GREMLIN Database
DIV4A - Septum site-determining protein DivIVA
UniProt: P71021 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 164 (147)
Sequences: 966 (659)
Seq/√Len: 54.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_V53_L5.2931.00
49_K54_D4.5631.00
76_E80_D2.8481.00
133_Q144_K2.8021.00
103_I107_S2.7471.00
42_K47_E2.7311.00
35_D38_I2.4121.00
97_E101_D2.3421.00
95_E99_N2.3251.00
99_N102_R2.1921.00
39_V43_K2.0591.00
101_D105_N2.0441.00
72_L75_Q2.0121.00
15_K22_E2.0051.00
102_R106_E1.9961.00
74_A78_A1.9341.00
43_K47_E1.9271.00
5_P40_L1.8740.99
43_K46_L1.8170.99
82_K88_E1.6980.99
75_Q79_E1.6880.99
90_K94_R1.6880.99
14_T24_E1.6580.99
20_Y26_N1.6500.99
8_I28_F1.6460.99
118_I121_L1.6010.98
17_F21_D1.5990.98
3_L32_V1.5760.98
57_I60_F1.5380.98
105_N109_S1.5160.98
108_L112_R1.5080.97
6_N9_H1.5050.97
106_E110_K1.4690.97
84_N87_K1.4230.96
30_A33_R1.3630.95
120_E124_Q1.3470.95
86_Q90_K1.3440.95
61_A64_E1.3330.95
16_S21_D1.3300.95
11_K33_R1.3130.94
45_E49_K1.3040.94
94_R97_E1.2880.94
26_N30_A1.2870.94
37_E41_R1.2850.94
91_L95_E1.2740.93
87_K91_L1.2720.93
77_A82_K1.2680.93
129_R139_Q1.2580.93
9_H33_R1.2540.93
110_K113_K1.2520.93
105_N108_L1.2500.93
107_S111_S1.2460.93
100_A107_S1.2460.93
141_D144_K1.2420.92
45_E48_A1.2370.92
11_K31_Q1.2250.92
5_P29_L1.2210.92
16_S22_E1.1750.90
78_A85_S1.1710.90
20_Y30_A1.1690.90
13_F25_V1.1580.90
128_F139_Q1.1560.89
92_I96_A1.1290.88
69_K75_Q1.1240.88
93_V97_E1.1200.88
137_E141_D1.1180.88
51_N57_I1.1050.87
24_E29_L1.0860.86
36_Y40_L1.0830.86
8_I36_Y1.0800.86
125_S129_R1.0790.86
79_E83_R1.0730.86
46_L50_V1.0460.84
80_D84_N1.0400.84
42_K133_Q1.0330.83
8_I37_E1.0280.83
21_D27_E0.9880.80
90_K97_E0.9770.80
89_A93_V0.9690.79
13_F30_A0.9650.79
62_N108_L0.9550.78
56_R61_A0.9480.78
60_F64_E0.9360.77
132_F143_L0.9340.77
26_N33_R0.9190.75
67_L81_V0.9070.74
27_E34_K0.9030.74
119_E122_K0.9010.74
76_E143_L0.8940.73
88_E97_E0.8910.73
138_A142_L0.8820.72
89_A96_A0.8710.71
129_R140_L0.8700.71
59_H68_N0.8700.71
125_S128_F0.8610.71
124_Q128_F0.8600.70
64_E67_L0.8550.70
83_R87_K0.8410.69
8_I23_D0.8310.68
137_E140_L0.8220.67
3_L28_F0.8210.67
69_K72_L0.8190.67
3_L9_H0.8180.67
78_A81_V0.8140.66
88_E91_L0.8140.66
70_S73_V0.8120.66
67_L135_L0.8070.66
69_K85_S0.8060.65
49_K52_E0.7940.64
133_Q137_E0.7920.64
67_L70_S0.7910.64
110_K121_L0.7850.63
84_N88_E0.7850.63
42_K46_L0.7830.63
17_F22_E0.7790.63
127_V131_R0.7730.62
118_I128_F0.7710.62
58_G143_L0.7670.62
