GREMLIN Database
LEPT - Signal peptidase I T
UniProt: P71013 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (166)
Sequences: 6773 (4618)
Seq/√Len: 358.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_T116_K3.5581.00
150_Y172_E3.1261.00
102_T142_P2.9761.00
101_E113_N2.9611.00
50_S53_Y2.7391.00
104_Q142_P2.7041.00
149_K171_A2.6291.00
150_Y175_I2.5501.00
76_R98_K2.4311.00
149_K169_L2.3891.00
74_L95_L2.3441.00
80_V152_V2.3111.00
102_T144_K2.2721.00
65_N68_V2.1481.00
76_R101_E1.9801.00
49_G58_D1.9741.00
53_Y57_H1.9471.00
69_N74_L1.9461.00
95_L152_V1.8441.00
76_R112_I1.8371.00
51_S93_K1.8111.00
84_G91_Y1.8111.00
38_R43_E1.7761.00
92_V179_S1.7641.00
43_E66_K1.7611.00
145_V169_L1.7221.00
64_V177_G1.7171.00
111_Y116_K1.6731.00
80_V175_I1.6651.00
171_A174_R1.6611.00
110_L117_V1.6601.00
93_K160_S1.6591.00
65_N180_K1.6421.00
30_A34_A1.6381.00
90_H176_V1.6231.00
154_G160_S1.5811.00
56_L92_V1.5561.00
64_V81_I1.5181.00
21_L25_K1.5051.00
99_P150_Y1.5041.00
146_P169_L1.4721.00
46_L61_R1.4561.00
98_K101_E1.3831.00
145_V149_K1.3811.00
148_G172_E1.3531.00
105_M110_L1.3471.00
26_A30_A1.3201.00
106_K111_Y1.3191.00
44_P183_F1.3131.00
78_D178_T1.2921.00
68_V72_G1.2851.00
47_V56_L1.2761.00
82_I91_Y1.2751.00
167_L170_I1.2751.00
161_M165_N1.2681.00
104_Q111_Y1.2601.00
146_P149_K1.2491.00
60_E188_E1.2341.00
102_T114_G1.2131.00
50_S58_D1.2101.00
103_V112_I1.2021.00
99_P172_E1.1871.00
19_T23_W1.1821.00
60_E182_V1.1721.00
82_I152_V1.1691.00
53_Y58_D1.1671.00
69_N178_T1.1651.00
42_F180_K1.1521.00
143_V169_L1.1181.00
47_V62_L1.0981.00
48_E58_D1.0931.00
83_N176_V1.0921.00
93_K154_G1.0821.00
73_E172_E1.0791.00
52_M79_I1.0781.00
37_I41_L1.0661.00
101_E112_I1.0651.00
83_N90_H1.0611.00
72_G78_D1.0491.00
106_K109_T1.0291.00
16_K20_Y1.0241.00
16_K19_T1.0101.00
62_L179_S1.0091.00
51_S160_S1.0091.00
19_T22_E0.9991.00
80_V95_L0.9791.00
110_L153_M0.9791.00
128_E164_R0.9671.00
119_E122_L0.9671.00
61_R184_F0.9571.00
119_E157_R0.9501.00
151_F163_S0.9451.00
17_T21_L0.9431.00
37_I42_F0.9341.00
20_Y24_G0.9291.00
84_G167_L0.9201.00
172_E175_I0.9191.00
97_G103_V0.9131.00
18_N21_L0.9081.00
179_S182_V0.8891.00
61_R183_F0.8801.00
38_R44_P0.8771.00
42_F63_F0.8711.00
140_F143_V0.8711.00
85_E174_R0.8671.00
113_N117_V0.8591.00
95_L98_K0.8561.00
62_L182_V0.8551.00
45_Y64_V0.8531.00
123_S126_K0.8521.00
23_W26_A0.8511.00
91_Y167_L0.8421.00
51_S154_G0.8371.00
50_S159_N0.8361.00
49_G167_L0.8331.00
113_N116_K0.8301.00
99_P147_K0.8271.00
182_V188_E0.8251.00
49_G56_L0.8241.00
84_G87_S0.8231.00
25_K29_I0.8191.00
45_Y90_H0.8181.00
81_I90_H0.8161.00
54_P57_H0.8161.00
22_E26_A0.8151.00
23_W27_I0.8061.00
108_D158_L0.8041.00
41_L67_T0.7991.00
21_L24_G0.7941.00
77_G121_Y0.7921.00
104_Q114_G0.7871.00
56_L79_I0.7871.00
