GREMLIN Database
EPSE - Putative glycosyltransferase EpsE
UniProt: P71054 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (226)
Sequences: 33705 (28776)
Seq/√Len: 1914.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_C95_G3.2351.00
162_A166_R3.1111.00
17_E47_G2.5891.00
106_K201_E2.4441.00
8_S87_G2.4341.00
184_D188_R2.4071.00
80_H84_H2.3971.00
41_D67_Q2.3661.00
49_L67_Q2.2911.00
13_I48_T2.1931.00
100_F205_K2.1731.00
89_Y111_L2.1691.00
36_E64_K2.1201.00
72_K76_A2.0971.00
49_L53_K2.0931.00
31_S105_E2.0711.00
11_M37_L2.0471.00
68_N80_H2.0131.00
117_Y197_Y2.0111.00
21_A25_E1.9761.00
10_I81_C1.9711.00
40_C81_C1.9641.00
22_E207_R1.8921.00
99_S103_R1.7931.00
21_A55_Y1.7881.00
8_S36_E1.7721.00
110_F199_L1.7671.00
91_A159_M1.7601.00
22_E98_L1.7481.00
78_L94_D1.7281.00
7_V108_V1.7281.00
164_A194_F1.7271.00
15_N45_T1.7261.00
107_Q159_M1.7211.00
17_E51_I1.7191.00
110_F197_Y1.7051.00
6_K88_D1.6991.00
66_I84_H1.6931.00
47_G50_R1.6841.00
118_Q161_R1.6691.00
11_M23_S1.6531.00
53_K67_Q1.6521.00
125_L205_K1.6291.00
32_Y108_V1.6011.00
41_D44_S1.5871.00
102_R106_K1.5801.00
103_R107_Q1.5751.00
98_L205_K1.5721.00
74_L78_L1.5471.00
93_Q99_S1.5351.00
91_A104_L1.5311.00
91_A103_R1.5201.00
49_L65_L1.5111.00
80_H83_S1.5071.00
39_L52_A1.5011.00
25_E55_Y1.4831.00
14_Y71_N1.4751.00
75_A181_E1.4721.00
21_A51_I1.4701.00
64_K84_H1.4681.00
118_Q194_F1.4631.00
21_A54_Q1.4471.00
6_K34_N1.4331.00
111_L159_M1.4231.00
89_Y159_M1.4121.00
13_I39_L1.3961.00
110_F114_H1.3951.00
119_V196_G1.3941.00
66_I80_H1.3911.00
76_A173_S1.3861.00
78_L92_R1.3851.00
36_E87_G1.3801.00
25_E29_S1.3791.00
106_K109_A1.3431.00
114_H117_Y1.3201.00
90_I162_A1.2961.00
7_V104_L1.2911.00
163_S167_T1.2831.00
32_Y35_W1.2821.00
167_T192_E1.2711.00
13_I16_C1.2661.00
8_S85_A1.2571.00
105_E109_A1.2541.00
24_I37_L1.2421.00
88_D161_R1.2421.00
107_Q122_T1.2251.00
114_H197_Y1.2151.00
15_N44_S1.2101.00
16_C19_T1.2091.00
98_L207_R1.2071.00
68_N72_K1.1911.00
69_K72_K1.1911.00
82_L165_Y1.1871.00
53_K56_A1.1851.00
74_L181_E1.1821.00
164_A189_F1.1801.00
26_S99_S1.1771.00
127_F205_K1.1751.00
158_I186_W1.1741.00
69_K80_H1.1671.00
167_T194_F1.1671.00
85_A162_A1.1651.00
68_N77_S1.1571.00
40_C77_S1.1381.00
41_D49_L1.1361.00
82_L92_R1.1341.00
108_V112_E1.1291.00
23_S93_Q1.1271.00
51_I55_Y1.1251.00
7_V159_M1.1221.00
36_E86_T1.1121.00
111_L120_V1.1011.00
42_D71_N1.0941.00
91_A99_S1.0881.00
123_G198_N1.0781.00
