CLSA - BACSU - GREMLIN Contacts

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CLSA - Major cardiolipin synthase ClsA

UniProt:	P71040	Sequences: MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIPVLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKDLIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKKLRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLNYRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILDWNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSILIQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVYIYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDLLVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	482 (457)
Sequences:	3786 (2772)
Seq/√Len:	129.7

ECOLI - CLSA CLSC CLSB
BACSU - CLSA CLS1 CLSB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
139_S	167_Q	6.293	1.00
390_T	455_K	5.758	1.00
168_K	171_E	5.753	1.00
137_D	234_Y	5.621	1.00
138_I	164_A	5.329	1.00
134_L	226_V	4.034	1.00
359_D	390_T	4.002	1.00
137_D	260_R	3.786	1.00
233_G	269_I	3.714	1.00
167_Q	171_E	3.275	1.00
135_L	164_A	3.252	1.00
152_Y	177_V	3.224	1.00
408_D	443_V	3.047	1.00
135_L	161_L	2.966	1.00
122_D	133_R	2.802	1.00
118_D	264_T	2.795	1.00
120_S	262_Q	2.784	1.00
354_C	389_A	2.629	1.00
174_Q	201_H	2.610	1.00
130_K	134_L	2.593	1.00
306_I	431_A	2.531	1.00
363_M	453_S	2.531	1.00
396_N	452_V	2.522	1.00
361_N	390_T	2.499	1.00
130_K	149_Y	2.496	1.00
166_I	198_A	2.483	1.00
334_L	361_N	2.459	1.00
448_E	451_L	2.448	1.00
411_A	439_A	2.444	1.00
137_D	140_K	2.429	1.00
233_G	266_V	2.378	1.00
137_D	232_T	2.364	1.00
411_A	442_L	2.360	1.00
332_S	443_V	2.291	1.00
412_S	430_N	2.287	1.00
454_R	460_E	2.226	1.00
234_Y	260_R	2.179	1.00
136_S	140_K	2.160	1.00
162_R	194_E	2.112	1.00
325_M	406_V	2.102	1.00
138_I	145_I	2.084	1.00
433_I	438_I	2.069	1.00
164_A	168_K	2.068	1.00
392_Y	455_K	2.063	1.00
395_D	454_R	2.048	1.00
147_L	226_V	2.041	1.00
133_R	137_D	2.040	1.00
142_K	231_M	2.028	1.00
464_R	472_E	2.028	1.00
332_S	408_D	2.019	1.00
146_H	176_R	2.016	1.00
458_Y	462_L	1.998	1.00
133_R	234_Y	1.995	1.00
334_L	359_D	1.980	1.00
166_I	170_K	1.972	1.00
361_N	450_L	1.962	1.00
142_K	171_E	1.957	1.00
368_P	374_Y	1.949	1.00
179_Y	204_V	1.939	1.00
195_L	200_G	1.919	1.00
201_H	283_H	1.917	1.00
162_R	166_I	1.911	1.00
336_Q	363_M	1.907	1.00
405_V	439_A	1.906	1.00
124_I	133_R	1.899	1.00
193_K	197_E	1.875	1.00
133_R	260_R	1.871	1.00
154_G	159_K	1.843	1.00
363_M	450_L	1.841	1.00
162_R	191_F	1.840	1.00
