GREMLIN Database
CLSA - Major cardiolipin synthase ClsA
UniProt: P71040 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 482 (457)
Sequences: 3786 (2772)
Seq/√Len: 129.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_S167_Q6.2931.00
390_T455_K5.7581.00
168_K171_E5.7531.00
137_D234_Y5.6211.00
138_I164_A5.3291.00
134_L226_V4.0341.00
359_D390_T4.0021.00
137_D260_R3.7861.00
233_G269_I3.7141.00
167_Q171_E3.2751.00
135_L164_A3.2521.00
152_Y177_V3.2241.00
408_D443_V3.0471.00
135_L161_L2.9661.00
122_D133_R2.8021.00
118_D264_T2.7951.00
120_S262_Q2.7841.00
354_C389_A2.6291.00
174_Q201_H2.6101.00
130_K134_L2.5931.00
306_I431_A2.5311.00
363_M453_S2.5311.00
396_N452_V2.5221.00
361_N390_T2.4991.00
130_K149_Y2.4961.00
166_I198_A2.4831.00
334_L361_N2.4591.00
448_E451_L2.4481.00
411_A439_A2.4441.00
137_D140_K2.4291.00
233_G266_V2.3781.00
137_D232_T2.3641.00
411_A442_L2.3601.00
332_S443_V2.2911.00
412_S430_N2.2871.00
454_R460_E2.2261.00
234_Y260_R2.1791.00
136_S140_K2.1601.00
162_R194_E2.1121.00
325_M406_V2.1021.00
138_I145_I2.0841.00
433_I438_I2.0691.00
164_A168_K2.0681.00
392_Y455_K2.0631.00
395_D454_R2.0481.00
147_L226_V2.0411.00
133_R137_D2.0401.00
142_K231_M2.0281.00
464_R472_E2.0281.00
332_S408_D2.0191.00
146_H176_R2.0161.00
458_Y462_L1.9981.00
133_R234_Y1.9951.00
334_L359_D1.9801.00
166_I170_K1.9721.00
361_N450_L1.9621.00
142_K171_E1.9571.00
368_P374_Y1.9491.00
179_Y204_V1.9391.00
195_L200_G1.9191.00
201_H283_H1.9171.00
162_R166_I1.9111.00
336_Q363_M1.9071.00
405_V439_A1.9061.00
124_I133_R1.8991.00
193_K197_E1.8751.00
133_R260_R1.8711.00
154_G159_K1.8431.00
363_M450_L1.8411.00
162_R191_F1.8401.00
225_L269_I1.8391.00
261_L265_A1.8381.00
366_N395_D1.8311.00
443_V447_K1.8281.00
381_I391_V1.8021.00
326_I333_I1.7941.00
139_S164_A1.7781.00
139_S160_K1.7721.00
378_L393_I1.7451.00
255_R449_D1.7291.00
334_L447_K1.7281.00
364_I381_I1.7161.00
144_H270_Q1.7141.00
333_I406_V1.7121.00
265_A304_M1.7011.00
450_L453_S1.6801.00
232_T260_R1.6431.00
156_E247_L1.6261.00
384_L389_A1.6261.00
146_H270_Q1.6231.00
351_R383_D1.6221.00
135_L160_K1.6031.00
126_D129_D1.5841.00
122_D260_R1.5751.00
116_T268_A1.5621.00
132_Q160_K1.5341.00
163_D166_I1.5211.00
119_N261_L1.5181.00
302_V435_D1.5121.00
386_K458_Y1.5111.00
318_I416_A1.5091.00
155_D158_G1.5091.00
128_R132_Q1.5021.00
144_H230_G1.5011.00
231_M262_Q1.5011.00
126_D253_Y1.4961.00
385_L458_Y1.4951.00
366_N454_R1.4791.00
