EPSD - BACSU - GREMLIN Contacts

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EPSD - Putative glycosyltransferase EpsD

UniProt:	P71053	Sequences: MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLPYVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARRHGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPGGRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEAAALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSVASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQLYHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	381 (334)
Sequences:	57294 (48847)
Seq/√Len:	2672.8

ECOLI - RFAG WCAL GLGA WCAI RFAB WBBK WCAC
BACSU - EPSD EPSF YPJH YTCC COTSA GLGA YQGM TUAC TUAH YKVP CGEB TAGE
HALSA - Q9HQQ0 Q9HSW1 Q9HS45 Q9HRP8 Q9HSV4 Q9HSV2 Q9HRP9 Q9HQT2
SULSO - Q97VL4 Q97ZD3 Q97V80 Q97V61 Q97UM0 Q97XT7 Q980C8 Q97XT8 Q97XT5 Q97UU3 Q97XU2 Q97XT9 Q7LXM9 Q7LXI2 Q97XF6 Q97XT1 Q7LXF8 Q97XT6 Q7LXF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
201_V	272_A	4.701	1.00
230_R	257_C	3.612	1.00
141_C	164_Q	3.254	1.00
240_E	244_Q	3.121	1.00
275_S	291_G	3.100	1.00
199_I	232_V	2.928	1.00
83_H	368_Y	2.880	1.00
221_L	328_A	2.735	1.00
232_V	259_Y	2.676	1.00
197_D	230_R	2.647	1.00
217_E	246_L	2.608	1.00
202_Y	212_Q	2.582	1.00
225_K	332_E	2.550	1.00
351_T	354_R	2.491	1.00
223_K	255_H	2.347	1.00
211_N	214_Q	2.167	1.00
198_F	335_Y	2.160	1.00
217_E	324_S	2.154	1.00
34_H	79_Y	2.133	1.00
34_H	77_Y	2.053	1.00
246_L	250_L	2.016	1.00
302_D	307_R	2.013	1.00
199_I	230_R	1.989	1.00
221_L	325_A	1.981	1.00
330_R	333_Q	1.974	1.00
234_A	268_L	1.965	1.00
232_V	257_C	1.949	1.00
219_A	231_L	1.946	1.00
337_K	340_L	1.945	1.00
349_R	353_L	1.942	1.00
198_F	273_D	1.912	1.00
31_W	365_A	1.903	1.00
200_L	274_V	1.885	1.00
310_I	316_G	1.878	1.00
199_I	271_L	1.873	1.00
333_Q	340_L	1.848	1.00
311_R	314_E	1.828	1.00
83_H	110_T	1.818	1.00
236_E	240_E	1.815	1.00
315_N	351_T	1.809	1.00
341_C	345_G	1.809	1.00
295_E	349_R	1.806	1.00
211_N	280_I	1.774	1.00
239_M	242_T	1.761	1.00
359_R	363_E	1.754	1.00
317_F	330_R	1.723	1.00
164_Q	370_A	1.712	1.00
141_C	367_I	1.711	1.00
248_E	253_S	1.699	1.00
320_K	326_A	1.695	1.00
302_D	320_K	1.689	1.00
215_L	231_L	1.683	1.00
147_E	150_Y	1.680	1.00
333_Q	337_K	1.673	1.00
29_M	362_E	1.670	1.00
144_T	163_T	1.668	1.00
150_Y	165_K	1.659	1.00
220_A	250_L	1.657	1.00
275_S	296_Q	1.655	1.00
332_E	336_H	1.642	1.00
109_Y	139_T	1.633	1.00
170_G	357_E	1.609	1.00
147_E	308_E	1.595	1.00
219_A	229_L	1.591	1.00
311_R	351_T	1.584	1.00
29_M	365_A	1.576	1.00
365_A	369_S	1.575	1.00
150_Y	154_K	1.555	1.00
314_E	347_E	1.549	1.00
215_L	276_V	1.537	1.00
