GREMLIN Database
ALBA - Antilisterial bacteriocin subtilosin biosynthesis protein AlbA
UniProt: P71011 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (381)
Sequences: 1761 (1460)
Seq/√Len: 74.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_L202_T6.1001.00
206_K252_L5.7301.00
234_D241_G5.2941.00
229_N244_A4.3661.00
230_S244_A4.3371.00
205_R208_S4.2711.00
358_E373_N4.2421.00
152_Q375_F3.8191.00
150_I183_E3.8031.00
149_S152_Q3.5581.00
130_N200_N3.5201.00
210_E256_H3.4551.00
148_V152_Q3.0071.00
233_H242_S2.7711.00
243_F280_K2.6611.00
358_E370_S2.6481.00
228_V232_V2.4991.00
373_N376_H2.4231.00
128_R147_T2.4071.00
354_S358_E2.3681.00
183_E186_D2.3401.00
236_F267_F2.3331.00
251_K284_L2.3191.00
154_K187_Y2.3131.00
153_F184_I2.3031.00
226_D237_R2.3011.00
211_L215_Y2.2771.00
344_C362_C2.2611.00
158_D187_Y2.2381.00
319_Y322_H2.2301.00
210_E214_T2.2281.00
185_L188_V2.2031.00
171_T363_A2.2021.00
148_V153_F2.1471.00
182_N211_L2.1291.00
402_H430_K2.0921.00
209_L253_L2.0771.00
155_K375_F2.0751.00
160_L168_C2.0741.00
369_F422_L2.0571.00
201_G223_I2.0511.00
362_C417_C2.0431.00
189_C215_Y2.0381.00
227_S237_R2.0221.00
221_V253_L2.0141.00
125_L181_A2.0141.00
209_L252_L2.0001.00
179_P208_S1.9991.00
146_G356_F1.8681.00
326_E329_D1.8551.00
186_D211_L1.8481.00
224_S265_S1.8471.00
154_K183_E1.8391.00
121_A160_L1.8101.00
235_S269_K1.8041.00
344_C417_C1.7741.00
327_F331_I1.7661.00
170_I195_V1.7571.00
150_I154_K1.7331.00
130_N203_L1.7281.00
155_K159_M1.7201.00
171_T198_L1.7031.00
327_F330_L1.6701.00
135_H226_D1.6541.00
262_V281_V1.6351.00
186_D190_K1.6291.00
44_L48_A1.6201.00
62_E66_A1.6151.00
232_V273_E1.5970.99
247_C284_L1.5920.99
138_L265_S1.5920.99
225_L262_V1.5810.99
51_L64_I1.5560.99
147_T178_H1.5390.99
138_L224_S1.5170.99
252_L255_D1.5150.99
229_N234_D1.5100.99
328_K331_I1.4870.99
227_S243_F1.4850.99
403_C408_C1.4680.99
222_G263_A1.4680.99
69_C74_E1.4640.99
208_S212_L1.4590.99
403_C414_C1.4580.99
54_R64_I1.4510.99
273_E276_D1.4480.99
176_F197_V1.4300.99
135_H171_T1.4030.99
127_H355_P1.3890.99
251_K255_D1.3870.98
322_H326_E1.3860.98
63_Q67_E1.3840.98
176_F203_L1.3830.98
225_L280_K1.3810.98
326_E330_L1.3770.98
202_T245_Q1.3750.98
211_L214_T1.3670.98
209_L213_K1.3620.98
179_P182_N1.3600.98
135_H198_L1.3490.98
268_E312_Q1.3480.98
44_L47_T1.3440.98
202_T241_G1.3420.98
245_Q248_K1.3350.98
185_L211_L1.3180.98
60_T63_Q1.3170.98
189_C214_T1.3160.98
408_C414_C1.3040.98
