GREMLIN Database
YWGA - Uncharacterized protein YwgA
UniProt: P71046 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (163)
Sequences: 142 (115)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_R151_E4.0940.98
127_D163_K3.9430.98
134_K156_L3.6800.97
42_Y113_S3.2260.93
9_M145_Q2.7360.86
31_A158_Y2.6520.84
67_L130_E2.5830.82
73_K76_G2.5110.80
36_F76_G2.4320.78
16_G31_A2.3750.76
12_F67_L2.2620.73
106_I158_Y2.2140.71
99_M146_K2.1140.67
8_L58_I2.0760.66
61_L125_Y2.0660.65
34_M114_S2.0390.64
123_I156_L1.9850.62
11_V42_Y1.8690.57
99_M151_E1.8610.57
16_G121_S1.8380.56
9_M12_F1.7990.54
119_L147_Y1.7740.53
34_M123_I1.7210.51
35_Q42_Y1.6510.48
141_I156_L1.6500.48
32_K110_N1.6460.48
11_V123_I1.6260.47
19_I151_E1.6210.46
4_E76_G1.6000.46
57_Q62_C1.5730.44
102_M105_Y1.5690.44
11_V158_Y1.5640.44
4_E39_Y1.5440.43
4_E41_K1.5160.42
96_D148_T1.4800.40
33_K127_D1.4600.40
8_L108_S1.4370.39
14_D55_T1.4260.38
58_I135_K1.4260.38
4_E156_L1.4010.37
158_Y162_L1.3910.37
32_K146_K1.3870.37
41_K84_L1.3620.36
73_K112_R1.3540.35
149_N160_E1.3530.35
20_G122_T1.3300.34
96_D132_E1.3210.34
55_T62_C1.3120.34
85_T155_A1.3040.33
2_L66_F1.2960.33
28_I37_P1.2860.33
30_I126_F1.2800.32
119_L142_K1.2690.32
108_S161_E1.2350.31
11_V28_I1.2150.30
88_G91_F1.1900.29
18_I106_I1.1730.28
114_S141_I1.1720.28
135_K149_N1.1470.28
93_D153_D1.1430.27
39_Y94_H1.1270.27
98_D103_K1.1220.27
89_S93_D1.1170.27
90_A108_S1.1160.26
90_A111_S1.1100.26
16_G75_G1.0980.26
31_A123_I1.0970.26
32_K84_L1.0760.25
135_K156_L1.0740.25
6_A127_D1.0670.25
36_F102_M1.0600.25
94_H100_P1.0600.25
84_L97_L1.0550.24
20_G47_Y1.0540.24
21_R80_Y1.0490.24
30_I44_F1.0480.24
8_L113_S1.0440.24
21_R116_F1.0410.24
67_L75_G1.0410.24
39_Y43_D1.0400.24
103_K111_S1.0350.24
139_F143_S1.0340.24
115_R142_K1.0280.24
30_I40_E1.0160.23
107_D157_Q1.0160.23
106_I156_L1.0060.23
135_K153_D1.0040.23
108_S158_Y0.9960.23
112_R154_E0.9960.23
129_L162_L0.9890.22
11_V113_S0.9840.22
114_S120_V0.9790.22
66_F155_A0.9730.22
39_Y64_L0.9580.21
8_L14_D0.9490.21
138_V152_Y0.9450.21
119_L122_T0.9360.21
13_S153_D0.9350.21
103_K157_Q0.9340.21
86_E161_E0.9310.21
111_S130_E0.9210.20
27_M102_M0.9210.20
9_M78_F0.9170.20
35_Q105_Y0.8970.20
143_S146_K0.8850.19
44_F126_F0.8800.19
93_D149_N0.8780.19
55_T123_I0.8690.19
86_E89_S0.8620.19
23_K69_E0.8450.18
125_Y149_N0.8320.18
3_K19_I0.8310.18
92_L147_Y0.8220.18
122_T142_K0.8170.18
105_Y153_D0.8160.18
39_Y163_K0.8160.18
47_Y114_S0.8120.18
123_I146_K0.8070.17
18_I136_E0.8030.17
1_M5_H0.7980.17
114_S121_S0.7930.17
80_Y122_T0.7890.17
17_E110_N0.7880.17
116_F120_V0.7880.17
17_E145_Q0.7840.17
157_Q161_E0.7830.17
34_M109_V0.7730.17
146_K151_E0.7700.16
4_E141_I0.7690.16
10_K43_D0.7680.16
