GREMLIN Database
YWHL - Uncharacterized protein YwhL
UniProt: P71004 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (376)
Sequences: 2306 (2041)
Seq/√Len: 105.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_V334_V5.3081.00
316_T334_V4.6351.00
193_S211_L4.3511.00
210_V250_A4.2871.00
292_A302_Y4.2271.00
235_G252_V4.0101.00
218_V252_V3.3281.00
198_N212_H3.2301.00
334_V347_I3.1871.00
213_G217_L3.0771.00
291_T332_A3.0251.00
316_T341_P2.9371.00
235_G255_A2.9151.00
333_Y370_F2.8701.00
279_D293_N2.7571.00
193_S215_T2.6441.00
252_V261_I2.5721.00
168_T201_V2.5311.00
211_L221_I2.4701.00
336_N341_P2.4571.00
333_Y377_A2.2911.00
335_L365_L2.2521.00
176_V211_L2.2211.00
291_T325_T2.1971.00
252_V255_A2.1551.00
150_V154_L2.1311.00
296_S300_D2.1161.00
211_L215_T2.1131.00
95_R98_Y2.1071.00
361_L379_F2.1001.00
259_Y271_V2.0781.00
169_A179_I2.0211.00
316_T336_N2.0031.00
235_G254_A1.9951.00
336_N343_G1.9831.00
258_I292_A1.9311.00
379_F395_V1.9121.00
322_L335_L1.9051.00
213_G219_S1.8711.00
333_Y368_I1.8711.00
112_E116_V1.8371.00
168_T199_L1.8331.00
251_Y280_F1.8311.00
73_I77_Y1.8181.00
275_P292_A1.8151.00
129_F132_I1.8111.00
210_V243_F1.8111.00
417_T420_K1.8041.00
200_G242_E1.7671.00
326_P329_G1.7561.00
70_P74_G1.7281.00
124_G128_D1.7221.00
210_V220_V1.6891.00
62_C66_T1.6801.00
125_R129_F1.6621.00
240_K253_M1.6591.00
63_L66_T1.6551.00
251_Y260_V1.6501.00
114_D118_Y1.6481.00
193_S221_I1.6171.00
122_Q126_C1.6071.00
130_S133_T1.5711.00
334_V341_P1.5541.00
402_I405_N1.5511.00
215_T219_S1.5481.00
155_V170_N1.5431.00
77_Y81_V1.5331.00
400_Q404_A1.5271.00
147_P150_V1.5241.00
323_I334_V1.5181.00
293_N320_P1.5161.00
139_I143_F1.5051.00
72_D76_R1.5051.00
117_V120_A1.5051.00
61_P64_I1.5011.00
316_T347_I1.4981.00
72_D82_Q1.4801.00
111_E114_D1.4721.00
113_I116_V1.4711.00
241_I252_V1.4661.00
66_T69_E1.4661.00
245_P286_G1.4631.00
219_S231_T1.4531.00
74_G78_A1.4491.00
170_N196_P1.4431.00
126_C131_Q1.4421.00
425_A435_V1.4371.00
251_Y289_V1.4291.00
315_D347_I1.4231.00
193_S213_G1.4131.00
335_L368_I1.4011.00
150_V179_I1.3821.00
56_S60_E1.3721.00
109_H113_I1.3721.00
117_V121_A1.3601.00
55_L59_S1.3340.99
168_T178_V1.3340.99
345_T357_D1.3150.99
102_D106_S1.3080.99
98_Y102_D1.3050.99
104_A108_I1.2930.99
76_R82_Q1.2820.99
45_S48_V1.2790.99
82_Q86_T1.2740.99
50_W55_L1.2640.99
113_I118_Y1.2530.99
