GREMLIN Database
YWNA - Putative HTH-type transcriptional regulator YwnA
UniProt: P71036 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (127)
Sequences: 1363 (1020)
Seq/√Len: 90.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_S119_E4.1521.00
72_L121_A3.6021.00
70_S124_S3.3341.00
72_L76_R3.1381.00
74_V125_L3.0341.00
126_K130_N2.9121.00
52_T61_S2.7371.00
67_A126_K2.7341.00
113_Q117_E2.7331.00
76_R117_E2.5331.00
31_V38_V2.5021.00
114_R118_N2.4411.00
66_P129_M2.3101.00
37_V40_R2.2891.00
65_D68_D2.2651.00
64_K69_I2.0351.00
52_T63_K1.9991.00
115_A119_E1.8851.00
118_N121_A1.7831.00
8_V31_V1.7661.00
64_K68_D1.7431.00
42_I51_L1.6841.00
62_L69_I1.6621.00
16_I51_L1.6431.00
13_L50_I1.6341.00
104_A128_V1.5841.00
13_L74_V1.5481.00
91_P98_G1.4871.00
15_L26_I1.4821.00
112_V115_A1.4811.00
53_S60_A1.4701.00
108_T128_V1.4420.99
72_L117_E1.4280.99
112_V120_L1.4080.99
17_S129_M1.3260.99
27_I31_V1.3200.99
8_V30_S1.3100.99
64_K73_E1.3080.99
26_I29_D1.2870.99
13_L125_L1.2250.98
112_V116_M1.2230.98
76_R121_A1.2000.98
14_S128_V1.1930.98
62_L66_P1.1920.98
85_F109_F1.1890.98
85_F88_H1.1790.98
99_K104_A1.1760.98
8_V38_V1.1690.98
3_N79_Q1.1640.97
14_S101_I1.1280.97
46_K60_A1.1150.97
13_L62_L1.1150.97
58_P109_F1.1030.97
16_I60_A1.0920.96
119_E122_S1.0800.96
110_E114_R1.0770.96
48_A77_A1.0310.95
18_M129_M1.0080.94
7_A87_V0.9950.94
72_L85_F0.9950.94
120_L123_K0.9750.93
6_L58_P0.9670.93
36_V40_R0.9550.92
92_N99_K0.9530.92
34_N95_C0.9450.92
43_S51_L0.9340.92
25_E29_D0.9330.92
86_A89_E0.9290.91
50_I64_K0.9260.91
74_V77_A0.9210.91
63_K69_I0.9120.91
75_Y113_Q0.8970.90
66_P125_L0.8960.90
44_L79_Q0.8880.89
99_K103_N0.8780.89
106_D110_E0.8680.88
7_A109_F0.8550.88
6_L45_L0.8510.87
43_S47_K0.8470.87
102_Q106_D0.8010.84
30_S98_G0.8000.84
11_H95_C0.7950.83
51_L60_A0.7900.83
94_K122_S0.7630.81
67_A118_N0.7620.81
15_L27_I0.7590.81
21_K53_S0.7580.80
107_E111_S0.7500.80
4_S89_E0.7460.79
19_D61_S0.7440.79
114_R126_K0.7400.79
27_I30_S0.7350.78
50_I69_I0.7300.78
108_T119_E0.7270.78
70_S73_E0.7180.77
25_E46_K0.7080.76
10_I71_L0.7050.75
98_G105_L0.7040.75
18_M27_I0.7010.75
4_S116_M0.7000.75
20_E26_I0.6970.75
47_K68_D0.6950.74
36_V59_G0.6920.74
42_I60_A0.6920.74
4_S37_V0.6910.74
40_R86_A0.6800.73
61_S67_A0.6780.73
73_E110_E0.6770.72
43_S60_A0.6720.72
75_Y80_K0.6690.72
33_T41_M0.6670.71
110_E118_N0.6570.70
83_E87_V0.6560.70
17_S66_P0.6540.70
15_L23_S0.6520.70
22_T27_I0.6520.70
70_S117_E0.6510.70
111_S123_K0.6500.69
65_D69_I0.6490.69
105_L128_V0.6440.69
32_N40_R0.6430.69
6_L16_I0.6400.68
22_T71_L0.6400.68
8_V41_M0.6360.68
4_S8_V0.6350.68
22_T26_I0.6350.68
28_A33_T0.6320.67
10_I105_L0.6320.67
29_D94_K0.6250.66
21_K61_S0.6150.65
8_V88_H0.6130.65
83_E89_E0.6120.65
74_V109_F0.6120.65
38_V53_S0.6110.65
46_K53_S0.6110.65
93_P130_N0.6100.65
3_N6_L0.5970.63
66_P126_K0.5920.62
55_A58_P0.5920.62
78_V98_G0.5920.62
33_T37_V0.5900.62
127_D130_N0.5880.62
73_E76_R0.5870.62
73_E123_K0.5870.62
75_Y82_E0.5860.61
46_K113_Q0.5790.61
12_I16_I0.5780.60
108_T126_K0.5770.60
5_R78_V0.5750.60
3_N55_A0.5740.60
26_I67_A0.5740.60
15_L29_D0.5730.60
33_T59_G0.5730.60
78_V92_N0.5720.60
28_A45_L0.5710.59
4_S7_A0.5700.59
38_V46_K0.5660.59
44_L109_F0.5630.58
33_T40_R0.5590.58
3_N8_V0.5560.57
66_P73_E0.5520.57
32_N41_M0.5500.57
88_H120_L0.5490.57
7_A88_H0.5480.56
15_L97_V0.5460.56
103_N130_N0.5410.55
38_V106_D0.5400.55
112_V119_E0.5400.55
98_G101_I0.5380.55
11_H128_V0.5360.55
42_I59_G0.5330.54
47_K52_T0.5260.53
26_I103_N0.5220.53
34_N78_V0.5220.53
28_A40_R0.5180.52
75_Y84_L0.5170.52
30_S50_I0.5170.52
23_S123_K0.5160.52
33_T87_V0.5160.52
49_D63_K0.5150.52
5_R37_V0.5150.52
59_G120_L0.5120.51
64_K94_K0.5100.51
12_I30_S0.5080.51
28_A128_V0.5080.51
31_V41_M0.5070.51
34_N88_H0.5030.50
51_L59_G0.5010.50
40_R55_A0.5010.50
42_I46_K0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xd7A 2 0.8722 100 0.408 Contact Map
1ylfA 5 0.8872 99.9 0.446 Contact Map
3k69A 2 0.9624 99.9 0.451 Contact Map
4hf1A 2 0.9549 99.9 0.452 Contact Map
4hf0A 3 0.8722 99.9 0.49 Contact Map
3lwfA 5 0.9248 99.9 0.493 Contact Map
4cicA 2 0.8797 99.9 0.509 Contact Map
3t8rA 2 0.8722 99.9 0.529 Contact Map
2y75A 5 0.9248 99.8 0.566 Contact Map
2jscA 2 0.609 97.7 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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