GREMLIN Database
PLSX - Phosphate acyltransferase
UniProt: P71018 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (324)
Sequences: 2534 (1654)
Seq/√Len: 91.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K43_E5.1981.00
317_N320_A4.7801.00
59_D77_N3.6651.00
83_M95_C3.1061.00
182_D197_K2.8771.00
277_S299_D2.8701.00
32_H54_T2.7941.00
27_A304_F2.7571.00
87_V92_A2.7181.00
39_K57_H2.7181.00
38_D41_T2.6301.00
5_V21_V2.5931.00
42_I55_V2.5291.00
38_D57_H2.5081.00
36_V86_E2.4581.00
16_A19_D2.3941.00
85_Q89_E2.3051.00
34_T92_A2.2931.00
25_I52_R2.2161.00
193_F204_F2.1441.00
311_R315_S2.0901.00
63_E66_D2.0591.00
77_N82_L2.0421.00
223_T227_T2.0411.00
204_F207_N2.0281.00
2_R32_H1.9561.00
176_L231_T1.9141.00
186_N189_T1.9061.00
205_I218_A1.8981.00
159_S173_V1.8571.00
253_T256_S1.8351.00
174_G208_V1.8311.00
251_T257_K1.8151.00
146_A154_Y1.8121.00
24_G307_I1.8101.00
162_S166_R1.7981.00
288_K323_Q1.7931.00
119_D149_E1.7811.00
4_A92_A1.7671.00
23_K304_F1.7381.00
24_G31_L1.7371.00
80_M104_L1.7151.00
43_E55_V1.7101.00
163_Q169_T1.7071.00
164_Q321_L1.6911.00
21_V33_I1.6821.00
45_H48_T1.6721.00
159_S163_Q1.6711.00
144_V178_V1.6571.00
208_V218_A1.6521.00
182_D193_F1.6381.00
212_D217_V1.6361.00
56_L91_R1.6281.00
187_E191_Q1.6261.00
255_T265_P1.6231.00
158_G220_V1.5891.00
28_F308_R1.5871.00
36_V58_A1.5791.00
15_K19_D1.5701.00
268_K271_K1.5611.00
123_L293_K1.5551.00
58_A82_L1.5531.00
34_T56_L1.5521.00
54_T91_R1.5521.00
135_F221_V1.5471.00
60_E77_N1.5301.00
2_R93_D1.5281.00
152_V195_I1.5271.00
27_A308_R1.5241.00
28_F311_R1.5161.00
108_G291_V1.5121.00
194_Q198_E1.4911.00
235_L238_S1.4871.00
259_A262_V1.4861.00
7_A35_L1.4861.00
96_I310_A1.4851.00
129_T135_F1.4811.00
170_S203_N1.4741.00
16_A300_S1.4731.00
214_L235_L1.4541.00
227_T230_V1.4511.00
254_L257_K1.4490.99
86_E91_R1.4240.99
82_L85_Q1.4220.99
104_L291_V1.4210.99
278_N301_N1.4180.99
4_A83_M1.4130.99
137_L140_V1.4000.99
213_L231_T1.3940.99
84_A107_A1.3940.99
155_A196_L1.3850.99
15_K45_H1.3740.99
145_D186_N1.3730.99
147_K150_H1.3700.99
127_L137_L1.3570.99
38_D58_A1.3440.99
60_E75_K1.3410.99
172_R205_I1.3320.99
34_T86_E1.3170.99
41_T44_S1.3150.99
248_D273_K1.3000.99
130_V244_K1.2980.99
109_L114_R1.2860.99
281_G292_I1.2810.99
13_A16_A1.2780.99
81_V111_I1.2610.99
30_D311_R1.2590.99
136_L162_S1.2460.98
250_M260_A1.2450.98
168_V172_R1.2440.98
101_T123_L1.2430.98
4_A87_V1.2350.98
294_A306_A1.2310.98
188_L192_T1.2270.98
193_F207_N1.2160.98
25_I53_I1.2120.98
104_L293_K1.2090.98
36_V82_L1.2060.98
176_L221_V1.1950.98
136_L166_R1.1940.98
7_A42_I1.1900.98
