GREMLIN Database
YWNB - Uncharacterized protein YwnB
UniProt: P71037 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (202)
Sequences: 51006 (34985)
Seq/√Len: 2461.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A29_A3.1541.00
75_H79_E2.5681.00
19_E190_I2.5591.00
28_T60_F2.3611.00
62_A196_L2.3181.00
191_A208_V2.3061.00
152_P192_V2.2601.00
99_V192_V2.2531.00
19_E193_L2.2361.00
54_A90_D2.1921.00
95_R146_S2.1681.00
30_I47_K2.1461.00
19_E23_R2.0621.00
65_N98_V1.9351.00
28_T43_A1.9221.00
117_D120_E1.9171.00
64_V196_L1.8881.00
4_G60_F1.8681.00
139_L147_W1.8471.00
28_T45_L1.8431.00
150_L195_E1.8311.00
82_R138_D1.7941.00
23_R193_L1.7821.00
190_I194_D1.7551.00
16_I189_A1.7361.00
81_G135_N1.7171.00
6_I65_N1.7061.00
165_S169_G1.6851.00
54_A87_I1.6461.00
133_G137_K1.6411.00
100_G104_S1.6381.00
193_L197_E1.6371.00
79_E82_R1.6161.00
52_L86_S1.6041.00
16_I66_A1.5971.00
23_R197_E1.5691.00
66_A99_V1.5571.00
82_R86_S1.5521.00
172_N177_A1.5491.00
194_D198_H1.5241.00
52_L83_A1.4971.00
5_I17_L1.4941.00
50_F75_H1.4831.00
74_E134_E1.4721.00
16_I64_V1.4721.00
54_A91_A1.4511.00
19_E189_A1.4181.00
19_E22_K1.4141.00
61_D94_T1.4121.00
95_R148_T1.4011.00
26_E43_A1.3961.00
164_G167_Q1.3911.00
3_I25_H1.3571.00
152_P188_Y1.3521.00
89_K143_D1.3481.00
12_A155_F1.3191.00
8_A17_L1.3141.00
17_L29_A1.3081.00
33_N44_I1.2921.00
122_P133_G1.2901.00
99_V152_P1.2871.00
98_V135_N1.2771.00
58_K91_A1.2691.00
25_H197_E1.2491.00
137_K140_Q1.2461.00
183_I188_Y1.2451.00
4_G30_I1.2411.00
128_T132_Q1.2301.00
156_F184_S1.2291.00
171_D175_V1.2221.00
88_L96_L1.2201.00
55_E59_P1.2161.00
113_T117_D1.2141.00
64_V192_V1.2111.00
15_E186_A1.2081.00
63_V88_L1.1841.00
49_V67_F1.1771.00
98_V149_F1.1691.00
57_I60_F1.1681.00
140_Q149_F1.1651.00
29_A42_V1.1641.00
164_G168_K1.1641.00
9_S31_V1.1631.00
150_L192_V1.1601.00
163_T167_Q1.1601.00
130_S134_E1.1591.00
19_E186_A1.1581.00
49_V80_A1.1561.00
116_M120_E1.1481.00
3_I20_A1.1441.00
69_A76_L1.1431.00
151_S205_R1.1381.00
77_H131_N1.1271.00
21_K42_V1.1261.00
97_L150_L1.1121.00
3_I62_A1.1091.00
86_S90_D1.1051.00
6_I84_L1.1031.00
86_S89_K1.1001.00
167_Q170_K1.0991.00
105_L207_T1.0941.00
98_V139_L1.0841.00
113_T120_E1.0831.00
20_A193_L1.0741.00
85_I96_L1.0721.00
18_K22_K1.0691.00
88_L93_H1.0661.00
53_T87_I1.0601.00
33_N36_K1.0591.00
18_K159_A1.0461.00
170_K175_V1.0381.00
11_K157_D1.0371.00
84_L96_L1.0361.00
185_Y189_A1.0331.00
54_A58_K1.0321.00
65_N81_G1.0231.00
21_K41_D1.0171.00
66_A192_V1.0151.00
55_E58_K1.0091.00
63_V84_L0.9941.00
102_A153_A0.9851.00
34_A46_E0.9851.00
45_L59_P0.9821.00
76_L80_A0.9761.00
15_E185_Y0.9721.00
83_A86_S0.9681.00
174_I177_A0.9601.00
136_L151_S0.9591.00
96_L139_L0.9591.00
52_L90_D0.9501.00
190_I193_L0.9491.00
79_E83_A0.9481.00
155_F188_Y0.9441.00
87_I90_D0.9441.00
11_K185_Y0.9371.00
74_E78_V0.9331.00
69_A72_G0.9311.00
31_V44_I0.9291.00
69_A73_Q0.9171.00
148_T195_E0.9121.00
74_E79_E0.9101.00
78_V134_E0.9081.00
57_I91_A0.9001.00
89_K145_I0.8981.00
138_D141_Q0.8981.00
87_I91_A0.8971.00
16_I20_A0.8961.00
194_D197_E0.8901.00
184_S187_D0.8871.00
171_D176_N0.8871.00
140_Q205_R0.8831.00
168_K172_N0.8821.00
45_L56_D0.8811.00
85_I139_L0.8791.00
173_V177_A0.8741.00
163_T168_K0.8691.00
15_E18_K0.8581.00
163_T169_G0.8501.00
30_I56_D0.8491.00
33_N46_E0.8491.00
