GREMLIN Database
BETB - Betaine aldehyde dehydrogenase
UniProt: P71016 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 490 (454)
Sequences: 36465 (21902)
Seq/√Len: 1027.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
293_D396_S4.9001.00
237_R241_G3.5601.00
293_D394_T3.1091.00
265_E302_E3.0661.00
296_H394_T2.9371.00
21_S33_T2.8791.00
353_K367_E2.7801.00
50_R219_D2.7641.00
260_K292_E2.7051.00
340_I379_R2.6081.00
269_D306_R2.6061.00
375_N378_M2.6031.00
328_A332_A2.5861.00
185_K188_K2.5681.00
339_E343_E2.4881.00
300_L392_V2.4601.00
260_K294_A2.4571.00
80_D83_E2.4121.00
21_S30_E2.3871.00
418_S424_C2.3701.00
78_R111_Q2.3101.00
191_E197_K2.2541.00
335_E339_E2.1801.00
38_G41_D2.1791.00
81_L104_D2.1561.00
76_L192_E2.1421.00
50_R221_D2.1361.00
338_V366_Y2.1341.00
82_E100_K2.1291.00
73_I190_M2.0991.00
409_I455_Q2.0731.00
340_I344_E2.0271.00
178_I327_S2.0181.00
139_E474_K2.0011.00
398_E423_K1.9981.00
347_K373_N1.9791.00
212_D216_V1.9791.00
335_E354_R1.9531.00
216_V238_A1.9501.00
83_E185_K1.9411.00
335_E366_Y1.9231.00
256_N271_A1.9211.00
298_Q302_E1.9211.00
304_V308_K1.9161.00
426_R430_R1.9131.00
349_E372_S1.9071.00
138_R468_E1.9001.00
234_K237_R1.8631.00
233_K455_Q1.8431.00
325_L334_V1.8301.00
69_I195_V1.8101.00
76_L79_R1.8101.00
80_D192_E1.7931.00
342_I348_L1.7921.00
261_D423_K1.7901.00
47_A219_D1.7891.00
43_I213_E1.7831.00
381_V393_E1.7661.00
290_L404_L1.7401.00
30_E33_T1.7261.00
43_I47_A1.7041.00
76_L193_A1.6981.00
432_R454_K1.6871.00
138_R471_T1.6601.00
71_L111_Q1.6371.00
87_L185_K1.6351.00
347_K372_S1.6331.00
304_V349_E1.6261.00
187_F202_L1.6231.00
54_D57_E1.6211.00
396_S400_E1.6181.00
400_E403_E1.6181.00
96_L100_K1.6051.00
376_S404_L1.6041.00
292_E395_F1.6021.00
78_R107_A1.5941.00
307_A370_I1.5791.00
371_F380_I1.5761.00
62_S65_E1.5751.00
76_L189_L1.5701.00
301_A305_K1.5621.00
296_H300_L1.5581.00
302_E305_K1.5561.00
336_K379_R1.5551.00
398_E426_R1.5431.00
271_A299_F1.5411.00
110_F162_A1.5391.00
328_A364_F1.5371.00
19_I33_T1.5361.00
276_F307_A1.5341.00
72_K75_E1.5301.00
75_E79_R1.5261.00
268_V302_E1.5171.00
290_L401_V1.5101.00
206_P209_T1.5061.00
53_F59_S1.4961.00
264_L302_E1.4821.00
170_T199_V1.4801.00
61_L65_E1.4791.00
65_E68_K1.4781.00
379_R383_E1.4731.00
60_S430_R1.4721.00
29_E362_N1.4621.00
259_F423_K1.4561.00
81_L100_K1.4551.00
86_E90_L1.4521.00
290_L395_F1.4361.00
188_K192_E1.4311.00
43_I217_N1.4301.00
306_R309_R1.4281.00
270_Q417_W1.4261.00
297_D394_T1.4241.00
339_E342_I1.4221.00
74_A111_Q1.4161.00
137_I429_A1.4141.00
71_L118_D1.4141.00
311_K319_E1.4121.00
296_H372_S1.4111.00
289_L390_L1.4071.00
400_E404_L1.4051.00
271_A289_L1.4041.00
298_Q301_A1.3941.00
291_V299_F1.3891.00
348_L371_F1.3841.00
82_E86_E1.3801.00
23_I30_E1.3761.00
80_D185_K1.3731.00
414_G433_M1.3721.00
116_L119_K1.3681.00
18_Q36_E1.3651.00
110_F158_S1.3501.00
334_V387_G1.3471.00
