GREMLIN Database
ALBF - Putative zinc protease AlbF
UniProt: P71006 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (392)
Sequences: 14517 (11268)
Seq/√Len: 569.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_I188_Q4.1981.00
348_A352_Q4.0121.00
339_Y342_Q3.8911.00
342_Q346_Q3.6551.00
129_K133_A3.3841.00
291_P350_W3.2981.00
397_D400_V3.1831.00
328_H331_A2.9861.00
295_E299_T2.9341.00
348_A398_A2.8991.00
274_I407_A2.8971.00
359_T394_Q2.8621.00
209_E212_E2.8471.00
112_R216_P2.7741.00
341_T345_E2.7191.00
27_R208_S2.7171.00
77_G124_N2.7171.00
400_V403_S2.6921.00
140_T180_E2.6681.00
185_S189_K2.6041.00
282_A308_S2.4221.00
61_P186_D2.4121.00
214_L218_H2.2551.00
158_L261_Q2.2381.00
204_L213_T2.2051.00
189_K193_A2.1851.00
335_V338_Y2.1801.00
20_D218_H2.1541.00
398_A402_L2.1531.00
133_A136_K2.1531.00
284_I347_V2.1271.00
42_I200_M2.1191.00
120_D124_N2.0891.00
18_Y24_K2.0721.00
295_E339_Y2.0211.00
281_A405_I2.0181.00
183_D186_D2.0041.00
403_S407_A1.9411.00
388_D391_H1.9121.00
78_R116_P1.8971.00
334_D338_Y1.8951.00
17_R214_L1.8881.00
94_F101_N1.8851.00
215_L219_L1.8711.00
344_K406_D1.8691.00
106_S114_T1.8641.00
40_V202_L1.8601.00
295_E300_Y1.8591.00
277_Y404_L1.8571.00
399_Q403_S1.8271.00
128_D131_I1.8131.00
352_Q355_K1.8061.00
176_I180_E1.7731.00
157_Q160_S1.7711.00
352_Q356_D1.7711.00
140_T176_I1.7491.00
175_R178_D1.7471.00
274_I403_S1.7441.00
16_I24_K1.7361.00
212_E215_L1.7311.00
402_L406_D1.7271.00
300_Y335_V1.7061.00
24_K201_T1.6721.00
78_R120_D1.6581.00
17_R25_I1.6571.00
65_A190_A1.6571.00
330_S334_D1.6531.00
83_D113_Q1.6521.00
28_L372_C1.6521.00
144_Q176_I1.6471.00
27_R210_N1.6451.00
15_D210_N1.6251.00
188_Q192_K1.6001.00
341_T344_K1.5971.00
331_A334_D1.5921.00
391_H394_Q1.5881.00
338_Y342_Q1.5871.00
100_T195_Y1.5761.00
123_W223_K1.5681.00
351_L398_A1.5501.00
277_Y400_V1.5411.00
50_C61_P1.5281.00
321_I336_A1.5251.00
186_D189_K1.5221.00
112_R219_L1.5201.00
15_D211_T1.5101.00
399_Q402_L1.5071.00
23_L202_L1.4991.00
273_S400_V1.4911.00
300_Y331_A1.4551.00
104_F114_T1.4531.00
77_G126_S1.4461.00
52_R62_Y1.4391.00
132_V184_I1.4361.00
303_E306_R1.4361.00
31_P207_G1.4321.00
280_I396_M1.4291.00
87_H113_Q1.4251.00
273_S392_I1.4241.00
16_I380_D1.4121.00
64_T182_L1.3631.00
212_E216_P1.3591.00
79_N82_S1.3571.00
388_D392_I1.3561.00
26_F201_T1.3551.00
29_K209_E1.3451.00
256_T261_Q1.3441.00
189_K192_K1.3411.00
47_R315_E1.3261.00
218_H222_E1.3141.00
256_T260_L1.3141.00
68_L127_F1.3111.00
52_R186_D1.2971.00
108_P207_G1.2881.00