172_N175_V0.8451.00
140_Q147_W0.8391.00
57_I63_V0.8361.00
151_S207_T0.8341.00
3_I64_V0.8291.00
165_S168_K0.8281.00
114_R120_E0.8281.00
168_K171_D0.8261.00
57_I87_I0.8261.00
89_K144_S0.8241.00
30_I53_T0.8201.00
130_S141_Q0.8201.00
81_G139_L0.8101.00
17_L27_V0.7981.00
170_K173_V0.7981.00
170_K176_N0.7961.00
169_G175_V0.7951.00
73_Q131_N0.7921.00
134_E137_K0.7911.00
33_N38_Q0.7851.00
167_Q171_D0.7831.00
134_E138_D0.7831.00
28_T59_P0.7821.00
15_E19_E0.7811.00
94_T146_S0.7811.00
65_N84_L0.7771.00
32_R48_D0.7751.00
169_G172_N0.7691.00
16_I192_V0.7691.00
171_D177_A0.7621.00
126_L129_A0.7561.00
62_A95_R0.7521.00
100_G136_L0.7521.00
172_N176_N0.7481.00
83_A87_I0.7381.00
169_G177_A0.7381.00
50_F76_L0.7371.00
153_A181_S0.7361.00
72_G76_L0.7351.00
164_G169_G0.7321.00
169_G173_V0.7271.00
85_I138_D0.7201.00
3_I196_L0.7171.00
20_A196_L0.7161.00
6_I67_F0.7161.00
158_P184_S0.7121.00
163_T170_K0.7111.00
189_A193_L0.7101.00
21_K27_V0.7101.00
130_S137_K0.6991.00
163_T166_Y0.6901.00
166_Y169_G0.6861.00
12_A188_Y0.6801.00
25_H61_D0.6761.00
72_G75_H0.6761.00
35_S38_Q0.6661.00
63_V96_L0.6661.00
165_S171_D0.6631.00
81_G85_I0.6621.00
149_F203_N0.6571.00
23_R194_D0.6561.00
124_E129_A0.6561.00
4_G57_I0.6551.00
155_F183_I0.6551.00
74_E130_S0.6521.00
135_N139_L0.6491.00
201_H204_E0.6481.00
14_N159_A0.6481.00
29_A44_I0.6481.00
113_T116_M0.6471.00
23_R190_I0.6461.00
152_P155_F0.6461.00
150_L191_A0.6461.00
147_W203_N0.6381.00
165_S172_N0.6351.00
127_P130_S0.6261.00
53_T83_A0.6261.00
171_D174_I0.6201.00
95_R199_P0.6201.00
112_T120_E0.6181.00
57_I88_L0.6171.00
15_E189_A0.6141.00
52_L87_I0.6141.00
170_K177_A0.6121.00
48_D51_E0.6081.00
137_K141_Q0.6071.00
103_G129_A0.6071.00
187_D190_I0.6071.00
173_V176_N0.6031.00
62_A94_T0.6021.00
25_H62_A0.6011.00
104_S136_L0.5981.00
53_T57_I0.5941.00
27_V31_V0.5941.00
139_L149_F0.5931.00
26_E41_D0.5851.00
146_S201_H0.5841.00
164_G172_N0.5801.00
97_L195_E0.5771.00
33_N37_V0.5771.00
132_Q136_L0.5751.00
149_F205_R0.5741.00
164_G170_K0.5741.00
169_G176_N0.5721.00
169_G174_I0.5701.00
166_Y171_D0.5701.00
97_L192_V0.5691.00
107_V125_Y0.5671.00
104_S151_S0.5661.00
80_A83_A0.5641.00
89_K142_T0.5611.00
124_E133_G0.5591.00
4_G56_D0.5561.00
66_A152_P0.5551.00
34_A38_Q0.5541.00
159_A162_R0.5531.00
130_S133_G0.5511.00
36_K39_E0.5511.00
165_S170_K0.5481.00
14_N18_K0.5461.00
47_K56_D0.5451.00
183_I187_D0.5451.00
167_Q173_V0.5421.00
97_L196_L0.5411.00
104_S122_P0.5381.00
16_I193_L0.5321.00
165_S173_V0.5311.00
43_A59_P0.5261.00
199_P203_N0.5261.00
170_K174_I0.5241.00
166_Y170_K0.5181.00
65_N96_L0.5171.00
18_K186_A0.5171.00
154_A182_Y0.5141.00
74_E131_N0.5131.00
4_G47_K0.5131.00
101_G104_S0.5111.00
56_D60_F0.5101.00
198_H206_F0.5081.00
31_V35_S0.5081.00
168_K177_A0.5021.00
128_T131_N0.5011.00
165_S174_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9859 100 0.229 Contact Map
3rufA 2 0.9859 100 0.235 Contact Map
2pzmA 2 0.9765 100 0.235 Contact Map
3m2pA 2 0.9624 100 0.239 Contact Map
2x4gA 2 0.9531 100 0.239 Contact Map
1rkxA 3 0.9906 100 0.241 Contact Map
2bllA 2 0.9812 100 0.246 Contact Map
2c20A 2 0.9859 100 0.247 Contact Map
4wkgA 5 0.9812 100 0.248 Contact Map
1gy8A 2 1 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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