171_T263_A1.3000.98
206_K210_E1.2800.97
46_K50_E1.2760.97
251_K283_D1.2660.97
88_N92_N1.2640.97
206_K209_L1.2550.97
123_F153_F1.2380.97
247_C251_K1.2380.97
213_K256_H1.2340.97
121_A353_I1.2320.97
250_I262_V1.2300.97
174_E200_N1.2260.97
246_T249_T1.2220.97
180_N183_E1.2200.97
367_K370_S1.2170.97
60_T64_I1.2170.97
418_Y421_G1.2120.96
242_S246_T1.2030.96
280_K284_L1.1870.96
325_D331_I1.1850.96
130_N174_E1.1830.96
185_L195_V1.1790.96
154_K158_D1.1700.96
224_S347_G1.1660.96
353_I359_V1.1620.95
248_K252_L1.1620.95
354_S360_R1.1600.95
187_Y190_K1.1460.95
159_M359_V1.1440.95
365_F419_L1.1340.95
153_F178_H1.1250.95
265_S363_A1.1220.95
225_L247_C1.1160.94
209_L221_V1.1150.94
262_V289_F1.1120.94
384_N387_L1.1090.94
176_F249_T1.1030.94
247_C280_K1.1010.94
169_E363_A1.0980.94
47_T50_E1.0970.94
185_L215_Y1.0950.94
230_S234_D1.0920.94
65_L72_Y1.0820.93
277_M281_V1.0820.93
50_E72_Y1.0810.93
131_L242_S1.0810.93
204_M253_L1.0800.93
157_A170_I1.0800.93
66_A70_A1.0790.93
347_G361_P1.0780.93
198_L363_A1.0750.93
126_T147_T1.0620.93
57_G64_I1.0590.93
156_T353_I1.0590.93
201_G250_I1.0420.92
170_I184_I1.0420.92
314_R318_E1.0360.92
326_E331_I1.0300.92
224_S363_A1.0280.91
49_Y52_C1.0250.91
53_M69_C1.0150.91
225_L289_F1.0130.91
176_F208_S1.0100.91
124_E127_H1.0080.91
309_D312_Q1.0070.91
245_Q249_T1.0020.90
229_N232_V1.0010.90
207_E210_E0.9990.90
328_K333_I0.9980.90
332_P335_P0.9980.90
271_M312_Q0.9960.90
327_F333_I0.9900.90
135_H236_F0.9870.90
403_C433_C0.9850.90
228_V273_E0.9820.90
126_T178_H0.9780.89
279_Q327_F0.9760.89
121_A351_I0.9720.89
70_A73_D0.9670.89
421_G425_N0.9650.89
130_N202_T0.9620.89
227_S238_G0.9570.88
280_K283_D0.9540.88
198_L364_L0.9520.88
69_C72_Y0.9450.88
315_K319_Y0.9450.88
263_A363_A0.9430.88
408_C433_C0.9400.87
135_H263_A0.9400.87
168_C188_V0.9330.87
248_K251_K0.9320.87
120_H169_E0.9320.87
50_E54_R0.9310.87
54_R68_Q0.9290.87
238_G241_G0.9270.87
56_D60_T0.9270.87
183_E187_Y0.9250.87
372_G377_D0.9210.86
47_T53_M0.9210.86
52_C60_T0.9170.86
331_I334_I0.9150.86
54_R67_E0.9120.86
67_E70_A0.9090.86
46_K64_I0.9070.85
271_M308_K0.9060.85
103_S404_M0.9040.85
124_E352_V0.8990.85
61_A64_I0.8990.85
233_H246_T0.8940.85
397_P411_S0.8940.85
233_H237_R0.8940.85
179_P211_L0.8910.84
54_R57_G0.8900.84
64_I68_Q0.8840.84
113_N384_N0.8830.84
49_Y53_M0.8820.84
225_L250_I0.8800.84
313_H317_M0.8790.84
224_S263_A0.8760.83
359_V382_I0.8750.83
176_F243_F0.8750.83
