GREMLIN Database
MTA - HTH-type transcriptional activator mta
UniProt: P71039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (227)
Sequences: 4559 (3662)
Seq/√Len: 243.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_K95_D5.8621.00
84_K102_D5.2561.00
42_S45_D4.2101.00
176_R196_A3.8081.00
28_L52_I3.4691.00
16_I20_H3.1381.00
48_R70_D3.0741.00
5_V20_H2.9291.00
88_M98_I2.8631.00
23_D29_N2.8331.00
91_K94_M2.8071.00
61_R64_E2.7431.00
31_S45_D2.5891.00
90_K93_R2.5521.00
34_T40_L2.4371.00
77_K105_L2.3841.00
64_E67_E2.3611.00
83_Q86_I2.3071.00
218_E222_T2.3041.00
81_Q105_L2.2721.00
88_M102_D2.2661.00
84_K98_I2.2341.00
21_H25_I2.2081.00
81_Q109_D2.1291.00
195_G199_D2.0861.00
56_K62_L2.0041.00
87_L94_M1.9431.00
59_G90_K1.9121.00
6_K10_E1.8981.00
77_K109_D1.8821.00
90_K94_M1.7591.00
84_K88_M1.7321.00
8_V49_L1.6931.00
187_D190_I1.6601.00
4_Q40_L1.6421.00
183_H189_E1.5961.00
87_L98_I1.5951.00
91_K98_I1.5671.00
85_E89_K1.5461.00
18_T21_H1.5301.00
200_H204_Y1.5261.00
84_K105_L1.5241.00
25_I62_L1.5141.00
75_D78_A1.5041.00
32_A40_L1.4951.00
167_M171_D1.4921.00
87_L101_I1.4781.00
21_H62_L1.4601.00
4_Q7_Q1.4521.00
7_Q10_E1.4401.00
80_L101_I1.4361.00
80_L105_L1.4361.00
176_R179_A1.4231.00
137_D141_K1.4191.00
146_E150_E1.4061.00
21_H24_N1.3561.00
88_M91_K1.3531.00
132_Q135_Y1.3271.00
212_I215_G1.3211.00
171_D175_R1.3091.00
53_L56_K1.3021.00
94_M98_I1.2961.00
159_S162_D1.2701.00
93_R97_M1.2661.00
132_Q136_A1.2511.00
31_S42_S1.2431.00
86_I90_K1.2411.00
9_A15_S1.2351.00
190_I194_V1.2341.00
136_A140_R1.2341.00
226_F230_I1.2011.00
9_A12_S1.1951.00
172_S176_R1.1901.00
5_V16_I1.1901.00
8_V46_L1.1881.00
3_Y43_D1.1841.00
178_A182_K1.1641.00
86_I89_K1.1541.00
173_I177_I1.1541.00
154_R159_S1.1511.00
36_A40_L1.1451.00
145_K149_E1.1411.00
33_L45_D1.1331.00
153_K157_A1.1331.00
137_D140_R1.1221.00
48_R69_L1.1141.00
87_L97_M1.1131.00
135_Y139_V1.1101.00
64_E82_S1.0991.00
33_L40_L1.0851.00
216_L219_V1.0821.00
50_Q54_F1.0781.00
84_K101_I1.0741.00
66_K70_D1.0721.00
15_S18_T1.0501.00
77_K81_Q1.0321.00
164_R168_A1.0311.00
102_D106_L1.0261.00
133_Q138_E1.0161.00
193_A196_A1.0111.00
60_F68_M1.0091.00
26_E29_N1.0091.00
199_D203_Q1.0041.00
118_D121_A1.0031.00
19_L23_D1.0011.00
135_Y138_E0.9921.00
56_K59_G0.9881.00
121_A124_S0.9841.00
14_V49_L0.9841.00
138_E142_L0.9751.00
180_R193_A0.9751.00
92_Q95_D0.9661.00
173_I176_R0.9631.00
8_V12_S0.9631.00
144_G147_I0.9601.00
179_A183_H0.9591.00