23_L200_M1.2871.00
116_P220_Q1.2861.00
113_Q116_P1.2831.00
202_L217_P1.2831.00
309_A320_L1.2741.00
210_N214_L1.2691.00
67_F132_V1.2641.00
119_L221_L1.2541.00
43_D199_R1.2511.00
216_P219_L1.2421.00
295_E335_V1.2371.00
256_T262_I1.2371.00
38_C204_L1.2281.00
29_K210_N1.2251.00
240_V244_K1.2231.00
216_P220_Q1.2201.00
112_R212_E1.2201.00
78_R124_N1.2161.00
384_C388_D1.2141.00
129_K184_I1.2141.00
215_L218_H1.2061.00
41_K377_A1.2061.00
277_Y396_M1.2021.00
208_S213_T1.2011.00
79_N83_D1.1941.00
241_L244_K1.1931.00
391_H395_D1.1931.00
297_Q304_I1.1921.00
115_I216_P1.1691.00
185_S188_Q1.1641.00
24_K380_D1.1611.00
98_T168_A1.1581.00
278_W404_L1.1571.00
46_S172_P1.1521.00
197_A224_R1.1511.00
17_R27_R1.1471.00
281_A404_L1.1411.00
125_H191_Y1.1331.00
136_K140_T1.1321.00
260_L337_S1.1261.00
110_R113_Q1.1221.00
76_N120_D1.1221.00
291_P339_Y1.1211.00
403_S406_D1.1211.00
132_V187_L1.1201.00
119_L123_W1.1191.00
16_I26_F1.1141.00
66_H70_H1.1141.00
112_R220_Q1.1121.00
141_S144_Q1.1071.00
355_K393_I1.1011.00
392_I395_D1.1001.00
40_V200_M1.0921.00
205_I373_F1.0901.00
337_S341_T1.0891.00
211_T214_L1.0781.00
27_R213_T1.0711.00
74_W135_E1.0701.00
282_A319_F1.0681.00
410_S413_K1.0651.00
71_L187_L1.0641.00
51_I170_V1.0621.00
294_Q298_Q1.0621.00
136_K179_I1.0611.00
44_F190_A1.0561.00
198_H229_A1.0501.00
288_L293_F1.0471.00
87_H110_R1.0431.00
351_L355_K1.0431.00
343_K347_V1.0401.00
37_L105_T1.0381.00
84_F91_L1.0381.00
84_F89_A1.0231.00
147_H176_I1.0201.00
42_I122_L1.0161.00
143_I173_A1.0151.00
44_F48_D1.0141.00
67_F136_K1.0131.00
80_L84_F1.0121.00
385_S388_D1.0071.00
34_H207_G1.0061.00
276_L392_I1.0051.00
83_D86_A1.0031.00
97_Y159_I1.0031.00
360_D364_Y0.9981.00
115_I217_P0.9981.00
36_R206_G0.9951.00
256_T329_S0.9931.00
335_V339_Y0.9901.00
131_I134_Q0.9811.00
296_I302_L0.9751.00
273_S277_Y0.9741.00
61_P193_A0.9731.00
283_R354_G0.9721.00
201_T380_D0.9711.00
52_R61_P0.9701.00
349_A353_Y0.9681.00
296_I335_V0.9661.00
284_I354_G0.9641.00
26_F380_D0.9621.00
140_T179_I0.9611.00
41_K101_N0.9611.00
36_R108_P0.9601.00
15_D214_L0.9591.00
323_H332_Y0.9591.00
274_I408_M0.9581.00
28_L205_I0.9571.00
387_L390_Y0.9561.00
66_H69_E0.9521.00
204_L208_S0.9501.00
256_T259_G0.9471.00
278_W408_M0.9461.00
143_I179_I0.9441.00
246_M249_D0.9411.00
355_K394_Q0.9341.00
359_T390_Y0.9311.00
196_Q199_R0.9281.00
23_L197_A0.9271.00
17_R210_N0.9271.00
140_T144_Q0.9261.00
72_L125_H0.9251.00
248_G251_E0.9191.00
68_L187_L0.9181.00
240_V243_Q0.9161.00
62_Y178_D0.9151.00
