GREMLIN Database
YWGB - Putative HTH-type transcriptional regulator YwgB
UniProt: P71047 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (135)
Sequences: 6243 (4367)
Seq/√Len: 375.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_Y124_R3.8851.00
72_A129_Q3.1911.00
56_E66_T2.9231.00
16_L34_R2.7521.00
92_G106_C2.7121.00
10_A83_V2.6961.00
129_Q133_D2.6491.00
14_L54_L2.5941.00
114_E122_L2.5701.00
69_K78_D2.5051.00
52_A82_A2.4011.00
14_L128_L2.2361.00
77_Y81_Q2.1951.00
81_Q124_R2.1661.00
13_V46_M2.0211.00
118_K122_L2.0021.00
25_S66_T1.9861.00
18_S132_M1.9801.00
17_L55_A1.8561.00
29_E39_P1.7941.00
70_P73_D1.7751.00
92_G100_F1.7501.00
118_K121_N1.7341.00
69_K73_D1.6371.00
29_E33_Q1.6251.00
16_L26_L1.5981.00
100_F106_C1.5941.00
114_E126_E1.5771.00
50_V57_S1.5631.00
115_I119_W1.5511.00
20_L24_A1.5051.00
58_L66_T1.4911.00
75_T127_S1.4481.00
47_R51_Q1.4451.00
122_L125_E1.4341.00
7_M80_Y1.4291.00
116_E120_S1.4181.00
81_Q120_S1.3941.00
37_V42_L1.3931.00
13_V42_L1.3791.00
75_T78_D1.2971.00
120_S124_R1.2891.00
69_K74_I1.2741.00
56_E68_T1.2611.00
28_S46_M1.2501.00
13_V31_I1.2411.00
21_P71_L1.2341.00
117_D121_N1.1921.00
111_V126_E1.1901.00
115_I123_M1.1861.00
16_L20_L1.1571.00
114_E134_R1.1461.00
20_L26_L1.1371.00
54_L74_I1.1311.00
16_L35_L1.1091.00
27_T30_A1.0681.00
6_G44_K1.0661.00
7_M84_E1.0651.00
110_T134_R1.0491.00
47_R50_V1.0441.00
121_N125_E1.0441.00
25_S58_L1.0411.00
67_L71_L1.0191.00
9_Q37_V1.0011.00
113_A117_D0.9751.00
54_L82_A0.9701.00
78_D124_R0.9631.00
57_S65_F0.9611.00
33_Q39_P0.9581.00
14_L79_V0.9451.00
46_M65_F0.9451.00
28_S43_K0.9371.00
80_Y123_M0.9301.00
40_S43_K0.9191.00
115_I118_K0.9151.00
8_E12_S0.9151.00
46_M55_A0.9141.00
6_G48_T0.9121.00
11_V76_L0.9091.00
5_S41_Y0.9051.00
47_R65_F0.8931.00
24_A30_A0.8881.00
30_A33_Q0.8871.00
21_P24_A0.8761.00
77_Y120_S0.8701.00
48_T52_A0.8671.00
14_L49_L0.8491.00
76_L111_V0.8461.00
127_S130_H0.8401.00
76_L131_V0.8401.00
89_M116_E0.8371.00
19_R132_M0.8351.00
15_L132_M0.8311.00
122_L126_E0.8241.00
87_G120_S0.8231.00
30_A34_R0.8081.00
6_G10_A0.8071.00
68_T74_I0.7941.00
114_E125_E0.7891.00
6_G41_Y0.7871.00
16_L30_A0.7851.00
71_L128_L0.7841.00
16_L31_I0.7831.00
121_N124_R0.7831.00
28_S39_P0.7811.00
109_E113_A0.7781.00
17_L26_L0.7761.00
70_P129_Q0.7641.00
114_E118_K0.7611.00
43_K65_F0.7561.00
50_V55_A0.7441.00
48_T51_Q0.7411.00
47_R57_S0.7381.00
3_M112_M0.7361.00
54_L78_D0.7311.00
7_M83_V0.7261.00
10_A45_L0.7211.00
78_D81_Q0.7201.00
71_L132_M0.7181.00
53_G68_T0.7111.00
130_H133_D0.7020.99
9_Q45_L0.7020.99
113_A116_E0.7010.99
43_K50_V0.7000.99
78_D82_A0.6870.99
74_I79_V0.6820.99
91_Q94_G0.6820.99
3_M80_Y0.6810.99
9_Q35_L0.6780.99
39_P43_K0.6750.99
41_Y45_L0.6740.99
81_Q86_R0.6690.99
40_S44_K0.6680.99
36_R101_E0.6680.99
79_V128_L0.6640.99
4_K84_E0.6620.99
15_L131_V0.6470.99
112_M119_W0.6450.99
102_G105_H0.6430.99
32_S37_V0.6400.99
38_S41_Y0.6360.99
9_Q41_Y0.6310.99
111_V122_L0.6230.99
3_M7_M0.6210.99
75_T124_R0.6210.99
115_I122_L0.6160.99
80_Y84_E0.6150.99
79_V82_A0.6110.99
92_G109_E0.6080.99
98_S103_E0.6050.98
4_K7_M0.6020.98
111_V114_E0.5910.98
54_L69_K0.5860.98
31_I46_M0.5860.98
71_L74_I0.5840.98
20_L30_A0.5770.98
114_E117_D0.5720.98
55_A65_F0.5710.98
27_T59_P0.5690.98
31_I35_L0.5690.98
59_P112_M0.5680.98
17_L63_G0.5680.98
12_S35_L0.5650.98
103_E109_E0.5650.98
106_C109_E0.5620.98
27_T62_K0.5550.97
94_G97_Q0.5530.97
133_D136_G0.5510.97
52_A78_D0.5510.97
129_Q132_M0.5510.97
5_S91_Q0.5490.97
101_E105_H0.5430.97
50_V65_F0.5410.97
20_L34_R0.5410.97
41_Y44_K0.5390.97
74_I128_L0.5390.97
86_R89_M0.5380.97
35_L42_L0.5370.97
19_R135_V0.5350.97
76_L126_E0.5350.97
17_L31_I0.5350.97
98_S101_E0.5340.97
118_K123_M0.5340.97
53_G56_E0.5330.97
108_L112_M0.5320.97
69_K72_A0.5280.96
75_T125_E0.5260.96
52_A69_K0.5220.96
22_V136_G0.5190.96
110_T113_A0.5180.96
8_E108_L0.5170.96
95_L105_H0.5150.96
117_D120_S0.5140.96
68_T71_L0.5140.96
17_L65_F0.5130.96
6_G50_V0.5130.96
22_V70_P0.5110.96
41_Y59_P0.5100.96
21_P70_P0.5070.95
6_G43_K0.5040.95
111_V115_I0.5000.95
44_K47_R0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hf1A 2 0.9103 100 0.249 Contact Map
1xd7A 2 0.7308 100 0.276 Contact Map
4hf0A 3 0.7821 100 0.304 Contact Map
1ylfA 5 0.7692 100 0.314 Contact Map
4cicA 2 0.859 100 0.319 Contact Map
3lwfA 5 0.8974 100 0.32 Contact Map
3k69A 2 0.9038 100 0.325 Contact Map
3t8rA 2 0.7756 100 0.36 Contact Map
2y75A 5 0.8205 99.9 0.397 Contact Map
2jscA 2 0.5641 98.3 0.772 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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