7251.00
213_F247_C0.7251.00
22_T25_M0.7241.00
113_P148_T0.7241.00
91_A374_Y0.7241.00
215_E287_L0.7211.00
269_E275_L0.7201.00
321_L352_I0.7201.00
336_E339_A0.7201.00
29_R57_L0.7201.00
211_A219_H0.7191.00
233_G236_F0.7191.00
176_P315_V0.7191.00
370_L374_Y0.7181.00
372_N375_N0.7171.00
107_A114_V0.7161.00
18_G212_R0.7141.00
202_A205_L0.7121.00
153_C293_V0.7111.00
12_L20_A0.7081.00
306_I341_A0.7071.00
292_P295_L0.7061.00
340_R343_A0.7051.00
93_H370_L0.7011.00
219_H246_L0.6981.00
284_M292_P0.6961.00
207_I236_F0.6951.00
116_V374_Y0.6901.00
95_H118_H0.6871.00
37_Q60_R0.6851.00
296_V361_Y0.6841.00
346_R350_E0.6781.00
314_K325_L0.6781.00
341_A348_K0.6761.00
107_A110_A0.6751.00
332_S335_A0.6731.00
132_D135_Q0.6721.00
246_L250_I0.6711.00
34_S367_V0.6711.00
308_S334_W0.6691.00
131_K134_L0.6651.00
173_H176_P0.6641.00
373_V376_I0.6631.00
211_A217_K0.6621.00
180_D184_F0.6611.00
108_R146_N0.6601.00
74_T78_N0.6601.00
242_G267_G0.6591.00
235_R262_D0.6591.00
175_L369_A0.6561.00
229_L234_I0.6541.00
176_P361_Y0.6531.00
81_N85_E0.6521.00
32_D38_F0.6521.00
280_D348_K0.6501.00
23_M370_L0.6491.00
251_E265_F0.6481.00
33_K364_Q0.6461.00
22_T269_E0.6451.00
291_L361_Y0.6421.00
181_L300_A0.6421.00
32_D58_G0.6401.00
91_A116_V0.6401.00
109_L112_V0.6391.00
27_L370_L0.6371.00
205_L345_G0.6371.00
317_A322_V0.6281.00
94_A103_I0.6281.00
207_I342_A0.6281.00
225_L338_I0.6281.00
138_V142_L0.6271.00
205_L208_G0.6241.00
275_L279_F0.6241.00
218_N329_E0.6241.00
226_A229_L0.6231.00
55_L58_G0.6221.00
92_V107_A0.6221.00
223_L263_V0.6221.00
353_K357_A0.6171.00
120_H177_N0.6161.00
304_P348_K0.6151.00
283_V334_W0.6151.00
133_R136_L0.6141.00
110_A113_P0.6141.00
208_G282_F0.6141.00
96_T99_Q0.6131.00
14_G21_E0.6131.00
326_S333_V0.6111.00
36_V375_N0.6101.00
213_F219_H0.6091.00
222_L226_A0.6041.00
29_R33_K0.6031.00
154_G157_A0.6011.00
282_F305_C0.6001.00
92_V112_V0.6001.00
206_I275_L0.5991.00
281_V306_I0.5991.00
310_S314_K0.5971.00
10_H93_H0.5961.00
272_I275_L0.5961.00
360_G365_Q0.5951.00
114_V148_T0.5951.00
234_I343_A0.5941.00
285_P308_S0.5931.00
35_K371_L0.5921.00
254_A260_L0.5921.00
152_A174_L0.5911.00
367_V371_L0.5901.00
229_L233_G0.5881.00
118_H370_L0.5871.00
157_A160_F0.5861.00
130_W133_R0.5851.00
9_L39_D0.5841.00
156_D314_K0.5841.00
276_M294_V0.5831.00
158_G169_R0.5831.00
118_H151_C0.5831.00
218_N285_P0.5811.00
28_Y38_F0.5811.00
230_K236_F0.5781.00
32_D36_V0.5771.00
130_W134_L0.5721.00
298_A305_C0.5711.00
119_S157_A0.5681.00
241_A272_I0.5661.00
221_F225_L0.5631.00
208_G239_V0.5631.00
346_R349_R0.5601.00
296_V316_D0.5581.00
309_D328_S0.5571.00
180_D363_A0.5571.00
20_A96_T0.5561.00
218_N308_S0.5561.00
227_A256_Q0.5541.00
123_S126_T0.5501.00
238_L263_V0.5491.00
176_P366_N0.5491.00
223_L250_I0.5491.00
292_P296_V0.5481.00
182_E185_A0.5471.00
208_G303_L0.5451.00
157_A290_G0.5441.00
205_L348_K0.5441.00
225_L229_L0.5431.00
286_S292_P0.5431.00
220_A250_I0.5431.00
26_N293_V0.5411.00
322_V353_K0.5401.00
23_M95_H0.5401.00
286_S294_V0.5391.00
155_E176_P0.5391.00
306_I338_I0.5371.00
107_A148_T0.5361.00
185_A277_R0.5361.00
141_R145_A0.5361.00
9_L92_V0.5361.00
185_A188_G0.5341.00
269_E274_E0.5331.00
122_T125_K0.5311.00
215_E249_E0.5311.00
212_R217_K0.5301.00
78_N81_N0.5291.00
294_V298_A0.5281.00
35_K38_F0.5281.00
12_L15_M0.5281.00
132_D136_L0.5271.00
84_K110_A0.5271.00
63_Y66_S0.5271.00
129_N132_D0.5261.00
57_L60_R0.5261.00
30_K363_A0.5251.00
320_G340_R0.5251.00
10_H374_Y0.5241.00
176_P291_L0.5241.00
241_A279_F0.5231.00
7_R90_S0.5221.00
149_A171_R0.5211.00
280_D345_G0.5211.00
28_Y59_G0.5191.00
369_A373_V0.5161.00
203_D206_I0.5161.00
149_A153_C0.5161.00
233_G342_A0.5161.00
205_L237_Q0.5151.00
142_L145_A0.5141.00
225_L283_V0.5111.00
91_A94_A0.5111.00
23_M27_L0.5101.00
250_I265_F0.5091.00
213_F242_G0.5091.00
204_R278_T0.5071.00
230_K261_S0.5051.00
82_A85_E0.5041.00
156_D315_V0.5011.00
29_R32_D0.5011.00
276_M282_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c48A 2 0.9688 100 0.171 Contact Map
2r60A 1 0.9714 100 0.171 Contact Map
1rzuA 1 0.9583 100 0.204 Contact Map
3froA 3 0.974 100 0.206 Contact Map
2qzsA 1 0.9531 100 0.213 Contact Map
4n9wA 1 0.8984 100 0.213 Contact Map
3okpA 1 0.9453 100 0.216 Contact Map
2iw1A 1 0.9271 100 0.228 Contact Map
2x6qA 1 0.9349 100 0.231 Contact Map
2jjmA 4 0.9115 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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