FABD - BACSU - GREMLIN Contacts

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FABD - Malonyl CoA-acyl carrier protein transacylase

UniProt:	P71019	Sequences: MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKLSSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAGALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLANLNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDACDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIGPGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	317 (285)
Sequences:	15401 (11539)
Seq/√Len:	683.5

ECOLI - FABD
BACSU - FABD PKSD PKSE PKSC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_Q	203_E	3.879	1.00
256_R	259_E	3.273	1.00
132_A	180_S	3.070	1.00
177_E	193_P	2.559	1.00
37_D	43_K	2.534	1.00
8_F	74_L	2.448	1.00
105_S	108_D	2.441	1.00
122_E	211_K	2.430	1.00
249_E	253_S	2.371	1.00
138_D	141_A	2.355	1.00
75_E	78_K	2.295	1.00
258_E	262_N	2.292	1.00
115_K	118_E	2.241	1.00
145_V	186_N	2.180	1.00
139_A	143_K	2.180	1.00
74_L	100_A	2.151	1.00
213_K	245_E	2.115	1.00
206_K	252_Y	2.104	1.00
5_A	269_V	2.030	1.00
67_L	109_A	1.985	1.00
23_Y	34_D	1.980	1.00
169_I	179_A	1.892	1.00
170_S	202_S	1.884	1.00
172_T	204_L	1.869	1.00
231_N	260_S	1.850	1.00
33_F	68_T	1.807	1.00
36_A	106_F	1.797	1.00
180_S	193_P	1.795	1.00
130_A	176_V	1.779	1.00
60_Y	121_N	1.778	1.00
78_K	83_T	1.772	1.00
103_A	224_A	1.740	1.00
7_L	285_V	1.727	1.00
213_K	248_I	1.723	1.00
245_E	249_E	1.720	1.00
173_A	193_P	1.720	1.00
155_L	172_T	1.718	1.00
46_S	50_E	1.683	1.00
32_L	75_E	1.678	1.00
182_L	186_N	1.674	1.00
86_F	269_V	1.657	1.00
265_I	289_N	1.651	1.00
156_V	179_A	1.647	1.00
235_D	263_K	1.642	1.00
32_L	35_E	1.637	1.00
172_T	175_G	1.631	1.00
99_V	109_A	1.631	1.00
58_L	121_N	1.619	1.00
28_A	79_E	1.612	1.00
115_K	215_V	1.612	1.00
35_E	107_K	1.610	1.00
180_S	184_K	1.599	1.00
173_A	177_E	1.575	1.00
70_S	96_S	1.570	1.00
5_A	264_L	1.568	1.00
33_F	48_I	1.567	1.00
229_I	263_K	1.563	1.00
141_A	144_Q	1.557	1.00
71_I	99_V	1.552	1.00
26_V	76_K	1.551	1.00
88_A	260_S	1.551	1.00
39_T	110_V	1.546	1.00
112_T	216_L	1.526	1.00
145_V	183_A	1.515	1.00
14_Q	18_M	1.501	1.00
180_S	191_A	1.493	1.00
130_A	173_A	1.480	1.00
229_I	236_V	1.479	1.00
30_K	34_D	1.462	1.00
6_F	84_P	1.449	1.00
132_A	176_V	1.446	1.00
263_K	267_E	1.431	1.00
159_A	170_S	1.427	1.00
261_I	285_V	1.421	1.00
39_T	107_K	1.418	1.00
20_K	24_E	1.417	1.00
148_K	182_L	1.415	1.00
139_A	256_R	1.413	1.00
155_L	175_G	1.409	1.00
87_T	226_V	1.408	1.00
43_K	46_S	1.398	1.00
229_I	267_E	1.395	1.00
37_D	45_S	1.387	1.00
19_G	69_T	1.381	1.00
137_M	188_A	1.366	1.00
216_L	221_I	1.365	1.00
33_F	72_A	1.363	1.00
114_R	118_E	1.345	1.00
34_D	45_S	1.344	1.00
211_K	214_E	1.339	1.00
213_K	217_D	1.328	1.00