225_L	269_I	1.839	1.00
261_L	265_A	1.838	1.00
366_N	395_D	1.831	1.00
443_V	447_K	1.828	1.00
381_I	391_V	1.802	1.00
326_I	333_I	1.794	1.00
139_S	164_A	1.778	1.00
139_S	160_K	1.772	1.00
378_L	393_I	1.745	1.00
255_R	449_D	1.729	1.00
334_L	447_K	1.728	1.00
364_I	381_I	1.716	1.00
144_H	270_Q	1.714	1.00
333_I	406_V	1.712	1.00
265_A	304_M	1.701	1.00
450_L	453_S	1.680	1.00
232_T	260_R	1.643	1.00
156_E	247_L	1.626	1.00
384_L	389_A	1.626	1.00
146_H	270_Q	1.623	1.00
351_R	383_D	1.622	1.00
135_L	160_K	1.603	1.00
126_D	129_D	1.584	1.00
122_D	260_R	1.575	1.00
116_T	268_A	1.562	1.00
132_Q	160_K	1.534	1.00
163_D	166_I	1.521	1.00
119_N	261_L	1.518	1.00
302_V	435_D	1.512	1.00
386_K	458_Y	1.511	1.00
318_I	416_A	1.509	1.00
155_D	158_G	1.509	1.00
128_R	132_Q	1.502	1.00
144_H	230_G	1.501	1.00
231_M	262_Q	1.501	1.00
126_D	253_Y	1.496	1.00
385_L	458_Y	1.495	1.00
366_N	454_R	1.479	1.00
225_L	429_V	1.478	1.00
334_L	443_V	1.471	1.00
461_Y	464_R	1.470	1.00
361_N	447_K	1.443	1.00
332_S	359_D	1.440	1.00
261_L	431_A	1.439	1.00
331_R	408_D	1.426	1.00
164_A	167_Q	1.415	1.00
123_V	445_T	1.412	1.00
232_T	262_Q	1.409	1.00
325_M	410_I	1.399	1.00
147_L	161_L	1.397	1.00
203_E	281_S	1.386	1.00
43_I	46_L	1.384	1.00
178_L	280_A	1.380	1.00
156_E	242_D	1.376	1.00
381_I	393_I	1.374	1.00
133_R	136_S	1.372	1.00
393_I	456_F	1.354	1.00
121_V	433_I	1.346	1.00
135_L	139_S	1.344	1.00
157_L	242_D	1.344	1.00
134_L	161_L	1.344	1.00
336_Q	399_I	1.324	1.00
230_G	270_Q	1.319	1.00
155_D	159_K	1.318	1.00
304_M	431_A	1.316	1.00
125_T	445_T	1.312	1.00
235_V	269_I	1.307	1.00
380_Y	476_R	1.306	1.00
175_V	200_G	1.306	1.00
272_R	308_T	1.277	1.00
132_Q	136_S	1.275	1.00
122_D	441_K	1.274	1.00
161_L	240_V	1.274	1.00
137_D	228_I	1.272	1.00
265_A	306_I	1.245	1.00
164_A	171_E	1.242	1.00
361_N	392_Y	1.229	1.00
457_T	460_E	1.217	1.00
321_G	432_F	1.216	1.00
81_Q	85_L	1.214	0.99
336_Q	403_T	1.207	0.99
181_E	204_V	1.206	0.99
319_K	343_D	1.203	0.99
150_Y	426_N	1.202	0.99
227_I	269_I	1.195	0.99
139_S	171_E	1.195	0.99
130_K	258_H	1.194	0.99
148_Q	221_N	1.191	0.99
332_S	405_V	1.181	0.99
149_Y	226_V	1.174	0.99
153_K	243_E	1.162	0.99
121_V	304_M	1.161	0.99
162_R	200_G	1.141	0.99
379_S	476_R	1.139	0.99
136_S	139_S	1.128	0.99
139_S	168_K	1.123	0.99
336_Q	446_F	1.121	0.99
143_D	231_M	1.110	0.99
272_R	429_V	1.108	0.99
413_V	442_L	1.107	0.99
221_N	276_D	1.105	0.99
124_I	234_Y	1.100	0.99
235_V	429_V	1.099	0.99
378_L	468_I	1.097	0.99
119_N	264_T	1.089	0.99
