GREMLIN Database
CZCR - HTH-type transcriptional regulator CzcR
UniProt: P71025 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (276)
Sequences: 79217 (57449)
Seq/√Len: 3458.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_K74_D3.6751.00
15_H24_E3.3751.00
155_Y280_V2.6161.00
11_C24_E2.5461.00
67_Y81_V2.5311.00
95_G138_L2.3881.00
156_D257_S2.3391.00
91_I120_S2.2381.00
45_T60_E2.2381.00
156_D159_T2.2191.00
159_T257_S2.1981.00
10_K69_N2.1631.00
8_I35_R2.1421.00
221_V228_T2.1401.00
10_K14_H2.0931.00
91_I118_D2.0741.00
163_T232_E2.0621.00
67_Y74_D2.0561.00
109_S278_T2.0251.00
11_C15_H2.0151.00
159_T255_C1.9871.00
222_A243_K1.9851.00
161_K232_E1.9821.00
93_K120_S1.9481.00
11_C14_H1.9231.00
20_G23_K1.9151.00
13_A57_L1.8961.00
10_K65_I1.8681.00
71_I75_V1.8541.00
172_N175_D1.8541.00
8_I32_V1.8521.00
166_T247_H1.8511.00
218_L238_L1.8471.00
182_L226_G1.8351.00
65_I69_N1.8211.00
222_A238_L1.8151.00
14_H69_N1.8081.00
163_T246_C1.8011.00
13_A65_I1.7481.00
180_P208_M1.7441.00
154_Q259_I1.7121.00
63_K81_V1.7011.00
132_K137_E1.6921.00
49_N56_S1.6691.00
15_H20_G1.6521.00
64_M78_L1.6471.00
67_Y70_K1.6181.00
153_E264_K1.5691.00
129_L141_A1.5651.00
17_S20_G1.5451.00
10_K68_V1.5441.00
155_Y262_R1.5391.00
18_I36_I1.5351.00
5_D42_E1.5251.00
5_D35_R1.5201.00
131_K135_N1.5091.00
14_H24_E1.4991.00
5_D38_Q1.4951.00
262_R276_L1.4671.00
28_V31_N1.4611.00
51_H56_S1.4561.00
67_Y77_E1.4461.00
143_I261_I1.4391.00
276_L280_V1.4381.00
11_C25_L1.4351.00
74_D77_E1.4351.00
153_E262_R1.4331.00
110_Y275_L1.4271.00
46_P49_N1.4191.00
9_F65_I1.4061.00
145_G259_I1.4051.00
113_K278_T1.4031.00
132_K138_L1.3991.00
8_I27_Y1.3851.00
179_T227_I1.3851.00
19_T29_Q1.3691.00
71_I78_L1.3581.00
110_Y117_V1.3581.00
93_K122_Q1.3561.00
274_S277_K1.3471.00
87_I116_N1.3451.00
133_V141_A1.3441.00
66_E70_K1.3361.00
89_S116_N1.3341.00
64_M79_E1.3331.00
268_L272_M1.3121.00
191_R195_E1.3111.00
217_I228_T1.3101.00
10_K72_L1.3091.00
260_F276_L1.3051.00
59_P62_R1.3021.00
67_Y78_L1.2951.00
160_E233_S1.2951.00
134_M151_I1.2871.00
140_G260_F1.2801.00
238_L243_K1.2801.00
219_N222_A1.2761.00
27_Y31_N1.2711.00
156_D259_I1.2681.00
109_S113_K1.2391.00
168_N245_Y1.2361.00
111_Y208_M1.2351.00
168_N243_K1.2221.00
63_K66_E1.2211.00
34_A38_Q1.2201.00
140_G272_M1.2111.00
108_A223_L1.2091.00
232_E246_C1.2061.00
63_K67_Y1.2031.00
42_E79_E1.1931.00
111_Y180_P1.1911.00
3_L75_V1.1901.00
124_G128_E1.1831.00
108_A112_K1.1811.00
9_F48_F1.1791.00
9_F13_A1.1731.00
105_T223_L1.1651.00
154_Q261_I1.1401.00
232_E236_M1.1331.00
246_C249_L1.1211.00
70_K77_E1.1211.00
124_G132_K1.1201.00
166_T227_I1.1201.00
171_F175_D1.1171.00
170_T250_P1.1141.00
6_L68_V1.1111.00
34_A37_K1.1091.00
236_M240_V1.1031.00
62_R66_E1.1031.00
180_P206_N1.1011.00
155_Y276_L1.0981.00
169_K245_Y1.0971.00
114_Y274_S1.0971.00
11_C21_A1.0961.00
218_L222_A1.0931.00
120_S210_E1.0831.00
219_N223_L1.0651.00
18_I55_V1.0561.00
71_I74_D1.0561.00