191_Q194_Q1.1870.98
250_M263_L1.1870.98
294_A303_V1.1810.98
84_A112_V1.1800.98
125_P140_V1.1570.98
256_S266_K1.1530.97
31_L311_R1.1490.97
173_V202_I1.1470.97
119_D150_H1.1330.97
34_T54_T1.1270.97
159_S202_I1.1260.97
152_V156_I1.1250.97
272_M278_N1.1220.97
254_L258_L1.1150.97
277_S301_N1.1110.97
43_E50_S1.1050.97
2_R34_T1.0900.96
19_D300_S1.0900.96
124_A136_L1.0890.96
25_I33_I1.0860.96
85_Q111_I1.0840.96
17_V303_V1.0810.96
246_M270_M1.0690.96
30_D315_S1.0650.96
211_R276_Y1.0630.96
130_V241_S1.0590.96
212_D215_D1.0570.96
249_V269_E1.0530.96
119_D153_Q1.0530.96
250_M256_S1.0420.95
283_S313_M1.0350.95
294_A298_S1.0330.95
162_S220_V1.0330.95
280_G294_A1.0310.95
98_A303_V1.0300.95
148_P191_Q1.0300.95
148_P192_T1.0260.95
44_S55_V1.0170.95
66_D75_K1.0170.95
320_A323_Q1.0090.95
63_E75_K1.0080.94
129_T216_D1.0060.94
257_K264_K0.9980.94
205_I217_V0.9960.94
298_S302_A0.9880.94
20_G303_V0.9850.94
38_D59_D0.9780.94
292_I310_A0.9740.93
3_I6_D0.9700.93
2_R92_A0.9700.93
23_K300_S0.9650.93
112_V289_A0.9650.93
247_R251_T0.9650.93
162_S168_V0.9640.93
175_L207_N0.9640.93
5_V33_I0.9640.93
13_A19_D0.9590.93
255_T266_K0.9580.93
160_V164_Q0.9560.93
218_A221_V0.9560.93
196_L202_I0.9540.93
84_A95_C0.9520.93
214_L234_T0.9520.93
70_R74_R0.9500.93
82_L86_E0.9480.92
152_V155_A0.9470.92
264_K268_K0.9430.92
208_V221_V0.9430.92
151_L192_T0.9410.92
20_G300_S0.9410.92
249_V252_S0.9400.92
137_L231_T0.9380.92
152_V196_L0.9310.92
86_E92_A0.9310.92
174_G205_I0.9280.92
13_A17_V0.9270.92
138_L158_G0.9260.92
62_I71_A0.9220.91
240_L276_Y0.9210.91
261_A264_K0.9210.91
183_K190_K0.9200.91
18_I22_I0.9200.91
88_A113_G0.9190.91
304_F308_R0.9170.91
21_V35_L0.9130.91
322_I326_V0.9080.91
163_Q325_E0.9060.91
115_I319_A0.9040.91
305_H308_R0.8970.90
62_I78_S0.8940.90
80_M100_N0.8930.90
122_A138_L0.8930.90
258_L262_V0.8920.90
41_T45_H0.8910.90
90_N289_A0.8910.90
7_A18_I0.8890.90
245_M249_V0.8880.90
126_T166_R0.8880.90
19_D23_K0.8870.90
152_V192_T0.8840.90
234_T238_S0.8810.89
193_F197_K0.8800.89
174_G218_A0.8780.89
276_Y297_S0.8770.89
56_L86_E0.8760.89
106_T110_F0.8750.89
112_V291_V0.8750.89
317_N321_L0.8750.89
78_S81_V0.8730.89
148_P195_I0.8680.89
107_A111_I0.8650.89
253_T257_K0.8640.88
259_A266_K0.8630.88
321_L324_E0.8560.88
81_V85_Q0.8560.88
80_M293_K0.8540.88
49_T52_R0.8520.88
263_L266_K0.8510.88
46_L55_V0.8480.88
144_V227_T0.8480.88
324_E327_K0.8470.87
152_V200_A0.8460.87
81_V107_A0.8450.87
95_C104_L0.8450.87
245_M273_K0.8430.87
18_I46_L0.8380.87
42_I46_L0.8360.87
260_A264_K0.8350.87
96_I292_I0.8340.87
214_L238_S0.8340.87