115_F	303_G	1.083	0.99
166_I	194_E	1.080	0.99
446_F	450_L	1.072	0.99
416_A	430_N	1.071	0.99
448_E	452_V	1.065	0.99
331_R	409_E	1.064	0.99
163_D	167_Q	1.063	0.99
444_S	448_E	1.063	0.99
474_V	478_L	1.057	0.99
130_K	238_F	1.055	0.99
161_L	164_A	1.053	0.99
169_A	198_A	1.044	0.98
372_F	475_S	1.043	0.98
351_R	355_L	1.043	0.98
259_I	433_I	1.036	0.98
269_I	429_V	1.030	0.98
333_I	350_L	1.021	0.98
159_K	163_D	1.019	0.98
59_R	63_L	1.017	0.98
375_W	472_E	1.013	0.98
123_V	438_I	1.007	0.98
382_G	462_L	1.004	0.98
323_I	346_L	1.002	0.98
363_M	446_F	1.002	0.98
380_Y	479_S	1.001	0.98
287_T	290_P	0.998	0.98
326_I	353_A	0.997	0.98
107_L	321_G	0.995	0.98
194_E	198_A	0.993	0.98
335_I	404_I	0.991	0.98
375_W	471_K	0.982	0.98
20_I	41_F	0.981	0.98
340_F	362_I	0.980	0.98
301_N	437_T	0.980	0.98
441_K	444_S	0.976	0.98
378_L	381_I	0.970	0.98
333_I	353_A	0.966	0.97
139_S	142_K	0.964	0.97
160_K	163_D	0.964	0.97
316_E	424_R	0.962	0.97
385_L	461_Y	0.959	0.97
153_K	241_G	0.958	0.97
235_V	431_A	0.956	0.97
364_I	377_T	0.954	0.97
169_A	200_G	0.954	0.97
191_F	194_E	0.953	0.97
302_V	433_I	0.952	0.97
408_D	440_K	0.951	0.97
411_A	438_I	0.947	0.97
327_S	349_A	0.941	0.97
362_I	391_V	0.941	0.97
129_D	132_Q	0.939	0.97
330_K	409_E	0.938	0.97
332_S	406_V	0.936	0.97
218_N	421_R	0.933	0.97
104_I	107_L	0.931	0.97
243_E	246_G	0.931	0.97
315_W	355_L	0.925	0.97
121_V	438_I	0.923	0.97
346_L	423_F	0.922	0.97
150_Y	248_N	0.922	0.97
152_Y	240_V	0.921	0.97
187_L	192_F	0.920	0.97
418_I	423_F	0.914	0.96
134_L	228_I	0.913	0.96
306_I	429_V	0.911	0.96
103_L	106_M	0.911	0.96
385_L	455_K	0.905	0.96
188_R	192_F	0.903	0.96
447_K	450_L	0.901	0.96
35_A	39_V	0.900	0.96
366_N	393_I	0.899	0.96
326_I	350_L	0.896	0.96
67_E	71_K	0.896	0.96
419_D	426_N	0.894	0.96
140_K	232_T	0.890	0.96
293_F	296_Y	0.889	0.96
405_V	443_V	0.888	0.96
467_W	471_K	0.885	0.96
146_H	230_G	0.883	0.96
331_R	359_D	0.883	0.96
403_T	446_F	0.881	0.96
322_Y	412_S	0.881	0.96
210_L	214_N	0.880	0.96
137_D	262_Q	0.875	0.95
78_L	81_Q	0.875	0.95
121_V	302_V	0.874	0.95
188_R	191_F	0.874	0.95
392_Y	450_L	0.874	0.95
138_I	161_L	0.874	0.95
124_I	260_R	0.873	0.95
366_N	374_Y	0.869	0.95
226_V	240_V	0.863	0.95
259_I	431_A	0.863	0.95
354_C	387_A	0.863	0.95
248_N	251_F	0.861	0.95
290_P	294_P	0.861	0.95
385_L	456_F	0.860	0.95
17_L	21_I	0.855	0.95
227_I	266_V	0.854	0.95
182_L	185_R	0.853	0.95
363_M	399_I	0.852	0.95
361_N	455_K	0.851	0.95
291_N	294_P	0.850	0.95
147_L	240_V	0.843	0.94
382_G	386_K	0.843	0.94
