EPSE - BACSU - GREMLIN Contacts

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EPSE - Putative glycosyltransferase EpsE

UniProt:	P71054	Sequences: MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDASTDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPRRLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMMRASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSFTYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVKHE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (226)
Sequences:	33705 (28776)
Seq/√Len:	1914.2

ECOLI - WCAA YIBD WCAE ARNC GTRB WBBL PGAC YAIP
BACSU - EPSE CGED GGAA EPSH EPSJ GGAB TUAG YFNE SPSA YWDF YKCC CSBB YDAM YKOT TAGF
HALSA - Q9HQP8 Q9HQP4 Q9HSC8 Q9HQP3 Q9HQQ6 Q9HNK3 Q9HR08 Q9HSB1
SULSO - Q7LXF7 Q97TZ0 Q97TY0 Q7LXG6 Q97X05 Q97W52 Q7LXY2 Q97YG5 Q97YN4 Q97UK7 Q97YM4 Q97WK7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_C	95_G	3.235	1.00
162_A	166_R	3.111	1.00
17_E	47_G	2.589	1.00
106_K	201_E	2.444	1.00
8_S	87_G	2.434	1.00
184_D	188_R	2.407	1.00
80_H	84_H	2.397	1.00
41_D	67_Q	2.366	1.00
49_L	67_Q	2.291	1.00
13_I	48_T	2.193	1.00
100_F	205_K	2.173	1.00
89_Y	111_L	2.169	1.00
36_E	64_K	2.120	1.00
72_K	76_A	2.097	1.00
49_L	53_K	2.093	1.00
31_S	105_E	2.071	1.00
11_M	37_L	2.047	1.00
68_N	80_H	2.013	1.00
117_Y	197_Y	2.011	1.00
21_A	25_E	1.976	1.00
10_I	81_C	1.971	1.00
40_C	81_C	1.964	1.00
22_E	207_R	1.892	1.00
99_S	103_R	1.793	1.00
21_A	55_Y	1.788	1.00
8_S	36_E	1.772	1.00
110_F	199_L	1.767	1.00
91_A	159_M	1.760	1.00
22_E	98_L	1.748	1.00
78_L	94_D	1.728	1.00
7_V	108_V	1.728	1.00
164_A	194_F	1.727	1.00
15_N	45_T	1.726	1.00
107_Q	159_M	1.721	1.00
17_E	51_I	1.719	1.00
110_F	197_Y	1.705	1.00
6_K	88_D	1.699	1.00
66_I	84_H	1.693	1.00
47_G	50_R	1.684	1.00
118_Q	161_R	1.669	1.00
11_M	23_S	1.653	1.00
53_K	67_Q	1.652	1.00
125_L	205_K	1.629	1.00
32_Y	108_V	1.601	1.00
41_D	44_S	1.587	1.00
102_R	106_K	1.580	1.00
103_R	107_Q	1.575	1.00
98_L	205_K	1.572	1.00
74_L	78_L	1.547	1.00
93_Q	99_S	1.535	1.00
91_A	104_L	1.531	1.00
91_A	103_R	1.520	1.00
49_L	65_L	1.511	1.00
80_H	83_S	1.507	1.00
39_L	52_A	1.501	1.00
25_E	55_Y	1.483	1.00
14_Y	71_N	1.475	1.00
75_A	181_E	1.472	1.00
21_A	51_I	1.470	1.00
64_K	84_H	1.468	1.00
118_Q	194_F	1.463	1.00
21_A	54_Q	1.447	1.00
6_K	34_N	1.433	1.00
111_L	159_M	1.423	1.00
89_Y	159_M	1.412	1.00
13_I	39_L	1.396	1.00
110_F	114_H	1.395	1.00
119_V	196_G	1.394	1.00
66_I	80_H	1.391	1.00
76_A	173_S	1.386	1.00
78_L	92_R	1.385	1.00
36_E	87_G	1.380	1.00
25_E	29_S	1.379	1.00
106_K	109_A	1.343	1.00
114_H	117_Y	1.320	1.00
90_I	162_A	1.296	1.00
7_V	104_L	1.291	1.00
163_S	167_T	1.283	1.00
32_Y	35_W	1.282	1.00
167_T	192_E	1.271	1.00
13_I	16_C	1.266	1.00
8_S	85_A	1.257	1.00
105_E	109_A	1.254	1.00
24_I	37_L	1.242	1.00
88_D	161_R	1.242	1.00
107_Q	122_T	1.225	1.00
114_H	197_Y	1.215	1.00
15_N	44_S	1.210	1.00
16_C	19_T	1.209	1.00
98_L	207_R	1.207	1.00
68_N	72_K	1.191	1.00
69_K	72_K	1.191	1.00
82_L	165_Y	1.187	1.00
53_K	56_A	1.185	1.00
