GREMLIN Database
GBSR - HTH-type transcriptional repressor GbsR
UniProt: P71015 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (154)
Sequences: 644 (441)
Seq/√Len: 35.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_S58_M4.6451.00
48_T88_T3.9421.00
84_I88_T3.5761.00
35_G38_Y3.5181.00
46_E81_H2.9891.00
37_L52_M2.7601.00
58_M87_H2.5191.00
137_D140_N2.3991.00
21_I38_Y2.1490.99
59_S65_T2.1030.99
46_E51_E2.0700.99
49_L63_M2.0540.99
140_N143_L2.0000.98
81_H88_T1.9390.98
72_D142_A1.8850.98
79_T88_T1.8820.98
157_D161_R1.8680.97
99_F156_Y1.8300.97
52_M63_M1.7430.96
21_I35_G1.7290.96
111_V161_R1.7250.96
13_A117_A1.7210.96
49_L60_K1.6930.95
50_D86_K1.6390.94
56_L70_L1.6300.94
139_K143_L1.5820.93
71_Q89_F1.5490.93
136_E140_N1.5330.92
97_K101_N1.5260.92
82_R99_F1.4890.91
119_E150_E1.4520.90
75_V98_F1.4430.90
36_I84_I1.4320.89
32_R36_I1.3980.88
110_E113_V1.3680.87
59_S82_R1.3610.87
103_F149_L1.3530.86
116_T119_E1.3300.85
115_V119_E1.2930.84
30_I86_K1.2890.83
24_T96_F1.2560.82
35_G39_G1.2520.82
94_D108_E1.2480.81
122_Q137_D1.2250.80
30_I34_V1.2240.80
11_E136_E1.2190.80
41_M81_H1.2140.79
127_K136_E1.2130.79
126_Q139_K1.2120.79
102_F149_L1.2100.79
39_G103_F1.2040.79
95_F99_F1.1840.78
61_P65_T1.1790.77
31_T111_V1.1700.77
111_V122_Q1.1560.76
63_M114_N1.1550.76
40_T47_M1.1490.76
16_L120_E1.1480.76
33_S99_F1.1430.75
124_D127_K1.1400.75
58_M99_F1.1390.75
9_A76_V1.1330.75
140_N144_Q1.1140.73
20_S23_E1.0970.72
156_Y160_K1.0930.72
22_A32_R1.0920.72
49_L64_S1.0830.71
47_M126_Q1.0770.71
79_T90_V1.0750.71
54_E157_D1.0750.71
136_E143_L1.0670.70
36_I87_H1.0640.70
51_E125_L1.0580.69
86_K148_Q1.0410.68
74_N112_Q1.0250.67
40_T52_M1.0190.66
103_F159_L1.0080.66
30_I57_Q1.0030.65
105_P117_A1.0020.65
13_A83_G1.0010.65
24_T95_F0.9910.64
31_T56_L0.9840.64
38_Y75_V0.9820.63
24_T49_L0.9740.63
14_R141_E0.9680.62
9_A130_C0.9610.62
10_I44_R0.9590.62
54_E140_N0.9510.61
129_L136_E0.9440.60
53_R67_V0.9350.60
105_P108_E0.9290.59
14_R55_E0.9280.59
125_L142_A0.9250.59
17_V91_A0.9210.58
49_L114_N0.9200.58
46_E88_T0.9140.58
68_K78_K0.9130.58
56_L66_G0.9070.57
17_V106_K0.9020.57
19_D57_Q0.9010.57
130_C134_L0.8900.56
119_E123_A0.8850.55
135_D138_I0.8830.55
22_A40_T0.8810.55
33_S62_S0.8790.55
41_M44_R0.8790.55
65_T88_T0.8680.54
12_Q124_D0.8660.54
140_N154_A0.8570.53
30_I42_Y0.8520.53
14_R145_L0.8500.52
71_Q87_H0.8490.52
22_A28_Y0.8470.52
17_V30_I0.8450.52
71_Q76_V0.8350.51
137_D147_D0.8320.51
17_V26_D0.8300.51
68_K77_K0.8240.50
40_T56_L0.8190.50
102_F106_K0.8180.50
39_G91_A0.8160.49
79_T87_H0.8150.49
56_L81_H0.8150.49