260_K423_K1.3431.00
146_Q171_I1.3371.00
86_E316_F1.3361.00
331_R335_E1.3331.00
41_D44_K1.3321.00
344_E379_R1.3201.00
222_L247_A1.3191.00
236_M458_F1.3091.00
28_Q362_N1.3091.00
399_E430_R1.2901.00
332_A336_K1.2881.00
337_Y385_V1.2881.00
24_N27_N1.2871.00
395_F404_L1.2861.00
328_A331_R1.2801.00
75_E111_Q1.2781.00
297_D301_A1.2781.00
259_F395_F1.2661.00
300_L304_V1.2581.00
89_S99_S1.2571.00
157_A173_M1.2551.00
257_I401_V1.2521.00
331_R354_R1.2521.00
305_K308_K1.2501.00
259_F427_V1.2491.00
187_F200_A1.2451.00
311_K321_E1.2451.00
308_K350_T1.2431.00
292_E397_S1.2411.00
331_R366_Y1.2401.00
53_F170_T1.2291.00
336_K340_I1.2261.00
295_I298_Q1.2231.00
302_E306_R1.2211.00
212_D238_A1.2091.00
36_E206_P1.2081.00
47_A51_R1.2071.00
74_A78_R1.2061.00
377_D382_Q1.2021.00
465_I468_E1.2011.00
402_I427_V1.2001.00
397_S400_E1.1951.00
464_K468_E1.1931.00
292_E295_I1.1861.00
138_R473_V1.1761.00
86_E96_L1.1631.00
123_E464_K1.1631.00
305_K309_R1.1551.00
61_L69_I1.1551.00
39_R213_E1.1541.00
46_I220_V1.1491.00
135_K425_E1.1481.00
376_S407_D1.1471.00
46_I219_D1.1471.00
303_L390_L1.1451.00
428_A476_V1.1401.00
313_G320_T1.1401.00
300_L372_S1.1401.00
89_S315_G1.1381.00
141_I222_L1.1361.00
234_K238_A1.1351.00
414_G436_V1.1281.00
184_I204_L1.1261.00
424_C438_I1.1241.00
198_G201_N1.1231.00
190_M200_A1.1131.00
399_E403_E1.1121.00
212_D234_K1.1101.00
299_F303_L1.1101.00
84_L185_K1.1061.00
230_E234_K1.1051.00
72_K76_L1.1011.00
20_R36_E1.0991.00
46_I217_N1.0981.00
48_A201_N1.0971.00
42_A210_V1.0871.00
399_E426_R1.0851.00
346_A371_F1.0811.00
355_P367_E1.0811.00
177_E208_A1.0791.00
231_T234_K1.0781.00
177_E206_P1.0781.00
356_E361_Q1.0771.00
382_Q409_I1.0741.00
451_G460_R1.0741.00
236_M246_I1.0721.00
256_N286_G1.0721.00
71_L115_G1.0721.00
300_L349_E1.0701.00
460_R472_E1.0651.00
465_I473_V1.0641.00
73_I195_V1.0641.00
32_A181_L1.0601.00
28_Q364_F1.0581.00
36_E209_T1.0571.00
257_I427_V1.0541.00
308_K367_E1.0491.00
73_I189_L1.0481.00
341_G371_F1.0461.00
161_I200_A1.0451.00
402_I430_R1.0421.00
145_G220_V1.0371.00
24_N314_N1.0341.00
304_V350_T1.0301.00
146_Q224_S1.0291.00
161_I171_I1.0291.00
340_I343_E1.0241.00
344_E378_M1.0211.00
73_I110_F1.0181.00
257_I405_A1.0171.00
382_Q407_D1.0171.00
57_E61_L1.0111.00
420_D423_K1.0061.00
213_E217_N1.0051.00
263_D419_K1.0041.00
26_F315_G1.0001.00
331_R364_F0.9971.00
263_D266_V0.9961.00
67_G118_D0.9961.00
152_Y282_V0.9941.00
395_F401_V0.9921.00
123_E465_I0.9881.00
106_I158_S0.9881.00
266_V270_Q0.9861.00
84_L189_L0.9841.00
188_K191_E0.9831.00
117_A166_A0.9831.00
233_K243_V0.9821.00
272_L306_R0.9801.00
50_R54_D0.9741.00
310_I322_S0.9711.00
398_E427_V0.9701.00
85_A100_K0.9681.00
177_E207_G0.9671.00
83_E86_E0.9651.00
143_V170_T0.9651.00
52_A170_T0.9641.00
336_K339_E0.9571.00
374_C378_M0.9561.00
71_L114_A0.9531.00
141_I245_K0.9531.00
137_I476_V0.9531.00
54_D403_E0.9531.00
39_R43_I0.9521.00