122_Q132_K1.0551.00
37_K41_N1.0541.00
167_S224_G1.0531.00
277_K280_V1.0421.00
35_R38_Q1.0381.00
33_T37_K1.0361.00
165_V246_C1.0341.00
237_H241_Q1.0331.00
134_M149_H1.0241.00
79_E83_L1.0221.00
183_V207_R1.0211.00
273_R277_K1.0151.00
9_F47_L1.0141.00
73_K77_E1.0111.00
161_K255_C1.0091.00
110_Y278_T1.0001.00
263_H266_A0.9991.00
278_T281_E0.9951.00
64_M68_V0.9921.00
124_G129_L0.9921.00
12_V21_A0.9861.00
110_Y114_Y0.9821.00
211_F217_I0.9791.00
109_S112_K0.9771.00
38_Q41_N0.9721.00
4_R7_Q0.9721.00
106_I279_I0.9701.00
12_V18_I0.9691.00
92_L275_L0.9641.00
192_S195_E0.9631.00
182_L217_I0.9551.00
198_L203_V0.9521.00
21_A32_V0.9511.00
75_V79_E0.9501.00
57_L61_G0.9481.00
70_K73_K0.9431.00
8_I25_L0.9371.00
76_E79_E0.9361.00
13_A48_F0.9351.00
27_Y32_V0.9341.00
20_G24_E0.9331.00
165_V235_V0.9231.00
7_Q76_E0.9211.00
9_F39_L0.9201.00
132_K135_N0.9161.00
9_F57_L0.9111.00
16_K56_S0.8971.00
173_I251_E0.8961.00
76_E80_Q0.8951.00
269_T272_M0.8951.00
211_F220_S0.8951.00
164_L227_I0.8891.00
197_W201_E0.8871.00
98_E213_I0.8841.00
60_E63_K0.8821.00
106_I278_T0.8801.00
145_G257_S0.8781.00
45_T82_F0.8771.00
108_A225_L0.8721.00
66_E69_N0.8721.00
153_E156_D0.8691.00
192_S196_Q0.8571.00
113_K281_E0.8561.00
48_F55_V0.8551.00
95_G143_I0.8501.00
77_E81_V0.8471.00
75_V78_L0.8471.00
138_L141_A0.8461.00
60_E82_F0.8451.00
19_T23_K0.8451.00
130_I134_M0.8431.00
122_Q138_L0.8421.00
180_P207_R0.8411.00
238_L241_Q0.8411.00
270_N274_S0.8391.00
90_G271_S0.8391.00
111_Y225_L0.8381.00
51_H54_G0.8351.00
166_T245_Y0.8271.00
29_Q33_T0.8271.00
15_H21_A0.8251.00
14_H65_I0.8241.00
7_Q11_C0.8241.00
25_L32_V0.8231.00
13_A16_K0.8201.00
118_D206_N0.8161.00
16_K54_G0.8131.00
74_D78_L0.8131.00
167_S225_L0.8091.00
9_F64_M0.8051.00
117_V271_S0.8031.00
95_G129_L0.7981.00
4_R35_R0.7981.00
94_I140_G0.7981.00
268_L273_R0.7971.00
62_R65_I0.7941.00
174_E177_S0.7901.00
69_N73_K0.7861.00
172_N250_P0.7851.00
12_V48_F0.7851.00
13_A61_G0.7801.00
16_K62_R0.7781.00
78_L82_F0.7781.00
220_S225_L0.7711.00
12_V32_V0.7681.00
235_V238_L0.7671.00
95_G141_A0.7641.00
68_V71_I0.7631.00
152_L261_I0.7631.00
194_L198_L0.7631.00
5_D8_I0.7581.00
136_H263_H0.7551.00
37_K46_P0.7551.00
7_Q10_K0.7531.00
3_L72_L0.7511.00
49_N58_S0.7511.00
18_I32_V0.7501.00
165_V228_T0.7471.00
274_S278_T0.7441.00
197_W200_D0.7441.00
181_I205_P0.7441.00
193_R197_W0.7361.00
235_V239_A0.7331.00
196_Q200_D0.7331.00
128_E131_K0.7311.00
266_A269_T0.7301.00
110_Y274_S0.7291.00
12_V36_I0.7291.00
277_K281_E0.7241.00
213_I216_T0.7241.00
161_K248_P0.7231.00
140_G275_L0.7231.00
90_G117_V0.7211.00
134_M152_L0.7171.00
165_V230_V0.7161.00
59_P63_K0.7161.00
177_S203_V0.7151.00
49_N54_G0.7081.00
139_D272_M0.7071.00
165_V239_A0.7071.00
185_N210_E0.7021.00
113_K274_S0.7001.00
60_E64_M0.6961.00
231_P234_A0.6941.00
67_Y71_I0.6881.00
175_D178_T0.6871.00
93_K139_D0.6861.00
31_N35_R0.6821.00
128_E132_K0.6821.00
64_M82_F0.6781.00
195_E199_K0.6771.00
