GREMLIN Database
YLMH - Putative RNA-binding protein YlmH
UniProt: P71020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (245)
Sequences: 1168 (972)
Seq/√Len: 62.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_N225_D4.4011.00
87_L133_I4.1301.00
243_K247_D3.0601.00
91_N129_A3.0361.00
176_D253_F2.9031.00
46_L71_A2.7881.00
39_D42_E2.7691.00
173_I252_T2.7331.00
190_M235_C2.6941.00
19_A46_L2.5721.00
36_D119_K2.5711.00
59_F71_A2.5641.00
70_R135_S2.4651.00
63_Y66_A2.4361.00
43_Q69_K2.3821.00
10_K13_R2.3341.00
106_L130_V2.3041.00
227_L235_C2.2601.00
221_V227_L2.2351.00
206_L231_G2.2301.00
209_V219_Y2.1651.00
34_L70_R2.1201.00
187_C198_S2.0841.00
89_A161_L2.0801.00
176_D189_S2.0591.00
177_T244_T2.0431.00
88_Q136_A1.9841.00
91_N131_Q1.9511.00
34_L86_E1.9141.00
12_E41_R1.9141.00
190_M253_F1.9051.00
134_V142_V1.8971.00
238_T254_E1.8531.00
183_L209_V1.8501.00
63_Y133_I1.8471.00
43_Q59_F1.8341.00
93_R157_E1.8101.00
191_S229_I1.7961.00
141_F145_Q1.7871.00
91_N157_E1.7460.99
92_V132_L1.6430.99
146_L149_A1.5980.99
207_V229_I1.5960.99
201_L229_I1.5860.99
88_Q139_A1.5820.99
146_L154_V1.5790.99
148_Q153_A1.5550.99
112_G149_A1.5510.99
109_A146_L1.5450.99
209_V221_V1.5440.99
109_A112_G1.5360.99
171_V254_E1.4970.98
139_A158_K1.4940.98
88_Q158_K1.4940.98
74_F80_P1.4400.98
106_L149_A1.4360.98
119_K137_D1.4320.98
149_A154_V1.4230.98
183_L207_V1.4170.98
223_E239_K1.4140.97
140_D143_A1.4100.97
205_G215_E1.4070.97
211_W234_R1.3970.97
119_K138_T1.3810.97
24_R28_E1.3780.97
175_D250_R1.3620.97
181_L237_L1.3570.97
191_S235_C1.3530.97
61_G66_A1.3500.97
236_S254_E1.3430.97
228_S234_R1.3390.97
133_I164_L1.3300.96
99_V152_A1.3300.96
18_Q22_W1.3180.96
110_L132_L1.3160.96
205_G213_V1.3070.96
38_L42_E1.2890.96
105_S109_A1.2860.96
15_F19_A1.2610.95
103_H108_G1.2450.95
60_S161_L1.2410.95
39_D68_R1.2340.94
201_L232_F1.2230.94
125_F130_V1.1790.93
243_K249_W1.1720.93
59_F69_K1.1700.93
177_T246_K1.1670.93
23_K49_V1.1620.92
235_C253_F1.1570.92
90_F134_V1.1550.92
143_A158_K1.1510.92
89_A159_I1.1400.92
16_I45_I1.1050.90
241_E252_T1.1040.90
26_V73_L1.1030.90
110_L142_V1.1030.90
21_E25_I1.0990.90
187_C229_I1.0990.90
148_Q151_K1.0970.90
26_V33_K1.0940.90
58_A74_F1.0810.89
68_R231_G1.0800.89
115_L138_T1.0740.89
17_D21_E1.0720.89
90_F139_A1.0650.89
15_F42_E1.0560.88
67_E114_G1.0550.88
119_K135_S1.0540.88
123_I130_V1.0500.88
107_L117_R1.0480.88
115_L142_V1.0470.88
176_D251_V1.0380.87
58_A85_F1.0330.87
103_H107_L1.0260.87
86_E137_D1.0180.86
179_S248_K1.0170.86
140_D144_A1.0120.86
94_Y106_L1.0090.86
50_T57_L1.0090.86
32_M78_I1.0070.86
242_G250_R1.0070.86
178_V251_V0.9950.85
244_T250_R0.9740.84
244_T247_D0.9730.84