136_A139_V0.9491.00
60_F79_A0.9451.00
170_F174_Y0.9391.00
169_E203_Q0.9161.00
216_L220_Y0.9131.00
138_E225_R0.9081.00
117_R120_F0.8921.00
174_Y178_A0.8861.00
14_V18_T0.8861.00
172_S175_R0.8861.00
60_F83_Q0.8841.00
138_E141_K0.8831.00
92_Q96_E0.8790.99
115_N119_L0.8790.99
85_E88_M0.8780.99
76_R108_V0.8740.99
82_S85_E0.8660.99
107_S112_E0.8650.99
17_R21_H0.8640.99
192_A195_G0.8630.99
201_I206_Y0.8590.99
198_R208_C0.8450.99
27_L52_I0.8380.99
134_T138_E0.8380.99
169_E196_A0.8360.99
177_I181_M0.8320.99
179_A182_K0.8280.99
8_V45_D0.8260.99
169_E173_I0.8260.99
181_M184_G0.8220.99
189_E192_A0.8220.99
215_G219_V0.8200.99
133_Q136_A0.8170.99
50_Q104_T0.8160.99
134_T137_D0.8160.99
136_A141_K0.8040.99
152_E156_S0.8000.99
94_M97_M0.7970.99
209_T212_I0.7900.99
22_Y49_L0.7890.99
19_L30_P0.7880.99
201_I208_C0.7880.99
148_A151_T0.7860.99
180_R183_H0.7810.99
152_E158_Y0.7810.99
193_A197_F0.7810.99
130_E134_T0.7800.99
178_A184_G0.7790.99
12_S46_L0.7780.99
175_R179_A0.7780.99
205_H212_I0.7760.99
125_M128_I0.7760.99
105_L109_D0.7720.99
225_R228_D0.7710.99
191_Q195_G0.7680.99
3_Y46_L0.7670.99
115_N118_D0.7660.99
89_K92_Q0.7640.99
171_D174_Y0.7630.99
56_K65_I0.7560.98
57_E97_M0.7540.98
154_R158_Y0.7530.98
164_R167_M0.7520.98
226_F229_S0.7490.98
165_T168_A0.7480.98
106_L111_G0.7480.98
14_V94_M0.7430.98
168_A171_D0.7430.98
56_K61_R0.7430.98
12_S28_L0.7410.98
3_Y40_L0.7400.98
108_V111_G0.7370.98
153_K158_Y0.7360.98
142_L145_K0.7350.98
186_D191_Q0.7340.98
62_L65_I0.7330.98
182_K193_A0.7300.98
139_V143_Y0.7270.98
206_Y212_I0.7260.98
124_S129_E0.7250.98
227_T230_I0.7250.98
151_T158_Y0.7240.98
29_N33_L0.7240.98
132_Q140_R0.7190.98
78_A82_S0.7170.98
155_T158_Y0.7150.98
149_E153_K0.7140.98
190_I193_A0.7140.98
219_V226_F0.7110.98
211_D214_R0.7030.98
12_S49_L0.6960.97
169_E172_S0.6910.97
23_D28_L0.6910.97
223_D226_F0.6900.97
89_K93_R0.6890.97
148_A154_R0.6860.97
83_Q97_M0.6800.97
132_Q138_E0.6800.97
210_L213_F0.6770.97
88_M92_Q0.6750.97
162_D165_T0.6750.97
225_R229_S0.6750.97
185_P190_I0.6730.97
133_Q137_D0.6730.97
149_E152_E0.6660.97
119_L122_G0.6650.97
44_A47_E0.6640.97
154_R157_A0.6620.96
15_S21_H0.6610.96
135_Y140_R0.6600.96
54_F104_T0.6560.96
9_A16_I0.6540.96
168_A175_R0.6520.96
40_L45_D0.6520.96
120_F124_S0.6470.96
83_Q101_I0.6440.96
108_V112_E0.6430.96
23_D41_Y0.6380.96
51_Q74_F0.6370.96
197_F213_F0.6370.96
141_K145_K0.6340.95
19_L49_L0.6320.95
210_L214_R0.6300.95
206_Y210_L0.6290.95