69_E116_F0.7650.16
78_F134_K0.7620.16
10_K14_D0.7620.16
14_D58_I0.7600.16
54_L125_Y0.7570.16
146_K152_Y0.7550.16
24_L137_K0.7540.16
125_Y128_G0.7530.16
27_M65_G0.7510.16
21_R69_E0.7480.16
11_V36_F0.7440.16
105_Y156_L0.7440.16
69_E126_F0.7440.16
11_V114_S0.7420.16
16_G110_N0.7370.16
31_A156_L0.7340.16
14_D123_I0.7330.16
17_E92_L0.7320.16
98_D130_E0.7300.16
37_P134_K0.7200.15
35_Q58_I0.7180.15
11_V14_D0.7150.15
131_D156_L0.7110.15
5_H57_Q0.7090.15
136_E140_T0.7020.15
73_K148_T0.7020.15
43_D47_Y0.6900.15
70_V108_S0.6850.15
7_K150_E0.6830.14
30_I124_L0.6810.14
91_F116_F0.6790.14
8_L90_A0.6740.14
93_D157_Q0.6730.14
35_Q107_D0.6720.14
101_D109_V0.6650.14
59_E126_F0.6610.14
31_A35_Q0.6540.14
116_F137_K0.6540.14
30_I60_E0.6470.14
4_E110_N0.6460.14
56_L63_N0.6460.14
119_L150_E0.6450.14
35_Q102_M0.6440.14
34_M87_T0.6410.14
40_E60_E0.6380.14
96_D104_G0.6370.14
10_K94_H0.6360.14
37_P100_P0.6310.13
58_I95_A0.6300.13
29_Y149_N0.6290.13
28_I64_L0.6280.13
77_Y159_I0.6270.13
21_R38_F0.6260.13
135_K141_I0.6240.13
17_E84_L0.6240.13
57_Q124_L0.6230.13
152_Y160_E0.6230.13
3_K161_E0.6130.13
14_D105_Y0.6100.13
5_H53_E0.6100.13
87_T100_P0.6070.13
69_E88_G0.6070.13
2_L5_H0.6040.13
130_E152_Y0.6040.13
103_K161_E0.6000.13
10_K13_S0.5960.13
75_G149_N0.5950.13
68_H97_L0.5950.13
11_V85_T0.5930.13
28_I100_P0.5840.12
47_Y154_E0.5760.12
128_G161_E0.5660.12
19_I81_R0.5640.12
134_K141_I0.5600.12
113_S146_K0.5570.12
58_I133_E0.5530.12
70_V104_G0.5520.12
10_K35_Q0.5510.12
83_S149_N0.5490.12
102_M109_V0.5450.12
134_K147_Y0.5440.12
133_E150_E0.5440.12
131_D160_E0.5440.12
52_E60_E0.5430.12
110_N150_E0.5430.12
30_I52_E0.5400.12
53_E60_E0.5380.12
3_K154_E0.5370.12
11_V46_F0.5330.12
13_S85_T0.5320.12
15_S106_I0.5290.11
89_S160_E0.5290.11
6_A124_L0.5290.11
42_Y154_E0.5270.11
152_Y163_K0.5260.11
123_I141_I0.5250.11
8_L12_F0.5210.11
143_S148_T0.5190.11
74_K138_V0.5190.11
96_D111_S0.5190.11
18_I43_D0.5160.11
29_Y143_S0.5150.11
84_L147_Y0.5130.11
62_C91_F0.5130.11
109_V114_S0.5130.11
133_E148_T0.5120.11
21_R122_T0.5120.11
3_K111_S0.5110.11
89_S161_E0.5090.11
42_Y152_Y0.5090.11
47_Y122_T0.5040.11
104_G112_R0.5030.11
119_L138_V0.5030.11
108_S132_E0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hqeA 2 0.5542 85.1 0.932 Contact Map
1yg2A 2 0.8012 83.4 0.933 Contact Map
2e1nA 2 0.5964 79.8 0.936 Contact Map
2wteA 2 0.4398 78.3 0.937 Contact Map
2fbiA 2 0.7229 73.8 0.939 Contact Map
2fswA 2 0.506 72.1 0.94 Contact Map
2gxgA 2 0.6807 71.7 0.94 Contact Map
3l9fA 2 0.8193 71.5 0.94 Contact Map
1yyvA 2 0.6325 71.1 0.94 Contact Map
2eshA 2 0.6205 70.4 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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