112_R116_P0.9121.00
40_V122_L0.9111.00
17_R218_H0.9111.00
280_I351_L0.9091.00
83_D87_H0.9081.00
296_I303_E0.9061.00
256_T263_G0.9051.00
108_P212_E0.9041.00
39_N101_N0.8991.00
198_H226_D0.8981.00
196_Q227_Y0.8961.00
71_L132_V0.8941.00
69_E95_T0.8931.00
333_I337_S0.8881.00
139_I179_I0.8871.00
52_R178_D0.8821.00
198_H227_Y0.8821.00
24_K43_D0.8801.00
276_L396_M0.8771.00
111_L213_T0.8711.00
38_C104_F0.8691.00
149_N152_L0.8691.00
405_I409_A0.8691.00
133_A137_A0.8681.00
162_L318_G0.8671.00
389_M393_I0.8661.00
48_D232_K0.8641.00
294_Q299_T0.8621.00
19_T25_I0.8611.00
25_I214_L0.8601.00
111_L216_P0.8571.00
368_Y371_K0.8541.00
119_L220_Q0.8521.00
137_A140_T0.8491.00
135_E138_V0.8491.00
355_K359_T0.8491.00
387_L391_H0.8491.00
237_C240_V0.8471.00
178_D181_A0.8461.00
118_L121_A0.8461.00
211_T215_L0.8451.00
338_Y341_T0.8451.00
213_T217_P0.8401.00
281_A401_F0.8391.00
72_L102_F0.8321.00
347_V351_L0.8291.00
158_L259_G0.8281.00
80_L121_A0.8271.00
354_G358_L0.8271.00
83_D117_I0.8251.00
266_P272_L0.8221.00
146_A152_L0.8211.00
253_M256_T0.8211.00
200_M224_R0.8211.00
66_H142_E0.8151.00
102_F195_Y0.8141.00
64_T68_L0.8141.00
94_F99_D0.8091.00
203_F376_A0.8081.00
359_T363_I0.8051.00
235_P238_P0.7991.00
192_K227_Y0.7991.00
301_R304_I0.7921.00
157_Q161_M0.7891.00
71_L74_W0.7891.00
262_I337_S0.7891.00
61_P182_L0.7861.00
345_E406_D0.7801.00
390_Y394_Q0.7801.00
331_A335_V0.7791.00
155_H159_I0.7791.00
245_M249_D0.7781.00
184_I187_L0.7781.00
66_H139_I0.7761.00
323_H336_A0.7751.00
343_K346_Q0.7751.00
383_D387_L0.7721.00
307_L322_L0.7671.00
70_H135_E0.7671.00
63_G174_G0.7611.00
70_H95_T0.7611.00
115_I220_Q0.7601.00
234_I237_C0.7571.00
130_K134_Q0.7561.00
284_I291_P0.7561.00
249_D252_R0.7551.00
43_D314_Y0.7541.00
82_S86_A0.7531.00
283_R357_S0.7501.00
89_A106_S0.7441.00
330_S333_I0.7431.00
279_D389_M0.7401.00
67_F139_I0.7381.00
89_A114_T0.7371.00
264_A310_E0.7351.00
254_E261_Q0.7341.00
349_A352_Q0.7341.00
139_I142_E0.7321.00
217_P220_Q0.7321.00
80_L117_I0.7291.00
190_A194_A0.7291.00
119_L223_K0.7291.00
164_P169_A0.7281.00
104_F118_L0.7261.00
198_H228_H0.7241.00
44_F194_A0.7231.00
72_L121_A0.7231.00
363_I390_Y0.7231.00
104_F107_L0.7231.00
339_Y343_K0.7221.00
40_V221_L0.7201.00
76_N125_H0.7171.00
283_R358_L0.7161.00
135_E139_I0.7151.00
280_I354_G0.7141.00
62_Y170_V0.7111.00
30_F369_V0.7101.00
66_H95_T0.7071.00
293_F298_Q0.7071.00
70_H142_E0.7071.00
177_E181_A0.7051.00
123_W224_R0.7051.00
220_Q223_K0.7041.00
336_A339_Y0.7031.00
156_Y160_S0.7031.00
