GREMLIN Database
YVEK - Uncharacterized protein YveK
UniProt: P71050 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 234 (215)
Sequences: 4047 (3504)
Seq/√Len: 239.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_Q174_N3.6561.00
15_R18_F3.3471.00
123_D129_A3.3341.00
130_A161_A3.0161.00
32_M178_A2.8671.00
35_V40_I2.8181.00
33_G37_F2.7531.00
28_V178_A2.6381.00
130_A134_N2.6291.00
197_D201_K2.5951.00
29_T179_F2.4111.00
123_D128_K2.3011.00
186_G190_A2.2941.00
178_A182_A2.2141.00
105_K123_D2.1731.00
134_N159_A2.1701.00
143_E146_E2.1421.00
170_A173_R2.1061.00
6_S9_E2.0741.00
83_T157_S2.0551.00
17_R193_L2.0371.00
121_V133_A1.8991.00
45_Q120_A1.8951.00
92_E135_T1.8371.00
33_G175_M1.8291.00
127_A131_E1.8281.00
24_I28_V1.7961.00
28_V32_M1.7531.00
45_Q122_Q1.7311.00
21_I25_T1.7301.00
49_Q157_S1.6781.00
28_V182_A1.6351.00
137_V143_E1.6241.00
128_K131_E1.5791.00
43_T122_Q1.5571.00
87_E91_A1.5461.00
135_T139_K1.5071.00
17_R190_A1.5071.00
21_I190_A1.4931.00
25_T186_G1.4911.00
29_T175_M1.4741.00
46_A162_S1.4701.00
122_Q168_K1.4611.00
25_T29_T1.4571.00
121_V132_I1.4461.00
106_V121_V1.4431.00
182_A186_G1.4431.00
86_M103_K1.4401.00
25_T183_V1.4391.00
36_Q178_A1.4021.00
36_Q175_M1.3741.00
137_V141_E1.3701.00
35_V39_V1.3631.00
98_S101_S1.3611.00
46_A159_A1.3561.00
87_E99_A1.2961.00
84_A157_S1.2901.00
17_R194_H1.2881.00
129_A133_A1.2841.00
13_I194_H1.2821.00
24_I186_G1.2771.00
168_K171_R1.2761.00
88_E92_E1.2671.00
72_Y76_F1.2661.00
34_F39_V1.2651.00
18_F22_L1.2631.00
130_A159_A1.2611.00
43_T168_K1.2581.00
36_Q171_R1.2511.00
125_D128_K1.2501.00
171_R175_M1.2491.00
189_L193_L1.2441.00
37_F171_R1.2361.00
133_A137_V1.2271.00
86_M136_L1.2221.00
83_T160_K1.2131.00
16_H194_H1.2041.00
41_S124_H1.2021.00
99_A103_K1.2011.00
137_V145_D1.1821.00
121_V136_L1.1811.00
126_P129_A1.1781.00
140_F143_E1.1721.00
86_M102_L1.1681.00
105_K121_V1.1681.00
191_F195_F1.1681.00
49_Q118_N1.1671.00
139_K142_K1.1651.00
75_T115_E1.1531.00
111_E114_S1.1371.00
17_R20_L1.1351.00
202_S205_Q1.1231.00
117_I126_P1.1221.00
13_I191_F1.1041.00
141_E144_V1.1011.00
8_K12_A1.0921.00
5_M10_L1.0921.00
131_E135_T1.0861.00
83_T103_K1.0841.00
32_M174_N1.0791.00
171_R174_N1.0651.00
62_N65_D1.0591.00
203_A207_S1.0561.00
43_T124_H1.0561.00
143_E147_R1.0541.00
140_F144_V1.0461.00
174_N177_M1.0381.00
119_V137_V1.0361.00
15_R19_V1.0341.00
97_E105_K1.0211.00
25_T179_F1.0161.00
40_I43_T1.0101.00
108_T126_P1.0081.00
168_K174_N1.0061.00
133_A159_A1.0061.00
32_M182_A1.0041.00
90_K95_L1.0001.00
36_Q40_I0.9991.00
126_P162_S0.9971.00
135_T138_N0.9941.00
200_C209_R0.9931.00
25_T28_V0.9911.00
78_S81_K0.9891.00
97_E101_S0.9821.00
31_I35_V0.9791.00
129_A134_N0.9701.00
123_D126_P0.9571.00
47_S118_N0.9571.00
27_G31_I0.9551.00
76_F140_F0.9551.00
181_A188_T0.9511.00
131_E134_N0.9491.00
101_S105_K0.9481.00
63_L67_Q0.9311.00
203_A217_S0.9251.00
32_M36_Q0.9241.00
82_S157_S0.9231.00
137_V147_R0.9221.00
13_I190_A0.9201.00
203_A214_C0.9181.00
48_T137_V0.9121.00
165_P171_R0.9111.00
83_T87_E0.9021.00
113_E117_I0.9011.00
67_Q71_Q0.9011.00
92_E139_K0.8941.00
14_V187_I0.8931.00
188_T192_F0.8830.99
77_Q81_K0.8810.99
88_E143_E0.8760.99
127_A130_A0.8750.99
106_V136_L0.8750.99
88_E139_K0.8630.99
51_L75_T0.8610.99
119_V126_P0.8590.99
139_K143_E0.8530.99
21_I186_G0.8390.99
49_Q78_S0.8360.99
6_S10_L0.8270.99
90_K102_L0.8210.99
48_T133_A0.8200.99
48_T155_I0.8200.99
180_G184_M0.8200.99
88_E91_A0.8140.99
50_V119_V0.8130.99
80_M119_V0.8110.99
78_S111_E0.8090.99
130_A133_A0.8090.99