8_S38_I1.0781.00
163_S166_R1.0781.00
102_R105_E1.0691.00
13_I95_G1.0661.00
110_F113_K1.0561.00
54_Q58_H1.0541.00
29_S101_P1.0371.00
125_L202_A1.0311.00
83_S170_G1.0261.00
37_L63_I1.0171.00
106_K199_L1.0161.00
74_L213_F1.0061.00
6_K87_G1.0011.00
116_H195_R0.9991.00
161_R164_A0.9871.00
109_A113_K0.9841.00
12_G77_S0.9821.00
124_M156_G0.9791.00
172_R184_D0.9751.00
6_K86_T0.9731.00
119_V189_F0.9721.00
31_S102_R0.9671.00
26_S98_L0.9581.00
52_A65_L0.9571.00
107_Q120_V0.9481.00
165_Y185_L0.9461.00
25_E28_L0.9441.00
82_L90_I0.9401.00
98_L127_F0.9351.00
27_I93_Q0.9341.00
89_Y108_V0.9321.00
50_R53_K0.9301.00
51_I54_Q0.9261.00
76_A80_H0.9251.00
69_K76_A0.9251.00
83_S169_K0.9241.00
103_R122_T0.9221.00
110_F120_V0.9201.00
28_L60_S0.9131.00
118_Q195_R0.9131.00
78_L181_E0.9121.00
64_K86_T0.8911.00
24_I55_Y0.8901.00
127_F131_G0.8871.00
103_R203_L0.8841.00
106_K110_F0.8731.00
47_G51_I0.8711.00
13_I52_A0.8611.00
28_L63_I0.8581.00
42_D77_S0.8561.00
9_V91_A0.8401.00
19_T207_R0.8391.00
9_V27_I0.8371.00
100_F125_L0.8311.00
209_D212_A0.8281.00
28_L55_Y0.8271.00
42_D73_R0.8201.00
28_L62_R0.8201.00
35_W104_L0.8161.00
75_A79_N0.8151.00
50_R54_Q0.8061.00
74_L155_H0.8041.00
107_Q111_L0.7981.00
118_Q164_A0.7931.00
224_N227_L0.7931.00
74_L94_D0.7911.00
23_S26_S0.7901.00
13_I20_L0.7901.00
24_I39_L0.7891.00
72_K77_S0.7791.00
168_L192_E0.7781.00
177_T180_M0.7771.00
54_Q57_A0.7751.00
7_V91_A0.7731.00
11_M27_I0.7711.00
31_S101_P0.7651.00
40_C80_H0.7621.00
56_A63_I0.7491.00
111_L117_Y0.7441.00
156_G204_Y0.7421.00
227_L231_A0.7401.00
128_D132_V0.7371.00
114_H195_R0.7331.00
172_R176_R0.7321.00
9_V104_L0.7321.00
16_C209_D0.7251.00
100_F203_L0.7241.00
126_V208_E0.7201.00
56_A65_L0.7191.00
27_I99_S0.7191.00
27_I37_L0.7181.00
122_T203_L0.7181.00
100_F103_R0.7151.00
42_D72_K0.7121.00
6_K112_E0.7111.00
160_M186_W0.7061.00
60_S63_I0.7041.00
25_E58_H0.6951.00
38_I81_C0.6921.00
32_Y104_L0.6901.00
121_G198_N0.6871.00
74_L77_S0.6861.00
20_L95_G0.6841.00
185_L189_F0.6821.00
72_K80_H0.6801.00
22_E25_E0.6781.00
82_L85_A0.6781.00
212_A215_R0.6761.00
155_H158_I0.6751.00
127_F207_R0.6731.00
165_Y170_G0.6701.00
42_D68_N0.6671.00
49_L52_A0.6661.00
123_G200_Q0.6641.00
12_G95_G0.6581.00
164_A167_T0.6581.00
38_I84_H0.6571.00
226_I230_Q0.6571.00
164_A168_L0.6561.00
32_Y105_E0.6541.00
92_R171_Y0.6541.00
53_K57_A0.6521.00
64_K67_Q0.6451.00
168_L189_F0.6411.00
108_V159_M0.6401.00