37_D	41_E	1.325	1.00
8_F	100_A	1.309	1.00
143_K	147_D	1.291	1.00
139_A	161_L	1.284	1.00
183_A	188_A	1.283	1.00
88_A	264_L	1.283	1.00
4_I	271_T	1.283	1.00
137_M	142_L	1.264	1.00
47_L	50_E	1.261	1.00
227_P	236_V	1.257	1.00
177_E	181_E	1.253	1.00
53_A	57_T	1.248	1.00
141_A	186_N	1.242	1.00
161_L	258_E	1.239	1.00
4_I	85_D	1.236	1.00
261_I	288_V	1.230	1.00
229_I	260_S	1.210	1.00
237_M	241_A	1.203	1.00
35_E	75_E	1.197	1.00
177_E	180_S	1.196	1.00
134_I	142_L	1.196	1.00
209_A	213_K	1.183	1.00
86_F	264_L	1.178	1.00
130_A	193_P	1.162	1.00
161_L	167_I	1.161	1.00
40_L	114_R	1.159	1.00
214_E	217_D	1.151	1.00
45_S	49_F	1.144	1.00
55_E	58_L	1.133	1.00
182_L	185_E	1.129	1.00
26_V	80_S	1.126	1.00
181_E	185_E	1.123	1.00
211_K	215_V	1.119	1.00
148_K	153_G	1.117	1.00
20_K	49_F	1.115	1.00
209_A	252_Y	1.111	1.00
6_F	275_I	1.108	1.00
272_F	285_V	1.107	1.00
119_F	211_K	1.105	1.00
181_E	184_K	1.100	1.00
206_K	209_A	1.094	1.00
115_K	119_F	1.094	1.00
118_E	122_E	1.088	1.00
31_R	34_D	1.085	1.00
163_C	284_L	1.083	1.00
134_I	183_A	1.082	1.00
31_R	35_E	1.072	1.00
209_A	248_I	1.071	1.00
144_Q	148_K	1.070	1.00
132_A	191_A	1.070	1.00
7_L	88_A	1.069	1.00
60_Y	117_G	1.068	1.00
215_V	218_A	1.062	1.00
21_E	25_Q	1.061	1.00
208_A	251_L	1.058	1.00
55_E	61_N	1.056	1.00
212_L	251_L	1.054	1.00
71_I	96_S	1.049	1.00
119_F	215_V	1.045	1.00
231_N	250_Q	1.043	1.00
36_A	68_T	1.043	1.00
145_V	182_L	1.039	1.00
32_L	72_A	1.038	1.00
23_Y	49_F	1.035	1.00
158_L	167_I	1.031	1.00
134_I	169_I	1.024	1.00
158_L	161_L	1.023	1.00
161_L	254_P	1.022	1.00
6_F	74_L	1.022	1.00
142_L	167_I	1.020	1.00
77_F	275_I	1.020	1.00
119_F	208_A	1.019	1.00
141_A	188_A	1.016	1.00
90_H	162_N	1.012	1.00
157_Q	202_S	1.005	1.00
161_L	259_E	1.000	1.00
223_D	240_K	0.995	1.00
7_L	272_F	0.995	1.00
178_L	182_L	0.994	1.00
239_E	242_D	0.991	1.00
36_A	110_V	0.988	1.00
5_A	272_F	0.985	1.00
228_V	242_D	0.977	1.00
236_V	263_K	0.967	1.00
263_K	266_A	0.967	1.00
111_Y	218_A	0.964	1.00
40_L	110_V	0.961	1.00
148_K	186_N	0.961	1.00
161_L	256_R	0.960	1.00
28_A	32_L	0.959	1.00
95_Y	113_V	0.959	1.00
128_E	173_A	0.957	1.00
29_A	72_A	0.956	1.00
17_G	20_K	0.951	1.00
87_T	228_V	0.946	1.00
210_E	213_K	0.946	1.00
6_F	82_I	0.935	1.00
178_L	181_E	0.933	1.00
145_V	179_A	0.932	1.00
87_T	100_A	0.927	1.00
9_P	70_S	0.926	1.00
67_L	71_I	0.924	1.00
176_V	193_P	0.924	1.00
262_N	266_A	0.923	1.00
76_K	79_E	0.915	1.00
98_L	247_L	0.914	1.00
144_Q	147_D	0.913	1.00
92_L	113_V	0.911	1.00
86_F	229_I	0.894	1.00
27_P	31_R	0.892	1.00
232_V	253_S	0.891	1.00
74_L	78_K	0.891	1.00
223_D	239_E	0.884	1.00
86_F	267_E	0.884	1.00
57_T	195_E	0.878	1.00
75_E	99_V	0.877	1.00
132_A	193_P	0.874	1.00
60_Y	118_E	0.873	1.00
156_V	175_G	0.872	1.00
206_K	248_I	0.865	1.00
