GREMLIN Database
EPSD - Putative glycosyltransferase EpsD
UniProt: P71053 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (334)
Sequences: 57294 (48847)
Seq/√Len: 2672.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_V272_A4.7011.00
230_R257_C3.6121.00
141_C164_Q3.2541.00
240_E244_Q3.1211.00
275_S291_G3.1001.00
199_I232_V2.9281.00
83_H368_Y2.8801.00
221_L328_A2.7351.00
232_V259_Y2.6761.00
197_D230_R2.6471.00
217_E246_L2.6081.00
202_Y212_Q2.5821.00
225_K332_E2.5501.00
351_T354_R2.4911.00
223_K255_H2.3471.00
211_N214_Q2.1671.00
198_F335_Y2.1601.00
217_E324_S2.1541.00
34_H79_Y2.1331.00
34_H77_Y2.0531.00
246_L250_L2.0161.00
302_D307_R2.0131.00
199_I230_R1.9891.00
221_L325_A1.9811.00
330_R333_Q1.9741.00
234_A268_L1.9651.00
232_V257_C1.9491.00
219_A231_L1.9461.00
337_K340_L1.9451.00
349_R353_L1.9421.00
198_F273_D1.9121.00
31_W365_A1.9031.00
200_L274_V1.8851.00
310_I316_G1.8781.00
199_I271_L1.8731.00
333_Q340_L1.8481.00
311_R314_E1.8281.00
83_H110_T1.8181.00
236_E240_E1.8151.00
315_N351_T1.8091.00
341_C345_G1.8091.00
295_E349_R1.8061.00
211_N280_I1.7741.00
239_M242_T1.7611.00
359_R363_E1.7541.00
317_F330_R1.7231.00
164_Q370_A1.7121.00
141_C367_I1.7111.00
248_E253_S1.6991.00
320_K326_A1.6951.00
302_D320_K1.6891.00
215_L231_L1.6831.00
147_E150_Y1.6801.00
333_Q337_K1.6731.00
29_M362_E1.6701.00
144_T163_T1.6681.00
150_Y165_K1.6591.00
220_A250_L1.6571.00
275_S296_Q1.6551.00
332_E336_H1.6421.00
109_Y139_T1.6331.00
170_G357_E1.6091.00
147_E308_E1.5951.00
219_A229_L1.5911.00
311_R351_T1.5841.00
29_M365_A1.5761.00
365_A369_S1.5751.00
150_Y154_K1.5551.00
314_E347_E1.5491.00
215_L276_V1.5371.00
203_P265_I1.5221.00
340_L343_K1.5191.00
323_D326_A1.5011.00
25_W28_Q1.4761.00
25_W358_A1.4671.00
150_Y163_T1.4591.00
326_A330_R1.4541.00
343_K347_E1.4521.00
317_F333_Q1.4411.00
214_Q280_I1.4401.00
147_E165_K1.4341.00
25_W361_V1.4291.00
311_R315_N1.4241.00
209_N281_R1.4181.00
222_L332_E1.4161.00
234_A259_Y1.4061.00
20_L24_K1.4011.00
264_D267_E1.3951.00
213_K246_L1.3931.00
214_Q324_S1.3801.00
272_A296_Q1.3681.00
300_A306_H1.3641.00
199_I273_D1.3621.00
266_H294_A1.3331.00
232_V268_L1.3321.00
262_C268_L1.3291.00
143_I367_I1.3171.00
259_Y262_C1.3041.00
84_C107_V1.3041.00
324_S328_A1.3021.00
319_I330_R1.2941.00
144_T150_Y1.2831.00
232_V272_A1.2791.00
206_L233_F1.2771.00
221_L324_S1.2771.00
202_Y215_L1.2721.00
143_I364_M1.2691.00
212_Q233_F1.2631.00
245_T249_K1.2471.00
200_L276_V1.2421.00
218_A327_F1.2391.00
200_L331_I1.2291.00
363_E366_D1.2251.00
347_E350_K1.2141.00
159_P162_R1.2091.00
246_L249_K1.2071.00
326_A329_R1.2051.00
201_V234_A1.1981.00
141_C370_A1.1941.00
234_A262_C1.1911.00
284_L289_L1.1851.00
359_R362_E1.1771.00
