GREMLIN Database
YVEL - Putative tyrosine-protein kinase YveL
UniProt: P71051 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (179)
Sequences: 18154 (12045)
Seq/√Len: 900.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_Y155_F4.2181.00
186_L216_K4.1971.00
62_A159_I3.7991.00
69_F157_L3.5121.00
75_K157_L3.4411.00
48_L178_T3.1451.00
78_L155_F2.6221.00
180_G210_L2.5221.00
48_L162_S2.5031.00
46_S152_Y2.3921.00
117_K124_Y2.2781.00
45_R180_G2.0981.00
76_K156_S2.0511.00
104_V114_T2.0351.00
70_A123_L2.0181.00
61_S213_L2.0141.00
187_S214_L2.0011.00
145_G177_Q1.9811.00
63_A93_F1.9761.00
62_A79_L1.9561.00
110_S113_E1.9471.00
75_K156_S1.9371.00
49_V65_L1.9251.00
82_A160_F1.9231.00
63_A89_I1.8751.00
79_L89_I1.8721.00
112_S154_Q1.8241.00
82_A101_L1.7391.00
80_V160_F1.7201.00
46_S160_F1.6861.00
183_L198_A1.6831.00
69_F159_I1.6661.00
57_G215_N1.6371.00
66_A79_L1.6301.00
92_T190_T1.6181.00
95_V125_V1.5601.00
61_S215_N1.5521.00
109_A114_T1.5331.00
66_A159_I1.5231.00
63_A92_T1.5201.00
78_L151_I1.5111.00
199_K203_E1.4811.00
69_F77_V1.4641.00
64_N67_A1.4211.00
180_G211_G1.4131.00
182_V213_L1.4081.00
49_V182_V1.3441.00
70_A122_N1.3231.00
100_G103_N1.3201.00
67_A71_Q1.2881.00
152_Y179_D1.2721.00
59_S89_I1.2641.00
72_Q75_K1.2601.00
104_V147_L1.2541.00
114_T126_L1.2471.00
51_S56_E1.2381.00
116_Q127_T1.2271.00
115_V124_Y1.2201.00
49_V62_A1.2161.00
184_V215_N1.1981.00
145_G149_S1.1931.00
78_L158_V1.1911.00
147_L151_I1.1761.00
187_S217_K1.1691.00
45_R179_D1.1681.00
66_A123_L1.1641.00
93_F123_L1.1561.00
99_T103_N1.1541.00
109_A113_E1.1431.00
99_T109_A1.1331.00
100_G129_G1.1241.00
148_I160_F1.1241.00
51_S58_K1.1231.00
103_N130_P1.1231.00
180_G208_K1.0971.00
111_L115_V1.0821.00
61_S184_V1.0771.00
137_E141_S1.0701.00
46_S178_T1.0611.00
58_K83_D1.0471.00
144_M147_L1.0441.00
113_E116_Q1.0261.00
102_T106_V1.0241.00
191_K194_T1.0211.00
53_V194_T1.0181.00
53_V56_E1.0151.00
76_K154_Q1.0121.00
61_S65_L1.0091.00
59_S161_D0.9901.00
66_A89_I0.9901.00
68_V72_Q0.9891.00
49_V61_S0.9721.00
202_L207_A0.9681.00
46_S148_I0.9611.00
111_L114_T0.9511.00
188_G191_K0.9461.00
185_V195_V0.9451.00
52_S56_E0.9421.00
82_A144_M0.9381.00
146_D150_E0.9341.00
47_I157_L0.9321.00
90_N127_T0.9321.00
111_L126_L0.9241.00
181_S202_L0.9221.00
118_T121_D0.9111.00
103_N108_N0.9001.00
84_L169_A0.8971.00
68_V71_Q0.8931.00
150_E154_Q0.8801.00
139_L143_A0.8791.00
88_T92_T0.8791.00
82_A173_I0.8771.00
165_L198_A0.8771.00
181_S207_A0.8741.00
186_L189_K0.8501.00
112_S150_E0.8481.00
200_D203_E0.8461.00
78_L115_V0.8431.00
77_V157_L0.8401.00
50_T198_A0.8341.00
138_L141_S0.8291.00
50_T170_D0.8291.00
115_V155_F0.8271.00
77_V159_I0.8261.00
138_L142_K0.8211.00
50_T162_S0.8201.00
84_L102_T0.8161.00
99_T114_T0.8151.00
124_Y127_T0.8141.00
185_V212_A0.8131.00
81_D90_N0.8071.00
52_S183_L0.8021.00
137_E140_S0.8021.00
136_A140_S0.7971.00
89_I92_T0.7961.00
103_N106_V0.7931.00
112_S116_Q0.7891.00
149_S152_Y0.7881.00
89_I125_V0.7811.00
74_E122_N0.7801.00