357_S360_D0.7031.00
375_W379_C0.7021.00
342_Q345_E0.7001.00
347_V398_A0.6991.00
127_F132_V0.6981.00
238_P241_L0.6971.00
36_R204_L0.6951.00
74_W131_I0.6941.00
284_I350_W0.6941.00
61_P64_T0.6931.00
43_D48_D0.6911.00
347_V402_L0.6901.00
262_I265_L0.6891.00
296_I306_R0.6891.00
21_S222_E0.6881.00
43_D201_T0.6861.00
153_S157_Q0.6851.00
97_Y172_P0.6811.00
254_E257_W0.6811.00
80_L83_D0.6811.00
15_D29_K0.6801.00
30_F372_C0.6771.00
296_I301_R0.6751.00
295_E342_Q0.6751.00
69_E73_F0.6731.00
260_L333_I0.6731.00
127_F191_Y0.6711.00
329_S333_I0.6711.00
325_Q328_H0.6691.00
194_A199_R0.6681.00
260_L263_G0.6681.00
346_Q402_L0.6661.00
274_I277_Y0.6641.00
103_M107_L0.6631.00
203_F377_A0.6621.00
308_S319_F0.6621.00
278_W281_A0.6611.00
350_W353_Y0.6611.00
273_S395_D0.6611.00
132_V136_K0.6591.00
34_H108_P0.6571.00
70_H139_I0.6561.00
190_A195_Y0.6561.00
65_A68_L0.6541.00
177_E180_E0.6521.00
293_F297_Q0.6511.00
67_F71_L0.6511.00
44_F100_T0.6511.00
70_H73_F0.6481.00
256_T264_A0.6441.00
76_N126_S0.6441.00
285_L340_V0.6441.00
146_A173_A0.6431.00
260_L416_I0.6431.00
291_P295_E0.6421.00
372_C376_A0.6411.00
39_N373_F0.6401.00
178_D182_L0.6381.00
203_F373_F0.6381.00
69_E93_A0.6381.00
245_M248_G0.6351.00
258_T329_S0.6321.00
371_K374_E0.6311.00
209_E213_T0.6301.00
404_L408_M0.6291.00
292_F306_R0.6291.00
277_Y281_A0.6291.00
69_E142_E0.6291.00
68_L190_A0.6271.00
36_R111_L0.6271.00
50_C193_A0.6271.00
344_K402_L0.6261.00
377_A381_R0.6231.00
67_F187_L0.6211.00
27_R217_P0.6211.00
40_V118_L0.6201.00
70_H92_N0.6201.00
402_L405_I0.6171.00
19_T218_H0.6171.00
69_E100_T0.6121.00
107_L110_R0.6111.00
392_I396_M0.6091.00
247_L250_E0.6091.00
74_W134_Q0.6091.00
303_E323_H0.6091.00
348_A355_K0.6081.00
27_R204_L0.6081.00
257_W261_Q0.6081.00
132_V182_L0.6071.00
46_S97_Y0.6061.00
362_I389_M0.6051.00
46_S49_V0.6051.00
156_Y171_F0.6041.00
236_A240_V0.6041.00
306_R336_A0.6031.00
95_T100_T0.6021.00
201_T381_R0.6011.00
31_P209_E0.6001.00
372_C380_D0.6001.00
210_N213_T0.5991.00
36_R208_S0.5961.00
351_L396_M0.5961.00
21_S197_A0.5951.00
165_S169_A0.5941.00
405_I408_M0.5931.00
127_F184_I0.5921.00
124_N223_K0.5921.00
237_C241_L0.5921.00
30_F205_I0.5911.00
291_P294_Q0.5901.00
255_D261_Q0.5901.00
237_C243_Q0.5901.00
39_N103_M0.5891.00
61_P65_A0.5871.00
357_S361_A0.5861.00
384_C387_L0.5851.00
314_Y317_G0.5821.00
26_F203_F0.5821.00
195_Y199_R0.5801.00
64_T186_D0.5791.00
280_I401_F0.5781.00
261_Q264_A0.5771.00
41_K203_F0.5771.00
313_I316_D0.5761.00
23_L221_L0.5761.00