280_I322_G1.1711.00
27_K30_G1.1711.00
147_E151_I1.1591.00
328_A332_E1.1471.00
198_F274_V1.1421.00
270_Q294_A1.1391.00
176_F294_A1.1331.00
18_F286_M1.1201.00
342_R346_Q1.1191.00
288_V306_H1.1131.00
7_F26_F1.1091.00
34_H55_R1.1081.00
345_G348_G1.1011.00
244_Q248_E1.0931.00
277_A288_V1.0901.00
279_S282_E1.0881.00
34_H53_P1.0871.00
7_F85_H1.0861.00
213_K217_E1.0831.00
265_I269_I1.0831.00
220_A224_E1.0821.00
304_R307_R1.0771.00
356_S359_R1.0771.00
357_E360_T1.0771.00
340_L344_L1.0751.00
151_I154_K1.0711.00
175_R266_H1.0701.00
199_I272_A1.0691.00
295_E346_Q1.0671.00
221_L225_K1.0631.00
319_I327_F1.0621.00
214_Q301_T1.0581.00
269_I294_A1.0571.00
198_F229_L1.0561.00
112_H286_M1.0551.00
145_I149_D1.0511.00
214_Q217_E1.0511.00
277_A287_N1.0481.00
25_W29_M1.0441.00
301_T319_I1.0421.00
144_T153_A1.0411.00
360_T363_E1.0401.00
296_Q345_G1.0361.00
312_D330_R1.0361.00
334_L344_L1.0341.00
278_S327_F1.0301.00
236_E261_F1.0231.00
241_H244_Q1.0201.00
317_F344_L1.0161.00
214_Q322_G1.0141.00
350_K353_L1.0121.00
201_V268_L1.0111.00
338_P341_C1.0061.00
241_H245_T0.9971.00
346_Q350_K0.9931.00
300_A318_L0.9911.00
305_G308_E0.9891.00
266_H270_Q0.9861.00
197_D228_S0.9781.00
221_L224_E0.9771.00
21_P24_K0.9771.00
85_H112_H0.9731.00
329_R333_Q0.9681.00
164_Q367_I0.9661.00
275_S287_N0.9651.00
205_E209_N0.9651.00
200_L219_A0.9621.00
259_Y268_L0.9581.00
198_F228_S0.9551.00
232_V271_L0.9541.00
360_T364_M0.9521.00
222_L229_L0.9511.00
288_V300_A0.9471.00
285_G306_H0.9441.00
213_K280_I0.9441.00
292_M298_A0.9421.00
213_K242_T0.9381.00
176_F266_H0.9381.00
21_P357_E0.9371.00
217_E250_L0.9371.00
247_A258_F0.9371.00
194_R197_D0.9371.00
203_P269_I0.9291.00
144_T149_D0.9291.00
215_L278_S0.9261.00
145_I283_G0.9251.00
282_E285_G0.9251.00
362_E366_D0.9241.00
247_A252_A0.9241.00
145_I169_I0.9241.00
338_P342_R0.9221.00
84_C109_Y0.9081.00
107_V139_T0.9061.00
18_F112_H0.9051.00
317_F334_L0.9051.00
230_R255_H0.9041.00
203_P234_A0.9041.00
291_G296_Q0.9011.00
13_Y16_K0.9001.00
173_T356_S0.8961.00
219_A255_H0.8911.00
292_M348_G0.8901.00
23_F35_V0.8891.00
68_R72_K0.8861.00
222_L331_I0.8801.00
216_I247_A0.8791.00
152_R155_G0.8791.00
202_Y233_F0.8761.00
342_R345_G0.8711.00
139_T142_L0.8711.00
317_F340_L0.8711.00
344_L347_E0.8711.00
7_F23_F0.8681.00
315_N348_G0.8661.00
288_V298_A0.8661.00
108_L143_I0.8621.00
170_G360_T0.8601.00
292_M351_T0.8581.00
222_L227_P0.8551.00
210_K282_E0.8541.00
207_N238_A0.8521.00
154_K160_G0.8511.00
214_Q327_F0.8511.00
43_L46_V0.8501.00
345_G349_R0.8461.00
299_I319_I0.8451.00
329_R332_E0.8451.00
300_A310_I0.8391.00
222_L328_A0.8361.00
229_L335_Y0.8351.00
202_Y278_S0.8291.00
297_P345_G0.8281.00
210_K287_N0.8281.00
23_F27_K0.8271.00