256_S262_V0.8330.87
75_K78_S0.8330.87
87_V289_A0.8320.87
36_V56_L0.8320.87
249_V273_K0.8300.86
129_T133_D0.8260.86
16_A299_D0.8180.86
250_M267_L0.8180.86
180_T293_K0.8170.86
23_K26_E0.8160.85
135_F213_L0.8150.85
96_I306_A0.8100.85
87_V90_N0.8070.85
231_T234_T0.8070.85
10_G13_A0.8010.84
62_I81_V0.8000.84
40_T44_S0.7980.84
43_E47_T0.7980.84
97_S104_L0.7940.84
251_T260_A0.7940.84
192_T196_L0.7940.84
131_S172_R0.7920.84
22_I53_I0.7860.83
280_G298_S0.7860.83
66_D71_A0.7790.83
249_V266_K0.7750.82
22_I46_L0.7720.82
113_G288_K0.7680.82
210_A234_T0.7620.81
126_T136_L0.7620.81
34_T91_R0.7570.81
160_V325_E0.7560.81
33_I53_I0.7520.80
57_H82_L0.7480.80
227_T231_T0.7470.80
177_N293_K0.7430.80
59_D82_L0.7400.79
159_S203_N0.7390.79
126_T162_S0.7390.79
28_F31_L0.7380.79
18_I45_H0.7380.79
5_V96_I0.7370.79
211_R297_S0.7330.79
149_E191_Q0.7320.79
172_R220_V0.7310.79
10_G17_V0.7280.78
94_A310_A0.7270.78
145_D189_T0.7240.78
18_I41_T0.7240.78
17_V21_V0.7240.78
41_T57_H0.7200.78
124_A285_F0.7200.78
130_V215_D0.7190.77
109_L113_G0.7180.77
275_E301_N0.7160.77
167_G312_E0.7140.77
146_A224_D0.7140.77
159_S220_V0.7130.77
178_V230_V0.7130.77
290_P313_M0.7120.77
23_K27_A0.7120.77
180_T210_A0.7050.76
242_I246_M0.7030.76
127_L135_F0.7010.76
172_R217_V0.7010.76
157_M322_I0.7000.76
68_P71_A0.6960.75
80_M95_C0.6950.75
145_D187_E0.6940.75
72_V81_V0.6930.75
84_A108_G0.6910.75
60_E76_K0.6840.74
302_A305_H0.6820.74
25_I51_D0.6800.73
260_A267_L0.6760.73
105_M123_L0.6760.73
66_D100_N0.6740.73
7_A10_G0.6730.73
259_A264_K0.6720.73
150_H154_Y0.6700.72
7_A33_I0.6700.72
149_E153_Q0.6690.72
68_P102_G0.6670.72
255_T262_V0.6660.72
154_Y178_V0.6600.71
250_M266_K0.6580.71
12_H17_V0.6570.71
18_I21_V0.6560.71
72_V107_A0.6550.71
42_I45_H0.6550.71
250_M259_A0.6540.71
105_M146_A0.6540.71
287_L293_K0.6540.71
252_S256_S0.6500.70
172_R212_D0.6500.70
105_M143_N0.6480.70
208_V217_V0.6460.70
177_N189_T0.6460.70
105_M121_P0.6380.69
131_S216_D0.6380.69
172_R218_A0.6370.69
255_T259_A0.6310.68
160_V326_V0.6270.67
172_R219_D0.6250.67
258_L261_A0.6220.67
174_G212_D0.6170.66
320_A324_E0.6160.66
5_V17_V0.6160.66
112_V287_L0.6160.66
313_M318_V0.6160.66
18_I53_I0.6160.66
122_A154_Y0.6150.66
2_R91_R0.6140.66
310_A314_V0.6130.66
250_M253_T0.6120.65
251_T255_T0.6110.65
186_N227_T0.6100.65
308_R312_E0.6100.65
110_F113_G0.6090.65
35_L53_I0.6090.65
165_V318_V0.6060.65
300_S304_F0.6040.64
140_V276_Y0.6040.64
298_S303_V0.6030.64
58_A61_V0.6030.64
256_S259_A0.5980.64
13_A98_A0.5980.64
245_M270_M0.5980.64
24_G28_F0.5960.63
143_N154_Y0.5960.63