371_K375_W0.5761.00
25_I217_P0.5751.00
94_F103_M0.5751.00
203_F380_D0.5731.00
239_P243_Q0.5731.00
194_A197_A0.5721.00
236_A239_P0.5710.99
81_Y91_L0.5700.99
117_I120_D0.5690.99
252_R255_D0.5690.99
23_L224_R0.5660.99
289_D294_Q0.5640.99
380_D383_D0.5630.99
38_C114_T0.5630.99
185_S192_K0.5620.99
102_F118_L0.5620.99
281_A343_K0.5620.99
251_E256_T0.5610.99
251_E261_Q0.5610.99
274_I404_L0.5590.99
93_A102_F0.5590.99
162_L261_Q0.5580.99
295_E338_Y0.5570.99
260_L264_A0.5560.99
98_T314_Y0.5540.99
127_F188_Q0.5530.99
138_V142_E0.5520.99
303_E307_L0.5510.99
322_L325_Q0.5500.99
95_T142_E0.5490.99
69_E195_Y0.5480.99
93_A142_E0.5470.99
122_L191_Y0.5450.99
22_G226_D0.5450.99
187_L191_Y0.5450.99
36_R106_S0.5430.99
163_S316_D0.5430.99
255_D260_L0.5420.99
251_E254_E0.5420.99
406_D410_S0.5400.99
376_A380_D0.5380.99
166_S169_A0.5380.99
144_Q147_H0.5360.99
272_L407_A0.5360.99
352_Q394_Q0.5360.99
154_Y259_G0.5340.99
297_Q303_E0.5340.99
249_D256_T0.5340.99
323_H326_G0.5310.99
152_L156_Y0.5310.99
389_M392_I0.5300.99
313_I317_G0.5290.99
17_R217_P0.5270.99
272_L408_M0.5270.99
188_Q191_Y0.5270.99
239_P244_K0.5270.99
281_A409_A0.5260.99
93_A121_A0.5260.99
401_F405_I0.5260.99
141_S145_T0.5260.99
115_I213_T0.5250.99
196_Q229_A0.5250.99
283_R286_F0.5250.99
81_Y84_F0.5240.99
136_K180_E0.5240.99
296_I336_A0.5220.99
204_L217_P0.5220.99
49_V65_A0.5220.99
38_C202_L0.5210.99
68_L191_Y0.5200.99
406_D411_S0.5190.99
287_Q293_F0.5190.99
377_A380_D0.5180.99
42_I100_T0.5160.99
378_E382_C0.5160.99
20_D222_E0.5120.99
253_M261_Q0.5110.99
263_G266_P0.5110.99
145_T149_N0.5100.99
204_L210_N0.5100.99
76_N124_N0.5090.99
37_L369_V0.5080.99
353_Y357_S0.5080.99
344_K410_S0.5080.99
273_S276_L0.5070.99
66_H138_V0.5070.99
255_D258_T0.5070.99
275_K312_Y0.5070.99
238_P244_K0.5070.99
404_L407_A0.5070.99
74_W138_V0.5060.99
70_H93_A0.5050.99
154_Y158_L0.5040.99
213_T216_P0.5040.99
161_M417_H0.5030.99
202_L221_L0.5010.99
114_T118_L0.5010.99
31_P34_H0.5010.99
280_I355_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3amiA 2 0.9531 100 0.182 Contact Map
1hr6B 1 0.9577 100 0.185 Contact Map
3eoqA 2 0.9249 100 0.186 Contact Map
1pp9A 1 0.9695 100 0.192 Contact Map
4nnzA 2 0.9038 100 0.193 Contact Map
3hdiA 2 0.9296 100 0.201 Contact Map
4xeaA 2 0.946 100 0.205 Contact Map
1q2lA 1 0.9695 100 0.212 Contact Map
3amjB 1 0.9296 100 0.224 Contact Map
1hr6A 1 0.9437 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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