203_P	265_I	1.522	1.00
340_L	343_K	1.519	1.00
323_D	326_A	1.501	1.00
25_W	28_Q	1.476	1.00
25_W	358_A	1.467	1.00
150_Y	163_T	1.459	1.00
326_A	330_R	1.454	1.00
343_K	347_E	1.452	1.00
317_F	333_Q	1.441	1.00
214_Q	280_I	1.440	1.00
147_E	165_K	1.434	1.00
25_W	361_V	1.429	1.00
311_R	315_N	1.424	1.00
209_N	281_R	1.418	1.00
222_L	332_E	1.416	1.00
234_A	259_Y	1.406	1.00
20_L	24_K	1.401	1.00
264_D	267_E	1.395	1.00
213_K	246_L	1.393	1.00
214_Q	324_S	1.380	1.00
272_A	296_Q	1.368	1.00
300_A	306_H	1.364	1.00
199_I	273_D	1.362	1.00
266_H	294_A	1.333	1.00
232_V	268_L	1.332	1.00
262_C	268_L	1.329	1.00
143_I	367_I	1.317	1.00
259_Y	262_C	1.304	1.00
84_C	107_V	1.304	1.00
324_S	328_A	1.302	1.00
319_I	330_R	1.294	1.00
144_T	150_Y	1.283	1.00
232_V	272_A	1.279	1.00
206_L	233_F	1.277	1.00
221_L	324_S	1.277	1.00
202_Y	215_L	1.272	1.00
143_I	364_M	1.269	1.00
212_Q	233_F	1.263	1.00
245_T	249_K	1.247	1.00
200_L	276_V	1.242	1.00
218_A	327_F	1.239	1.00
200_L	331_I	1.229	1.00
363_E	366_D	1.225	1.00
347_E	350_K	1.214	1.00
159_P	162_R	1.209	1.00
246_L	249_K	1.207	1.00
326_A	329_R	1.205	1.00
201_V	234_A	1.198	1.00
141_C	370_A	1.194	1.00
234_A	262_C	1.191	1.00
284_L	289_L	1.185	1.00
359_R	362_E	1.177	1.00
280_I	322_G	1.171	1.00
27_K	30_G	1.171	1.00
147_E	151_I	1.159	1.00
328_A	332_E	1.147	1.00
198_F	274_V	1.142	1.00
270_Q	294_A	1.139	1.00
176_F	294_A	1.133	1.00
18_F	286_M	1.120	1.00
342_R	346_Q	1.119	1.00
288_V	306_H	1.113	1.00
7_F	26_F	1.109	1.00
34_H	55_R	1.108	1.00
345_G	348_G	1.101	1.00
244_Q	248_E	1.093	1.00
277_A	288_V	1.090	1.00
279_S	282_E	1.088	1.00
34_H	53_P	1.087	1.00
7_F	85_H	1.086	1.00
213_K	217_E	1.083	1.00
265_I	269_I	1.083	1.00
220_A	224_E	1.082	1.00
304_R	307_R	1.077	1.00
356_S	359_R	1.077	1.00
357_E	360_T	1.077	1.00
340_L	344_L	1.075	1.00
151_I	154_K	1.071	1.00
175_R	266_H	1.070	1.00
199_I	272_A	1.069	1.00
295_E	346_Q	1.067	1.00
221_L	225_K	1.063	1.00
319_I	327_F	1.062	1.00
214_Q	301_T	1.058	1.00
269_I	294_A	1.057	1.00
198_F	229_L	1.056	1.00
112_H	286_M	1.055	1.00
145_I	149_D	1.051	1.00
214_Q	217_E	1.051	1.00
277_A	287_N	1.048	1.00
25_W	29_M	1.044	1.00
301_T	319_I	1.042	1.00
144_T	153_A	1.041	1.00
360_T	363_E	1.040	1.00
296_Q	345_G	1.036	1.00
312_D	330_R	1.036	1.00
334_L	344_L	1.034	1.00
278_S	327_F	1.030	1.00
236_E	261_F	1.023	1.00
241_H	244_Q	1.020	1.00
317_F	344_L	1.016	1.00
214_Q	322_G	1.014	1.00
350_K	353_L	1.012	1.00
201_V	268_L	1.011	1.00
338_P	341_C	1.006	1.00
241_H	245_T	0.997	1.00
346_Q	350_K	0.993	1.00
300_A	318_L	0.991	1.00
305_G	308_E	0.989	1.00
266_H	270_Q	0.986	1.00
197_D	228_S	0.978	1.00
221_L	224_E	0.977	1.00