67_L	99_V	0.863	1.00
163_C	287_K	0.860	1.00
67_L	113_V	0.858	1.00
5_A	86_F	0.856	1.00
24_E	49_F	0.853	1.00
210_E	214_E	0.850	1.00
54_E	57_T	0.850	1.00
108_D	111_Y	0.847	1.00
165_G	287_K	0.846	1.00
59_T	200_F	0.843	1.00
265_I	272_F	0.841	1.00
164_P	288_V	0.829	1.00
35_E	39_T	0.829	1.00
140_E	143_K	0.827	1.00
175_G	178_L	0.825	1.00
258_E	288_V	0.811	1.00
76_K	80_S	0.811	1.00
136_G	165_G	0.804	1.00
139_A	167_I	0.802	1.00
132_A	169_I	0.801	1.00
142_L	169_I	0.795	1.00
265_I	270_T	0.794	1.00
94_E	231_N	0.793	1.00
113_V	117_G	0.791	1.00
206_K	210_E	0.785	1.00
234_A	260_S	0.782	1.00
34_D	38_E	0.777	1.00
184_K	191_A	0.777	1.00
257_F	285_V	0.771	1.00
19_G	29_A	0.770	1.00
66_L	70_S	0.770	1.00
103_A	221_I	0.770	1.00
32_L	36_A	0.770	1.00
33_F	45_S	0.768	1.00
234_A	259_E	0.767	1.00
137_M	141_A	0.766	1.00
23_Y	30_K	0.766	1.00
75_E	106_F	0.761	1.00
136_G	190_R	0.758	1.00
217_D	244_K	0.755	1.00
48_I	69_T	0.754	1.00
28_A	31_R	0.753	1.00
142_L	146_T	0.750	1.00
104_L	221_I	0.750	1.00
29_A	69_T	0.749	1.00
259_E	262_N	0.746	1.00
108_D	222_K	0.746	1.00
262_N	288_V	0.742	1.00
237_M	242_D	0.733	1.00
261_I	272_F	0.732	1.00
102_G	225_D	0.732	1.00
136_G	188_A	0.730	1.00
11_Q	196_V	0.725	1.00
179_A	183_A	0.722	1.00
112_T	219_C	0.720	1.00
88_A	257_F	0.719	1.00
47_L	61_N	0.719	1.00
52_D	55_E	0.718	1.00
111_Y	115_K	0.718	1.00
233_S	249_E	0.716	1.00
139_A	259_E	0.716	1.00
13_S	66_L	0.715	1.00
29_A	32_L	0.712	1.00
272_F	292_L	0.711	1.00
196_V	200_F	0.710	1.00
42_T	61_N	0.710	1.00
5_A	270_T	0.710	1.00
141_A	165_G	0.710	1.00
265_I	292_L	0.708	1.00
111_Y	215_V	0.707	1.00
233_S	246_K	0.705	1.00
71_I	75_E	0.703	1.00
104_L	112_T	0.702	1.00
44_L	68_T	0.693	1.00
229_I	264_L	0.691	1.00
108_D	219_C	0.689	1.00
83_T	225_D	0.688	1.00
122_E	208_A	0.684	1.00
62_A	66_L	0.683	1.00
95_Y	216_L	0.683	1.00
214_E	218_A	0.682	1.00
205_M	251_L	0.680	1.00
60_Y	64_P	0.676	1.00
37_D	44_L	0.673	1.00
71_I	100_A	0.671	1.00
134_I	191_A	0.669	1.00
230_S	246_K	0.668	1.00
105_S	222_K	0.666	1.00
262_N	292_L	0.665	1.00
4_I	273_I	0.664	1.00
120_M	205_M	0.661	1.00
40_L	64_P	0.660	1.00
265_I	290_R	0.658	1.00
51_G	54_E	0.654	1.00
200_F	251_L	0.653	1.00
38_E	41_E	0.649	1.00
279_K	283_G	0.646	1.00
73_V	275_I	0.645	1.00
144_Q	186_N	0.645	1.00
68_T	110_V	0.640	1.00
154_N	172_T	0.638	1.00
228_V	237_M	0.638	1.00
39_T	111_Y	0.637	1.00
148_K	154_N	0.636	1.00
46_S	55_E	0.634	1.00
23_Y	33_F	0.632	1.00
204_L	207_P	0.630	1.00
283_G	286_K	0.630	1.00
67_L	110_V	0.628	1.00
233_S	237_M	0.628	1.00
92_L	200_F	0.627	1.00
262_N	265_I	0.622	1.00
123_A	205_M	0.620	1.00
99_V	106_F	0.618	1.00
112_T	212_L	0.617	1.00
155_L	178_L	0.616	1.00
9_P	276_G	0.616	1.00
34_D	37_D	0.614	1.00
95_Y	219_C	0.612	1.00
63_Q	116_R	0.611	1.00