40_P67_E0.9710.84
177_T248_K0.9630.83
106_L129_A0.9600.83
96_D128_T0.9520.83
111_M117_R0.9500.82
174_R192_R0.9480.82
40_P211_W0.9480.82
113_I146_L0.9400.82
92_V106_L0.9380.82
57_L71_A0.9350.81
197_K200_T0.9310.81
90_F137_D0.9180.80
177_T245_K0.9070.79
22_W33_K0.9030.79
237_L253_F0.9020.79
12_E45_I0.8950.78
110_L120_F0.8950.78
103_H117_R0.8930.78
67_E234_R0.8920.78
70_R86_E0.8920.78
85_F149_A0.8910.78
106_L123_I0.8870.78
112_G150_G0.8840.78
106_L113_I0.8820.77
20_L49_V0.8810.77
30_Y77_Y0.8800.77
183_L202_V0.8800.77
226_M234_R0.8790.77
19_A22_W0.8770.77
177_T250_R0.8750.77
90_F132_L0.8720.77
139_A142_V0.8720.77
175_D241_E0.8690.76
133_I161_L0.8690.76
238_T252_T0.8660.76
74_F77_Y0.8650.76
40_P208_K0.8640.76
61_G68_R0.8610.76
186_V221_V0.8610.76
92_V154_V0.8600.76
140_D158_K0.8570.75
112_G148_Q0.8560.75
101_V106_L0.8550.75
175_D252_T0.8550.75
43_Q71_A0.8550.75
139_A143_A0.8480.75
199_Q217_P0.8470.75
208_K234_R0.8450.74
200_T203_K0.8340.73
63_Y124_V0.8330.73
137_D197_K0.8310.73
120_F142_V0.8270.73
191_S232_F0.8270.73
60_S87_L0.8270.73
208_K228_S0.8220.72
181_L240_I0.8200.72
199_Q220_I0.8200.72
131_Q165_N0.8110.71
124_V133_I0.8100.71
179_S185_A0.8080.71
60_S133_I0.8040.71
120_F134_V0.8010.70
42_E118_Q0.7970.70
237_L251_V0.7920.69
38_L43_Q0.7910.69
34_L85_F0.7900.69
206_L230_R0.7890.69
30_Y131_Q0.7820.68
214_V219_Y0.7820.68
193_Q232_F0.7800.68
104_R117_R0.7790.68
107_L111_M0.7780.68
223_E240_I0.7750.68
199_Q203_K0.7740.68
21_E73_L0.7730.68
129_A165_N0.7720.67
138_T202_V0.7650.67
150_G211_W0.7630.67
34_L72_I0.7610.66
183_L214_V0.7600.66
189_S248_K0.7590.66
32_M72_I0.7580.66
67_E70_R0.7550.66
30_Y75_P0.7530.66
187_C191_S0.7510.65
92_V130_V0.7470.65
89_A133_I0.7420.64
94_Y152_A0.7410.64
108_G117_R0.7400.64
35_T38_L0.7400.64
202_V217_P0.7380.64
131_Q159_I0.7360.64
96_D127_E0.7330.63
200_T204_N0.7310.63
35_T70_R0.7310.63
108_G234_R0.7230.62
108_G228_S0.7220.62
189_S253_F0.7220.62
89_A164_L0.7220.62
23_K50_T0.7210.62
92_V156_L0.7210.62
62_G68_R0.7200.62
21_E28_E0.7190.62
138_T141_F0.7160.62
127_E168_A0.7140.61
88_Q138_T0.7120.61
27_Q55_V0.7110.61
50_T71_A0.7090.61
196_Q199_Q0.7070.61
130_V199_Q0.7060.61
93_R128_T0.7040.60
73_L208_K0.7020.60
201_L206_L0.7010.60
78_I84_D0.7000.60
240_I251_V0.6990.60
12_E15_F0.6970.60
20_L24_R0.6930.59
135_S138_T0.6900.59
106_L156_L0.6870.58
223_E251_V0.6850.58
90_F120_F0.6850.58
102_D188_A0.6840.58
208_K211_W0.6830.58
241_E250_R0.6820.58
102_D105_S0.6800.58
175_D244_T0.6790.58
21_E117_R0.6730.57
180_S205_G0.6730.57
32_M80_P0.6720.57
38_L46_L0.6670.56
126_S129_A0.6600.55
193_Q204_N0.6540.55
41_R45_I0.6540.55
12_E42_E0.6530.55
193_Q229_I0.6520.55