453_Y472_E0.9521.00
253_K287_S0.9491.00
351_G367_E0.9451.00
403_E407_D0.9431.00
314_N317_H0.9421.00
39_R209_T0.9401.00
80_D188_K0.9401.00
54_D432_R0.9391.00
76_L80_D0.9381.00
79_R192_E0.9351.00
145_G214_L0.9351.00
184_I202_L0.9311.00
265_E298_Q0.9301.00
80_D189_L0.9291.00
274_A286_G0.9201.00
415_A441_F0.9191.00
236_M240_S0.9191.00
90_L316_F0.9171.00
24_N90_L0.9161.00
144_C222_L0.9161.00
351_G369_T0.9151.00
106_I154_L0.9141.00
216_V241_G0.9111.00
425_E429_A0.9081.00
337_Y340_I0.9081.00
68_K72_K0.9071.00
334_V389_V0.9021.00
134_S448_A0.9011.00
92_T179_T0.8991.00
67_G71_L0.8941.00
63_G67_G0.8911.00
264_L268_V0.8911.00
255_P414_G0.8911.00
44_K48_A0.8851.00
178_I329_E0.8851.00
275_V287_S0.8841.00
236_M239_A0.8831.00
139_E429_A0.8811.00
187_F191_E0.8811.00
139_E453_Y0.8801.00
334_V385_V0.8781.00
256_N417_W0.8771.00
23_I364_F0.8771.00
59_S432_R0.8741.00
233_K237_R0.8741.00
135_K478_R0.8731.00
60_S429_A0.8721.00
94_K102_D0.8671.00
259_F418_S0.8651.00
296_H392_V0.8651.00
42_A145_G0.8601.00
184_I188_K0.8571.00
414_G431_L0.8541.00
167_A471_T0.8501.00
143_V220_V0.8501.00
332_A335_E0.8501.00
259_F398_E0.8481.00
221_D432_R0.8461.00
393_E404_L0.8461.00
24_N29_E0.8421.00
77_I106_I0.8411.00
297_D300_L0.8381.00
337_Y379_R0.8361.00
223_I239_A0.8351.00
58_W199_V0.8351.00
74_A114_A0.8351.00
448_A475_H0.8321.00
228_G231_T0.8301.00
40_E44_K0.8261.00
421_I424_C0.8251.00
26_F365_F0.8251.00
245_K472_E0.8251.00
346_A378_M0.8231.00
268_V303_L0.8211.00
57_E60_S0.8211.00
54_D60_S0.8181.00
44_K47_A0.8161.00
268_V306_R0.8131.00
342_I371_F0.8121.00
48_A198_G0.8101.00
376_S393_E0.8101.00
141_I472_E0.8091.00
329_E332_A0.8091.00
173_M183_T0.8091.00
164_A171_I0.8071.00
20_R206_P0.8071.00
40_E43_I0.8061.00
301_A304_V0.8051.00
175_P204_L0.8051.00
67_G114_A0.8041.00
49_A201_N0.8031.00
37_G41_D0.8031.00
157_A161_I0.8031.00
71_L75_E0.8031.00
163_P466_G0.8001.00
236_M243_V0.7991.00
402_I406_N0.7961.00
160_K461_E0.7941.00
268_V299_F0.7931.00
158_S186_V0.7931.00
78_R81_L0.7891.00
52_A199_V0.7881.00
208_A212_D0.7831.00
267_A271_A0.7811.00
232_G250_L0.7781.00
28_Q328_A0.7771.00
233_K241_G0.7741.00
338_V389_V0.7741.00
141_I169_N0.7731.00
433_M436_V0.7721.00
401_V404_L0.7701.00
97_E321_E0.7691.00
31_I90_L0.7681.00
416_V427_V0.7651.00
395_F400_E0.7651.00
90_L181_L0.7631.00
205_G210_V0.7611.00
123_E126_S0.7611.00
92_T326_I0.7581.00
264_L295_I0.7571.00
232_G248_L0.7551.00
341_G385_V0.7551.00
195_V199_V0.7541.00
229_I455_Q0.7511.00
258_V299_F0.7501.00
223_I235_I0.7481.00
89_S96_L0.7481.00
78_R104_D0.7481.00
372_S394_T0.7481.00
154_L182_T0.7481.00
317_H320_T0.7471.00
69_I193_A0.7461.00
255_P405_A0.7451.00
64_L118_D0.7451.00
70_V166_A0.7441.00
345_G378_M0.7431.00
51_R54_D0.7401.00
37_G45_A0.7391.00
356_E362_N0.7381.00
342_I353_K0.7361.00
292_E398_E0.7361.00
211_G215_A0.7351.00
210_V213_E0.7351.00
352_G369_T0.7311.00