299_D302_A0.5950.63
69_V73_R0.5950.63
118_I153_Q0.5940.63
230_V234_T0.5920.63
104_L177_N0.5910.63
276_Y302_A0.5910.63
84_A111_I0.5900.63
10_G14_P0.5900.63
251_T264_K0.5870.62
25_I31_L0.5860.62
67_E70_R0.5860.62
22_I49_T0.5850.62
249_V267_L0.5850.62
3_I94_A0.5830.62
240_L247_R0.5820.62
246_M250_M0.5820.62
45_H55_V0.5810.61
108_G112_V0.5800.61
256_S263_L0.5780.61
107_A280_G0.5780.61
28_F304_F0.5770.61
176_L210_A0.5770.61
23_K301_N0.5760.61
80_M84_A0.5730.60
68_P100_N0.5710.60
312_E315_S0.5700.60
287_L290_P0.5690.60
64_P210_A0.5680.60
90_N288_K0.5630.59
177_N297_S0.5610.59
5_V307_I0.5590.58
245_M248_D0.5590.58
278_N305_H0.5580.58
160_V163_Q0.5570.58
155_A192_T0.5560.58
75_K81_V0.5550.58
308_R311_R0.5540.58
262_V265_P0.5540.58
287_L298_S0.5540.58
143_N146_A0.5540.58
94_A314_V0.5540.58
223_T238_S0.5530.58
168_V171_P0.5520.58
69_V207_N0.5510.57
88_A112_V0.5510.57
4_A95_C0.5500.57
123_L140_V0.5480.57
101_T104_L0.5480.57
15_K48_T0.5460.57
4_A289_A0.5450.57
292_I313_M0.5450.57
36_V83_M0.5440.56
247_R257_K0.5410.56
28_F315_S0.5400.56
160_V322_I0.5400.56
39_K55_V0.5400.56
276_Y298_S0.5390.56
172_R203_N0.5370.55
156_I159_S0.5350.55
252_S269_E0.5330.55
244_K248_D0.5330.55
39_K59_D0.5320.55
251_T254_L0.5300.55
301_N305_H0.5300.55
260_A263_L0.5290.54
43_E48_T0.5280.54
64_P180_T0.5280.54
32_H51_D0.5260.54
84_A87_V0.5260.54
64_P100_N0.5250.54
323_Q327_K0.5250.54
75_K107_A0.5240.54
61_V64_P0.5240.54
258_L263_L0.5240.54
173_V222_V0.5240.54
239_A243_F0.5210.53
316_Q326_V0.5180.53
71_A106_T0.5170.53
25_I50_S0.5170.53
105_M109_L0.5170.53
256_S260_A0.5160.53
126_T135_F0.5160.53
215_D241_S0.5150.52
62_I107_A0.5140.52
177_N303_V0.5140.52
30_D52_R0.5130.52
243_F271_K0.5120.52
292_I309_Q0.5100.52
40_T43_E0.5100.52
135_F158_G0.5100.52
239_A242_I0.5100.52
39_K58_A0.5080.51
259_A263_L0.5080.51
302_A306_A0.5080.51
112_V288_K0.5080.51
93_D314_V0.5070.51
129_T235_L0.5070.51
69_V72_V0.5060.51
115_I326_V0.5060.51
44_S48_T0.5050.51
98_A294_A0.5040.51
131_S217_V0.5030.51
211_R215_D0.5010.51
256_S269_E0.5010.51
2_R54_T0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u7nA 2 0.961 100 0.346 Contact Map
1vi1A 2 0.985 100 0.35 Contact Map
1vmiA 2 0.8108 100 0.58 Contact Map
2af4C 2 0.8318 100 0.583 Contact Map
1td9A 3 0.8138 100 0.605 Contact Map
1r5jA 4 0.8228 100 0.609 Contact Map
3uf6A 2 0.7477 100 0.62 Contact Map
4e4rA 2 0.8138 100 0.621 Contact Map
1ycoA 2 0.7327 100 0.638 Contact Map
3lxyA 2 0.8318 100 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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