173_I254_E0.6500.54
105_S145_Q0.6500.54
134_V159_I0.6450.54
131_Q164_L0.6440.54
132_L146_L0.6430.53
183_L206_L0.6430.53
11_D57_L0.6430.53
115_L120_F0.6390.53
73_L234_R0.6380.53
11_D15_F0.6370.53
39_D178_V0.6340.52
16_I49_V0.6320.52
116_K119_K0.6310.52
103_H234_R0.6300.52
231_G244_T0.6280.52
142_V192_R0.6270.52
197_K244_T0.6250.51
107_L123_I0.6230.51
62_G66_A0.6220.51
100_S155_S0.6220.51
25_I130_V0.6200.51
134_V139_A0.6170.51
227_L237_L0.6160.50
177_T190_M0.6160.50
39_D51_G0.6110.50
12_E100_S0.6110.50
186_V225_D0.6080.50
227_L252_T0.6060.49
176_D190_M0.6020.49
23_K51_G0.6000.49
48_A51_G0.6000.49
188_A197_K0.5990.48
24_R82_E0.5990.48
76_E79_T0.5960.48
174_R177_T0.5950.48
15_F73_L0.5950.48
103_H230_R0.5920.48
190_M247_D0.5900.47
123_I246_K0.5850.47
188_A230_R0.5850.47
39_D228_S0.5840.47
105_S191_S0.5820.47
193_Q197_K0.5800.46
41_R44_V0.5800.46
47_S51_G0.5790.46
77_Y185_A0.5780.46
58_A186_V0.5780.46
136_A140_D0.5770.46
197_K232_F0.5750.46
171_V236_S0.5750.46
172_E192_R0.5740.46
111_M142_V0.5730.46
112_G141_F0.5730.46
62_G133_I0.5730.46
75_P78_I0.5720.45
74_F78_I0.5710.45
55_V78_I0.5710.45
107_L246_K0.5700.45
30_Y41_R0.5700.45
18_Q21_E0.5670.45
52_Q234_R0.5650.45
104_R224_G0.5640.45
104_R155_S0.5630.44
25_I28_E0.5620.44
209_V214_V0.5610.44
15_F45_I0.5610.44
133_I159_I0.5580.44
45_I228_S0.5580.44
45_I75_P0.5580.44
70_R210_N0.5580.44
73_L247_D0.5580.44
190_M229_I0.5570.44
172_E237_L0.5570.44
17_D45_I0.5560.44
103_H228_S0.5530.43
41_R77_Y0.5510.43
155_S221_V0.5450.42
183_L205_G0.5440.42
91_N159_I0.5430.42
95_A98_F0.5430.42
45_I106_L0.5420.42
21_E29_Q0.5350.41
181_L186_V0.5320.41
75_P117_R0.5320.41
94_Y98_F0.5320.41
222_A225_D0.5320.41
19_A71_A0.5310.41
22_W102_D0.5310.41
44_V134_V0.5290.41
120_F138_T0.5280.40
176_D235_C0.5260.40
132_L156_L0.5240.40
114_G141_F0.5200.40
49_V222_A0.5190.39
13_R109_A0.5160.39
143_A149_A0.5160.39
56_G158_K0.5150.39
187_C207_V0.5130.39
237_L240_I0.5130.39
89_A132_L0.5100.39
192_R198_S0.5100.39
173_I203_K0.5090.38
92_V149_A0.5080.38
126_S145_Q0.5070.38
35_T151_K0.5060.38
123_I132_L0.5020.38
110_L163_D0.5020.38
116_K141_F0.5000.37
39_D43_Q0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fphX 1 0.6381 100 0.436 Contact Map
4tp8D 1 0.6498 99 0.859 Contact Map
2k6pA 1 0.2957 99 0.86 Contact Map
3zey6 1 0.6148 98.9 0.864 Contact Map
4bpeD 2 0.607 98.7 0.873 Contact Map
2cqjA 1 0.2646 98.7 0.875 Contact Map
1dm9A 1 0.3152 98.6 0.878 Contact Map
3bbnD 1 0.6304 98.6 0.878 Contact Map
1vioA 2 0.2724 98.6 0.878 Contact Map
3j80J 1 0.6226 98.6 0.878 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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