123_A212_N0.6771.00
151_I264_K0.6751.00
88_P114_Y0.6751.00
239_A242_G0.6741.00
239_A246_C0.6721.00
93_K138_L0.6651.00
57_L62_R0.6651.00
222_A241_Q0.6651.00
105_T108_A0.6641.00
9_F61_G0.6621.00
170_T248_P0.6621.00
23_K26_N0.6601.00
7_Q72_L0.6581.00
56_S62_R0.6561.00
184_F217_I0.6501.00
40_E50_R0.6491.00
103_L106_I0.6471.00
181_I227_I0.6431.00
77_E80_Q0.6391.00
209_M220_S0.6371.00
118_D210_E0.6361.00
194_L197_W0.6361.00
196_Q199_K0.6331.00
237_H240_V0.6311.00
172_N251_E0.6311.00
144_S256_I0.6291.00
270_N273_R0.6281.00
164_L229_V0.6241.00
174_E201_E0.6231.00
192_S197_W0.6211.00
4_R38_Q0.6201.00
72_L76_E0.6201.00
36_I40_E0.6161.00
73_K76_E0.6151.00
164_L176_F0.6131.00
193_R196_Q0.6121.00
13_A62_R0.6111.00
40_E45_T0.6101.00
140_G276_L0.6041.00
43_L64_M0.6021.00
161_K252_K0.6011.00
211_F216_T0.6011.00
109_S281_E0.6001.00
92_L140_G0.6001.00
12_V17_S0.5991.00
105_T109_S0.5961.00
80_Q84_D0.5951.00
185_N212_N0.5911.00
168_N242_G0.5911.00
178_T206_N0.5831.00
4_R8_I0.5831.00
195_E198_L0.5801.00
45_T49_N0.5781.00
92_L271_S0.5781.00
191_R210_E0.5781.00
114_Y117_V0.5771.00
160_E256_I0.5751.00
68_V72_L0.5751.00
21_A25_L0.5741.00
48_F57_L0.5721.00
133_V152_L0.5711.00
63_K82_F0.5691.00
43_L82_F0.5691.00
190_Y194_L0.5691.00
45_T85_T0.5691.00
101_R104_P0.5681.00
275_L279_I0.5671.00
18_I29_Q0.5611.00
105_T219_N0.5591.00
262_R273_R0.5571.00
89_S118_D0.5561.00
157_V260_F0.5551.00
31_N34_A0.5541.00
43_L46_P0.5491.00
96_T103_L0.5491.00
230_V235_V0.5471.00
81_V84_D0.5471.00
271_S274_S0.5451.00
134_M137_E0.5451.00
104_P108_A0.5451.00
80_Q83_L0.5441.00
27_Y35_R0.5431.00
28_V34_A0.5421.00
162_L229_V0.5421.00
198_L205_P0.5411.00
90_G116_N0.5411.00
46_P60_E0.5401.00
30_S34_A0.5401.00
95_G122_Q0.5381.00
16_K55_V0.5381.00
145_G154_Q0.5361.00
102_I106_I0.5331.00
214_L231_P0.5321.00
123_A213_I0.5311.00
96_T121_L0.5311.00
97_V100_V0.5291.00
217_I221_V0.5281.00
133_V261_I0.5271.00
78_L81_V0.5261.00
38_Q42_E0.5261.00
84_D88_P0.5231.00
108_A111_Y0.5231.00
174_E203_V0.5231.00
101_R215_E0.5231.00
186_Q210_E0.5221.00
118_D208_M0.5201.00
164_L181_I0.5201.00
8_I36_I0.5171.00
243_K246_C0.5171.00
88_P116_N0.5151.00
30_S33_T0.5151.00
57_L65_I0.5151.00
18_I50_R0.5141.00
190_Y193_R0.5131.00
158_Y258_T0.5101.00
131_K137_E0.5091.00
129_L136_H0.5081.00
177_S204_L0.5081.00
6_L64_M0.5031.00
220_S226_G0.5021.00
184_F214_L0.5011.00
249_L252_K0.5011.00
102_I105_T0.5001.00
43_L79_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9861 100 0.1 Contact Map
3fxqA 3 0.9861 100 0.105 Contact Map
1uthA 2 0.7535 100 0.105 Contact Map
1ixcA 4 0.9792 100 0.109 Contact Map
2h98A 2 0.684 100 0.11 Contact Map
1al3A 1 0.7014 100 0.115 Contact Map
3fzvA 4 0.9618 100 0.116 Contact Map
4x6gA 4 1 100 0.117 Contact Map
2h9bA 2 0.684 100 0.117 Contact Map
3szpA 3 0.9722 100 0.123 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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