138_L263_A0.8740.83
53_M56_D0.8730.83
268_E309_D0.8630.82
51_L54_R0.8620.82
188_V195_V0.8600.82
48_A52_C0.8560.82
401_E404_M0.8530.82
55_M60_T0.8510.82
64_I67_E0.8500.81
234_D242_S0.8490.81
361_P365_F0.8470.81
65_L73_D0.8410.81
198_L263_A0.8380.81
124_E171_T0.8270.80
44_L52_C0.8260.80
148_V156_T0.8230.79
124_E366_P0.8220.79
212_L253_L0.8200.79
184_I188_V0.8200.79
209_L249_T0.8160.79
309_D435_W0.8160.79
140_S299_R0.8100.78
64_I72_Y0.8100.78
122_T169_E0.8100.78
52_C55_M0.8090.78
135_H242_S0.8080.78
77_E80_K0.8040.78
56_D91_Q0.8040.78
53_M57_G0.8020.78
416_G421_G0.7880.76
206_K248_K0.7860.76
88_N91_Q0.7850.76
170_I222_G0.7810.76
327_F334_I0.7780.75
74_E77_E0.7770.75
185_L189_C0.7770.75
138_L171_T0.7760.75
48_A55_M0.7750.75
66_A92_N0.7750.75
133_C136_C0.7740.75
135_H138_L0.7720.75
396_A400_S0.7710.75
328_K334_I0.7690.75
152_Q156_T0.7690.75
320_E324_I0.7680.74
350_S363_A0.7680.74
414_C433_C0.7670.74
130_N241_G0.7670.74
65_L71_V0.7650.74
186_D215_Y0.7650.74
244_A248_K0.7620.74
83_Y88_N0.7610.74
328_K335_P0.7600.74
352_V363_A0.7590.74
66_A69_C0.7590.74
225_L243_F0.7570.73
65_L80_K0.7570.73
414_C417_C0.7560.73
223_I246_T0.7530.73
169_E198_L0.7510.73
264_M281_V0.7490.73
227_S242_S0.7470.72
67_E71_V0.7460.72
89_M93_K0.7460.72
276_D279_Q0.7440.72
200_N237_R0.7430.72
61_A65_L0.7420.72
174_E227_S0.7410.72
57_G60_T0.7410.72
385_S388_V0.7390.72
51_L55_M0.7350.71
148_V159_M0.7330.71
44_L55_M0.7330.71
137_Y171_T0.7330.71
153_F170_I0.7320.71
57_G63_Q0.7310.71
204_M249_T0.7310.71
108_T112_S0.7260.70
52_C61_A0.7250.70
362_C408_C0.7210.70
344_C408_C0.7190.70
122_T135_H0.7180.69
137_Y265_S0.7180.69
47_T54_R0.7170.69
345_G363_A0.7150.69
402_H407_K0.7150.69
227_S233_H0.7140.69
204_M252_L0.7140.69
346_A418_Y0.7140.69
51_L62_E0.7110.69
52_C197_V0.7110.69
47_T56_D0.7100.69
131_L237_R0.7080.68
203_L249_T0.7080.68
152_Q155_K0.7030.68
389_H392_W0.7030.68
429_R432_I0.7010.68
55_M66_A0.7000.67
353_I374_I0.6980.67
315_K318_E0.6980.67
319_Y323_V0.6970.67
351_I359_V0.6970.67
308_K312_Q0.6950.67
170_I185_L0.6930.67
354_S366_P0.6930.67
121_A359_V0.6920.67
64_I73_D0.6910.66
50_E53_M0.6870.66
74_E80_K0.6830.66
52_C56_D0.6830.66
72_Y79_H0.6830.66
297_F300_G0.6820.65
137_Y363_A0.6820.65
135_H246_T0.6810.65
265_S347_G0.6800.65
275_H278_A0.6780.65
123_F148_V0.6770.65
177_V240_K0.6770.65
44_L50_E0.6760.65
200_N241_G0.6760.65
137_Y364_L0.6750.65
51_L72_Y0.6750.65
64_I70_A0.6740.65