146_Q160_K0.7311.00
215_A235_I0.7311.00
310_I321_E0.7301.00
312_L355_P0.7271.00
239_A246_I0.7251.00
145_G223_I0.7231.00
23_I28_Q0.7231.00
225_F231_T0.7231.00
265_E306_R0.7221.00
334_V366_Y0.7211.00
303_L370_I0.7211.00
85_A96_L0.7201.00
307_A350_T0.7191.00
333_K336_K0.7191.00
254_N287_S0.7181.00
141_I221_D0.7161.00
100_K318_A0.7161.00
96_L316_F0.7151.00
49_A170_T0.7131.00
337_Y383_E0.7131.00
83_E188_K0.7111.00
82_E96_L0.7091.00
291_V295_I0.7071.00
296_H373_N0.7061.00
157_A183_T0.7041.00
421_I478_R0.7041.00
438_I478_R0.7031.00
54_D59_S0.7031.00
148_T157_A0.7031.00
178_I326_I0.7031.00
58_W69_I0.7021.00
134_S475_H0.6991.00
421_I425_E0.6981.00
43_I219_D0.6981.00
267_A299_F0.6971.00
419_K422_E0.6961.00
209_T212_D0.6951.00
85_A89_S0.6941.00
77_I107_A0.6931.00
173_M200_A0.6901.00
19_I35_S0.6891.00
52_A57_E0.6881.00
50_R53_F0.6871.00
18_Q209_T0.6861.00
215_A238_A0.6831.00
238_A241_G0.6811.00
279_A322_S0.6781.00
195_V200_A0.6771.00
237_R240_S0.6751.00
304_V307_A0.6731.00
59_S430_R0.6721.00
87_L181_L0.6711.00
72_K193_A0.6711.00
290_L381_V0.6701.00
327_S330_H0.6691.00
307_A310_I0.6661.00
258_V267_A0.6651.00
259_F292_E0.6601.00
330_H333_K0.6591.00
290_L376_S0.6581.00
75_E78_R0.6571.00
63_G117_A0.6571.00
65_E69_I0.6561.00
428_A438_I0.6551.00
245_K469_E0.6551.00
271_A303_L0.6551.00
137_I474_K0.6541.00
134_S477_Y0.6511.00
268_V272_L0.6511.00
344_E377_D0.6491.00
261_D418_S0.6491.00
266_V269_D0.6481.00
272_L303_L0.6461.00
157_A186_V0.6461.00
58_W165_L0.6461.00
42_A46_I0.6451.00
24_N316_F0.6451.00
88_E91_D0.6441.00
120_D471_T0.6431.00
468_E471_T0.6431.00
376_S381_V0.6421.00
266_V419_K0.6411.00
468_E473_V0.6401.00
329_E333_K0.6401.00
145_G211_G0.6401.00
264_L298_Q0.6391.00
289_L299_F0.6391.00
81_L85_A0.6381.00
133_E425_E0.6381.00
261_D420_D0.6371.00
272_L310_I0.6371.00
54_D430_R0.6371.00
432_R453_Y0.6361.00
169_N471_T0.6351.00
190_M195_V0.6341.00
42_A213_E0.6321.00
404_L407_D0.6321.00
48_A197_K0.6321.00
59_S140_P0.6311.00
425_E478_R0.6301.00
366_Y369_T0.6271.00
59_S139_E0.6261.00
424_C428_A0.6251.00
103_M107_A0.6231.00
247_A469_E0.6191.00
398_E402_I0.6161.00
45_A203_V0.6161.00
207_G211_G0.6151.00
312_L322_S0.6141.00
74_A107_A0.6131.00
328_A354_R0.6131.00
236_M248_L0.6131.00
303_L392_V0.6121.00
215_A223_I0.6111.00
39_R212_D0.6111.00
35_S204_L0.6101.00
374_C380_I0.6091.00
120_D467_L0.6071.00
374_C381_V0.6061.00
291_V296_H0.6061.00
22_I91_D0.6051.00
39_R216_V0.6041.00
177_E333_K0.6031.00
185_K189_L0.6031.00
160_K224_S0.6031.00
86_E89_S0.6031.00
88_E99_S0.6031.00
355_P361_Q0.6011.00
350_T370_I0.6011.00
94_K98_E0.5991.00
314_N320_T0.5981.00
161_I173_M0.5981.00
376_S403_E0.5981.00
397_S403_E0.5971.00
331_R355_P0.5971.00
338_V371_F0.5961.00
208_A234_K0.5961.00
335_E338_V0.5951.00
88_E182_T0.5941.00
348_L351_G0.5941.00
154_L186_V0.5941.00
22_I32_A0.5931.00
274_A441_F0.5921.00