27_P	30_K	0.611	1.00
11_Q	63_Q	0.609	1.00
138_D	165_G	0.609	1.00
134_I	137_M	0.608	1.00
140_E	144_Q	0.608	1.00
156_V	169_I	0.606	1.00
143_K	161_L	0.605	1.00
86_F	236_V	0.604	1.00
28_A	76_K	0.603	1.00
35_E	106_F	0.603	1.00
29_A	76_K	0.603	1.00
138_D	142_L	0.602	1.00
106_F	110_V	0.597	1.00
50_E	54_E	0.596	1.00
99_V	104_L	0.596	1.00
146_T	158_L	0.596	1.00
30_K	45_S	0.595	1.00
290_R	293_K	0.593	1.00
67_L	96_S	0.591	1.00
47_L	55_E	0.588	1.00
57_T	62_A	0.586	1.00
289_N	296_A	0.581	1.00
131_M	196_V	0.581	1.00
90_H	255_V	0.578	1.00
260_S	263_K	0.578	1.00
230_S	237_M	0.577	1.00
35_E	38_E	0.576	1.00
203_E	206_K	0.576	1.00
208_A	212_L	0.575	1.00
119_F	122_E	0.575	1.00
221_I	244_K	0.574	1.00
28_A	75_E	0.573	1.00
96_S	99_V	0.572	1.00
174_K	177_E	0.572	1.00
264_L	269_V	0.572	1.00
236_V	267_E	0.570	1.00
192_I	195_E	0.569	1.00
11_Q	120_M	0.569	1.00
141_A	145_V	0.567	1.00
70_S	275_I	0.567	1.00
164_P	258_E	0.567	1.00
120_M	123_A	0.567	1.00
61_N	64_P	0.564	1.00
128_E	172_T	0.562	1.00
23_Y	45_S	0.560	1.00
16_I	53_A	0.559	1.00
232_V	249_E	0.559	1.00
123_A	208_A	0.556	1.00
11_Q	200_F	0.554	1.00
94_E	230_S	0.553	1.00
248_I	252_Y	0.553	1.00
155_L	203_E	0.552	1.00
77_F	82_I	0.551	1.00
133_A	166_Q	0.550	1.00
199_P	204_L	0.549	1.00
133_A	136_G	0.548	1.00
104_L	109_A	0.548	1.00
9_P	278_G	0.548	1.00
131_M	170_S	0.547	1.00
120_M	198_G	0.546	1.00
235_D	259_E	0.546	1.00
74_L	77_F	0.545	1.00
199_P	205_M	0.544	1.00
72_A	76_K	0.542	1.00
169_I	176_V	0.542	1.00
64_P	117_G	0.542	1.00
207_P	210_E	0.539	1.00
74_L	275_I	0.538	1.00
222_K	225_D	0.538	1.00
98_L	103_A	0.536	1.00
139_A	158_L	0.536	1.00
107_K	111_Y	0.535	1.00
160_N	168_V	0.534	1.00
230_S	233_S	0.533	1.00
228_V	241_A	0.533	1.00
119_F	212_L	0.532	1.00
71_I	110_V	0.531	1.00
32_L	106_F	0.526	1.00
274_E	281_L	0.526	1.00
67_L	106_F	0.524	1.00
130_A	177_E	0.518	0.99
9_P	275_I	0.517	0.99
142_L	183_A	0.516	0.99
84_P	226_V	0.516	0.99
84_P	87_T	0.515	0.99
32_L	99_V	0.515	0.99
209_A	249_E	0.515	0.99
123_A	126_A	0.514	0.99
200_F	205_M	0.511	0.99
143_K	254_P	0.508	0.99
104_L	108_D	0.507	0.99
215_V	219_C	0.506	0.99
128_E	207_P	0.505	0.99
105_S	220_D	0.501	0.99
47_L	51_G	0.500	0.99
86_F	263_K	0.500	0.99
289_N	292_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ptwA	1	0.9874	100	0.053	Contact Map
4mz0A	2	0.9685	100	0.059	Contact Map
2qo3A	2	0.9779	100	0.06	Contact Map
3tqeA	1	0.9811	100	0.061	Contact Map
1mlaA	1	0.959	100	0.062	Contact Map
3qatA	2	0.9716	100	0.063	Contact Map
3k89A	1	0.9811	100	0.064	Contact Map
3im8A	1	0.9621	100	0.065	Contact Map
3ezoA	1	0.9621	100	0.066	Contact Map
2h1yA	1	0.9653	100	0.067	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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