81_V85_I1.2470.99
316_T345_T1.2460.99
107_V110_T1.2300.99
51_S55_L1.2290.99
127_P130_S1.2290.99
49_T54_N1.2280.99
48_V59_S1.2210.99
251_Y282_L1.2150.99
121_A127_P1.2150.99
401_R404_A1.2120.99
113_I117_V1.2070.99
139_I144_Y1.2040.99
321_S337_G1.1980.99
98_Y101_G1.1860.99
151_A154_L1.1820.99
234_V261_I1.1810.99
47_A51_S1.1760.99
95_R101_G1.1760.99
95_R99_G1.1750.99
79_V82_Q1.1710.99
118_Y122_Q1.1670.99
139_I142_P1.1660.98
59_S62_C1.1650.98
97_Q101_G1.1650.98
427_Q431_N1.1640.98
82_Q85_I1.1590.98
426_A436_Y1.1560.98
333_Y346_E1.1550.98
69_E73_I1.1510.98
344_V379_F1.1460.98
81_V84_T1.1450.98
228_I231_T1.1390.98
119_Y123_S1.1380.98
63_L70_P1.1350.98
197_T214_N1.1260.98
73_I80_R1.1250.98
389_I393_Y1.1140.98
67_G75_V1.1130.98
71_E74_G1.1070.98
74_G80_R1.1020.98
75_V79_V1.1000.98
77_Y82_Q1.0990.98
97_Q102_D1.0980.98
70_P79_V1.0950.98
368_I377_A1.0910.98
60_E65_Q1.0900.98
76_R80_R1.0890.98
71_E80_R1.0890.98
100_Q111_E1.0880.98
408_L411_A1.0860.98
253_M277_A1.0850.98
71_E76_R1.0830.98
111_E122_Q1.0790.98
143_F146_S1.0770.97
74_G79_V1.0760.97
341_P345_T1.0650.97
110_T114_D1.0620.97
400_Q405_N1.0610.97
99_G103_G1.0590.97
48_V53_D1.0490.97
123_S128_D1.0490.97
108_I111_E1.0480.97
149_T153_T1.0480.97
203_F247_D1.0470.97
69_E75_V1.0440.97
254_A257_S1.0400.97
116_V121_A1.0330.97
115_Q119_Y1.0310.97
395_V402_I1.0270.97
344_V365_L1.0250.97
65_Q68_P1.0130.96
75_V84_T1.0080.96
123_S126_C1.0080.96
111_E116_V1.0060.96
47_A50_W1.0040.96
99_G102_D1.0020.96
140_V147_P1.0010.96
137_L143_F1.0000.96
428_P431_N0.9960.96
52_T57_C0.9950.96
292_A296_S0.9940.96
67_G71_E0.9900.96
122_Q125_R0.9850.96
79_V83_G0.9840.96
367_T380_L0.9790.96
114_D119_Y0.9780.96
235_G259_Y0.9780.96
396_N399_R0.9750.95
65_Q74_G0.9710.95
50_W53_D0.9570.95
74_G90_S0.9540.95
112_E115_Q0.9500.95
45_S51_S0.9490.95
115_Q118_Y0.9450.95
45_S53_D0.9410.95
400_Q403_I0.9380.94
88_L92_S0.9360.94
125_R131_Q0.9310.94
141_P144_Y0.9310.94
378_Y416_V0.9270.94
52_T56_S0.9270.94
114_D120_A0.9270.94
53_D57_C0.9270.94
171_T175_T0.9220.94
334_V345_T0.9220.94
106_S110_T0.9220.94
45_S52_T0.9200.94
125_R128_D0.9170.94
234_V255_A0.9130.94
230_N266_Q0.9130.94
63_L67_G0.9120.94
102_D105_V0.9070.93
77_Y85_I0.9050.93
142_P145_G0.9050.93
108_I133_T0.9050.93
65_Q76_R0.9030.93
149_T152_G0.9020.93
53_D56_S0.9010.93
126_C130_S0.9000.93