51_N55_E0.7540.60
81_V85_S0.7540.60
26_N142_L0.7360.58
44_T47_E0.7340.58
5_P12_T0.7300.58
3_L10_N0.7270.57
19_G25_V0.7250.57
38_I42_K0.7200.57
59_H63_I0.7180.57
102_R105_N0.7150.56
104_I108_L0.7040.55
121_L136_I0.7020.55
14_T21_D0.6980.54
108_L134_M0.6970.54
73_V81_V0.6920.54
12_T15_K0.6920.54
67_L85_S0.6910.54
130_T138_A0.6910.54
77_A81_V0.6900.54
98_K102_R0.6890.53
125_S139_Q0.6870.53
123_K127_V0.6860.53
132_F139_Q0.6780.52
21_D35_D0.6720.52
51_N54_D0.6680.51
12_T33_R0.6630.51
73_V128_F0.6560.50
99_N140_L0.6550.50
136_I139_Q0.6500.49
93_V143_L0.6480.49
52_E61_A0.6440.49
9_H16_S0.6410.48
70_S75_Q0.6360.48
68_N72_L0.6340.48
56_R59_H0.6340.48
68_N81_V0.6340.48
20_Y53_L0.6270.47
59_H81_V0.6260.47
42_K49_K0.6260.47
60_F72_L0.6220.46
35_D41_R0.6220.46
48_A52_E0.6210.46
18_R22_E0.6200.46
82_K86_Q0.6190.46
93_V103_I0.6110.45
54_D58_G0.6100.45
131_R139_Q0.6080.45
6_N31_Q0.6070.45
99_N145_N0.6070.45
110_K144_K0.6040.44
5_P10_N0.5960.44
77_A85_S0.5950.43
26_N34_K0.5940.43
6_N120_E0.5920.43
54_D61_A0.5910.43
119_E139_Q0.5910.43
115_A119_E0.5900.43
20_Y141_D0.5890.43
10_N56_R0.5850.42
128_F143_L0.5850.42
41_R48_A0.5840.42
68_N73_V0.5810.42
34_K37_E0.5780.42
66_T90_K0.5720.41
32_V35_D0.5710.41
68_N77_A0.5700.41
15_K39_V0.5650.40
139_Q142_L0.5650.40
62_N94_R0.5650.40
136_I143_L0.5640.40
6_N12_T0.5590.40
99_N106_E0.5580.40
17_F78_A0.5580.40
64_E70_S0.5520.39
83_R134_M0.5520.39
63_I77_A0.5480.39
100_A104_I0.5450.38
111_S118_I0.5420.38
20_Y67_L0.5420.38
28_F48_A0.5410.38
107_S110_K0.5410.38
60_F66_T0.5350.37
64_E85_S0.5350.37
5_P37_E0.5340.37
33_R36_Y0.5300.37
118_I125_S0.5250.36
23_D42_K0.5250.36
3_L26_N0.5240.36
58_G61_A0.5240.36
146_D149_D0.5230.36
3_L35_D0.5220.36
124_Q142_L0.5220.36
3_L7_D0.5210.36
42_K131_R0.5210.36
109_S113_K0.5180.36
59_H71_I0.5110.35
108_L144_K0.5110.35
96_A100_A0.5060.34
93_V105_N0.5040.34
71_I82_K0.5010.34
6_N37_E0.5010.34
112_R116_M0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wujA 2 0.3049 99.7 0.537 Contact Map
2kk7A 1 0.3171 86.4 0.876 Contact Map
3v6iB 1 0.5488 85.4 0.878 Contact Map
3mq9A 4 0.689 82.5 0.882 Contact Map
2dm9A 2 0.2073 82.3 0.882 Contact Map
1i84S 2 0 66 0.897 Contact Map
3v6iA 1 0.6098 65.4 0.897 Contact Map
2dfsA 2 0.7195 64.1 0.898 Contact Map
4xa6A 2 0.811 51.8 0.906 Contact Map
1l2pA 1 0.3476 51.1 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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