GREMLIN Database
SLRR - HTH-type transcriptional regulator SlrR
UniProt: P71049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (121)
Sequences: 450 (408)
Seq/√Len: 37.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_L31_L4.1321.00
3_G37_G3.1191.00
2_I6_I2.9231.00
18_N22_V2.5671.00
15_Y53_T2.5071.00
10_R35_E2.4091.00
26_V31_L2.3151.00
23_E53_T2.1980.99
5_I63_D2.1630.99
119_T123_I2.0700.99
52_A64_A2.0290.99
31_L34_I2.0030.99
27_S30_Y1.8900.98
20_L54_L1.8220.97
59_T64_A1.7880.97
18_N28_K1.7600.97
120_E123_I1.7590.97
9_Y54_L1.7590.97
9_Y56_V1.7570.97
34_I46_F1.7230.96
12_R68_M1.6680.95
102_R106_E1.6620.95
33_K40_T1.6600.95
30_Y33_K1.6460.95
17_I21_A1.6290.95
17_I28_K1.6210.95
17_I31_L1.6140.95
25_G49_K1.5820.94
29_S33_K1.5680.94
118_L122_N1.5590.93
33_K38_V1.5160.93
44_V47_L1.4950.92
2_I44_V1.4800.92
28_K32_S1.4510.91
29_S32_S1.4370.90
24_S50_V1.3880.89
92_E95_E1.3560.88
4_R37_G1.3310.87
32_S42_P1.3200.86
36_R40_T1.2980.85
30_Y34_I1.2650.84
6_I31_L1.2480.83
119_T122_N1.2480.83
43_S46_F1.2420.82
21_A31_L1.2080.81
27_S32_S1.2000.80
5_I60_E1.1870.79
28_K46_F1.1700.78
104_K108_P1.1360.76
65_E68_M1.1310.76
86_A90_G1.1280.76
6_I54_L1.1220.75
58_L62_F1.1130.75
82_H85_Q1.1000.74
34_I40_T1.0810.73
13_K55_E1.0700.72
26_V33_K1.0650.72
60_E65_E1.0460.70
67_M70_E1.0430.70
86_A89_A1.0290.69
5_I66_T1.0280.69
9_Y60_E1.0230.68
79_W82_H1.0160.68
20_L25_G1.0100.67
42_P47_L0.9960.66
95_E98_T0.9910.66
19_Q22_V0.9890.66
38_V54_L0.9630.64
56_V60_E0.9400.62
71_K75_G0.9270.61
24_S30_Y0.9270.61
24_S53_T0.9180.60
47_L62_F0.9160.60
117_K120_E0.9030.59
58_L64_A0.9000.58
34_I64_A0.8850.57
6_I20_L0.8650.55
26_V30_Y0.8640.55
117_K123_I0.8610.55
117_K122_N0.8610.55
18_N26_V0.8580.55
31_L41_N0.8490.54
81_V85_Q0.8410.53
10_R17_I0.8370.53
111_A115_N0.8320.52
77_E83_L0.8240.52
102_R117_K0.8130.51
91_M116_R0.8070.50
6_I81_V0.8060.50
95_E114_R0.8040.50
43_S52_A0.7990.50
65_E70_E0.7970.49
26_V50_V0.7920.49
5_I8_L0.7900.49
41_N44_V0.7870.48
115_N120_E0.7750.47
6_I15_Y0.7710.47
51_S64_A0.7690.47
29_S40_T0.7500.45
95_E103_L0.7440.45
18_N30_Y0.7410.44
42_P59_T0.7390.44
28_K38_V0.7340.44
34_I43_S0.7330.44
87_V91_M0.7260.43
116_R119_T0.7260.43
32_S40_T0.7210.43
97_F101_N0.7130.42
72_I75_G0.7050.41
101_N105_K0.7010.41
45_Q74_G0.6930.40
15_Y20_L0.6910.40
9_Y53_T0.6890.40
7_R18_N0.6880.40
101_N107_Q0.6870.40
95_E110_T0.6810.39
53_T56_V0.6700.38
101_N106_E0.6700.38
20_L53_T0.6670.38
24_S54_L0.6650.38
3_G6_I0.6640.38
96_L108_P0.6640.38
22_V28_K0.6630.38
79_W89_A0.6460.36
71_K74_G0.6390.36
102_R105_K0.6370.36
47_L59_T0.6360.36
103_L108_P0.6290.35
27_S34_I0.6280.35
30_Y41_N0.6260.35
2_I43_S0.6240.35
98_T103_L0.6170.34
102_R114_R0.6170.34
29_S43_S0.6130.34
98_T106_E0.6090.33
18_N32_S0.6050.33
21_A28_K0.6030.33
51_S58_L0.5990.33
91_M105_K0.5960.32
87_V100_T0.5940.32
91_M99_F0.5920.32
101_N108_P0.5880.32
88_Q102_R0.5850.32
27_S42_P0.5840.31
7_R11_K0.5820.31
48_K59_T0.5770.31
14_G29_S0.5700.30
32_S36_R0.5660.30
29_S34_I0.5620.30
57_E60_E0.5610.30
21_A36_R0.5600.30
60_E68_M0.5600.30
92_E98_T0.5600.30
71_K79_W0.5600.30
25_G51_S0.5580.30
33_K36_R0.5580.30
78_E86_A0.5570.29
11_K24_S0.5540.29
100_T114_R0.5530.29
20_L50_V0.5500.29
99_F106_E0.5460.29
77_E82_H0.5420.28
34_I42_P0.5410.28
3_G14_G0.5410.28
5_I58_L0.5390.28
16_S54_L0.5370.28
92_E104_K0.5360.28
98_T102_R0.5310.28
89_A101_N0.5300.28
82_H109_E0.5220.27
33_K44_V0.5220.27
77_E85_Q0.5180.27
79_W85_Q0.5170.27
19_Q23_E0.5170.27
77_E114_R0.5140.26
87_V90_G0.5100.26
30_Y40_T0.5050.26
17_I50_V0.5030.26
43_S54_L0.5030.26
89_A98_T0.5020.26
114_R119_T0.5020.26
3_G115_N0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b0nA 2 0.6711 99.8 0.472 Contact Map
4ndwA 2 0.7237 99.7 0.493 Contact Map
3r1fA 2 0.7237 99.7 0.504 Contact Map
4o8bA 2 0.6382 99.7 0.508 Contact Map
3op9A 4 0.6842 99.7 0.511 Contact Map
4jcyA 2 0.5789 99.7 0.514 Contact Map
3qwgA 2 0.4868 99.7 0.515 Contact Map
2ebyA 2 0.6447 99.6 0.541 Contact Map
3ivpA 2 0.6974 99.6 0.543 Contact Map
3u3wA 2 0.9408 99.6 0.543 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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