GREMLIN Database
GBSB - Alcohol dehydrogenase
UniProt: P71017 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 402 (370)
Sequences: 9978 (6893)
Seq/√Len: 358.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
367_K384_E3.8191.00
363_E388_N3.8141.00
241_K346_D3.5441.00
303_E341_Y3.2271.00
92_E96_K3.1601.00
359_P392_K2.9261.00
85_R168_E2.8841.00
246_D249_D2.8781.00
242_R249_D2.7691.00
90_G117_I2.7681.00
239_Y255_G2.5711.00
383_N386_A2.5551.00
194_V250_L2.5451.00
43_K71_E2.4931.00
59_D63_E2.4811.00
26_I191_E2.4061.00
362_I388_N2.3991.00
77_K89_E2.3701.00
278_M391_Y2.3631.00
351_T354_E2.2801.00
388_N392_K2.2611.00
212_A232_A2.2541.00
31_H34_E2.2221.00
358_S361_M2.1941.00
44_A101_G2.1761.00
231_M234_E2.1761.00
28_A31_H2.1621.00
226_D312_K2.0771.00
188_I257_A2.0731.00
27_G191_E2.0561.00
342_D346_D2.0471.00
209_L233_I2.0031.00
208_A236_A1.9881.00
94_Y144_P1.9581.00
111_M148_T1.9081.00
366_S388_N1.8861.00
73_V97_E1.8801.00
384_E388_N1.8781.00
201_T253_R1.8761.00
237_A320_F1.8411.00
365_L391_Y1.8221.00
339_W342_D1.8151.00
102_L114_A1.8131.00
203_M292_Q1.8041.00
305_N378_N1.7961.00
389_W393_R1.7951.00
79_E86_L1.7821.00
303_E393_R1.7811.00
94_Y121_A1.7791.00
88_N126_S1.7691.00
51_G55_A1.7641.00
62_I66_K1.7171.00
233_I316_I1.7041.00
26_I250_L1.6781.00
59_D62_I1.6781.00
366_S384_E1.6711.00
241_K245_A1.6571.00
42_S100_N1.6381.00
245_A346_D1.6311.00
53_Y76_N1.6031.00
279_S293_C1.5951.00
317_A336_S1.5921.00
73_V93_L1.5891.00
296_A355_Q1.5881.00
193_H253_R1.5881.00
251_E255_G1.5571.00
300_P394_C1.5571.00
363_E384_E1.5481.00
205_G240_I1.5331.00
86_L89_E1.5261.00
89_E92_E1.5241.00
93_L97_E1.5231.00
33_G64_S1.5081.00
285_I364_R1.5081.00
104_A146_L1.5081.00
73_V99_C1.5011.00
198_P202_A1.4891.00
389_W392_K1.4871.00
230_L315_R1.4861.00
36_V101_G1.4841.00
63_E67_E1.4761.00
21_V35_E1.4691.00
26_I254_Y1.4681.00
361_M364_R1.4671.00
338_N342_D1.4501.00
47_V117_I1.4401.00
44_A103_V1.4351.00
364_R368_E1.4271.00
302_M340_M1.4241.00
87_V165_I1.4241.00
66_K72_V1.4151.00
303_E334_K1.3981.00
30_K60_P1.3961.00
35_E38_A1.3951.00
43_K73_V1.3881.00
191_E250_L1.3841.00
104_A114_A1.3631.00
205_G256_M1.3611.00
93_L96_K1.3561.00
193_H257_A1.3531.00
199_H292_Q1.3511.00
278_M297_M1.3481.00
84_V88_N1.3401.00
122_T142_R1.3351.00
62_I72_V1.3341.00
206_I344_V1.3301.00
91_S120_E1.3291.00
306_W334_K1.3291.00
288_V293_C1.3161.00
23_K35_E1.3111.00
35_E185_L1.3001.00
249_D252_A1.2851.00
118_G143_I1.2841.00
334_K338_N1.2811.00
47_V78_V1.2691.00
94_Y99_C1.2641.00
198_P244_F1.2611.00
367_K371_K1.2581.00
300_P393_R1.2541.00
102_L118_G1.2521.00
79_E83_P1.2511.00
147_T185_L1.2461.00
126_S129_D1.2461.00
242_R246_D1.2431.00
304_Y386_A1.2421.00
201_T247_G1.2411.00
125_G129_D1.2341.00
45_L99_C1.2321.00
239_Y242_R1.2271.00
60_P191_E1.2221.00
88_N92_E1.2191.00
28_A187_I1.2151.00
22_I261_M1.2141.00
206_I349_V1.2131.00
362_I392_K1.2111.00
239_Y252_A1.2071.00
286_I361_M1.2061.00