21_P	24_K	0.977	1.00
85_H	112_H	0.973	1.00
329_R	333_Q	0.968	1.00
164_Q	367_I	0.966	1.00
275_S	287_N	0.965	1.00
205_E	209_N	0.965	1.00
200_L	219_A	0.962	1.00
259_Y	268_L	0.958	1.00
198_F	228_S	0.955	1.00
232_V	271_L	0.954	1.00
360_T	364_M	0.952	1.00
222_L	229_L	0.951	1.00
288_V	300_A	0.947	1.00
285_G	306_H	0.944	1.00
213_K	280_I	0.944	1.00
292_M	298_A	0.942	1.00
213_K	242_T	0.938	1.00
176_F	266_H	0.938	1.00
21_P	357_E	0.937	1.00
217_E	250_L	0.937	1.00
247_A	258_F	0.937	1.00
194_R	197_D	0.937	1.00
203_P	269_I	0.929	1.00
144_T	149_D	0.929	1.00
215_L	278_S	0.926	1.00
145_I	283_G	0.925	1.00
282_E	285_G	0.925	1.00
362_E	366_D	0.924	1.00
247_A	252_A	0.924	1.00
145_I	169_I	0.924	1.00
338_P	342_R	0.922	1.00
84_C	109_Y	0.908	1.00
107_V	139_T	0.906	1.00
18_F	112_H	0.905	1.00
317_F	334_L	0.905	1.00
230_R	255_H	0.904	1.00
203_P	234_A	0.904	1.00
291_G	296_Q	0.901	1.00
13_Y	16_K	0.900	1.00
173_T	356_S	0.896	1.00
219_A	255_H	0.891	1.00
292_M	348_G	0.890	1.00
23_F	35_V	0.889	1.00
68_R	72_K	0.886	1.00
222_L	331_I	0.880	1.00
216_I	247_A	0.879	1.00
152_R	155_G	0.879	1.00
202_Y	233_F	0.876	1.00
342_R	345_G	0.871	1.00
139_T	142_L	0.871	1.00
317_F	340_L	0.871	1.00
344_L	347_E	0.871	1.00
7_F	23_F	0.868	1.00
315_N	348_G	0.866	1.00
288_V	298_A	0.866	1.00
108_L	143_I	0.862	1.00
170_G	360_T	0.860	1.00
292_M	351_T	0.858	1.00
222_L	227_P	0.855	1.00
210_K	282_E	0.854	1.00
207_N	238_A	0.852	1.00
154_K	160_G	0.851	1.00
214_Q	327_F	0.851	1.00
43_L	46_V	0.850	1.00
345_G	349_R	0.846	1.00
299_I	319_I	0.845	1.00
329_R	332_E	0.845	1.00
300_A	310_I	0.839	1.00
222_L	328_A	0.836	1.00
229_L	335_Y	0.835	1.00
202_Y	278_S	0.829	1.00
297_P	345_G	0.828	1.00
210_K	287_N	0.828	1.00
23_F	27_K	0.827	1.00
164_Q	363_E	0.822	1.00
292_M	315_N	0.821	1.00
303_N	306_H	0.820	1.00
274_V	334_L	0.820	1.00
242_T	245_T	0.815	1.00
17_A	21_P	0.813	1.00
362_E	365_A	0.813	1.00
71_K	75_D	0.812	1.00
218_A	328_A	0.810	1.00
222_L	335_Y	0.809	1.00
325_A	329_R	0.809	1.00
172_N	175_R	0.808	1.00
269_I	296_Q	0.808	1.00
106_K	140_D	0.806	1.00
143_I	166_I	0.802	1.00
242_T	246_L	0.802	1.00
148_E	151_I	0.792	1.00
245_T	248_E	0.792	1.00
277_A	306_H	0.791	1.00
19_H	85_H	0.791	1.00
320_K	323_D	0.790	1.00
220_A	223_K	0.790	1.00
310_I	318_L	0.787	1.00
356_S	360_T	0.787	1.00
201_V	269_I	0.785	1.00
268_L	271_L	0.785	1.00
94_R	98_R	0.782	1.00
18_F	110_T	0.779	1.00
299_I	330_R	0.772	1.00
288_V	309_I	0.771	1.00
112_H	145_I	0.768	1.00
276_V	331_I	0.768	1.00
297_P	334_L	0.766	1.00
351_T	355_F	0.766	1.00
267_E	271_L	0.759	1.00
134_W	138_Y	0.759	1.00
73_V	77_Y	0.757	1.00
217_E	220_A	0.757	1.00
108_L	141_C	0.756	1.00
