GREMLIN Database
SP2Q - Stage II sporulation protein Q
UniProt: P71044 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (221)
Sequences: 573 (485)
Seq/√Len: 32.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_V170_L9.1751.00
170_L188_G4.3951.00
136_A157_V4.1551.00
192_K198_D3.6981.00
101_A125_A3.1611.00
151_L168_Q3.0351.00
137_S205_F2.7831.00
155_V170_L2.6491.00
122_I216_P2.5921.00
145_A175_V2.5641.00
208_R213_A2.5251.00
153_Y195_Y2.4711.00
154_V166_V2.4520.99
175_V179_D2.3430.99
232_T236_E2.3240.99
156_E164_S2.2740.99
196_S199_S2.2600.99
122_I217_L2.2170.99
176_E182_K2.1080.98
154_V168_Q2.0300.98
174_S189_K2.0160.98
126_E190_S2.0160.98
145_A173_V1.9870.98
143_V158_E1.9750.98
159_H165_T1.9500.97
215_N218_N1.9040.97
142_V170_L1.8900.97
104_E118_L1.8600.96
128_D192_K1.8500.96
231_A234_E1.8190.96
106_E118_L1.8020.96
119_S196_S1.7580.95
68_D76_M1.7550.95
142_V175_V1.7490.95
119_S199_S1.7250.95
136_A205_F1.7200.94
227_I232_T1.6620.93
109_L116_Y1.6260.93
133_D189_K1.6250.93
147_K153_Y1.6150.92
169_S196_S1.5770.91
139_S230_A1.5730.91
29_L34_V1.5450.91
108_A111_T1.5370.90
128_D171_S1.5170.90
105_K118_L1.5100.90
143_V156_E1.4880.89
137_S206_E1.4780.89
111_T196_S1.4670.88
151_L206_E1.4300.87
140_G157_V1.4110.86
91_V183_Q1.4030.86
31_S38_A1.3700.84
78_N83_V1.3470.83
99_D102_K1.3370.83
119_S202_H1.3270.82
155_V173_V1.3130.82
156_E166_V1.3130.82
100_A125_A1.3090.81
142_V155_V1.3060.81
130_K133_D1.3040.81
120_K213_A1.3000.81
33_A41_W1.2930.81
109_L114_N1.2300.77
145_A155_V1.2240.77
81_M214_M1.2240.77
37_T134_V1.2170.76
165_T207_I1.2100.76
76_M79_V1.2080.76
244_E247_D1.2030.76
61_S64_D1.1910.75
238_S241_Q1.1690.73
65_N68_D1.1610.73
144_K148_D1.1560.73
237_E240_Q1.1520.72
113_N197_E1.1520.72
38_A43_Q1.1430.72
20_K27_I1.1370.71
150_V168_Q1.1160.70
68_D71_E1.1050.69
64_D68_D1.1050.69
175_V192_K1.1000.69
80_A84_V1.0980.69
80_A214_M1.0970.69
24_F28_Y1.0930.68
209_K214_M1.0890.68
136_A206_E1.0770.67
176_E179_D1.0540.65
126_E201_N1.0440.65
137_S212_V1.0360.64
150_V197_E1.0340.64
95_F100_A1.0210.63
144_K154_V1.0180.63
42_Y176_E1.0160.63
36_L142_V1.0150.62
111_T119_S1.0140.62
28_Y33_A1.0010.61
83_V90_S1.0010.61
169_S195_Y0.9980.61
22_W25_P0.9910.61
94_K111_T0.9870.60
90_S111_T0.9820.60
100_A104_E0.9790.60
37_T40_L0.9790.60
27_I31_S0.9530.58
105_K116_Y0.9470.57
155_V175_V0.9450.57
67_D70_V0.9420.57
164_S211_G0.9420.57
206_E209_K0.9410.57
137_S183_Q0.9390.56