99_F149_L0.8140.49
115_V123_A0.8130.49
32_R75_V0.8060.49
33_S43_M0.7870.47
38_Y66_G0.7780.46
62_S65_T0.7740.46
145_L159_L0.7740.46
45_D130_C0.7550.44
117_A121_A0.7500.44
58_M61_P0.7410.43
23_E41_M0.7400.43
32_R109_R0.7340.42
140_N150_E0.7340.42
122_Q153_K0.7340.42
12_Q51_E0.7290.42
142_A157_D0.7290.42
28_Y102_F0.7270.42
11_E93_K0.7270.42
55_E118_I0.7270.42
52_M76_V0.7220.41
138_I143_L0.7210.41
9_A45_D0.7200.41
24_T114_N0.7190.41
136_E139_K0.7140.41
126_Q157_D0.7120.41
108_E123_A0.7100.40
126_Q150_E0.7090.40
50_D156_Y0.7050.40
45_D147_D0.7030.40
38_Y148_Q0.7010.40
9_A135_D0.6960.39
122_Q154_A0.6950.39
53_R87_H0.6930.39
22_A84_I0.6890.39
30_I94_D0.6850.38
10_I150_E0.6720.37
74_N156_Y0.6710.37
129_L134_L0.6700.37
11_E88_T0.6680.37
14_R44_R0.6620.36
147_D165_S0.6620.36
48_T156_Y0.6620.36
31_T36_I0.6580.36
100_T103_F0.6570.36
23_E162_L0.6550.36
17_V43_M0.6550.36
15_D137_D0.6540.36
72_D81_H0.6520.36
92_E101_N0.6520.36
37_L66_G0.6510.36
20_S114_N0.6470.35
123_A130_C0.6470.35
96_F110_E0.6460.35
147_D161_R0.6430.35
61_P109_R0.6390.35
31_T73_L0.6340.34
57_Q78_K0.6330.34
17_V25_M0.6330.34
13_A51_E0.6280.34
91_A164_E0.6260.34
77_K87_H0.6200.33
92_E98_F0.6140.33
35_G103_F0.6080.32
37_L75_V0.5970.31
50_D53_R0.5960.31
43_M145_L0.5890.31
28_Y60_K0.5850.31
20_S68_K0.5850.31
94_D97_K0.5790.30
65_T82_R0.5750.30
73_L105_P0.5720.30
35_G59_S0.5700.29
21_I25_M0.5700.29
31_T65_T0.5690.29
11_E161_R0.5650.29
17_V21_I0.5630.29
49_L96_F0.5630.29
21_I39_G0.5580.29
51_E55_E0.5550.28
14_R43_M0.5530.28
43_M74_N0.5450.28
22_A146_Y0.5440.28
23_E110_E0.5440.28
19_D89_F0.5430.28
32_R96_F0.5410.27
34_V66_G0.5350.27
27_L63_M0.5350.27
25_M102_F0.5330.27
143_L147_D0.5290.27
67_V96_F0.5280.27
109_R113_V0.5260.26
81_H84_I0.5250.26
21_I28_Y0.5200.26
129_L139_K0.5120.25
92_E158_W0.5110.25
25_M158_W0.5100.25
22_A36_I0.5100.25
81_H90_V0.5100.25
48_T58_M0.5100.25
155_Y158_W0.5090.25
32_R56_L0.5080.25
49_L107_W0.5080.25
42_Y95_F0.5060.25
43_M148_Q0.5050.25
45_D137_D0.5050.25
62_S70_L0.5030.25
62_S114_N0.5000.25
43_M95_F0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nb5A 4 0.8167 99.5 0.73 Contact Map
1ku9A 2 0.8333 99.2 0.77 Contact Map
3qphA 2 0.8278 99 0.786 Contact Map
3bjaA 2 0.7667 98.8 0.798 Contact Map
2ethA 4 0.7778 98.7 0.807 Contact Map
4yifA 2 0.7722 98.7 0.808 Contact Map
3nqoA 2 0.9 98.7 0.808 Contact Map
2fxaA 4 0.9222 98.7 0.809 Contact Map
3s2wA 3 0.7833 98.7 0.809 Contact Map
3oopA 2 0.7444 98.7 0.809 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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