84_A158_E0.8060.99
90_K99_A0.7990.99
141_E145_D0.7950.99
89_V136_L0.7940.99
93_L132_I0.7920.99
25_T182_A0.7920.99
169_P174_N0.7880.99
20_L24_I0.7840.99
85_L139_K0.7840.99
116_I156_L0.7820.99
76_F144_V0.7710.99
49_Q116_I0.7680.99
20_L193_L0.7600.98
214_C217_S0.7590.98
134_N138_N0.7590.98
109_S126_P0.7580.98
129_A132_I0.7570.98
162_S165_P0.7570.98
11_Y15_R0.7550.98
48_T159_A0.7540.98
76_F79_I0.7530.98
110_S114_S0.7510.98
98_S126_P0.7460.98
147_R154_H0.7410.98
206_L210_T0.7390.98
47_S120_A0.7360.98
77_Q110_S0.7320.98
35_V174_N0.7300.98
80_M85_L0.7290.98
111_E118_N0.7250.98
127_A161_A0.7200.98
37_F175_M0.7170.98
192_F196_L0.7110.98
109_S118_N0.7100.98
19_V30_L0.7060.97
42_P171_R0.7060.97
80_M108_T0.7010.97
80_M136_L0.7010.97
117_I129_A0.7000.97
142_K145_D0.6970.97
137_V144_V0.6920.97
23_L30_L0.6920.97
17_R197_D0.6910.97
138_N142_K0.6900.97
51_L115_E0.6900.97
90_K94_H0.6890.97
16_H19_V0.6830.97
102_L121_V0.6830.97
100_S104_G0.6800.97
114_S119_V0.6790.97
170_A174_N0.6770.97
99_A102_L0.6710.97
211_G214_C0.6680.96
36_Q39_V0.6640.96
137_V140_F0.6610.96
67_Q70_L0.6600.96
46_A130_A0.6540.96
14_V21_I0.6500.96
86_M89_V0.6480.96
28_V185_G0.6480.96
17_R21_I0.6460.96
102_L106_V0.6450.96
22_L26_I0.6430.96
73_S77_Q0.6410.96
120_A126_P0.6400.95
50_V137_V0.6400.95
92_E138_N0.6360.95
179_F186_G0.6350.95
84_A88_E0.6340.95
18_F23_L0.6340.95
22_L25_T0.6330.95
144_V148_M0.6320.95
180_G187_I0.6310.95
117_I123_D0.6290.95
208_E212_L0.6290.95
20_L189_L0.6270.95
69_N115_E0.6260.95
82_S156_L0.6260.95
62_N66_I0.6250.95
51_L54_E0.6240.95
10_L13_I0.6220.95
121_V126_P0.6210.95
173_R176_V0.6210.95
89_V93_L0.6200.95
7_F11_Y0.6170.95
73_S117_I0.6170.95
29_T33_G0.6140.94
30_L33_G0.6110.94
13_I17_R0.6100.94
69_N72_Y0.6080.94
50_V80_M0.6060.94
90_K98_S0.6050.94
85_L90_K0.6020.94
42_P165_P0.6020.94
119_V123_D0.6010.94
73_S76_F0.6010.94
187_I191_F0.5980.94
141_E147_R0.5970.93
109_S120_A0.5960.93
173_R177_M0.5950.93
179_F182_A0.5900.93
172_L176_V0.5900.93
123_D132_I0.5900.93
184_M188_T0.5870.93
108_T119_V0.5870.93
68_R71_Q0.5860.93
79_I156_L0.5850.93
8_K17_R0.5840.93
68_R73_S0.5840.93
78_S116_I0.5810.93
205_Q209_R0.5770.92
194_H201_K0.5760.92
205_Q208_E0.5760.92
104_G164_S0.5710.92
30_L34_F0.5710.92
27_G30_L0.5690.92
100_S103_K0.5630.91
6_S13_I0.5610.91
83_T99_A0.5590.91
144_V147_R0.5590.91
138_N141_E0.5580.91
21_I187_I0.5580.91
218_V221_V0.5530.91
14_V191_F0.5510.90
87_E160_K0.5500.90
148_M151_Q0.5500.90
164_S172_L0.5450.90
107_V122_Q0.5450.90
85_L89_V0.5430.90
85_L136_L0.5400.90
145_D148_M0.5350.89
129_A137_V0.5330.89
24_I189_L0.5320.89
66_I72_Y0.5290.89
44_Y165_P0.5290.89
89_V132_I0.5250.88
20_L23_L0.5230.88
79_I82_S0.5210.88
133_A136_L0.5210.88
51_L76_F0.5170.88
77_Q80_M0.5170.88
98_S102_L0.5140.87
200_C205_Q0.5130.87
19_V37_F0.5130.87
65_D72_Y0.5130.87
40_I174_N0.5130.87
71_Q74_S0.5110.87
128_K133_A0.5110.87
26_I33_G0.5080.87
128_K132_I0.5050.86
148_M152_G0.5040.86
142_K149_N0.5010.86
89_V135_T0.5010.86
45_Q162_S0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wl1A 3 0.5299 99.9 0.457 Contact Map
2ww9B 1 0.2564 24.1 0.935 Contact Map
4w252 1 0.265 22.6 0.936 Contact Map
3fymA 1 0.2906 17.7 0.939 Contact Map
2kncB 1 0.2564 11.6 0.944 Contact Map
3b8mA 3 0.688 11.1 0.944 Contact Map
2kluA 1 0.2607 10.7 0.945 Contact Map
2m20A 2 0.2436 9.4 0.946 Contact Map
3tx3A 2 0.2564 9 0.947 Contact Map
4k0jA 3 0.9615 8.8 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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