93_F125_V0.7761.00
144_M148_I0.7731.00
83_D86_K0.7721.00
83_D164_P0.7701.00
77_V156_S0.7651.00
90_N97_N0.7631.00
91_Q193_D0.7621.00
59_S88_T0.7601.00
101_L126_L0.7531.00
103_N107_G0.7351.00
104_V126_L0.7341.00
115_V126_L0.7301.00
136_A141_S0.7151.00
147_L150_E0.7111.00
76_K124_Y0.7111.00
143_A146_D0.7101.00
155_F158_V0.7071.00
85_R167_A0.7041.00
162_S174_L0.7031.00
198_A202_L0.7021.00
140_S143_A0.7001.00
46_S179_D0.6951.00
80_V158_V0.6921.00
67_A120_I0.6921.00
197_K200_D0.6921.00
104_V107_G0.6901.00
160_F178_T0.6891.00
47_I159_I0.6891.00
146_D149_S0.6891.00
70_A77_V0.6871.00
139_L142_K0.6821.00
101_L104_V0.6801.00
111_L151_I0.6771.00
183_L199_K0.6761.00
50_T181_S0.6751.00
45_R157_L0.6721.00
67_A123_L0.6661.00
120_I123_L0.6571.00
54_P167_A0.6561.00
204_Q207_A0.6421.00
162_S173_I0.6411.00
172_Q175_A0.6401.00
190_T195_V0.6391.00
175_A207_A0.6391.00
101_L105_L0.6391.00
114_T118_T0.6341.00
136_A139_L0.6331.00
192_T196_L0.6321.00
119_P124_Y0.6321.00
171_A201_A0.6261.00
58_K161_D0.6241.00
111_L150_E0.6231.00
86_K128_S0.6221.00
196_L199_K0.6221.00
85_R170_D0.6211.00
78_L126_L0.6211.00
125_V130_P0.6201.00
126_L147_L0.6111.00
79_L123_L0.6101.00
48_L181_S0.6091.00
49_V159_I0.6061.00
63_A79_L0.6051.00
183_L209_L0.6031.00
137_E142_K0.6011.00
48_L174_L0.6011.00
46_S158_V0.6001.00
168_V171_A0.5991.00
115_V118_T0.5961.00
57_G161_D0.5941.00
214_L217_K0.5931.00
134_N137_E0.5921.00
58_K164_P0.5901.00
88_T91_Q0.5901.00
76_K155_F0.5891.00
162_S170_D0.5881.00
183_L195_V0.5861.00
110_S150_E0.5801.00
169_A173_I0.5781.00
87_P90_N0.5781.00
124_Y153_E0.5751.00
196_L200_D0.5731.00
112_S115_V0.5721.00
56_E191_K0.5661.00
44_L152_Y0.5651.00
81_D87_P0.5631.00
118_T125_V0.5611.00
86_K129_G0.5581.00
59_S92_T0.5571.00
81_D89_I0.5571.00
135_P140_S0.5561.00
142_K146_D0.5551.00
142_K145_G0.5541.00
106_V109_A0.5541.00
151_I154_Q0.5491.00
180_G209_L0.5481.00
172_Q201_A0.5461.00
77_V123_L0.5451.00
116_Q119_P0.5441.00
88_T194_T0.5401.00
99_T113_E0.5401.00
51_S87_P0.5371.00
205_S209_L0.5361.00
53_V190_T0.5361.00
52_S198_A0.5361.00
64_N68_V0.5361.00
79_L159_I0.5341.00
65_L182_V0.5331.00
126_L151_I0.5331.00
86_K164_P0.5321.00
69_F72_Q0.5291.00
91_Q189_K0.5261.00
104_V111_L0.5261.00
47_I210_L0.5241.00
170_D174_L0.5241.00
80_V126_L0.5231.00
89_I93_F0.5231.00
148_I177_Q0.5211.00
185_V190_T0.5191.00
195_V199_K0.5171.00
182_V211_G0.5151.00
52_S201_A0.5131.00
124_Y154_Q0.5131.00
210_L213_L0.5111.00
189_K193_D0.5111.00
45_R152_Y0.5051.00
182_V210_L0.5051.00
82_A163_P0.5011.00
186_L190_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3la6A 4 0.9824 100 0.143 Contact Map
3cioA 2 0.9956 100 0.149 Contact Map
4jlvA 1 0.9031 100 0.152 Contact Map
4jmpA 1 0.9207 100 0.156 Contact Map
4rz3A 2 0.8018 100 0.283 Contact Map
4pfsA 1 0.7974 100 0.315 Contact Map
3pg5A 2 0.7753 100 0.317 Contact Map
1g3qA 1 0.8018 100 0.329 Contact Map
3ea0A 2 0.815 100 0.331 Contact Map
1hyqA 1 0.793 100 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.