GREMLIN Database
FABD - Malonyl CoA-acyl carrier protein transacylase
UniProt: P71019 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (285)
Sequences: 15401 (11539)
Seq/√Len: 683.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_Q203_E3.8791.00
256_R259_E3.2731.00
132_A180_S3.0701.00
177_E193_P2.5591.00
37_D43_K2.5341.00
8_F74_L2.4481.00
105_S108_D2.4411.00
122_E211_K2.4301.00
249_E253_S2.3711.00
138_D141_A2.3551.00
75_E78_K2.2951.00
258_E262_N2.2921.00
115_K118_E2.2411.00
145_V186_N2.1801.00
139_A143_K2.1801.00
74_L100_A2.1511.00
213_K245_E2.1151.00
206_K252_Y2.1041.00
5_A269_V2.0301.00
67_L109_A1.9851.00
23_Y34_D1.9801.00
169_I179_A1.8921.00
170_S202_S1.8841.00
172_T204_L1.8691.00
231_N260_S1.8501.00
33_F68_T1.8071.00
36_A106_F1.7971.00
180_S193_P1.7951.00
130_A176_V1.7791.00
60_Y121_N1.7781.00
78_K83_T1.7721.00
103_A224_A1.7401.00
7_L285_V1.7271.00
213_K248_I1.7231.00
245_E249_E1.7201.00
173_A193_P1.7201.00
155_L172_T1.7181.00
46_S50_E1.6831.00
32_L75_E1.6781.00
182_L186_N1.6741.00
86_F269_V1.6571.00
265_I289_N1.6511.00
156_V179_A1.6471.00
235_D263_K1.6421.00
32_L35_E1.6371.00
172_T175_G1.6311.00
99_V109_A1.6311.00
58_L121_N1.6191.00
28_A79_E1.6121.00
115_K215_V1.6121.00
35_E107_K1.6101.00
180_S184_K1.5991.00
173_A177_E1.5751.00
70_S96_S1.5701.00
5_A264_L1.5681.00
33_F48_I1.5671.00
229_I263_K1.5631.00
141_A144_Q1.5571.00
71_I99_V1.5521.00
26_V76_K1.5511.00
88_A260_S1.5511.00
39_T110_V1.5461.00
112_T216_L1.5261.00
145_V183_A1.5151.00
14_Q18_M1.5011.00
180_S191_A1.4931.00
130_A173_A1.4801.00
229_I236_V1.4791.00
30_K34_D1.4621.00
6_F84_P1.4491.00
132_A176_V1.4461.00
263_K267_E1.4311.00
159_A170_S1.4271.00
261_I285_V1.4211.00
39_T107_K1.4181.00
20_K24_E1.4171.00
148_K182_L1.4151.00
139_A256_R1.4131.00
155_L175_G1.4091.00
87_T226_V1.4081.00
43_K46_S1.3981.00
229_I267_E1.3951.00
37_D45_S1.3871.00
19_G69_T1.3811.00
137_M188_A1.3661.00
216_L221_I1.3651.00
33_F72_A1.3631.00
114_R118_E1.3451.00
34_D45_S1.3441.00
211_K214_E1.3391.00
213_K217_D1.3281.00
37_D41_E1.3251.00
8_F100_A1.3091.00
143_K147_D1.2911.00
139_A161_L1.2841.00
183_A188_A1.2831.00
88_A264_L1.2831.00
4_I271_T1.2831.00
137_M142_L1.2641.00
47_L50_E1.2611.00
227_P236_V1.2571.00
177_E181_E1.2531.00
53_A57_T1.2481.00
141_A186_N1.2421.00
161_L258_E1.2391.00
4_I85_D1.2361.00
261_I288_V1.2301.00
229_I260_S1.2101.00
237_M241_A1.2031.00
35_E75_E1.1971.00
177_E180_S1.1961.00
134_I142_L1.1961.00
209_A213_K1.1831.00
86_F264_L1.1781.00
130_A193_P1.1621.00
161_L167_I1.1611.00
40_L114_R1.1591.00
214_E217_D1.1511.00
45_S49_F1.1441.00
55_E58_L1.1331.00
182_L185_E1.1291.00
26_V80_S1.1261.00
181_E185_E1.1231.00
211_K215_V1.1191.00
148_K153_G1.1171.00
20_K49_F1.1151.00
209_A252_Y1.1111.00
6_F275_I1.1081.00
272_F285_V1.1071.00
119_F211_K1.1051.00
181_E184_K1.1001.00
206_K209_A1.0941.00
115_K119_F1.0941.00
118_E122_E1.0881.00
31_R34_D1.0851.00
163_C284_L1.0831.00
134_I183_A1.0821.00
31_R35_E1.0721.00
209_A248_I1.0711.00
144_Q148_K1.0701.00
132_A191_A1.0701.00
7_L88_A1.0691.00
60_Y117_G1.0681.00