98_Y103_G0.8980.93
48_V55_L0.8980.93
59_S65_Q0.8960.93
98_Y104_A0.8950.93
127_P133_T0.8950.93
322_L327_Y0.8900.93
70_P73_I0.8900.93
122_Q127_P0.8870.93
192_F221_I0.8850.93
101_G106_S0.8830.92
169_A177_S0.8810.92
143_F147_P0.8780.92
116_V119_Y0.8730.92
78_A82_Q0.8720.92
157_P200_G0.8710.92
46_A50_W0.8710.92
169_A173_D0.8700.92
120_A129_F0.8700.92
107_V117_V0.8700.92
71_E83_G0.8690.92
126_C133_T0.8690.92
100_Q105_V0.8680.92
66_T71_E0.8660.92
283_D325_T0.8660.92
66_T87_L0.8630.92
108_I114_D0.8610.91
108_I112_E0.8610.91
89_V93_P0.8610.91
67_G72_D0.8580.91
193_S219_S0.8580.91
192_F211_L0.8580.91
197_T213_G0.8570.91
78_A87_L0.8520.91
70_P76_R0.8520.91
124_G131_Q0.8520.91
52_T59_S0.8510.91
294_G298_S0.8510.91
218_V238_P0.8490.91
379_F393_Y0.8490.91
376_R380_L0.8450.91
48_V51_S0.8430.91
141_P146_S0.8420.91
140_V145_G0.8410.90
78_A85_I0.8390.90
80_R87_L0.8390.90
176_V190_I0.8380.90
94_V98_Y0.8360.90
55_L58_I0.8360.90
196_P212_H0.8320.90
166_V171_T0.8320.90
244_D282_L0.8300.90
69_E72_D0.8290.90
101_G105_V0.8280.90
137_L140_V0.8270.90
48_V56_S0.8270.90
51_S59_S0.8220.89
413_D427_Q0.8180.89
48_V62_C0.8160.89
122_Q131_Q0.8150.89
158_P167_F0.8120.89
79_V85_I0.8100.89
46_A53_D0.8070.89
121_A124_G0.8060.89
65_Q73_I0.8040.88
124_G129_F0.7990.88
60_E67_G0.7970.88
75_V78_A0.7970.88
242_E281_A0.7950.88
234_V259_Y0.7940.88
284_P329_G0.7930.88
111_E115_Q0.7910.88
378_Y381_E0.7900.88
65_Q79_V0.7900.88
55_L62_C0.7890.87
94_V107_V0.7890.87
54_N57_C0.7870.87
127_P131_Q0.7860.87
60_E69_E0.7860.87
68_P71_E0.7830.87
65_Q71_E0.7790.87
45_S49_T0.7780.87
100_Q103_G0.7750.87
56_S67_G0.7750.87
264_A267_S0.7740.86
58_I63_L0.7730.86
54_N59_S0.7730.86
137_L141_P0.7700.86
141_P147_P0.7690.86
87_L90_S0.7660.86
49_T52_T0.7660.86
114_D128_D0.7600.85
407_S410_G0.7590.85
116_V124_G0.7560.85
51_S56_S0.7560.85
335_L342_K0.7540.85
138_L141_P0.7510.85
140_V144_Y0.7500.85
323_I332_A0.7480.85
284_P325_T0.7460.84
73_I78_A0.7440.84
117_V124_G0.7440.84
73_I85_I0.7430.84
93_P98_Y0.7430.84
61_P65_Q0.7420.84
76_R79_V0.7420.84
52_T67_G0.7370.84
88_L94_V0.7370.84
57_C61_P0.7360.84
74_G84_T0.7360.84
324_T369_V0.7350.83
78_A86_T0.7340.83
92_S120_A0.7310.83
69_E74_G0.7310.83
420_K423_I0.7300.83
90_S93_P0.7300.83
354_R357_D0.7290.83
112_E132_I0.7290.83
50_W54_N0.7290.83
116_V123_S0.7280.83
173_D177_S0.7270.83