325_D330_L0.6740.65
44_L56_D0.6740.65
278_A282_R0.6740.65
64_I71_V0.6730.64
204_M221_V0.6730.64
201_G348_W0.6720.64
267_F294_V0.6720.64
171_T265_S0.6690.64
57_G62_E0.6650.63
361_P419_L0.6640.63
46_K63_Q0.6620.63
237_R241_G0.6580.63
204_M208_S0.6570.63
328_K332_P0.6560.62
310_A434_S0.6560.62
45_N52_C0.6560.62
181_A197_V0.6560.62
84_Y87_L0.6550.62
51_L71_V0.6540.62
45_N48_A0.6500.62
46_K54_R0.6490.62
56_D66_A0.6480.61
306_P310_A0.6470.61
138_L363_A0.6460.61
279_Q282_R0.6460.61
210_E252_L0.6450.61
55_M65_L0.6450.61
49_Y57_G0.6450.61
161_F191_K0.6450.61
224_S361_P0.6450.61
170_I188_V0.6440.61
129_C136_C0.6400.61
125_L170_I0.6390.60
52_C66_A0.6390.60
129_C133_C0.6380.60
138_L222_G0.6370.60
135_H363_A0.6360.60
46_K61_A0.6350.60
93_K157_A0.6340.60
270_N437_K0.6330.60
64_I69_C0.6330.60
234_D237_R0.6320.60
60_T69_C0.6320.60
62_E71_V0.6300.59
213_K257_G0.6300.59
209_L256_H0.6290.59
60_T65_L0.6290.59
312_Q315_K0.6280.59
50_E55_M0.6280.59
404_M407_K0.6270.59
47_T64_I0.6260.59
225_L233_H0.6260.59
203_L209_L0.6250.59
311_E314_R0.6250.59
330_L335_P0.6240.59
62_E67_E0.6240.59
65_L69_C0.6240.59
197_V221_V0.6230.58
150_I186_D0.6230.58
233_H241_G0.6230.58
138_L267_F0.6190.58
289_F294_V0.6150.58
376_H393_Q0.6140.57
171_T364_L0.6140.57
212_L221_V0.6140.57
48_A56_D0.6120.57
189_C216_K0.6110.57
210_E213_K0.6110.57
67_E73_D0.6100.57
431_N436_A0.6100.57
48_A51_L0.6100.57
128_R132_K0.6090.57
213_K216_K0.6090.57
200_N362_C0.6090.57
158_D161_F0.6070.57
210_E255_D0.6070.57
383_F392_W0.6050.56
52_C68_Q0.6050.56
361_P369_F0.6030.56
123_F185_L0.6030.56
61_A66_A0.6020.56
57_G87_L0.6020.56
226_D265_S0.6010.56
131_L226_D0.6010.56
365_F369_F0.6010.56
51_L61_A0.5980.55
311_E318_E0.5960.55
94_Q103_S0.5960.55
176_F233_H0.5950.55
223_I250_I0.5950.55
221_V258_I0.5950.55
50_E71_V0.5940.55
128_R178_H0.5940.55
122_T171_T0.5940.55
209_L212_L0.5930.55
206_K256_H0.5930.55
268_E302_D0.5930.55
124_E135_H0.5910.55
357_G373_N0.5900.54
351_I383_F0.5890.54
108_T111_G0.5880.54
374_I388_V0.5850.54
109_T112_S0.5850.54
274_I278_A0.5830.54
171_T178_H0.5820.53
124_E265_S0.5810.53
222_G265_S0.5800.53
237_R243_F0.5800.53
47_T57_G0.5780.53
47_T51_L0.5770.53
275_H319_Y0.5760.53
153_F157_A0.5750.53
390_K393_Q0.5730.52
352_V366_P0.5730.52
387_L391_L0.5720.52
49_Y72_Y0.5720.52
46_K66_A0.5710.52
51_L68_Q0.5710.52
46_K56_D0.5690.52
71_V254_S0.5690.52
296_D299_R0.5680.52
46_K53_M0.5670.52
124_E365_F0.5660.51