74_L	181_E	1.182	1.00
164_A	189_F	1.180	1.00
26_S	99_S	1.177	1.00
127_F	205_K	1.175	1.00
158_I	186_W	1.174	1.00
69_K	80_H	1.167	1.00
167_T	194_F	1.167	1.00
85_A	162_A	1.165	1.00
68_N	77_S	1.157	1.00
40_C	77_S	1.138	1.00
41_D	49_L	1.136	1.00
82_L	92_R	1.134	1.00
108_V	112_E	1.129	1.00
23_S	93_Q	1.127	1.00
51_I	55_Y	1.125	1.00
7_V	159_M	1.122	1.00
36_E	86_T	1.112	1.00
111_L	120_V	1.101	1.00
42_D	71_N	1.094	1.00
91_A	99_S	1.088	1.00
123_G	198_N	1.078	1.00
8_S	38_I	1.078	1.00
163_S	166_R	1.078	1.00
102_R	105_E	1.069	1.00
13_I	95_G	1.066	1.00
110_F	113_K	1.056	1.00
54_Q	58_H	1.054	1.00
29_S	101_P	1.037	1.00
125_L	202_A	1.031	1.00
83_S	170_G	1.026	1.00
37_L	63_I	1.017	1.00
106_K	199_L	1.016	1.00
74_L	213_F	1.006	1.00
6_K	87_G	1.001	1.00
116_H	195_R	0.999	1.00
161_R	164_A	0.987	1.00
109_A	113_K	0.984	1.00
12_G	77_S	0.982	1.00
124_M	156_G	0.979	1.00
172_R	184_D	0.975	1.00
6_K	86_T	0.973	1.00
119_V	189_F	0.972	1.00
31_S	102_R	0.967	1.00
26_S	98_L	0.958	1.00
52_A	65_L	0.957	1.00
107_Q	120_V	0.948	1.00
165_Y	185_L	0.946	1.00
25_E	28_L	0.944	1.00
82_L	90_I	0.940	1.00
98_L	127_F	0.935	1.00
27_I	93_Q	0.934	1.00
89_Y	108_V	0.932	1.00
50_R	53_K	0.930	1.00
51_I	54_Q	0.926	1.00
76_A	80_H	0.925	1.00
69_K	76_A	0.925	1.00
83_S	169_K	0.924	1.00
103_R	122_T	0.922	1.00
110_F	120_V	0.920	1.00
28_L	60_S	0.913	1.00
118_Q	195_R	0.913	1.00
78_L	181_E	0.912	1.00
64_K	86_T	0.891	1.00
24_I	55_Y	0.890	1.00
127_F	131_G	0.887	1.00
103_R	203_L	0.884	1.00
106_K	110_F	0.873	1.00
47_G	51_I	0.871	1.00
13_I	52_A	0.861	1.00
28_L	63_I	0.858	1.00
42_D	77_S	0.856	1.00
9_V	91_A	0.840	1.00
19_T	207_R	0.839	1.00
9_V	27_I	0.837	1.00
100_F	125_L	0.831	1.00
209_D	212_A	0.828	1.00
28_L	55_Y	0.827	1.00
42_D	73_R	0.820	1.00
28_L	62_R	0.820	1.00
35_W	104_L	0.816	1.00
75_A	79_N	0.815	1.00
50_R	54_Q	0.806	1.00
74_L	155_H	0.804	1.00
107_Q	111_L	0.798	1.00
118_Q	164_A	0.793	1.00
224_N	227_L	0.793	1.00
74_L	94_D	0.791	1.00
23_S	26_S	0.790	1.00
13_I	20_L	0.790	1.00
24_I	39_L	0.789	1.00
72_K	77_S	0.779	1.00
168_L	192_E	0.778	1.00
177_T	180_M	0.777	1.00
54_Q	57_A	0.775	1.00
7_V	91_A	0.773	1.00
11_M	27_I	0.771	1.00
31_S	101_P	0.765	1.00
40_C	80_H	0.762	1.00
56_A	63_I	0.749	1.00
111_L	117_Y	0.744	1.00
156_G	204_Y	0.742	1.00
227_L	231_A	0.740	1.00
128_D	132_V	0.737	1.00
114_H	195_R	0.733	1.00
172_R	176_R	0.732	1.00
9_V	104_L	0.732	1.00
16_C	209_D	0.725	1.00
100_F	203_L	0.724	1.00
126_V	208_E	0.720	1.00
56_A	65_L	0.719	1.00
27_I	99_S	0.719	1.00
27_I	37_L	0.718	1.00
122_T	203_L	0.718	1.00
100_F	103_R	0.715	1.00
42_D	72_K	0.712	1.00
6_K	112_E	0.711	1.00
160_M	186_W	0.706	1.00
60_S	63_I	0.704	1.00
25_E	58_H	0.695	1.00
38_I	81_C	0.692	1.00
32_Y	104_L	0.690	1.00
121_G	198_N	0.687	1.00
74_L	77_S	0.686	1.00
20_L	95_G	0.684	1.00
185_L	189_F	0.682	1.00
72_K	80_H	0.680	1.00
22_E	25_E	0.678	1.00
82_L	85_A	0.678	1.00
212_A	215_R	0.676	1.00
155_H	158_I	0.675	1.00
127_F	207_R	0.673	1.00
165_Y	170_G	0.670	1.00
42_D	68_N	0.667	1.00
49_L	52_A	0.666	1.00
123_G	200_Q	0.664	1.00