126_E188_G0.9330.56
37_T230_A0.9270.55
153_Y173_V0.9190.55
103_E215_N0.9160.55
92_V219_F0.9090.54
168_Q196_S0.9060.54
123_D191_G0.9060.54
137_S165_T0.9050.54
147_K173_V0.9040.54
144_K156_E0.8960.53
230_A233_Q0.8920.53
100_A103_E0.8840.52
111_T169_S0.8830.52
142_V192_K0.8830.52
37_T47_N0.8830.52
142_V179_D0.8820.52
109_L118_L0.8700.51
208_R236_E0.8690.51
119_S123_D0.8680.51
18_F24_F0.8660.50
101_A104_E0.8660.50
142_V188_G0.8660.50
107_A118_L0.8630.50
154_V208_R0.8620.50
181_V187_I0.8590.50
239_I245_K0.8580.50
124_L220_M0.8560.50
35_I43_Q0.8550.49
128_D190_S0.8510.49
112_Y198_D0.8470.49
148_D197_E0.8430.48
111_T199_S0.8400.48
196_S200_G0.8390.48
36_L43_Q0.8330.48
119_S129_G0.8330.48
28_Y32_A0.8310.47
64_D69_A0.8300.47
108_A112_Y0.8300.47
70_V76_M0.8290.47
160_A166_V0.8180.46
91_V97_E0.8170.46
92_V209_K0.8150.46
61_S69_A0.8140.46
110_V113_N0.8120.46
151_L204_H0.8120.46
23_V157_V0.8090.46
25_P33_A0.8080.46
31_S176_E0.8080.46
148_D154_V0.8070.46
94_K201_N0.8050.45
143_V205_F0.7970.45
60_N66_N0.7970.45
24_F27_I0.7880.44
65_N70_V0.7860.44
137_S185_Q0.7860.44
61_S65_N0.7820.43
138_L222_K0.7810.43
47_N185_Q0.7760.43
119_S195_Y0.7730.43
144_K168_Q0.7650.42
69_A72_V0.7600.42
77_E221_D0.7590.42
177_Q233_Q0.7570.41
233_Q237_E0.7570.41
79_V163_L0.7530.41
33_A44_S0.7530.41
239_I242_S0.7510.41
110_V183_Q0.7510.41
135_S207_I0.7510.41
191_G196_S0.7480.41
165_T195_Y0.7470.41
28_Y43_Q0.7450.40
103_E106_E0.7450.40
168_Q208_R0.7440.40
175_V206_E0.7430.40
151_L166_V0.7410.40
22_W26_A0.7390.40
108_A169_S0.7390.40
29_L47_N0.7300.39
114_N147_K0.7250.39
103_E185_Q0.7240.39
135_S188_G0.7210.39
35_I171_S0.7210.39
135_S186_V0.7170.38
166_V213_A0.7080.38
122_I207_I0.7040.37
202_H216_P0.7030.37
18_F31_S0.7020.37
78_N90_S0.7010.37
94_K119_S0.6940.36
93_K97_E0.6940.36
119_S201_N0.6850.36
110_V159_H0.6850.36
247_D250_T0.6850.36
70_V75_S0.6840.36
39_V42_Y0.6840.36
95_F223_P0.6830.36
123_D195_Y0.6820.36
108_A113_N0.6800.35
87_E242_S0.6790.35
137_S204_H0.6780.35
244_E249_S0.6780.35
61_S66_N0.6750.35
207_I214_M0.6750.35
147_K154_V0.6710.35
62_A67_D0.6710.35
25_P39_V0.6680.35
183_Q227_I0.6660.34
59_G182_K0.6660.34
69_A158_E0.6650.34
110_V195_Y0.6620.34
234_E237_E0.6620.34
79_V83_V0.6590.34
30_V36_L0.6560.34
145_A153_Y0.6520.33
35_I39_V0.6510.33
152_G167_Y0.6500.33
244_E250_T0.6500.33
43_Q47_N0.6480.33
78_N188_G0.6480.33
85_D187_I0.6450.33
22_W36_L0.6440.33
19_R41_W0.6440.33
171_S189_K0.6440.33