225_L429_V1.4781.00
334_L443_V1.4711.00
461_Y464_R1.4701.00
361_N447_K1.4431.00
332_S359_D1.4401.00
261_L431_A1.4391.00
331_R408_D1.4261.00
164_A167_Q1.4151.00
123_V445_T1.4121.00
232_T262_Q1.4091.00
325_M410_I1.3991.00
147_L161_L1.3971.00
203_E281_S1.3861.00
43_I46_L1.3841.00
178_L280_A1.3801.00
156_E242_D1.3761.00
381_I393_I1.3741.00
133_R136_S1.3721.00
393_I456_F1.3541.00
121_V433_I1.3461.00
135_L139_S1.3441.00
157_L242_D1.3441.00
134_L161_L1.3441.00
336_Q399_I1.3241.00
230_G270_Q1.3191.00
155_D159_K1.3181.00
304_M431_A1.3161.00
125_T445_T1.3121.00
235_V269_I1.3071.00
380_Y476_R1.3061.00
175_V200_G1.3061.00
272_R308_T1.2771.00
132_Q136_S1.2751.00
122_D441_K1.2741.00
161_L240_V1.2741.00
137_D228_I1.2721.00
265_A306_I1.2451.00
164_A171_E1.2421.00
361_N392_Y1.2291.00
457_T460_E1.2171.00
321_G432_F1.2161.00
81_Q85_L1.2140.99
336_Q403_T1.2070.99
181_E204_V1.2060.99
319_K343_D1.2030.99
150_Y426_N1.2020.99
227_I269_I1.1950.99
139_S171_E1.1950.99
130_K258_H1.1940.99
148_Q221_N1.1910.99
332_S405_V1.1810.99
149_Y226_V1.1740.99
153_K243_E1.1620.99
121_V304_M1.1610.99
162_R200_G1.1410.99
379_S476_R1.1390.99
136_S139_S1.1280.99
139_S168_K1.1230.99
336_Q446_F1.1210.99
143_D231_M1.1100.99
272_R429_V1.1080.99
413_V442_L1.1070.99
221_N276_D1.1050.99
124_I234_Y1.1000.99
235_V429_V1.0990.99
378_L468_I1.0970.99
119_N264_T1.0890.99
115_F303_G1.0830.99
166_I194_E1.0800.99
446_F450_L1.0720.99
416_A430_N1.0710.99
448_E452_V1.0650.99
331_R409_E1.0640.99
163_D167_Q1.0630.99
444_S448_E1.0630.99
474_V478_L1.0570.99
130_K238_F1.0550.99
161_L164_A1.0530.99
169_A198_A1.0440.98
372_F475_S1.0430.98
351_R355_L1.0430.98
259_I433_I1.0360.98
269_I429_V1.0300.98
333_I350_L1.0210.98
159_K163_D1.0190.98
59_R63_L1.0170.98
375_W472_E1.0130.98
123_V438_I1.0070.98
382_G462_L1.0040.98
323_I346_L1.0020.98
363_M446_F1.0020.98
380_Y479_S1.0010.98
287_T290_P0.9980.98
326_I353_A0.9970.98
107_L321_G0.9950.98
194_E198_A0.9930.98
335_I404_I0.9910.98
375_W471_K0.9820.98
20_I41_F0.9810.98
340_F362_I0.9800.98
301_N437_T0.9800.98
441_K444_S0.9760.98
378_L381_I0.9700.98
333_I353_A0.9660.97
139_S142_K0.9640.97
160_K163_D0.9640.97
316_E424_R0.9620.97
385_L461_Y0.9590.97
153_K241_G0.9580.97
235_V431_A0.9560.97
364_I377_T0.9540.97
169_A200_G0.9540.97
191_F194_E0.9530.97
302_V433_I0.9520.97
408_D440_K0.9510.97
411_A438_I0.9470.97
327_S349_A0.9410.97
362_I391_V0.9410.97
129_D132_Q0.9390.97
330_K409_E0.9380.97