164_Q363_E0.8221.00
292_M315_N0.8211.00
303_N306_H0.8201.00
274_V334_L0.8201.00
242_T245_T0.8151.00
17_A21_P0.8131.00
362_E365_A0.8131.00
71_K75_D0.8121.00
218_A328_A0.8101.00
222_L335_Y0.8091.00
325_A329_R0.8091.00
172_N175_R0.8081.00
269_I296_Q0.8081.00
106_K140_D0.8061.00
143_I166_I0.8021.00
242_T246_L0.8021.00
148_E151_I0.7921.00
245_T248_E0.7921.00
277_A306_H0.7911.00
19_H85_H0.7911.00
320_K323_D0.7901.00
220_A223_K0.7901.00
310_I318_L0.7871.00
356_S360_T0.7871.00
201_V269_I0.7851.00
268_L271_L0.7851.00
94_R98_R0.7821.00
18_F110_T0.7791.00
299_I330_R0.7721.00
288_V309_I0.7711.00
112_H145_I0.7681.00
276_V331_I0.7681.00
297_P334_L0.7661.00
351_T355_F0.7661.00
267_E271_L0.7591.00
134_W138_Y0.7591.00
73_V77_Y0.7571.00
217_E220_A0.7571.00
108_L141_C0.7561.00
313_G333_Q0.7531.00
218_A324_S0.7531.00
113_G209_N0.7511.00
21_P172_N0.7511.00
167_H363_E0.7511.00
166_I367_I0.7491.00
225_K328_A0.7481.00
34_H38_N0.7481.00
130_P134_W0.7461.00
195_E198_F0.7461.00
217_E221_L0.7441.00
223_K227_P0.7411.00
274_V331_I0.7401.00
154_K157_Q0.7371.00
247_A256_V0.7371.00
247_A250_L0.7361.00
366_D370_A0.7341.00
357_E361_V0.7341.00
67_Y71_K0.7321.00
267_E270_Q0.7291.00
312_D315_N0.7291.00
71_K99_Q0.7261.00
85_H110_T0.7251.00
21_P25_W0.7241.00
302_D318_L0.7231.00
167_H308_E0.7211.00
103_H106_K0.7181.00
148_E152_R0.7181.00
169_I286_M0.7171.00
273_D341_C0.7151.00
202_Y231_L0.7151.00
358_A362_E0.7061.00
51_S54_I0.7051.00
204_A212_Q0.7031.00
225_K336_H0.7021.00
179_V270_Q0.7011.00
225_K329_R0.6981.00
130_P133_K0.6971.00
200_L229_L0.6951.00
210_K279_S0.6951.00
202_Y275_S0.6951.00
206_L240_E0.6941.00
203_P275_S0.6941.00
64_L68_R0.6931.00
333_Q336_H0.6921.00
301_T321_I0.6911.00
50_F53_P0.6901.00
344_L348_G0.6901.00
364_M368_Y0.6881.00
213_K239_M0.6861.00
29_M358_A0.6861.00
208_L213_K0.6841.00
220_A252_A0.6841.00
164_Q167_H0.6831.00
198_F338_P0.6831.00
72_K76_T0.6791.00
343_K346_Q0.6791.00
166_I364_M0.6761.00
244_Q258_F0.6761.00
285_G288_V0.6751.00
83_H364_M0.6731.00
366_D369_S0.6721.00
325_A328_A0.6701.00
301_T327_F0.6701.00
94_R97_A0.6691.00
108_L368_Y0.6681.00
151_I155_G0.6661.00
68_R71_K0.6651.00
145_I286_M0.6631.00
339_E343_K0.6631.00
299_I334_L0.6621.00
17_A20_L0.6621.00
9_A15_F0.6621.00
13_Y205_E0.6581.00
204_A210_K0.6561.00
208_L280_I0.6561.00
277_A285_G0.6561.00
9_A19_H0.6551.00
27_K33_V0.6521.00
29_M361_V0.6501.00
18_F364_M0.6491.00
18_F169_I0.6451.00
307_R318_L0.6431.00
7_F33_V0.6411.00
81_I368_Y0.6411.00
349_R352_A0.6401.00
42_K47_D0.6391.00
367_I370_A0.6341.00
334_L341_C0.6331.00
289_L355_F0.6331.00
166_I169_I0.6311.00
315_N347_E0.6311.00
262_C265_I0.6271.00
348_G351_T0.6231.00
86_T89_G0.6181.00
44_P47_D0.6151.00