122_T363_A0.5660.51
200_N227_S0.5660.51
62_E68_Q0.5650.51
138_L364_L0.5650.51
125_L153_F0.5650.51
127_H354_S0.5640.51
403_C417_C0.5640.51
139_E142_P0.5620.51
263_A293_W0.5620.51
138_L141_S0.5590.51
421_G430_K0.5590.51
386_P390_K0.5580.50
66_A73_D0.5560.50
157_A184_I0.5550.50
80_K84_Y0.5550.50
56_D83_Y0.5550.50
179_P212_L0.5540.50
44_L49_Y0.5530.50
386_P389_H0.5530.50
138_L361_P0.5530.50
223_I281_V0.5500.49
168_C195_V0.5500.49
63_Q70_A0.5500.49
48_A54_R0.5500.49
142_P146_G0.5500.49
157_A168_C0.5490.49
56_D70_A0.5490.49
160_L365_F0.5480.49
47_T72_Y0.5470.49
111_G114_E0.5470.49
325_D328_K0.5470.49
292_N295_D0.5460.49
124_E263_A0.5450.49
233_H372_G0.5430.49
132_K241_G0.5430.49
90_L96_I0.5420.48
227_S263_A0.5410.48
135_H159_M0.5410.48
70_A74_E0.5390.48
364_L418_Y0.5380.48
263_A292_N0.5380.48
157_A193_K0.5380.48
160_L166_L0.5370.48
47_T61_A0.5350.48
73_D77_E0.5340.47
49_Y62_E0.5340.47
209_L216_K0.5330.47
358_E367_K0.5330.47
181_A185_L0.5330.47
342_A345_G0.5320.47
327_F332_P0.5310.47
97_Q102_A0.5300.47
377_D382_I0.5300.47
65_L77_E0.5290.47
407_K427_Y0.5270.47
172_G414_C0.5260.46
275_H323_V0.5250.46
317_M321_Q0.5250.46
138_L369_F0.5240.46
49_Y60_T0.5240.46
131_L227_S0.5230.46
255_D283_D0.5220.46
138_L352_V0.5200.46
196_A222_G0.5200.46
52_C95_V0.5200.46
69_C73_D0.5180.45
83_Y87_L0.5180.45
134_A236_F0.5170.45
345_G397_P0.5170.45
204_M209_L0.5170.45
119_L349_K0.5160.45
123_F377_D0.5160.45
371_L377_D0.5160.45
124_E138_L0.5160.45
118_P121_A0.5150.45
169_E364_L0.5150.45
224_S246_T0.5140.45
83_Y86_M0.5140.45
109_T113_N0.5140.45
151_E322_H0.5140.45
48_A82_W0.5130.45
197_V212_L0.5130.45
51_L57_G0.5120.45
409_P437_K0.5110.45
198_L222_G0.5110.45
262_V286_A0.5080.44
137_Y263_A0.5080.44
281_V323_V0.5080.44
383_F386_P0.5070.44
103_S107_I0.5060.44
350_S364_L0.5050.44
314_R438_N0.5050.44
62_E70_A0.5040.44
101_R283_D0.5020.43
56_D61_A0.5020.43
150_I180_N0.5010.43
396_A418_Y0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.7277 100 0.449 Contact Map
1tv8A 2 0.6585 100 0.593 Contact Map
4m7tA 1 0.529 100 0.595 Contact Map
4rtbA 2 0.8371 100 0.619 Contact Map
4wcxA 1 0.8772 100 0.657 Contact Map
3c8fA 1 0.5022 100 0.679 Contact Map
2yx0A 1 0.6496 100 0.701 Contact Map
2qgqA 1 0.5357 100 0.71 Contact Map
2z2uA 1 0.5558 100 0.712 Contact Map
3t7vA 1 0.7232 100 0.717 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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