332_S406_V0.9360.97
218_N421_R0.9330.97
104_I107_L0.9310.97
243_E246_G0.9310.97
315_W355_L0.9250.97
121_V438_I0.9230.97
346_L423_F0.9220.97
150_Y248_N0.9220.97
152_Y240_V0.9210.97
187_L192_F0.9200.97
418_I423_F0.9140.96
134_L228_I0.9130.96
306_I429_V0.9110.96
103_L106_M0.9110.96
385_L455_K0.9050.96
188_R192_F0.9030.96
447_K450_L0.9010.96
35_A39_V0.9000.96
366_N393_I0.8990.96
326_I350_L0.8960.96
67_E71_K0.8960.96
419_D426_N0.8940.96
140_K232_T0.8900.96
293_F296_Y0.8890.96
405_V443_V0.8880.96
467_W471_K0.8850.96
146_H230_G0.8830.96
331_R359_D0.8830.96
403_T446_F0.8810.96
322_Y412_S0.8810.96
210_L214_N0.8800.96
137_D262_Q0.8750.95
78_L81_Q0.8750.95
121_V302_V0.8740.95
188_R191_F0.8740.95
392_Y450_L0.8740.95
138_I161_L0.8740.95
124_I260_R0.8730.95
366_N374_Y0.8690.95
226_V240_V0.8630.95
259_I431_A0.8630.95
354_C387_A0.8630.95
248_N251_F0.8610.95
290_P294_P0.8610.95
385_L456_F0.8600.95
17_L21_I0.8550.95
227_I266_V0.8540.95
182_L185_R0.8530.95
363_M399_I0.8520.95
361_N455_K0.8510.95
291_N294_P0.8500.95
147_L240_V0.8430.94
382_G386_K0.8430.94
152_Y191_F0.8400.94
415_T429_V0.8390.94
384_L391_V0.8370.94
305_Q309_S0.8330.94
359_D455_K0.8310.94
353_A356_S0.8300.94
385_L391_V0.8290.94
132_Q135_L0.8280.94
116_T119_N0.8270.94
82_L85_L0.8270.94
122_D262_Q0.8260.94
382_G464_R0.8250.94
316_E319_K0.8240.94
131_F240_V0.8220.94
151_I243_E0.8220.94
166_I200_G0.8190.94
16_I20_I0.8190.94
254_W397_G0.8190.94
257_T401_A0.8190.94
253_Y394_Y0.8170.93
127_G131_F0.8160.93
239_N244_Y0.8160.93
409_E436_I0.8130.93
301_N435_D0.8110.93
332_S361_N0.8080.93
367_K371_A0.8080.93
447_K451_L0.8060.93
404_I412_S0.8050.93
290_P293_F0.8040.93
364_I393_I0.8030.93
166_I169_A0.8020.93
333_I358_I0.8010.93
179_Y202_V0.8010.93
241_G245_L0.8010.93
38_L41_F0.8000.93
446_F449_D0.7990.93
382_G458_Y0.7910.92
323_I327_S0.7910.92
468_I471_K0.7900.92
64_F67_E0.7900.92
349_A353_A0.7890.92
140_K228_I0.7890.92
176_R201_H0.7870.92
167_Q170_K0.7870.92
311_P427_F0.7830.92
270_Q293_F0.7800.92
444_S447_K0.7780.92
405_V411_A0.7750.92
340_F347_L0.7720.91
140_K143_D0.7720.91
62_H66_W0.7720.91
140_K231_M0.7720.91
257_T403_T0.7700.91
329_A406_V0.7690.91
412_S432_F0.7670.91
237_G244_Y0.7670.91
285_T289_I0.7660.91
149_Y258_H0.7660.91
307_V321_G0.7640.91
134_L137_D0.7640.91
319_K345_S0.7610.91
381_I456_F0.7580.91
159_K194_E0.7570.91
148_Q240_V0.7550.90
340_F391_V0.7540.90
93_N104_I0.7540.90
174_Q292_H0.7540.90