386_A389_W1.2021.00
87_V113_T1.1951.00
385_K388_N1.1941.00
236_A256_M1.1891.00
101_G147_T1.1881.00
92_E95_K1.1861.00
238_H255_G1.1811.00
274_A382_L1.1791.00
94_Y117_I1.1791.00
191_E194_V1.1781.00
125_G130_Y1.1771.00
215_C266_S1.1771.00
364_R367_K1.1731.00
23_K31_H1.1701.00
230_L319_A1.1621.00
230_L234_E1.1621.00
201_T243_A1.1611.00
114_A146_L1.1561.00
83_P86_L1.1491.00
231_M235_Y1.1491.00
43_K97_E1.1471.00
314_A332_A1.1391.00
315_R318_K1.1371.00
43_K98_N1.1261.00
190_P254_Y1.1211.00
227_A231_M1.1211.00
47_V114_A1.1191.00
45_L93_L1.1181.00
91_S95_K1.1161.00
308_G380_R1.1141.00
167_D170_R1.1141.00
153_A201_T1.1071.00
25_G28_A1.0951.00
51_G54_K1.0941.00
27_G30_K1.0891.00
63_E66_K1.0881.00
26_I194_V1.0871.00
307_K380_R1.0851.00
370_M384_E1.0821.00
29_I149_I1.0791.00
306_W333_A1.0741.00
162_W177_G1.0691.00
196_M200_V1.0641.00
278_M387_Y1.0571.00
46_L72_V1.0521.00
36_V147_T1.0461.00
316_I336_S1.0431.00
159_V261_M1.0411.00
198_P245_A1.0411.00
50_P76_N1.0381.00
61_V105_V1.0371.00
49_D52_I1.0341.00
37_A68_A1.0311.00
52_I55_A1.0301.00
50_P77_K1.0291.00
314_A333_A1.0291.00
275_A298_M1.0271.00
285_I368_E1.0241.00
212_A263_A1.0221.00
202_A244_F1.0211.00
85_R169_E1.0181.00
84_V168_E1.0181.00
53_Y59_D1.0181.00
32_T61_V1.0081.00
277_A375_T1.0051.00
385_K389_W1.0001.00
209_L236_A1.0001.00
48_T76_N0.9981.00
242_R251_E0.9961.00
219_K222_Q0.9901.00
46_L58_A0.9801.00
275_A294_V0.9791.00
242_R252_A0.9781.00
45_L94_Y0.9721.00
237_A339_W0.9711.00
29_I60_P0.9681.00
78_V113_T0.9671.00
247_G253_R0.9651.00
234_E318_K0.9641.00
216_Y315_R0.9621.00
83_P168_E0.9591.00
335_A338_N0.9571.00
206_I295_A0.9541.00
304_Y380_R0.9531.00
46_L62_I0.9511.00
199_H203_M0.9481.00
104_A148_T0.9401.00
234_E238_H0.9371.00
215_C226_D0.9371.00
236_A259_A0.9361.00
232_A263_A0.9301.00
91_S117_I0.9301.00
44_A70_I0.9281.00
244_F348_E0.9271.00
226_D229_A0.9251.00
44_A100_N0.9241.00
34_E68_A0.9241.00
235_Y255_G0.9191.00
79_E89_E0.9161.00
148_T183_A0.9151.00
30_K64_S0.9141.00
194_V248_E0.9131.00
81_N287_P0.9121.00
244_F347_L0.9101.00
104_A111_M0.9031.00
111_M150_P0.8971.00
210_A298_M0.8941.00
318_K332_A0.8941.00
53_Y58_A0.8931.00
243_A247_G0.8891.00
27_G189_D0.8871.00
203_M289_A0.8871.00
274_A301_V0.8871.00
324_T332_A0.8861.00
50_P54_K0.8821.00
121_A144_P0.8811.00
87_V116_A0.8771.00
145_P184_H0.8751.00
159_V186_T0.8731.00
268_G271_S0.8721.00
213_I316_I0.8711.00
228_V262_L0.8701.00
21_V38_A0.8701.00
322_I335_A0.8681.00
113_T117_I0.8681.00
91_S121_A0.8671.00
83_P287_P0.8641.00
279_S283_G0.8631.00
215_C229_A0.8591.00
258_Q262_L0.8571.00
213_I233_I0.8531.00
47_V110_S0.8531.00
363_E367_K0.8511.00
60_P192_L0.8511.00
304_Y382_L0.8491.00
52_I58_A0.8481.00
235_Y259_A0.8481.00
243_A252_A0.8461.00
58_A62_I0.8411.00
33_G67_E0.8391.00
148_T186_T0.8381.00
75_F90_G0.8371.00
75_F89_E0.8351.00
53_Y62_I0.8351.00
281_T391_Y0.8351.00
66_K71_E0.8311.00
202_A349_V0.8301.00
302_M313_F0.8291.00
350_P354_E0.8231.00