152_Y	191_F	0.840	0.94
415_T	429_V	0.839	0.94
384_L	391_V	0.837	0.94
305_Q	309_S	0.833	0.94
359_D	455_K	0.831	0.94
353_A	356_S	0.830	0.94
385_L	391_V	0.829	0.94
132_Q	135_L	0.828	0.94
116_T	119_N	0.827	0.94
82_L	85_L	0.827	0.94
122_D	262_Q	0.826	0.94
382_G	464_R	0.825	0.94
316_E	319_K	0.824	0.94
131_F	240_V	0.822	0.94
151_I	243_E	0.822	0.94
166_I	200_G	0.819	0.94
16_I	20_I	0.819	0.94
254_W	397_G	0.819	0.94
257_T	401_A	0.819	0.94
253_Y	394_Y	0.817	0.93
127_G	131_F	0.816	0.93
239_N	244_Y	0.816	0.93
409_E	436_I	0.813	0.93
301_N	435_D	0.811	0.93
332_S	361_N	0.808	0.93
367_K	371_A	0.808	0.93
447_K	451_L	0.806	0.93
404_I	412_S	0.805	0.93
290_P	293_F	0.804	0.93
364_I	393_I	0.803	0.93
166_I	169_A	0.802	0.93
333_I	358_I	0.801	0.93
179_Y	202_V	0.801	0.93
241_G	245_L	0.801	0.93
38_L	41_F	0.800	0.93
446_F	449_D	0.799	0.93
382_G	458_Y	0.791	0.92
323_I	327_S	0.791	0.92
468_I	471_K	0.790	0.92
64_F	67_E	0.790	0.92
349_A	353_A	0.789	0.92
140_K	228_I	0.789	0.92
176_R	201_H	0.787	0.92
167_Q	170_K	0.787	0.92
311_P	427_F	0.783	0.92
270_Q	293_F	0.780	0.92
444_S	447_K	0.778	0.92
405_V	411_A	0.775	0.92
340_F	347_L	0.772	0.91
140_K	143_D	0.772	0.91
62_H	66_W	0.772	0.91
140_K	231_M	0.772	0.91
257_T	403_T	0.770	0.91
329_A	406_V	0.769	0.91
412_S	432_F	0.767	0.91
237_G	244_Y	0.767	0.91
285_T	289_I	0.766	0.91
149_Y	258_H	0.766	0.91
307_V	321_G	0.764	0.91
134_L	137_D	0.764	0.91
319_K	345_S	0.761	0.91
381_I	456_F	0.758	0.91
159_K	194_E	0.757	0.91
148_Q	240_V	0.755	0.90
340_F	391_V	0.754	0.90
93_N	104_I	0.754	0.90
174_Q	292_H	0.754	0.90
403_T	442_L	0.753	0.90
146_H	274_I	0.751	0.90
181_E	206_F	0.749	0.90
145_I	228_I	0.747	0.90
146_H	174_Q	0.747	0.90
404_I	418_I	0.746	0.90
287_T	291_N	0.745	0.90
146_H	227_I	0.742	0.90
394_Y	452_V	0.740	0.90
286_L	290_P	0.739	0.90
244_Y	254_W	0.739	0.90
340_F	384_L	0.736	0.89
211_R	214_N	0.735	0.89
127_G	237_G	0.730	0.89
40_L	48_F	0.729	0.89
125_T	448_E	0.729	0.89
466_L	469_R	0.729	0.89
157_L	245_L	0.727	0.89
246_G	252_G	0.725	0.89
190_K	193_K	0.724	0.89
191_F	195_L	0.721	0.88
376_A	475_S	0.720	0.88
455_K	458_Y	0.719	0.88
194_E	197_E	0.718	0.88
394_Y	397_G	0.718	0.88
139_S	175_V	0.717	0.88
243_E	251_F	0.716	0.88
302_V	438_I	0.715	0.88
176_R	277_W	0.714	0.88
405_V	450_L	0.712	0.88
363_M	449_D	0.711	0.88
340_F	418_I	0.708	0.87
152_Y	162_R	0.707	0.87
99_D	409_E	0.706	0.87
152_Y	179_Y	0.705	0.87
318_I	430_N	0.704	0.87
19_A	22_V	0.703	0.87
382_G	461_Y	0.702	0.87
374_Y	393_I	0.699	0.87