403_T442_L0.7530.90
146_H274_I0.7510.90
181_E206_F0.7490.90
145_I228_I0.7470.90
146_H174_Q0.7470.90
404_I418_I0.7460.90
287_T291_N0.7450.90
146_H227_I0.7420.90
394_Y452_V0.7400.90
286_L290_P0.7390.90
244_Y254_W0.7390.90
340_F384_L0.7360.89
211_R214_N0.7350.89
127_G237_G0.7300.89
40_L48_F0.7290.89
125_T448_E0.7290.89
466_L469_R0.7290.89
157_L245_L0.7270.89
246_G252_G0.7250.89
190_K193_K0.7240.89
191_F195_L0.7210.88
376_A475_S0.7200.88
455_K458_Y0.7190.88
194_E197_E0.7180.88
394_Y397_G0.7180.88
139_S175_V0.7170.88
243_E251_F0.7160.88
302_V438_I0.7150.88
176_R277_W0.7140.88
405_V450_L0.7120.88
363_M449_D0.7110.88
340_F418_I0.7080.87
152_Y162_R0.7070.87
99_D409_E0.7060.87
152_Y179_Y0.7050.87
318_I430_N0.7040.87
19_A22_V0.7030.87
382_G461_Y0.7020.87
374_Y393_I0.6990.87
393_I454_R0.6970.87
169_A174_Q0.6960.87
238_F258_H0.6950.86
248_N252_G0.6950.86
464_R469_R0.6940.86
116_T265_A0.6940.86
415_T426_N0.6930.86
160_K164_A0.6920.86
440_K444_S0.6910.86
265_A268_A0.6910.86
155_D242_D0.6900.86
152_Y161_L0.6900.86
320_N355_L0.6900.86
125_T129_D0.6880.86
261_L304_M0.6850.86
158_G162_R0.6840.86
459_E463_Q0.6830.85
166_I195_L0.6820.85
218_N237_G0.6810.85
306_I309_S0.6800.85
351_R387_A0.6800.85
124_I130_K0.6770.85
43_I50_L0.6760.85
60_R64_F0.6740.85
288_Y292_H0.6740.85
235_V259_I0.6730.85
378_L472_E0.6730.85
83_E86_E0.6730.85
189_K193_K0.6720.85
438_I442_L0.6720.85
179_Y191_F0.6720.85
147_L177_V0.6710.84
347_L351_R0.6680.84
19_A52_L0.6660.84
323_I349_A0.6650.84
16_I22_V0.6650.84
243_E370_H0.6630.84
256_D365_P0.6620.84
438_I441_K0.6610.84
131_F157_L0.6610.84
462_L465_P0.6600.84
101_K105_Y0.6570.83
20_I37_L0.6570.83
454_R457_T0.6570.83
409_E435_D0.6560.83
246_G253_Y0.6540.83
381_I385_L0.6540.83
102_D330_K0.6540.83
307_V312_D0.6530.83
38_L42_F0.6530.83
373_V377_T0.6530.83
158_G240_V0.6510.83
157_L240_V0.6510.83
237_G446_F0.6510.83
470_I474_V0.6500.83
464_R468_I0.6490.82
124_I137_D0.6480.82
157_L160_K0.6480.82
405_V408_D0.6460.82
228_I234_Y0.6450.82
466_L470_I0.6440.82
56_H60_R0.6430.82
245_L398_F0.6420.82
322_Y337_T0.6410.82
192_F202_V0.6400.82
276_D310_G0.6390.82
338_P398_F0.6390.82
377_T380_Y0.6380.81
410_I432_F0.6360.81
39_V43_I0.6350.81
104_I115_F0.6340.81
219_Y425_L0.6310.81
56_H59_R0.6300.81
440_K443_V0.6300.81
344_A348_D0.6300.81
253_Y396_N0.6290.80
44_P47_G0.6270.80
234_Y258_H0.6260.80
170_K198_A0.6260.80
115_F434_Y0.6250.80
242_D247_L0.6240.80