368_E371_K0.8201.00
118_G146_L0.8191.00
171_E287_P0.8151.00
217_T302_M0.8151.00
118_G144_P0.8141.00
366_S370_M0.8131.00
198_P348_E0.8081.00
341_Y345_E0.8081.00
212_A229_A0.8041.00
29_I191_E0.8031.00
85_R89_E0.7981.00
242_R245_A0.7931.00
209_L213_I0.7921.00
60_P64_S0.7911.00
25_G31_H0.7901.00
119_V181_I0.7861.00
48_T74_L0.7861.00
111_M157_S0.7841.00
331_E335_A0.7831.00
227_A234_E0.7801.00
29_I192_L0.7761.00
36_V103_V0.7731.00
281_T368_E0.7721.00
161_Q179_P0.7711.00
198_P247_G0.7701.00
123_H141_N0.7701.00
32_T149_I0.7671.00
29_I189_D0.7631.00
44_A72_V0.7631.00
23_K28_A0.7571.00
49_D55_A0.7551.00
29_I61_V0.7541.00
274_A387_Y0.7521.00
342_D345_E0.7521.00
239_Y256_M0.7511.00
216_Y230_L0.7511.00
370_M387_Y0.7501.00
60_P63_E0.7491.00
325_S332_A0.7481.00
300_P303_E0.7471.00
251_E254_Y0.7451.00
316_I340_M0.7451.00
234_E315_R0.7431.00
239_Y251_E0.7431.00
153_A257_A0.7381.00
31_H35_E0.7341.00
146_L184_H0.7311.00
196_M204_T0.7301.00
302_M336_S0.7281.00
238_H241_K0.7271.00
45_L75_F0.7261.00
42_S71_E0.7261.00
29_I64_S0.7241.00
221_A312_K0.7210.99
362_I391_Y0.7200.99
207_D290_H0.7180.99
306_W310_P0.7170.99
314_A318_K0.7160.99
237_A241_K0.7160.99
193_H201_T0.7140.99
303_E337_V0.7140.99
335_A339_W0.7130.99
62_I74_L0.7120.99
297_M390_I0.7090.99
322_I339_W0.7080.99
234_E319_A0.7040.99
24_H254_Y0.7040.99
64_S67_E0.7030.99
280_Q372_D0.7010.99
127_V131_E0.7010.99
43_K99_C0.7010.99
276_H290_H0.7010.99
88_N91_S0.6990.99
37_A42_S0.6990.99
52_I57_V0.6990.99
316_I320_F0.6960.99
127_V130_Y0.6950.99
59_D66_K0.6940.99
56_G59_D0.6940.99
279_S294_V0.6890.99
299_G344_V0.6890.99
230_L318_K0.6870.99
188_I261_M0.6860.99
282_L293_C0.6850.99
133_A137_K0.6840.99
45_L97_E0.6810.99
340_M344_V0.6740.99
363_E366_S0.6740.99
217_T313_F0.6740.99
104_A110_S0.6730.99
350_P355_Q0.6730.99
292_Q350_P0.6730.99
205_G347_L0.6690.99
43_K100_N0.6670.99
241_K244_F0.6670.99
49_D54_K0.6660.99
302_M337_V0.6660.99
122_T144_P0.6620.99
250_L254_Y0.6620.99
239_Y243_A0.6620.99
213_I336_S0.6560.99
231_M262_L0.6560.99
87_V117_I0.6540.99
282_L391_Y0.6540.99
116_A163_A0.6530.99
221_A226_D0.6520.99
380_R386_A0.6500.99
153_A193_H0.6500.99
89_E93_L0.6470.99
238_H242_R0.6460.99
343_L347_L0.6440.99
30_K67_E0.6430.99
210_A294_V0.6430.99
220_F271_S0.6420.99
34_E37_A0.6420.99
304_Y383_N0.6410.99
210_A275_A0.6390.99
282_L352_L0.6380.99
323_D332_A0.6370.99
147_T187_I0.6360.99
149_I187_I0.6320.99
322_I336_S0.6310.99
159_V265_L0.6310.99
94_Y102_L0.6300.99
382_L390_I0.6290.99
190_P250_L0.6280.99
295_A344_V0.6250.99
23_K185_L0.6240.99
33_G68_A0.6230.99
216_Y312_K0.6230.99
288_V355_Q0.6230.99
233_I237_A0.6220.98
285_I361_M0.6180.98
66_K69_G0.6180.98
382_L387_Y0.6170.98
24_H258_Q0.6160.98
207_D276_H0.6160.98
30_K191_E0.6120.98
88_N120_E0.6110.98
33_G37_A0.6100.98
132_A137_K0.6090.98
213_I298_M0.6090.98
315_R319_A0.6080.98
243_A256_M0.6080.98
46_L105_V0.6080.98
219_K377_G0.6080.98
163_A176_T0.6060.98