393_I	454_R	0.697	0.87
169_A	174_Q	0.696	0.87
238_F	258_H	0.695	0.86
248_N	252_G	0.695	0.86
464_R	469_R	0.694	0.86
116_T	265_A	0.694	0.86
415_T	426_N	0.693	0.86
160_K	164_A	0.692	0.86
440_K	444_S	0.691	0.86
265_A	268_A	0.691	0.86
155_D	242_D	0.690	0.86
152_Y	161_L	0.690	0.86
320_N	355_L	0.690	0.86
125_T	129_D	0.688	0.86
261_L	304_M	0.685	0.86
158_G	162_R	0.684	0.86
459_E	463_Q	0.683	0.85
166_I	195_L	0.682	0.85
218_N	237_G	0.681	0.85
306_I	309_S	0.680	0.85
351_R	387_A	0.680	0.85
124_I	130_K	0.677	0.85
43_I	50_L	0.676	0.85
60_R	64_F	0.674	0.85
288_Y	292_H	0.674	0.85
235_V	259_I	0.673	0.85
378_L	472_E	0.673	0.85
83_E	86_E	0.673	0.85
189_K	193_K	0.672	0.85
438_I	442_L	0.672	0.85
179_Y	191_F	0.672	0.85
147_L	177_V	0.671	0.84
347_L	351_R	0.668	0.84
19_A	52_L	0.666	0.84
323_I	349_A	0.665	0.84
16_I	22_V	0.665	0.84
243_E	370_H	0.663	0.84
256_D	365_P	0.662	0.84
438_I	441_K	0.661	0.84
131_F	157_L	0.661	0.84
462_L	465_P	0.660	0.84
101_K	105_Y	0.657	0.83
20_I	37_L	0.657	0.83
454_R	457_T	0.657	0.83
409_E	435_D	0.656	0.83
246_G	253_Y	0.654	0.83
381_I	385_L	0.654	0.83
102_D	330_K	0.654	0.83
307_V	312_D	0.653	0.83
38_L	42_F	0.653	0.83
373_V	377_T	0.653	0.83
158_G	240_V	0.651	0.83
157_L	240_V	0.651	0.83
237_G	446_F	0.651	0.83
470_I	474_V	0.650	0.83
464_R	468_I	0.649	0.82
124_I	137_D	0.648	0.82
157_L	160_K	0.648	0.82
405_V	408_D	0.646	0.82
228_I	234_Y	0.645	0.82
466_L	470_I	0.644	0.82
56_H	60_R	0.643	0.82
245_L	398_F	0.642	0.82
322_Y	337_T	0.641	0.82
192_F	202_V	0.640	0.82
276_D	310_G	0.639	0.82
338_P	398_F	0.639	0.82
377_T	380_Y	0.638	0.81
410_I	432_F	0.636	0.81
39_V	43_I	0.635	0.81
104_I	115_F	0.634	0.81
219_Y	425_L	0.631	0.81
56_H	59_R	0.630	0.81
440_K	443_V	0.630	0.81
344_A	348_D	0.630	0.81
253_Y	396_N	0.629	0.80
44_P	47_G	0.627	0.80
234_Y	258_H	0.626	0.80
170_K	198_A	0.626	0.80
115_F	434_Y	0.625	0.80
242_D	247_L	0.624	0.80
57_N	60_R	0.623	0.80
334_L	405_V	0.623	0.80
79_K	82_L	0.623	0.80
397_G	427_F	0.622	0.80
309_S	318_I	0.621	0.80
154_G	191_F	0.621	0.80
174_Q	291_N	0.620	0.80
34_W	38_L	0.620	0.80
19_A	41_F	0.619	0.79
365_P	427_F	0.619	0.79
75_E	79_K	0.616	0.79
97_T	103_L	0.616	0.79
170_K	199_G	0.616	0.79
188_R	193_K	0.616	0.79
170_K	197_E	0.614	0.79
359_D	447_K	0.614	0.79
153_K	240_V	0.613	0.79
322_Y	430_N	0.613	0.79
278_N	281_S	0.612	0.79
246_G	250_K	0.612	0.79
192_F	200_G	0.612	0.79
65_Q	68_D	0.611	0.79
338_P	421_R	0.610	0.78
343_D	423_F	0.610	0.78
80_H	84_D	0.609	0.78
144_H	274_I	0.609	0.78