313_G	333_Q	0.753	1.00
218_A	324_S	0.753	1.00
113_G	209_N	0.751	1.00
21_P	172_N	0.751	1.00
167_H	363_E	0.751	1.00
166_I	367_I	0.749	1.00
225_K	328_A	0.748	1.00
34_H	38_N	0.748	1.00
130_P	134_W	0.746	1.00
195_E	198_F	0.746	1.00
217_E	221_L	0.744	1.00
223_K	227_P	0.741	1.00
274_V	331_I	0.740	1.00
154_K	157_Q	0.737	1.00
247_A	256_V	0.737	1.00
247_A	250_L	0.736	1.00
366_D	370_A	0.734	1.00
357_E	361_V	0.734	1.00
67_Y	71_K	0.732	1.00
267_E	270_Q	0.729	1.00
312_D	315_N	0.729	1.00
71_K	99_Q	0.726	1.00
85_H	110_T	0.725	1.00
21_P	25_W	0.724	1.00
302_D	318_L	0.723	1.00
167_H	308_E	0.721	1.00
103_H	106_K	0.718	1.00
148_E	152_R	0.718	1.00
169_I	286_M	0.717	1.00
273_D	341_C	0.715	1.00
202_Y	231_L	0.715	1.00
358_A	362_E	0.706	1.00
51_S	54_I	0.705	1.00
204_A	212_Q	0.703	1.00
225_K	336_H	0.702	1.00
179_V	270_Q	0.701	1.00
225_K	329_R	0.698	1.00
130_P	133_K	0.697	1.00
200_L	229_L	0.695	1.00
210_K	279_S	0.695	1.00
202_Y	275_S	0.695	1.00
206_L	240_E	0.694	1.00
203_P	275_S	0.694	1.00
64_L	68_R	0.693	1.00
333_Q	336_H	0.692	1.00
301_T	321_I	0.691	1.00
50_F	53_P	0.690	1.00
344_L	348_G	0.690	1.00
364_M	368_Y	0.688	1.00
213_K	239_M	0.686	1.00
29_M	358_A	0.686	1.00
208_L	213_K	0.684	1.00
220_A	252_A	0.684	1.00
164_Q	167_H	0.683	1.00
198_F	338_P	0.683	1.00
72_K	76_T	0.679	1.00
343_K	346_Q	0.679	1.00
166_I	364_M	0.676	1.00
244_Q	258_F	0.676	1.00
285_G	288_V	0.675	1.00
83_H	364_M	0.673	1.00
366_D	369_S	0.672	1.00
325_A	328_A	0.670	1.00
301_T	327_F	0.670	1.00
94_R	97_A	0.669	1.00
108_L	368_Y	0.668	1.00
151_I	155_G	0.666	1.00
68_R	71_K	0.665	1.00
145_I	286_M	0.663	1.00
339_E	343_K	0.663	1.00
299_I	334_L	0.662	1.00
17_A	20_L	0.662	1.00
9_A	15_F	0.662	1.00
13_Y	205_E	0.658	1.00
204_A	210_K	0.656	1.00
208_L	280_I	0.656	1.00
277_A	285_G	0.656	1.00
9_A	19_H	0.655	1.00
27_K	33_V	0.652	1.00
29_M	361_V	0.650	1.00
18_F	364_M	0.649	1.00
18_F	169_I	0.645	1.00
307_R	318_L	0.643	1.00
7_F	33_V	0.641	1.00
81_I	368_Y	0.641	1.00
349_R	352_A	0.640	1.00
42_K	47_D	0.639	1.00
367_I	370_A	0.634	1.00
334_L	341_C	0.633	1.00
289_L	355_F	0.633	1.00
166_I	169_I	0.631	1.00
315_N	347_E	0.631	1.00
262_C	265_I	0.627	1.00
348_G	351_T	0.623	1.00
86_T	89_G	0.618	1.00
44_P	47_D	0.615	1.00
81_I	108_L	0.615	1.00
167_H	355_F	0.614	1.00
82_V	105_T	0.612	1.00
200_L	335_Y	0.611	1.00
166_I	363_E	0.611	1.00
268_L	272_A	0.609	1.00
152_R	156_L	0.608	1.00
310_I	315_N	0.606	1.00
172_N	176_F	0.603	1.00
133_K	137_A	0.603	1.00
275_S	298_A	0.601	1.00
79_Y	105_T	0.600	1.00
28_Q	358_A	0.600	1.00
276_V	327_F	0.600	1.00
208_L	239_M	0.600	1.00
319_I	326_A	0.599	1.00
218_A	331_I	0.597	1.00
148_E	307_R	0.595	1.00