51_S54_N0.7250.83
178_V190_I0.7230.82
157_P199_L0.7220.82
88_L91_V0.7220.82
87_L96_N0.7190.82
101_G107_V0.7180.82
49_T65_Q0.7170.82
86_T89_V0.7150.82
59_S67_G0.7140.82
69_E80_R0.7140.82
75_V85_I0.7110.81
125_R130_S0.7090.81
48_V60_E0.7070.81
109_H118_Y0.7060.81
63_L77_Y0.7050.81
46_A55_L0.7030.81
46_A59_S0.7030.81
84_T88_L0.7020.81
140_V143_F0.7020.81
56_S59_S0.7000.80
55_L66_T0.6990.80
113_I120_A0.6990.80
63_L87_L0.6990.80
235_G261_I0.6980.80
46_A52_T0.6960.80
70_P83_G0.6940.80
56_S68_P0.6900.79
294_G297_W0.6890.79
92_S95_R0.6890.79
393_Y402_I0.6870.79
51_S63_L0.6850.79
66_T72_D0.6820.79
77_Y88_L0.6810.79
361_L381_E0.6800.78
158_P243_F0.6790.78
192_F238_P0.6790.78
47_A57_C0.6780.78
318_E336_N0.6770.78
105_V108_I0.6770.78
68_P72_D0.6760.78
58_I65_Q0.6740.78
293_N323_I0.6730.78
323_I335_L0.6720.78
67_G73_I0.6710.78
128_D132_I0.6700.77
58_I67_G0.6700.77
88_L93_P0.6680.77
112_E120_A0.6670.77
128_D131_Q0.6670.77
61_P81_V0.6660.77
77_Y80_R0.6650.77
134_V143_F0.6630.77
56_S61_P0.6550.76
101_G114_D0.6540.76
119_Y129_F0.6530.76
137_L147_P0.6500.75
71_E77_Y0.6480.75
138_L144_Y0.6470.75
47_A58_I0.6460.75
48_V57_C0.6450.75
218_V250_A0.6450.75
111_E118_Y0.6440.75
100_Q106_S0.6430.75
52_T58_I0.6430.75
84_T87_L0.6410.74
116_V120_A0.6390.74
79_V84_T0.6390.74
65_Q80_R0.6380.74
103_G110_T0.6370.74
142_P147_P0.6360.74
107_V116_V0.6360.74
51_S58_I0.6340.73
406_V410_G0.6340.73
48_V58_I0.6330.73
113_I123_S0.6320.73
124_G127_P0.6320.73
65_Q81_V0.6300.73
87_L105_V0.6290.73
108_I116_V0.6270.73
46_A51_S0.6270.73
52_T66_T0.6260.73
361_L395_V0.6250.72
281_A323_I0.6250.72
51_S74_G0.6250.72
62_C74_G0.6240.72
68_P80_R0.6230.72
316_T320_P0.6230.72
51_S68_P0.6220.72
80_R89_V0.6210.72
86_T91_V0.6210.72
47_A52_T0.6210.72
118_Y124_G0.6210.72
292_A300_D0.6190.72
94_V120_A0.6190.72
269_I272_I0.6180.72
397_T402_I0.6180.72
88_L96_N0.6170.71
265_S268_V0.6160.71
138_L145_G0.6140.71
112_E122_Q0.6140.71
79_V86_T0.6130.71
378_Y392_L0.6110.71
254_A261_I0.6070.70
56_S63_L0.6070.70
68_P78_A0.6060.70
69_E77_Y0.6040.70
123_S133_T0.6030.70
75_V83_G0.6020.70
117_V122_Q0.6020.70
218_V241_I0.6010.69
150_V169_A0.6010.69
211_L219_S0.6000.69
47_A56_S0.6000.69
120_A126_C0.6000.69
407_S411_A0.5940.69
193_S196_P0.5920.68
166_V178_V0.5920.68
49_T56_S0.5910.68
70_P75_V0.5900.68
46_A58_I0.5900.68
137_L142_P0.5890.68