205_G211_G0.5921.00
89_S316_F0.5911.00
94_K152_Y0.5911.00
47_A50_R0.5911.00
31_I181_L0.5901.00
265_E305_K0.5901.00
422_E425_E0.5891.00
229_I233_K0.5891.00
416_V438_I0.5891.00
77_I110_F0.5881.00
77_I186_V0.5851.00
63_G166_A0.5841.00
418_S423_K0.5841.00
177_E234_K0.5831.00
135_K476_V0.5801.00
401_V405_A0.5801.00
352_G367_E0.5791.00
312_L321_E0.5771.00
325_L330_H0.5761.00
144_C169_N0.5751.00
422_E426_R0.5741.00
385_V389_V0.5741.00
291_V392_V0.5711.00
112_Y116_L0.5701.00
256_N415_A0.5701.00
84_L154_L0.5701.00
275_V390_L0.5681.00
45_A201_N0.5681.00
416_V424_C0.5681.00
402_I426_R0.5671.00
64_L68_K0.5651.00
167_A467_L0.5621.00
88_E102_D0.5621.00
256_N289_L0.5601.00
85_A103_M0.5591.00
63_G121_G0.5581.00
264_L299_F0.5581.00
77_I154_L0.5571.00
222_L469_E0.5571.00
172_V201_N0.5561.00
373_N394_T0.5561.00
338_V369_T0.5551.00
51_R57_E0.5531.00
68_K71_L0.5531.00
74_A110_F0.5531.00
348_L369_T0.5531.00
264_L267_A0.5521.00
48_A52_A0.5521.00
37_G203_V0.5511.00
18_Q38_G0.5501.00
34_V180_P0.5491.00
212_D215_A0.5481.00
311_K317_H0.5471.00
398_E430_R0.5471.00
380_I385_V0.5461.00
143_V221_D0.5451.00
289_L392_V0.5451.00
165_L200_A0.5441.00
50_R143_V0.5421.00
103_M154_L0.5421.00
282_V285_A0.5411.00
437_W440_D0.5411.00
49_A172_V0.5411.00
254_N413_A0.5401.00
402_I431_L0.5401.00
246_I458_F0.5391.00
269_D273_N0.5391.00
371_F374_C0.5361.00
436_V474_K0.5361.00
209_T213_E0.5331.00
104_D107_A0.5321.00
405_A431_L0.5321.00
354_R367_E0.5311.00
115_G118_D0.5311.00
186_V190_M0.5301.00
335_E342_I0.5301.00
349_E373_N0.5301.00
224_S470_Y0.5291.00
230_E329_E0.5271.00
260_K395_F0.5251.00
170_T201_N0.5251.00
261_D419_K0.5241.00
139_E432_R0.5231.00
325_L366_Y0.5231.00
22_I180_P0.5231.00
113_Y163_P0.5221.00
116_L464_K0.5221.00
81_L107_A0.5211.00
136_I473_V0.5201.00
155_L159_W0.5201.00
403_E430_R0.5201.00
286_G415_A0.5191.00
144_C171_I0.5191.00
432_R472_E0.5191.00
333_K337_Y0.5191.00
191_E198_G0.5181.00
92_T278_H0.5181.00
73_I76_L0.5181.00
159_W462_L0.5181.00
293_D296_H0.5171.00
49_A143_V0.5161.00
262_A267_A0.5161.00
304_V370_I0.5141.00
427_V431_L0.5131.00
132_S440_D0.5111.00
45_A172_V0.5111.00
34_V181_L0.5101.00
84_L103_M0.5071.00
100_K104_D0.5071.00
342_I346_A0.5061.00
105_D155_L0.5061.00
229_I409_I0.5031.00
36_E177_E0.5031.00
379_R382_Q0.5021.00
284_S443_P0.5011.00
177_E230_E0.5001.00
276_F310_I0.5001.00
85_A99_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qtoA 4 0.9959 100 0.032 Contact Map
4o5hA 4 0.9735 100 0.036 Contact Map
3ek1A 5 0.9673 100 0.036 Contact Map
4yweA 5 0.9673 100 0.037 Contact Map
1a4sA 4 0.9857 100 0.038 Contact Map
4pxlA 4 0.9816 100 0.038 Contact Map
4pz2A 4 0.9816 100 0.039 Contact Map
3u4jA 4 0.9857 100 0.04 Contact Map
4qf6A 4 0.9714 100 0.04 Contact Map
2d4eA 4 0.9918 100 0.04 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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