130_E133_Q0.6280.95
153_K159_S0.6270.95
6_K16_I0.6250.95
126_K129_E0.6250.95
163_W166_I0.6240.95
180_R190_I0.6230.95
157_A161_D0.6210.95
124_S127_D0.6210.95
90_K97_M0.6190.95
198_R202_C0.6180.95
148_A152_E0.6180.95
177_I182_K0.6170.95
217_G220_Y0.6170.95
15_S38_Y0.6130.95
151_T157_A0.6120.95
176_R180_R0.6110.94
17_R51_Q0.6070.94
18_T49_L0.6070.94
33_L38_Y0.6050.94
213_F216_L0.6040.94
139_V142_L0.6010.94
4_Q20_H0.6010.94
151_T156_S0.6000.94
170_F173_I0.5990.94
201_I204_Y0.5980.94
156_S159_S0.5970.94
98_I102_D0.5950.94
194_V214_R0.5940.94
223_D229_S0.5930.94
51_Q76_R0.5920.94
219_V222_T0.5890.93
31_S44_A0.5860.93
115_N120_F0.5860.93
53_L57_E0.5820.93
123_L128_I0.5820.93
84_K87_L0.5810.93
5_V39_R0.5810.93
12_S56_K0.5800.93
124_S128_I0.5790.93
146_E149_E0.5780.93
196_A199_D0.5740.92
96_E99_Q0.5740.92
116_K121_A0.5740.92
121_A125_M0.5700.92
49_L53_L0.5680.92
200_H203_Q0.5670.92
8_V28_L0.5670.92
185_P194_V0.5670.92
22_Y37_G0.5660.92
143_Y147_I0.5630.92
142_L154_R0.5600.92
195_G198_R0.5590.91
106_L110_G0.5580.91
136_A144_G0.5580.91
15_S230_I0.5580.91
217_G221_I0.5570.91
169_E174_Y0.5560.91
17_R23_D0.5540.91
119_L124_S0.5540.91
166_I170_F0.5540.91
23_D56_K0.5480.91
123_L126_K0.5470.91
221_I224_E0.5460.90
132_Q139_V0.5450.90
220_Y226_F0.5430.90
81_Q85_E0.5400.90
92_Q160_A0.5390.90
210_L217_G0.5380.90
88_M95_D0.5350.90
25_I63_D0.5320.89
162_D203_Q0.5320.89
103_R118_D0.5310.89
160_A163_W0.5310.89
153_K156_S0.5300.89
166_I204_Y0.5300.89
212_I216_L0.5290.89
45_D48_R0.5280.89
168_A172_S0.5240.89
177_I213_F0.5200.88
174_Y179_A0.5190.88
218_E223_D0.5180.88
30_P33_L0.5180.88
219_V223_D0.5170.88
121_A129_E0.5160.88
167_M172_S0.5130.88
140_R145_K0.5120.87
50_Q83_Q0.5110.87
95_D99_Q0.5100.87
135_Y143_Y0.5090.87
23_D52_I0.5080.87
212_I220_Y0.5080.87
176_R193_A0.5070.87
122_G125_M0.5070.87
156_S160_A0.5050.87
23_D32_A0.5030.87
175_R178_A0.5020.86
23_D30_P0.5020.86
150_E153_K0.5010.86
83_Q90_K0.5010.86
202_C206_Y0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qaoA 2 0.5409 100 0.286 Contact Map
1r8eA 2 0.9222 100 0.434 Contact Map
3gp4A 4 0.4903 99.9 0.511 Contact Map
1r8dA 2 0.4241 99.9 0.512 Contact Map
3hh0A 4 0.5097 99.9 0.515 Contact Map
3gpvA 2 0.428 99.9 0.523 Contact Map
2vz4A 2 0.3891 99.9 0.528 Contact Map
4ua1A 2 0.463 99.9 0.528 Contact Map
1q06A 2 0.4708 99.9 0.531 Contact Map
2zhgA 2 0.463 99.9 0.536 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.