215_V218_A1.0621.00
21_E25_Q1.0611.00
208_A251_L1.0581.00
55_E61_N1.0561.00
212_L251_L1.0541.00
71_I96_S1.0491.00
119_F215_V1.0451.00
231_N250_Q1.0431.00
36_A68_T1.0431.00
145_V182_L1.0391.00
32_L72_A1.0381.00
23_Y49_F1.0351.00
158_L167_I1.0311.00
134_I169_I1.0241.00
158_L161_L1.0231.00
161_L254_P1.0221.00
6_F74_L1.0221.00
142_L167_I1.0201.00
77_F275_I1.0201.00
119_F208_A1.0191.00
141_A188_A1.0161.00
90_H162_N1.0121.00
157_Q202_S1.0051.00
161_L259_E1.0001.00
223_D240_K0.9951.00
7_L272_F0.9951.00
178_L182_L0.9941.00
239_E242_D0.9911.00
36_A110_V0.9881.00
5_A272_F0.9851.00
228_V242_D0.9771.00
236_V263_K0.9671.00
263_K266_A0.9671.00
111_Y218_A0.9641.00
40_L110_V0.9611.00
148_K186_N0.9611.00
161_L256_R0.9601.00
28_A32_L0.9591.00
95_Y113_V0.9591.00
128_E173_A0.9571.00
29_A72_A0.9561.00
17_G20_K0.9511.00
87_T228_V0.9461.00
210_E213_K0.9461.00
6_F82_I0.9351.00
178_L181_E0.9331.00
145_V179_A0.9321.00
87_T100_A0.9271.00
9_P70_S0.9261.00
67_L71_I0.9241.00
176_V193_P0.9241.00
262_N266_A0.9231.00
76_K79_E0.9151.00
98_L247_L0.9141.00
144_Q147_D0.9131.00
92_L113_V0.9111.00
86_F229_I0.8941.00
27_P31_R0.8921.00
232_V253_S0.8911.00
74_L78_K0.8911.00
223_D239_E0.8841.00
86_F267_E0.8841.00
57_T195_E0.8781.00
75_E99_V0.8771.00
132_A193_P0.8741.00
60_Y118_E0.8731.00
156_V175_G0.8721.00
206_K248_I0.8651.00
67_L99_V0.8631.00
163_C287_K0.8601.00
67_L113_V0.8581.00
5_A86_F0.8561.00
24_E49_F0.8531.00
210_E214_E0.8501.00
54_E57_T0.8501.00
108_D111_Y0.8471.00
165_G287_K0.8461.00
59_T200_F0.8431.00
265_I272_F0.8411.00
164_P288_V0.8291.00
35_E39_T0.8291.00
140_E143_K0.8271.00
175_G178_L0.8251.00
258_E288_V0.8111.00
76_K80_S0.8111.00
136_G165_G0.8041.00
139_A167_I0.8021.00
132_A169_I0.8011.00
142_L169_I0.7951.00
265_I270_T0.7941.00
94_E231_N0.7931.00
113_V117_G0.7911.00
206_K210_E0.7851.00
234_A260_S0.7821.00
34_D38_E0.7771.00
184_K191_A0.7771.00
257_F285_V0.7711.00
19_G29_A0.7701.00
66_L70_S0.7701.00
103_A221_I0.7701.00
32_L36_A0.7701.00
33_F45_S0.7681.00
234_A259_E0.7671.00
137_M141_A0.7661.00
23_Y30_K0.7661.00
75_E106_F0.7611.00
136_G190_R0.7581.00
217_D244_K0.7551.00
48_I69_T0.7541.00
28_A31_R0.7531.00
142_L146_T0.7501.00
104_L221_I0.7501.00
29_A69_T0.7491.00
259_E262_N0.7461.00
108_D222_K0.7461.00
262_N288_V0.7421.00
237_M242_D0.7331.00
261_I272_F0.7321.00
102_G225_D0.7321.00
136_G188_A0.7301.00
11_Q196_V0.7251.00
179_A183_A0.7221.00
112_T219_C0.7201.00
88_A257_F0.7191.00
47_L61_N0.7191.00
52_D55_E0.7181.00
111_Y115_K0.7181.00
233_S249_E0.7161.00
139_A259_E0.7161.00
13_S66_L0.7151.00
29_A32_L0.7121.00
272_F292_L0.7111.00
196_V200_F0.7101.00
42_T61_N0.7101.00
5_A270_T0.7101.00
141_A165_G0.7101.00
265_I292_L0.7081.00
111_Y215_V0.7071.00
233_S246_K0.7051.00
71_I75_E0.7031.00
104_L112_T0.7021.00
44_L68_T0.6931.00
229_I264_L0.6911.00
108_D219_C0.6891.00
83_T225_D0.6881.00
122_E208_A0.6841.00
62_A66_L0.6831.00
95_Y216_L0.6831.00
214_E218_A0.6821.00
205_M251_L0.6801.00
60_Y64_P0.6761.00
37_D44_L0.6731.00
71_I100_A0.6711.00
134_I191_A0.6691.00
230_S246_K0.6681.00
105_S222_K0.6661.00