257_T	449_D	0.609	0.78
365_P	370_H	0.604	0.78
370_H	374_Y	0.604	0.78
320_N	352_I	0.604	0.78
289_I	292_H	0.604	0.78
445_T	449_D	0.603	0.78
286_L	292_H	0.602	0.78
135_L	157_L	0.602	0.78
136_S	142_K	0.600	0.77
412_S	416_A	0.600	0.77
346_L	418_I	0.599	0.77
148_Q	223_R	0.599	0.77
138_I	147_L	0.595	0.77
305_Q	432_F	0.593	0.76
350_L	389_A	0.592	0.76
155_D	239_N	0.592	0.76
334_L	450_L	0.590	0.76
192_F	196_R	0.589	0.76
355_L	387_A	0.589	0.76
177_V	202_V	0.588	0.76
93_N	96_A	0.586	0.76
99_D	330_K	0.586	0.76
16_I	23_I	0.584	0.75
223_R	276_D	0.584	0.75
58_L	61_K	0.583	0.75
29_D	32_A	0.583	0.75
237_G	449_D	0.583	0.75
324_K	328_N	0.582	0.75
81_Q	84_D	0.581	0.75
298_P	301_N	0.580	0.75
98_F	101_K	0.580	0.75
130_K	226_V	0.579	0.75
242_D	252_G	0.578	0.75
289_I	293_F	0.578	0.75
375_W	464_R	0.577	0.75
241_G	244_Y	0.577	0.75
323_I	326_I	0.575	0.74
131_F	135_L	0.574	0.74
131_F	161_L	0.574	0.74
79_K	83_E	0.573	0.74
161_L	226_V	0.573	0.74
103_L	107_L	0.572	0.74
285_T	288_Y	0.572	0.74
205_F	218_N	0.571	0.74
403_T	413_V	0.571	0.74
126_D	391_V	0.569	0.74
340_F	389_A	0.569	0.74
124_I	129_D	0.568	0.73
465_P	470_I	0.568	0.73
287_T	292_H	0.567	0.73
436_I	440_K	0.567	0.73
76_R	80_H	0.566	0.73
145_I	175_V	0.566	0.73
102_D	356_S	0.565	0.73
169_A	175_V	0.565	0.73
21_I	25_K	0.565	0.73
63_L	67_E	0.565	0.73
97_T	100_N	0.564	0.73
22_V	56_H	0.563	0.73
178_L	203_E	0.562	0.73
315_W	387_A	0.562	0.73
135_L	145_I	0.561	0.72
285_T	291_N	0.559	0.72
254_W	369_D	0.559	0.72
203_E	280_A	0.559	0.72
163_D	194_E	0.559	0.72
23_I	26_E	0.559	0.72
127_G	258_H	0.559	0.72
18_L	21_I	0.558	0.72
156_E	160_K	0.555	0.72
143_D	174_Q	0.555	0.72
371_A	471_K	0.555	0.72
145_I	300_G	0.554	0.72
286_L	289_I	0.554	0.72
71_K	74_I	0.554	0.72
126_D	132_Q	0.553	0.71
333_I	359_D	0.552	0.71
433_I	439_A	0.552	0.71
107_L	307_V	0.552	0.71
306_I	311_P	0.551	0.71
156_E	159_K	0.550	0.71
365_P	398_F	0.550	0.71
154_G	188_R	0.550	0.71
179_Y	184_S	0.549	0.71
285_T	292_H	0.549	0.71
48_F	52_L	0.549	0.71
335_I	350_L	0.548	0.71
320_N	351_R	0.547	0.71
456_F	460_E	0.547	0.71
54_F	409_E	0.547	0.71
19_A	48_F	0.545	0.70
59_R	67_E	0.545	0.70
22_V	26_E	0.544	0.70
205_F	427_F	0.543	0.70
305_Q	434_Y	0.542	0.70
325_M	333_I	0.542	0.70
181_E	207_P	0.541	0.70
377_T	381_I	0.540	0.70
435_D	438_I	0.540	0.70
207_P	210_L	0.540	0.70
365_P	421_R	0.540	0.70
127_G	157_L	0.538	0.69
82_L	98_F	0.537	0.69
58_L	63_L	0.537	0.69
379_S	472_E	0.537	0.69
326_I	349_A	0.537	0.69
180_D	220_R	0.536	0.69