219_A	222_L	0.594	1.00
93_A	97_A	0.594	1.00
292_M	345_G	0.593	1.00
346_Q	349_R	0.592	1.00
22_Y	364_M	0.592	1.00
339_E	342_R	0.587	1.00
284_L	355_F	0.587	1.00
312_D	317_F	0.585	1.00
65_A	69_Q	0.585	1.00
247_A	253_S	0.585	1.00
337_K	341_C	0.584	1.00
173_T	293_A	0.584	1.00
23_F	33_V	0.584	1.00
32_E	53_P	0.581	1.00
24_K	28_Q	0.579	1.00
21_P	286_M	0.579	1.00
214_Q	218_A	0.579	1.00
144_T	165_K	0.577	1.00
158_R	162_R	0.575	1.00
228_S	255_H	0.573	1.00
27_K	31_W	0.572	1.00
211_N	322_G	0.572	1.00
201_V	275_S	0.571	1.00
361_V	365_A	0.570	1.00
31_W	369_S	0.570	1.00
347_E	351_T	0.569	1.00
206_L	212_Q	0.567	1.00
223_K	229_L	0.567	1.00
173_T	353_L	0.566	1.00
146_N	149_D	0.563	1.00
198_F	201_V	0.563	1.00
149_D	152_R	0.558	1.00
110_T	364_M	0.558	1.00
199_I	268_L	0.557	1.00
216_I	256_V	0.556	1.00
265_I	268_L	0.553	1.00
174_E	177_R	0.553	1.00
273_D	338_P	0.552	1.00
274_V	299_I	0.552	1.00
74_I	79_Y	0.551	1.00
297_P	341_C	0.547	1.00
213_K	243_Y	0.545	1.00
177_R	270_Q	0.544	1.00
15_F	86_T	0.544	1.00
42_K	45_Y	0.544	1.00
227_P	336_H	0.543	1.00
215_L	219_A	0.542	1.00
269_I	287_N	0.540	1.00
84_C	90_G	0.540	1.00
211_N	278_S	0.539	1.00
198_F	341_C	0.538	1.00
62_Q	66_V	0.537	1.00
147_E	167_H	0.536	1.00
279_S	285_G	0.535	1.00
18_F	22_Y	0.535	1.00
278_S	301_T	0.535	1.00
42_K	46_V	0.534	1.00
167_H	284_L	0.532	1.00
243_Y	246_L	0.529	1.00
299_I	331_I	0.528	1.00
149_D	283_G	0.527	1.00
110_T	143_I	0.527	1.00
112_H	169_I	0.526	1.00
302_D	321_I	0.526	1.00
287_N	291_G	0.525	1.00
43_L	47_D	0.525	1.00
216_I	243_Y	0.524	1.00
291_G	298_A	0.524	1.00
289_L	309_I	0.522	1.00
111_A	149_D	0.522	1.00
285_G	289_L	0.522	1.00
84_C	93_A	0.521	1.00
194_R	230_R	0.521	1.00
18_F	85_H	0.520	1.00
31_W	80_D	0.519	1.00
11_V	16_K	0.518	1.00
73_V	76_T	0.518	1.00
211_N	301_T	0.517	1.00
201_V	296_Q	0.516	1.00
354_R	359_R	0.514	1.00
292_M	352_A	0.513	1.00
150_Y	160_G	0.512	1.00
218_A	222_L	0.512	1.00
303_N	307_R	0.510	1.00
75_D	103_H	0.510	1.00
193_F	271_L	0.510	1.00
234_A	265_I	0.509	1.00
279_S	283_G	0.508	1.00
36_A	73_V	0.501	1.00
231_L	256_V	0.501	1.00
208_L	242_T	0.500	1.00
243_Y	258_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c48A	2	0.9711	100	0.176	Contact Map
2r60A	1	0.9685	100	0.18	Contact Map
3okpA	1	0.937	100	0.197	Contact Map
2qzsA	1	0.9475	100	0.203	Contact Map
1rzuA	1	0.9554	100	0.203	Contact Map
2jjmA	4	0.9265	100	0.209	Contact Map
3froA	3	0.9738	100	0.211	Contact Map
4n9wA	1	0.9003	100	0.215	Contact Map
3s28A	4	0.9895	100	0.218	Contact Map
2iw1A	1	0.9265	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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