262_N292_L0.6651.00
4_I273_I0.6641.00
120_M205_M0.6611.00
40_L64_P0.6601.00
265_I290_R0.6581.00
51_G54_E0.6541.00
200_F251_L0.6531.00
38_E41_E0.6491.00
279_K283_G0.6461.00
73_V275_I0.6451.00
144_Q186_N0.6451.00
68_T110_V0.6401.00
154_N172_T0.6381.00
228_V237_M0.6381.00
39_T111_Y0.6371.00
148_K154_N0.6361.00
46_S55_E0.6341.00
23_Y33_F0.6321.00
204_L207_P0.6301.00
283_G286_K0.6301.00
67_L110_V0.6281.00
233_S237_M0.6281.00
92_L200_F0.6271.00
262_N265_I0.6221.00
123_A205_M0.6201.00
99_V106_F0.6181.00
112_T212_L0.6171.00
155_L178_L0.6161.00
9_P276_G0.6161.00
34_D37_D0.6141.00
95_Y219_C0.6121.00
63_Q116_R0.6111.00
27_P30_K0.6111.00
11_Q63_Q0.6091.00
138_D165_G0.6091.00
134_I137_M0.6081.00
140_E144_Q0.6081.00
156_V169_I0.6061.00
143_K161_L0.6051.00
86_F236_V0.6041.00
28_A76_K0.6031.00
35_E106_F0.6031.00
29_A76_K0.6031.00
138_D142_L0.6021.00
106_F110_V0.5971.00
50_E54_E0.5961.00
99_V104_L0.5961.00
146_T158_L0.5961.00
30_K45_S0.5951.00
290_R293_K0.5931.00
67_L96_S0.5911.00
47_L55_E0.5881.00
57_T62_A0.5861.00
289_N296_A0.5811.00
131_M196_V0.5811.00
90_H255_V0.5781.00
260_S263_K0.5781.00
230_S237_M0.5771.00
35_E38_E0.5761.00
203_E206_K0.5761.00
208_A212_L0.5751.00
119_F122_E0.5751.00
221_I244_K0.5741.00
28_A75_E0.5731.00
96_S99_V0.5721.00
174_K177_E0.5721.00
264_L269_V0.5721.00
236_V267_E0.5701.00
192_I195_E0.5691.00
11_Q120_M0.5691.00
141_A145_V0.5671.00
70_S275_I0.5671.00
164_P258_E0.5671.00
120_M123_A0.5671.00
61_N64_P0.5641.00
128_E172_T0.5621.00
23_Y45_S0.5601.00
16_I53_A0.5591.00
232_V249_E0.5591.00
123_A208_A0.5561.00
11_Q200_F0.5541.00
94_E230_S0.5531.00
248_I252_Y0.5531.00
155_L203_E0.5521.00
77_F82_I0.5511.00
133_A166_Q0.5501.00
199_P204_L0.5491.00
133_A136_G0.5481.00
104_L109_A0.5481.00
9_P278_G0.5481.00
131_M170_S0.5471.00
120_M198_G0.5461.00
235_D259_E0.5461.00
74_L77_F0.5451.00
199_P205_M0.5441.00
72_A76_K0.5421.00
169_I176_V0.5421.00
64_P117_G0.5421.00
207_P210_E0.5391.00
74_L275_I0.5381.00
222_K225_D0.5381.00
98_L103_A0.5361.00
139_A158_L0.5361.00
107_K111_Y0.5351.00
160_N168_V0.5341.00
230_S233_S0.5331.00
228_V241_A0.5331.00
119_F212_L0.5321.00
71_I110_V0.5311.00
32_L106_F0.5261.00
274_E281_L0.5261.00
67_L106_F0.5241.00
130_A177_E0.5180.99
9_P275_I0.5170.99
142_L183_A0.5160.99
84_P226_V0.5160.99
84_P87_T0.5150.99
32_L99_V0.5150.99
209_A249_E0.5150.99
123_A126_A0.5140.99
200_F205_M0.5110.99
143_K254_P0.5080.99
104_L108_D0.5070.99
215_V219_C0.5060.99
128_E207_P0.5050.99
105_S220_D0.5010.99
47_L51_G0.5000.99
86_F263_K0.5000.99
289_N292_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ptwA 1 0.9874 100 0.053 Contact Map
4mz0A 2 0.9685 100 0.059 Contact Map
2qo3A 2 0.9779 100 0.06 Contact Map
3tqeA 1 0.9811 100 0.061 Contact Map
1mlaA 1 0.959 100 0.062 Contact Map
3qatA 2 0.9716 100 0.063 Contact Map
3k89A 1 0.9811 100 0.064 Contact Map
3im8A 1 0.9621 100 0.065 Contact Map
3ezoA 1 0.9621 100 0.066 Contact Map
2h1yA 1 0.9653 100 0.067 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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