81_I108_L0.6151.00
167_H355_F0.6141.00
82_V105_T0.6121.00
200_L335_Y0.6111.00
166_I363_E0.6111.00
268_L272_A0.6091.00
152_R156_L0.6081.00
310_I315_N0.6061.00
172_N176_F0.6031.00
133_K137_A0.6031.00
275_S298_A0.6011.00
79_Y105_T0.6001.00
28_Q358_A0.6001.00
276_V327_F0.6001.00
208_L239_M0.6001.00
319_I326_A0.5991.00
218_A331_I0.5971.00
148_E307_R0.5951.00
219_A222_L0.5941.00
93_A97_A0.5941.00
292_M345_G0.5931.00
346_Q349_R0.5921.00
22_Y364_M0.5921.00
339_E342_R0.5871.00
284_L355_F0.5871.00
312_D317_F0.5851.00
65_A69_Q0.5851.00
247_A253_S0.5851.00
337_K341_C0.5841.00
173_T293_A0.5841.00
23_F33_V0.5841.00
32_E53_P0.5811.00
24_K28_Q0.5791.00
21_P286_M0.5791.00
214_Q218_A0.5791.00
144_T165_K0.5771.00
158_R162_R0.5751.00
228_S255_H0.5731.00
27_K31_W0.5721.00
211_N322_G0.5721.00
201_V275_S0.5711.00
361_V365_A0.5701.00
31_W369_S0.5701.00
347_E351_T0.5691.00
206_L212_Q0.5671.00
223_K229_L0.5671.00
173_T353_L0.5661.00
146_N149_D0.5631.00
198_F201_V0.5631.00
149_D152_R0.5581.00
110_T364_M0.5581.00
199_I268_L0.5571.00
216_I256_V0.5561.00
265_I268_L0.5531.00
174_E177_R0.5531.00
273_D338_P0.5521.00
274_V299_I0.5521.00
74_I79_Y0.5511.00
297_P341_C0.5471.00
213_K243_Y0.5451.00
177_R270_Q0.5441.00
15_F86_T0.5441.00
42_K45_Y0.5441.00
227_P336_H0.5431.00
215_L219_A0.5421.00
269_I287_N0.5401.00
84_C90_G0.5401.00
211_N278_S0.5391.00
198_F341_C0.5381.00
62_Q66_V0.5371.00
147_E167_H0.5361.00
279_S285_G0.5351.00
18_F22_Y0.5351.00
278_S301_T0.5351.00
42_K46_V0.5341.00
167_H284_L0.5321.00
243_Y246_L0.5291.00
299_I331_I0.5281.00
149_D283_G0.5271.00
110_T143_I0.5271.00
112_H169_I0.5261.00
302_D321_I0.5261.00
287_N291_G0.5251.00
43_L47_D0.5251.00
216_I243_Y0.5241.00
291_G298_A0.5241.00
289_L309_I0.5221.00
111_A149_D0.5221.00
285_G289_L0.5221.00
84_C93_A0.5211.00
194_R230_R0.5211.00
18_F85_H0.5201.00
31_W80_D0.5191.00
11_V16_K0.5181.00
73_V76_T0.5181.00
211_N301_T0.5171.00
201_V296_Q0.5161.00
354_R359_R0.5141.00
292_M352_A0.5131.00
150_Y160_G0.5121.00
218_A222_L0.5121.00
303_N307_R0.5101.00
75_D103_H0.5101.00
193_F271_L0.5101.00
234_A265_I0.5091.00
279_S283_G0.5081.00
36_A73_V0.5011.00
231_L256_V0.5011.00
208_L242_T0.5001.00
243_Y258_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c48A 2 0.9711 100 0.176 Contact Map
2r60A 1 0.9685 100 0.18 Contact Map
3okpA 1 0.937 100 0.197 Contact Map
2qzsA 1 0.9475 100 0.203 Contact Map
1rzuA 1 0.9554 100 0.203 Contact Map
2jjmA 4 0.9265 100 0.209 Contact Map
3froA 3 0.9738 100 0.211 Contact Map
4n9wA 1 0.9003 100 0.215 Contact Map
3s28A 4 0.9895 100 0.218 Contact Map
2iw1A 1 0.9265 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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