182_K185_Q0.6430.33
136_A204_H0.6410.33
27_I33_A0.6410.33
176_E233_Q0.6400.32
119_S169_S0.6390.32
28_Y77_E0.6360.32
120_K206_E0.6340.32
37_T43_Q0.6310.32
136_A151_L0.6310.32
157_V242_S0.6280.32
115_T145_A0.6270.32
62_A69_A0.6230.31
144_K208_R0.6230.31
28_Y215_N0.6210.31
205_F222_K0.6200.31
31_S155_V0.6170.31
148_D151_L0.6170.31
26_A32_A0.6170.31
121_G204_H0.6160.31
102_K108_A0.6140.31
34_V179_D0.6140.31
169_S198_D0.6110.30
223_P230_A0.6090.30
138_L160_A0.6040.30
91_V135_S0.5970.29
75_S231_A0.5970.29
172_E189_K0.5960.29
83_V235_T0.5930.29
103_E217_L0.5930.29
120_K136_A0.5930.29
108_A138_L0.5920.29
141_T180_K0.5900.29
35_I42_Y0.5890.29
130_K185_Q0.5890.29
169_S199_S0.5880.29
155_V166_V0.5860.29
130_K190_S0.5800.28
36_L238_S0.5790.28
29_L41_W0.5780.28
99_D125_A0.5780.28
110_V130_K0.5760.28
107_A179_D0.5750.28
90_S222_K0.5740.28
36_L59_G0.5740.28
36_L39_V0.5690.28
144_K177_Q0.5680.27
129_G191_G0.5670.27
244_E248_G0.5650.27
186_V225_S0.5650.27
78_N222_K0.5620.27
170_L175_V0.5610.27
129_G201_N0.5600.27
186_V241_Q0.5580.27
97_E100_A0.5570.27
154_V197_E0.5570.27
30_V38_A0.5570.27
215_N247_D0.5560.27
126_E156_E0.5550.27
72_V112_Y0.5510.26
33_A103_E0.5480.26
29_L38_A0.5480.26
239_I243_S0.5470.26
186_V237_E0.5460.26
111_T195_Y0.5460.26
248_G251_E0.5450.26
34_V240_Q0.5440.26
26_A45_V0.5430.26
164_S208_R0.5410.26
129_G199_S0.5410.26
90_S94_K0.5400.26
166_V170_L0.5390.26
229_K232_T0.5380.26
144_K150_V0.5350.25
150_V169_S0.5330.25
190_S201_N0.5330.25
206_E216_P0.5320.25
92_V206_E0.5280.25
207_I243_S0.5270.25
129_G187_I0.5270.25
63_Y75_S0.5260.25
28_Y35_I0.5250.25
111_T201_N0.5220.25
124_L221_D0.5210.24
212_V240_Q0.5200.24
222_K227_I0.5180.24
205_F209_K0.5170.24
143_V164_S0.5160.24
108_A196_S0.5150.24
24_F32_A0.5120.24
38_A41_W0.5090.24
243_S247_D0.5070.24
38_A142_V0.5070.24
126_E180_K0.5070.24
170_L203_V0.5070.24
142_V145_A0.5060.24
150_V208_R0.5000.23
110_V125_A0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sluA 1 0.8445 100 0.447 Contact Map
4rnzA 1 0.8834 100 0.463 Contact Map
2gu1A 1 0.7527 100 0.467 Contact Map
3tufB 1 0.5053 100 0.472 Contact Map
2hsiA 1 0.6219 100 0.529 Contact Map
4bh5A 4 0.4594 100 0.56 Contact Map
4qp5A 1 0.4523 100 0.572 Contact Map
3nyyA 2 0.7562 100 0.573 Contact Map
1qwyA 1 0.5936 100 0.579 Contact Map
4lxcA 4 0.6643 100 0.58 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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