137_D	231_M	0.536	0.69
75_E	80_H	0.535	0.69
23_I	33_S	0.535	0.69
307_V	311_P	0.533	0.69
31_S	35_A	0.533	0.69
94_N	101_K	0.533	0.69
347_L	383_D	0.532	0.69
244_Y	397_G	0.532	0.69
244_Y	248_N	0.532	0.69
405_V	446_F	0.532	0.69
131_F	245_L	0.531	0.68
78_L	85_L	0.531	0.68
234_Y	266_V	0.531	0.68
313_S	318_I	0.531	0.68
325_M	332_S	0.531	0.68
420_V	424_R	0.530	0.68
119_N	304_M	0.530	0.68
127_G	256_D	0.530	0.68
273_F	277_W	0.529	0.68
307_V	310_G	0.529	0.68
219_Y	311_P	0.528	0.68
64_F	71_K	0.527	0.68
27_R	30_A	0.527	0.68
165_L	240_V	0.527	0.68
327_S	418_I	0.526	0.68
311_P	421_R	0.525	0.67
130_K	234_Y	0.525	0.67
241_G	248_N	0.524	0.67
34_W	37_L	0.524	0.67
244_Y	398_F	0.524	0.67
457_T	461_Y	0.523	0.67
119_N	300_G	0.523	0.67
120_S	301_N	0.522	0.67
46_L	50_L	0.522	0.67
308_T	311_P	0.522	0.67
135_L	168_K	0.521	0.67
187_L	191_F	0.521	0.67
395_D	452_V	0.521	0.67
345_S	349_A	0.520	0.67
24_F	50_L	0.520	0.67
297_G	300_G	0.520	0.67
319_K	325_M	0.520	0.67
131_F	237_G	0.519	0.67
154_G	162_R	0.518	0.66
159_K	162_R	0.517	0.66
180_D	183_G	0.517	0.66
76_R	86_E	0.516	0.66
302_V	437_T	0.516	0.66
380_Y	383_D	0.515	0.66
408_D	439_A	0.514	0.66
322_Y	416_A	0.514	0.66
143_D	289_I	0.514	0.66
65_Q	448_E	0.513	0.66
341_I	420_V	0.512	0.66
422_S	428_E	0.512	0.66
41_F	68_D	0.512	0.66
16_I	27_R	0.511	0.65
291_N	295_D	0.511	0.65
205_F	237_G	0.511	0.65
184_S	187_L	0.510	0.65
280_A	283_H	0.510	0.65
22_V	27_R	0.509	0.65
143_D	291_N	0.509	0.65
126_D	238_F	0.509	0.65
138_I	226_V	0.508	0.65
17_L	67_E	0.507	0.65
323_I	352_I	0.507	0.65
302_V	436_I	0.506	0.65
134_L	415_T	0.506	0.65
319_K	346_L	0.506	0.65
96_A	99_D	0.506	0.65
288_Y	295_D	0.506	0.65
193_K	196_R	0.506	0.65
129_D	253_Y	0.506	0.65
79_K	85_L	0.505	0.65
99_D	102_D	0.504	0.64
265_A	431_A	0.504	0.64
145_I	161_L	0.503	0.64
336_Q	453_S	0.503	0.64
122_D	129_D	0.502	0.64
80_H	83_E	0.501	0.64
365_P	373_V	0.501	0.64
226_V	258_H	0.500	0.64
255_R	445_T	0.500	0.64
180_D	223_R	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1v0wA	1	0.7905	100	0.483	Contact Map
3hsiA	2	0.7842	100	0.494	Contact Map
1xdpA	4	0.7448	100	0.612	Contact Map
2o8rA	2	0.8548	100	0.613	Contact Map
4urjA	1	0.3382	100	0.791	Contact Map
1byrA	2	0.3112	100	0.806	Contact Map
2c1lA	2	0.3693	99.9	0.807	Contact Map
4gelA	2	0.3548	99.9	0.81	Contact Map
4ggjA	2	0.3402	99.9	0.815	Contact Map
4rctA	2	0.3651	99.4	0.891	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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