57_V192_L0.6030.98
47_V90_G0.6020.98
34_E38_A0.6020.98
103_V147_T0.6010.98
303_E306_W0.6000.98
26_I251_E0.5990.98
36_V65_L0.5960.98
382_L386_A0.5950.98
116_A165_I0.5950.98
35_E39_L0.5930.98
235_Y262_L0.5920.98
357_V362_I0.5910.98
310_P333_A0.5910.98
143_I184_H0.5890.98
274_A277_A0.5890.98
16_F262_L0.5890.98
142_R180_L0.5880.98
317_A322_I0.5880.98
88_N127_V0.5880.98
205_G236_A0.5870.98
345_E354_E0.5840.98
271_S377_G0.5810.98
162_W175_N0.5810.98
216_Y226_D0.5800.98
303_E338_N0.5790.98
120_E124_E0.5780.98
241_K343_L0.5770.98
264_G267_Y0.5760.98
81_N109_S0.5760.98
123_H143_I0.5750.97
65_L72_V0.5740.97
22_I186_T0.5740.97
55_A58_A0.5720.97
299_G341_Y0.5710.97
206_I347_L0.5690.97
150_P260_A0.5680.97
289_A292_Q0.5670.97
61_V64_S0.5670.97
292_Q349_V0.5660.97
57_V105_V0.5650.97
122_T143_I0.5650.97
150_P188_I0.5650.97
119_V139_L0.5630.97
45_L73_V0.5630.97
310_P313_F0.5620.97
338_N341_Y0.5610.97
190_P257_A0.5610.97
277_A374_Q0.5610.97
285_I365_L0.5610.97
218_M377_G0.5590.97
79_E287_P0.5590.97
50_P53_Y0.5580.97
37_A70_I0.5570.97
124_E130_Y0.5570.97
352_L357_V0.5550.97
211_H290_H0.5550.97
39_L147_T0.5540.97
194_V253_R0.5530.97
33_G36_V0.5520.97
40_G100_N0.5510.97
274_A378_N0.5510.97
128_L169_E0.5510.97
219_K223_P0.5510.97
36_V70_I0.5500.97
93_L99_C0.5500.97
71_E97_E0.5440.97
95_K121_A0.5430.96
332_A335_A0.5410.96
23_K187_I0.5400.96
359_P362_I0.5390.96
211_H263_A0.5360.96
239_Y259_A0.5360.96
94_Y97_E0.5350.96
318_K321_G0.5350.96
112_D290_H0.5340.96
362_I366_S0.5320.96
116_A176_T0.5320.96
240_I343_L0.5310.96
30_K63_E0.5310.96
369_A391_Y0.5290.96
81_N283_G0.5290.96
101_G145_P0.5280.96
195_S248_E0.5280.96
53_Y74_L0.5260.96
267_Y272_A0.5260.96
235_Y239_Y0.5250.96
366_S387_Y0.5250.96
304_Y389_W0.5240.96
333_A336_S0.5240.96
48_T110_S0.5240.96
344_V347_L0.5220.96
280_Q283_G0.5220.96
200_V204_T0.5210.96
173_K290_H0.5210.96
273_G377_G0.5210.96
278_M369_A0.5210.96
294_V297_M0.5200.95
353_E359_P0.5200.95
344_V349_V0.5190.95
213_I302_M0.5190.95
237_A343_L0.5180.95
280_Q374_Q0.5170.95
20_T182_A0.5170.95
313_F336_S0.5160.95
87_V91_S0.5140.95
58_A105_V0.5130.95
311_E314_A0.5130.95
32_T64_S0.5100.95
319_A322_I0.5100.95
86_L113_T0.5080.95
296_A352_L0.5060.95
311_E315_R0.5060.95
219_K381_D0.5050.95
296_A299_G0.5050.95
233_I319_A0.5050.95
304_Y390_I0.5040.95
278_M390_I0.5020.95
53_Y56_G0.5020.95
292_Q355_Q0.5000.94
161_Q268_G0.5000.94
295_A349_V0.5000.94
123_H140_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9478 100 0.143 Contact Map
3bfjA 5 0.9453 100 0.145 Contact Map
4fr2A 2 0.9453 100 0.156 Contact Map
1rrmA 2 0.9502 100 0.157 Contact Map
3zdrA 2 0.9502 100 0.174 Contact Map
1vljA 2 0.9552 100 0.175 Contact Map
4qgsA 2 0.9204 100 0.207 Contact Map
1o2dA 1 0.893 100 0.214 Contact Map
3iv7A 2 0.8657 100 0.247 Contact Map
3w5sA 2 0.8632 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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