38_I64_K0.6371.00
12_G78_L0.6341.00
139_P142_P0.6311.00
53_K65_L0.6301.00
9_V35_W0.6291.00
28_L58_H0.6271.00
220_Y223_D0.6271.00
6_K32_Y0.6201.00
160_M185_L0.6191.00
23_S27_I0.6181.00
17_E21_A0.6181.00
227_L230_Q0.6161.00
24_I28_L0.6161.00
97_D206_V0.6101.00
79_N170_G0.6101.00
155_H171_Y0.6071.00
88_D163_S0.6041.00
219_T223_D0.6021.00
128_D131_G0.6021.00
110_F117_Y0.6011.00
225_A228_V0.6001.00
55_Y58_H0.5971.00
12_G42_D0.5971.00
23_S96_D0.5951.00
122_T157_T0.5921.00
199_L202_A0.5921.00
99_S104_L0.5901.00
77_S80_H0.5891.00
83_S172_R0.5891.00
121_G153_F0.5881.00
20_L52_A0.5871.00
172_R188_R0.5871.00
6_K108_V0.5851.00
14_Y42_D0.5821.00
170_G173_S0.5811.00
180_M183_I0.5811.00
68_N76_A0.5791.00
189_F194_F0.5781.00
117_Y120_V0.5761.00
106_K203_L0.5751.00
166_R169_K0.5741.00
85_A90_I0.5731.00
231_A234_R0.5731.00
31_S35_W0.5721.00
43_A71_N0.5711.00
10_I85_A0.5691.00
218_F221_S0.5681.00
224_N228_V0.5671.00
111_L161_R0.5661.00
91_A157_T0.5641.00
97_D204_Y0.5601.00
153_F158_I0.5591.00
109_A112_E0.5541.00
14_Y43_A0.5491.00
39_L63_I0.5481.00
168_L172_R0.5451.00
30_Q105_E0.5441.00
190_F196_G0.5441.00
56_A60_S0.5441.00
103_R157_T0.5421.00
88_D112_E0.5421.00
89_Y161_R0.5381.00
138_L142_P0.5361.00
136_R140_S0.5361.00
202_A205_K0.5351.00
68_N71_N0.5341.00
228_V232_C0.5341.00
229_Y232_C0.5341.00
11_M24_I0.5331.00
21_A58_H0.5331.00
170_G185_L0.5321.00
6_K36_E0.5271.00
121_G158_I0.5261.00
141_V144_P0.5251.00
79_N83_S0.5241.00
118_Q193_G0.5241.00
160_M165_Y0.5211.00
23_S95_G0.5191.00
11_M39_L0.5181.00
8_S162_A0.5181.00
20_L51_I0.5171.00
17_E20_L0.5131.00
23_S97_D0.5131.00
43_A68_N0.5121.00
156_G206_V0.5121.00
38_I85_A0.5101.00
30_Q104_L0.5101.00
183_I187_L0.5081.00
108_V111_L0.5081.00
99_S204_Y0.5061.00
137_I141_V0.5061.00
232_C235_L0.5051.00
19_T209_D0.5041.00
43_A69_K0.5021.00
94_D181_E0.5011.00
6_K35_W0.5011.00
208_E215_R0.5011.00
153_F186_W0.5011.00
8_S86_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.6475 100 0.252 Contact Map
2z86A 2 0.9101 100 0.266 Contact Map
1qg8A 1 0.8022 100 0.267 Contact Map
3l7iA 4 0 100 0.291 Contact Map
2d7iA 1 0.982 100 0.305 Contact Map
1xhbA 1 0.946 100 0.317 Contact Map
5ajoA 1 0.9712 100 0.327 Contact Map
4fixA 3 0.9784 100 0.368 Contact Map
4p02A 1 0.982 100 0.392 Contact Map
3ckjA 2 0.9388 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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