57_N60_R0.6230.80
334_L405_V0.6230.80
79_K82_L0.6230.80
397_G427_F0.6220.80
309_S318_I0.6210.80
154_G191_F0.6210.80
174_Q291_N0.6200.80
34_W38_L0.6200.80
19_A41_F0.6190.79
365_P427_F0.6190.79
75_E79_K0.6160.79
97_T103_L0.6160.79
170_K199_G0.6160.79
188_R193_K0.6160.79
170_K197_E0.6140.79
359_D447_K0.6140.79
153_K240_V0.6130.79
322_Y430_N0.6130.79
278_N281_S0.6120.79
246_G250_K0.6120.79
192_F200_G0.6120.79
65_Q68_D0.6110.79
338_P421_R0.6100.78
343_D423_F0.6100.78
80_H84_D0.6090.78
144_H274_I0.6090.78
257_T449_D0.6090.78
365_P370_H0.6040.78
370_H374_Y0.6040.78
320_N352_I0.6040.78
289_I292_H0.6040.78
445_T449_D0.6030.78
286_L292_H0.6020.78
135_L157_L0.6020.78
136_S142_K0.6000.77
412_S416_A0.6000.77
346_L418_I0.5990.77
148_Q223_R0.5990.77
138_I147_L0.5950.77
305_Q432_F0.5930.76
350_L389_A0.5920.76
155_D239_N0.5920.76
334_L450_L0.5900.76
192_F196_R0.5890.76
355_L387_A0.5890.76
177_V202_V0.5880.76
93_N96_A0.5860.76
99_D330_K0.5860.76
16_I23_I0.5840.75
223_R276_D0.5840.75
58_L61_K0.5830.75
29_D32_A0.5830.75
237_G449_D0.5830.75
324_K328_N0.5820.75
81_Q84_D0.5810.75
298_P301_N0.5800.75
98_F101_K0.5800.75
130_K226_V0.5790.75
242_D252_G0.5780.75
289_I293_F0.5780.75
375_W464_R0.5770.75
241_G244_Y0.5770.75
323_I326_I0.5750.74
131_F135_L0.5740.74
131_F161_L0.5740.74
79_K83_E0.5730.74
161_L226_V0.5730.74
103_L107_L0.5720.74
285_T288_Y0.5720.74
205_F218_N0.5710.74
403_T413_V0.5710.74
126_D391_V0.5690.74
340_F389_A0.5690.74
124_I129_D0.5680.73
465_P470_I0.5680.73
287_T292_H0.5670.73
436_I440_K0.5670.73
76_R80_H0.5660.73
145_I175_V0.5660.73
102_D356_S0.5650.73
169_A175_V0.5650.73
21_I25_K0.5650.73
63_L67_E0.5650.73
97_T100_N0.5640.73
22_V56_H0.5630.73
178_L203_E0.5620.73
315_W387_A0.5620.73
135_L145_I0.5610.72
285_T291_N0.5590.72
254_W369_D0.5590.72
203_E280_A0.5590.72
163_D194_E0.5590.72
23_I26_E0.5590.72
127_G258_H0.5590.72
18_L21_I0.5580.72
156_E160_K0.5550.72
143_D174_Q0.5550.72
371_A471_K0.5550.72
145_I300_G0.5540.72
286_L289_I0.5540.72
71_K74_I0.5540.72
126_D132_Q0.5530.71
333_I359_D0.5520.71
433_I439_A0.5520.71
107_L307_V0.5520.71
306_I311_P0.5510.71
156_E159_K0.5500.71
365_P398_F0.5500.71
154_G188_R0.5500.71
179_Y184_S0.5490.71
285_T292_H0.5490.71
48_F52_L0.5490.71
335_I350_L0.5480.71
320_N351_R0.5470.71
456_F460_E0.5470.71
54_F409_E0.5470.71
19_A48_F0.5450.70
59_R67_E0.5450.70
22_V26_E0.5440.70
205_F427_F0.5430.70
305_Q434_Y0.5420.70
325_M333_I0.5420.70