61_P68_P0.5880.68
90_S94_V0.5880.68
173_D179_I0.5870.68
63_L83_G0.5860.68
262_N282_L0.5850.67
84_T89_V0.5850.67
112_E117_V0.5850.67
50_W56_S0.5850.67
139_I146_S0.5840.67
96_N113_I0.5830.67
66_T78_A0.5820.67
275_P294_G0.5810.67
63_L68_P0.5800.67
116_V126_C0.5790.67
88_L95_R0.5790.67
103_G106_S0.5790.67
48_V67_G0.5770.66
69_E78_A0.5770.66
99_G114_D0.5750.66
49_T60_E0.5750.66
389_I395_V0.5730.66
104_A110_T0.5730.66
117_V123_S0.5720.66
327_Y374_S0.5720.66
97_Q104_A0.5680.65
96_N100_Q0.5670.65
270_D274_I0.5670.65
120_A123_S0.5660.65
112_E119_Y0.5660.65
110_T118_Y0.5660.65
58_I61_P0.5660.65
90_S95_R0.5660.65
52_T68_P0.5650.65
91_V97_Q0.5640.65
210_V241_I0.5630.64
76_R81_V0.5610.64
73_I87_L0.5590.64
127_P132_I0.5590.64
97_Q108_I0.5580.64
412_F429_N0.5580.64
142_P146_S0.5570.64
101_G108_I0.5560.64
212_H238_P0.5540.63
64_I75_V0.5540.63
113_I121_A0.5530.63
54_N70_P0.5530.63
141_P148_L0.5520.63
213_G221_I0.5460.62
91_V94_V0.5450.62
260_V282_L0.5430.62
47_A68_P0.5420.62
79_V87_L0.5420.62
55_L61_P0.5400.61
83_G95_R0.5390.61
326_P370_F0.5390.61
56_S65_Q0.5380.61
71_E79_V0.5370.61
62_C68_P0.5360.61
256_G297_W0.5340.60
49_T62_C0.5340.60
58_I73_I0.5330.60
120_A124_G0.5320.60
47_A54_N0.5320.60
201_V371_S0.5320.60
70_P89_V0.5310.60
85_I89_V0.5310.60
109_H112_E0.5290.60
64_I68_P0.5270.59
406_V409_P0.5270.59
376_R381_E0.5260.59
45_S50_W0.5260.59
275_P298_S0.5230.59
61_P79_V0.5230.59
55_L72_D0.5210.59
77_Y90_S0.5200.58
71_E86_T0.5190.58
159_S162_P0.5190.58
69_E90_S0.5190.58
196_P345_T0.5190.58
65_Q72_D0.5180.58
67_G78_A0.5170.58
120_A125_R0.5170.58
58_I62_C0.5160.58
70_P80_R0.5160.58
408_L436_Y0.5140.58
47_A78_A0.5120.57
123_S127_P0.5120.57
348_S351_P0.5100.57
122_Q128_D0.5090.57
200_G243_F0.5090.57
401_R405_N0.5090.57
63_L108_I0.5090.57
82_Q92_S0.5080.57
242_E280_F0.5060.56
277_A294_G0.5030.56
169_A433_V0.5020.56
115_Q131_Q0.5010.56
82_Q87_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.631 100 0.339 Contact Map
4u1eI 1 0.6616 100 0.378 Contact Map
1gotB 1 0.7118 100 0.388 Contact Map
3j60g 1 0.7533 100 0.402 Contact Map
4j87A 1 0.6223 100 0.403 Contact Map
4wjuA 1 0.7817 100 0.404 Contact Map
3ow8A 3 0.631 100 0.404 Contact Map
1erjA 1 0.7293 100 0.405 Contact Map
3dm0A 1 0.8428 100 0.414 Contact Map
3zey7 1 0.6201 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.