12_G	95_G	0.658	1.00
164_A	167_T	0.658	1.00
38_I	84_H	0.657	1.00
226_I	230_Q	0.657	1.00
164_A	168_L	0.656	1.00
32_Y	105_E	0.654	1.00
92_R	171_Y	0.654	1.00
53_K	57_A	0.652	1.00
64_K	67_Q	0.645	1.00
168_L	189_F	0.641	1.00
108_V	159_M	0.640	1.00
38_I	64_K	0.637	1.00
12_G	78_L	0.634	1.00
139_P	142_P	0.631	1.00
53_K	65_L	0.630	1.00
9_V	35_W	0.629	1.00
28_L	58_H	0.627	1.00
220_Y	223_D	0.627	1.00
6_K	32_Y	0.620	1.00
160_M	185_L	0.619	1.00
23_S	27_I	0.618	1.00
17_E	21_A	0.618	1.00
227_L	230_Q	0.616	1.00
24_I	28_L	0.616	1.00
97_D	206_V	0.610	1.00
79_N	170_G	0.610	1.00
155_H	171_Y	0.607	1.00
88_D	163_S	0.604	1.00
219_T	223_D	0.602	1.00
128_D	131_G	0.602	1.00
110_F	117_Y	0.601	1.00
225_A	228_V	0.600	1.00
55_Y	58_H	0.597	1.00
12_G	42_D	0.597	1.00
23_S	96_D	0.595	1.00
122_T	157_T	0.592	1.00
199_L	202_A	0.592	1.00
99_S	104_L	0.590	1.00
77_S	80_H	0.589	1.00
83_S	172_R	0.589	1.00
121_G	153_F	0.588	1.00
20_L	52_A	0.587	1.00
172_R	188_R	0.587	1.00
6_K	108_V	0.585	1.00
14_Y	42_D	0.582	1.00
170_G	173_S	0.581	1.00
180_M	183_I	0.581	1.00
68_N	76_A	0.579	1.00
189_F	194_F	0.578	1.00
117_Y	120_V	0.576	1.00
106_K	203_L	0.575	1.00
166_R	169_K	0.574	1.00
85_A	90_I	0.573	1.00
231_A	234_R	0.573	1.00
31_S	35_W	0.572	1.00
43_A	71_N	0.571	1.00
10_I	85_A	0.569	1.00
218_F	221_S	0.568	1.00
224_N	228_V	0.567	1.00
111_L	161_R	0.566	1.00
91_A	157_T	0.564	1.00
97_D	204_Y	0.560	1.00
153_F	158_I	0.559	1.00
109_A	112_E	0.554	1.00
14_Y	43_A	0.549	1.00
39_L	63_I	0.548	1.00
168_L	172_R	0.545	1.00
30_Q	105_E	0.544	1.00
190_F	196_G	0.544	1.00
56_A	60_S	0.544	1.00
103_R	157_T	0.542	1.00
88_D	112_E	0.542	1.00
89_Y	161_R	0.538	1.00
138_L	142_P	0.536	1.00
136_R	140_S	0.536	1.00
202_A	205_K	0.535	1.00
68_N	71_N	0.534	1.00
228_V	232_C	0.534	1.00
229_Y	232_C	0.534	1.00
11_M	24_I	0.533	1.00
21_A	58_H	0.533	1.00
170_G	185_L	0.532	1.00
6_K	36_E	0.527	1.00
121_G	158_I	0.526	1.00
141_V	144_P	0.525	1.00
79_N	83_S	0.524	1.00
118_Q	193_G	0.524	1.00
160_M	165_Y	0.521	1.00
23_S	95_G	0.519	1.00
11_M	39_L	0.518	1.00
8_S	162_A	0.518	1.00
20_L	51_I	0.517	1.00
17_E	20_L	0.513	1.00
23_S	97_D	0.513	1.00
43_A	68_N	0.512	1.00
156_G	206_V	0.512	1.00
38_I	85_A	0.510	1.00
30_Q	104_L	0.510	1.00
183_I	187_L	0.508	1.00
108_V	111_L	0.508	1.00
99_S	204_Y	0.506	1.00
137_I	141_V	0.506	1.00
232_C	235_L	0.505	1.00
19_T	209_D	0.504	1.00
43_A	69_K	0.502	1.00
94_D	181_E	0.501	1.00
6_K	35_W	0.501	1.00
208_E	215_R	0.501	1.00
153_F	186_W	0.501	1.00
8_S	86_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bcvA	2	0.6475	100	0.252	Contact Map
2z86A	2	0.9101	100	0.266	Contact Map
1qg8A	1	0.8022	100	0.267	Contact Map
3l7iA	4	0	100	0.291	Contact Map
2d7iA	1	0.982	100	0.305	Contact Map
1xhbA	1	0.946	100	0.317	Contact Map
5ajoA	1	0.9712	100	0.327	Contact Map
4fixA	3	0.9784	100	0.368	Contact Map
4p02A	1	0.982	100	0.392	Contact Map
3ckjA	2	0.9388	100	0.392	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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