181_E207_P0.5410.70
377_T381_I0.5400.70
435_D438_I0.5400.70
207_P210_L0.5400.70
365_P421_R0.5400.70
127_G157_L0.5380.69
82_L98_F0.5370.69
58_L63_L0.5370.69
379_S472_E0.5370.69
326_I349_A0.5370.69
180_D220_R0.5360.69
137_D231_M0.5360.69
75_E80_H0.5350.69
23_I33_S0.5350.69
307_V311_P0.5330.69
31_S35_A0.5330.69
94_N101_K0.5330.69
347_L383_D0.5320.69
244_Y397_G0.5320.69
244_Y248_N0.5320.69
405_V446_F0.5320.69
131_F245_L0.5310.68
78_L85_L0.5310.68
234_Y266_V0.5310.68
313_S318_I0.5310.68
325_M332_S0.5310.68
420_V424_R0.5300.68
119_N304_M0.5300.68
127_G256_D0.5300.68
273_F277_W0.5290.68
307_V310_G0.5290.68
219_Y311_P0.5280.68
64_F71_K0.5270.68
27_R30_A0.5270.68
165_L240_V0.5270.68
327_S418_I0.5260.68
311_P421_R0.5250.67
130_K234_Y0.5250.67
241_G248_N0.5240.67
34_W37_L0.5240.67
244_Y398_F0.5240.67
457_T461_Y0.5230.67
119_N300_G0.5230.67
120_S301_N0.5220.67
46_L50_L0.5220.67
308_T311_P0.5220.67
135_L168_K0.5210.67
187_L191_F0.5210.67
395_D452_V0.5210.67
345_S349_A0.5200.67
24_F50_L0.5200.67
297_G300_G0.5200.67
319_K325_M0.5200.67
131_F237_G0.5190.67
154_G162_R0.5180.66
159_K162_R0.5170.66
180_D183_G0.5170.66
76_R86_E0.5160.66
302_V437_T0.5160.66
380_Y383_D0.5150.66
408_D439_A0.5140.66
322_Y416_A0.5140.66
143_D289_I0.5140.66
65_Q448_E0.5130.66
341_I420_V0.5120.66
422_S428_E0.5120.66
41_F68_D0.5120.66
16_I27_R0.5110.65
291_N295_D0.5110.65
205_F237_G0.5110.65
184_S187_L0.5100.65
280_A283_H0.5100.65
22_V27_R0.5090.65
143_D291_N0.5090.65
126_D238_F0.5090.65
138_I226_V0.5080.65
17_L67_E0.5070.65
323_I352_I0.5070.65
302_V436_I0.5060.65
134_L415_T0.5060.65
319_K346_L0.5060.65
96_A99_D0.5060.65
288_Y295_D0.5060.65
193_K196_R0.5060.65
129_D253_Y0.5060.65
79_K85_L0.5050.65
99_D102_D0.5040.64
265_A431_A0.5040.64
145_I161_L0.5030.64
336_Q453_S0.5030.64
122_D129_D0.5020.64
80_H83_E0.5010.64
365_P373_V0.5010.64
226_V258_H0.5000.64
255_R445_T0.5000.64
180_D223_R0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v0wA 1 0.7905 100 0.483 Contact Map
3hsiA 2 0.7842 100 0.494 Contact Map
1xdpA 4 0.7448 100 0.612 Contact Map
2o8rA 2 0.8548 100 0.613 Contact Map
4urjA 1 0.3382 100 0.791 Contact Map
1byrA 2 0.3112 100 0.806 Contact Map
2c1lA 2 0.3693 99.9 0.807 Contact Map
4gelA 2 0.3548 99.9 0.81 Contact Map
4ggjA 2 0.3402 99.9 0.815 Contact Map
4rctA 2 0.3651 99.4 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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