96_I110_L0.7771.00
65_N70_Y0.7701.00
53_Y156_N0.7651.00
24_G28_V0.7641.00
35_L39_H0.7571.00
153_M157_R0.7571.00
44_P61_R0.7531.00
54_P123_S0.7481.00
87_S174_R0.7391.00
67_T70_Y0.7391.00
95_L150_Y0.7371.00
97_G101_E0.7351.00
48_E56_L0.7331.00
84_G90_H0.7291.00
83_N174_R0.7281.00
79_I179_S0.7210.99
91_Y161_M0.7140.99
148_G171_A0.7140.99
163_S168_G0.7130.99
57_H188_E0.7110.99
48_E60_E0.7070.99
136_L139_D0.7030.99
20_Y23_W0.7010.99
68_V71_I0.6980.99
56_L179_S0.6950.99
36_L40_F0.6940.99
96_I153_M0.6930.99
91_Y170_I0.6910.99
125_N128_E0.6860.99
152_V170_I0.6860.99
137_T165_N0.6840.99
34_A38_R0.6800.99
57_H185_P0.6790.99
161_M167_L0.6780.99
47_V58_D0.6770.99
31_V35_L0.6750.99
114_G117_V0.6730.99
124_K127_K0.6720.99
65_N178_T0.6720.99
103_V151_F0.6700.99
135_S138_G0.6680.99
50_S57_H0.6620.99
47_V92_V0.6620.99
33_L36_L0.6600.99
145_V148_G0.6590.99
182_V185_P0.6590.99
156_N159_N0.6530.99
137_T140_F0.6520.99
45_Y81_I0.6450.99
151_F169_L0.6440.99
57_H60_E0.6430.99
27_I31_V0.6420.99
62_L92_V0.6410.99
103_V145_V0.6360.99
33_L37_I0.6300.99
117_V121_Y0.6270.99
112_I157_R0.6240.99
74_L98_K0.6230.99
68_V178_T0.6220.98
76_R97_G0.6170.98
81_I176_V0.6160.98
72_G75_K0.6150.98
185_P188_E0.6110.98
45_Y62_L0.6110.98
81_I179_S0.6040.98
63_F180_K0.6020.98
74_L175_I0.6010.98
75_K147_K0.5950.98
45_Y182_V0.5940.98
113_N120_P0.5920.98
67_T71_I0.5900.98
82_I170_I0.5900.98
50_S156_N0.5880.98
45_Y176_V0.5870.98
49_G154_G0.5810.98
55_T79_I0.5800.98
112_I117_V0.5770.98
37_I40_F0.5770.98
115_K147_K0.5770.98
18_N22_E0.5730.97
50_S59_G0.5710.97
29_I33_L0.5680.97
123_S156_N0.5670.97
30_A33_L0.5670.97
32_L35_L0.5610.97
17_T20_Y0.5530.97
103_V153_M0.5520.97
121_Y124_K0.5510.97
71_I74_L0.5460.97
53_Y60_E0.5450.97
143_V151_F0.5410.96
77_G97_G0.5400.96
96_I103_V0.5380.96
17_T25_K0.5380.96
28_V32_L0.5320.96
104_Q140_F0.5320.96
27_I30_A0.5310.96
85_E88_K0.5290.96
94_R155_D0.5270.96
104_Q141_G0.5250.96
119_E123_S0.5240.96
172_E176_V0.5220.96
75_K178_T0.5220.96
19_T24_G0.5220.96
38_R45_Y0.5150.95
139_D142_P0.5150.95
81_I177_G0.5130.95
49_G60_E0.5120.95
41_L44_P0.5100.95
82_I93_K0.5070.95
79_I93_K0.5040.95
72_G178_T0.5030.95
22_E25_K0.5030.95
49_G91_Y0.5010.95
126_K158_L0.5010.95
25_K28_V0.5000.94
135_S139_D0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b12A 1 0.8031 100 0.226 Contact Map
4nv4A 2 0.5751 100 0.231 Contact Map
4me8A 1 0.5699 100 0.281 Contact Map
4n31A 5 0.7306 100 0.314 Contact Map
4k8wA 2 0.6062 100 0.367 Contact Map
1kcaA 6 0.4922 98.9 0.785 Contact Map
1umuA 2 0.544 98.5 0.814 Contact Map
3bdnA 2 0.6736 98.3 0.826 Contact Map
2hnfA 1 0.6062 97.6 0.851 Contact Map
3k2zA 2 0.6632 97.3 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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