GREMLIN Database
URE2 - Urease subunit beta
UniProt: P71035 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (101)
Sequences: 1542 (774)
Seq/√Len: 77.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_D80_S3.6891.00
47_G96_M3.2611.00
14_T17_E3.0651.00
20_E59_M2.9211.00
59_M83_E2.7901.00
84_I90_I2.6391.00
20_E83_E2.5461.00
19_R85_R2.4781.00
25_T76_Q2.3311.00
23_E78_T2.2731.00
21_I62_D2.2311.00
29_T50_L2.2241.00
47_G94_N2.2061.00
24_V56_A2.2041.00
22_R59_M2.0301.00
57_I97_A2.0241.00
25_T78_T2.0061.00
42_F81_L1.9591.00
89_T100_F1.9541.00
83_E88_K1.9241.00
84_I93_L1.8381.00
60_R84_I1.8271.00
93_L97_A1.7651.00
63_V67_T1.6311.00
21_I80_S1.6071.00
27_K76_Q1.6011.00
26_V42_F1.5911.00
88_K102_D1.5270.99
52_D55_L1.4780.99
2_K5_A1.4650.99
16_N62_D1.4400.99
23_E80_S1.3310.98
95_G98_D1.3190.98
40_F94_N1.3090.98
35_Q72_E1.2680.98
75_E98_D1.2610.97
30_G48_A1.2420.97
8_I11_G1.2180.97
91_R98_D1.2170.97
43_A57_I1.1380.95
44_E95_G1.1230.95
21_I82_V0.9630.89
26_V81_L0.9620.89
32_R35_Q0.9440.88
43_A56_A0.9410.88
21_I59_M0.9370.88
28_N34_I0.9210.87
45_A49_L0.9160.87
21_I83_E0.9080.86
44_E97_A0.9070.86
43_A93_L0.8940.85
43_A96_M0.8910.85
34_I45_A0.8660.84
33_S37_G0.8600.83
24_V55_L0.8420.82
57_I101_I0.8240.80
31_S35_Q0.8190.80
88_K101_I0.8150.80
22_R80_S0.8120.79
40_F44_E0.8120.79
32_R37_G0.8100.79
24_V78_T0.8000.78
75_E95_G0.7990.78
29_T48_A0.7810.77
43_A90_I0.7660.75
42_F51_F0.7580.75
19_R83_E0.7560.74
34_I48_A0.7510.74
41_H93_L0.7480.74
50_L55_L0.7470.74
36_V56_A0.7460.73
31_S72_E0.7420.73
32_R72_E0.7340.72
27_K50_L0.7290.72
40_F93_L0.7190.71
80_S83_E0.7150.70
57_I102_D0.7150.70
93_L98_D0.7100.70
49_L71_F0.7020.69
22_R56_A0.7010.69
33_S68_S0.6990.69
51_F81_L0.6830.67
68_S72_E0.6810.67
31_S40_F0.6810.67
59_M82_V0.6770.66
14_T18_G0.6680.65
7_Q63_V0.6660.65
60_R87_R0.6630.64
25_T89_T0.6620.64
2_K7_Q0.6560.64
35_Q68_S0.6520.63
54_E57_I0.6460.62
15_I64_P0.6430.62
15_I66_G0.6320.61
44_E98_D0.6300.60
33_S60_R0.6260.60
43_A47_G0.6250.60
60_R82_V0.6170.59
24_V87_R0.6170.59
37_G63_V0.6140.59
22_R55_L0.5960.56
35_Q70_R0.5930.56
42_F61_L0.5840.55
16_N60_R0.5820.55
64_P75_E0.5810.54
28_N68_S0.5810.54
90_I93_L0.5810.54
63_V68_S0.5810.54
85_R95_G0.5800.54
36_V49_L0.5800.54
36_V45_A0.5770.54
44_E93_L0.5680.53
43_A54_E0.5670.53
12_T25_T0.5650.52
40_F52_D0.5640.52
26_V79_V0.5640.52
44_E96_M0.5620.52
22_R81_L0.5600.52
40_F45_A0.5570.51
15_I62_D0.5540.51
8_I15_I0.5530.51
44_E91_R0.5500.50
15_I95_G0.5490.50
37_G68_S0.5470.50
31_S37_G0.5460.50
26_V49_L0.5460.50
66_G102_D0.5450.50
16_N37_G0.5440.50
65_S68_S0.5420.49
59_M68_S0.5360.49
29_T45_A0.5350.49
64_P77_K0.5320.48
16_N21_I0.5320.48
8_I52_D0.5290.48
50_L76_Q0.5290.48
87_R100_F0.5280.48
33_S71_F0.5250.47
90_I97_A0.5240.47
7_Q50_L0.5150.46
9_A52_D0.5140.46
23_E54_E0.5100.45
37_G40_F0.5080.45
6_F78_T0.5070.45
15_I49_L0.5060.45
26_V61_L0.5040.45
20_E56_A0.5040.45
57_I94_N0.5040.45
57_I96_M0.5020.44
43_A91_R0.5020.44
14_T34_I0.5020.44
15_I77_K0.5010.44
89_T98_D0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gy7A 3 1 100 0.05 Contact Map
1e9yA 5 1 100 0.051 Contact Map
3qgaA 3 0.9677 100 0.057 Contact Map
4ac7B 1 0.9677 100 0.07 Contact Map
4ep8B 1 0.8145 100 0.121 Contact Map
4phzA 3 0.8871 79.3 0.922 Contact Map
1yewA 3 0.8952 73.3 0.926 Contact Map
3ay2A 1 0.8306 64.5 0.931 Contact Map
1cuoA 1 0.8306 53.5 0.935 Contact Map
2x41A 1 0.879 50.8 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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