GREMLIN Database
YWHK - Uncharacterized protein YwhK
UniProt: P71003 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (382)
Sequences: 1841 (1623)
Seq/√Len: 83.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_P216_L5.4131.00
240_D257_V4.3211.00
295_V304_V4.1821.00
198_P220_N3.9751.00
400_V419_T3.8921.00
215_V255_A3.8861.00
173_T206_I3.4051.00
335_V348_I3.2541.00
223_I257_V3.2191.00
294_Y326_T3.0331.00
257_V266_I2.9861.00
256_Y293_A2.8351.00
155_S174_A2.8351.00
181_V216_L2.7791.00
246_I257_V2.5471.00
218_P222_V2.3531.00
173_T183_V2.3491.00
256_Y286_I2.3131.00
174_A178_D2.2871.00
155_S184_I2.2701.00
301_V335_V2.2371.00
318_E335_V2.1701.00
294_Y333_A2.1661.00
283_D296_L2.1161.00
400_V404_A2.0831.00
176_P180_S2.0621.00
215_V246_I2.0611.00
215_V248_F2.0211.00
240_D266_I2.0171.00
337_E342_F2.0111.00
122_V126_S2.0041.00
126_S129_S1.9771.00
203_G217_H1.9711.00
216_L220_N1.9571.00
240_D259_T1.9191.00
240_D260_G1.9181.00
155_S178_D1.8361.00
345_L379_Y1.8281.00
94_L97_V1.8191.00
371_T374_A1.8151.00
121_Q125_Y1.8151.00
135_I138_I1.8111.00
133_P136_S1.8081.00
263_V295_V1.8001.00
171_A418_A1.7751.00
129_S134_D1.7521.00
220_N224_S1.7281.00
264_Y276_S1.7221.00
42_G46_D1.7191.00
410_T413_G1.6661.00
125_Y128_E1.6311.00
119_I123_V1.6301.00
41_E48_A1.6271.00
421_F424_Q1.6121.00
198_P218_P1.6101.00
101_R104_Y1.6071.00
318_E342_F1.6061.00
227_D230_T1.5991.00
327_N370_F1.5821.00
77_D85_V1.5651.00
216_L226_I1.5631.00
86_R90_T1.5561.00
380_D384_G1.5481.00
85_V91_V1.5481.00
44_V50_A1.5461.00
122_V127_D1.5451.00
70_I89_G1.5451.00
280_E295_V1.5431.00
380_D404_A1.5411.00
263_V293_A1.5311.00
266_I273_V1.5170.99
47_P53_N1.5160.99
127_D133_P1.5150.99
47_P50_A1.5130.99
129_S136_S1.5100.99
84_A89_G1.4970.99
327_N330_E1.4820.99
334_Y370_F1.4820.99
185_D188_T1.4740.99
423_E427_I1.4680.99
249_I286_I1.4670.99
335_V346_T1.4420.99
299_G302_Q1.4400.99
67_R73_G1.4380.99
114_I129_S1.4370.99
174_A184_I1.4270.99
41_E46_D1.4250.99
164_P171_A1.4190.99
80_G87_L1.4170.99
128_E134_D1.4150.99
45_V51_V1.4100.99
101_R107_G1.3990.99
84_A88_Q1.3800.99
122_V125_Y1.3760.99
336_L343_N1.3660.99
41_E45_V1.3570.99
48_A51_V1.3520.99
155_S176_P1.3500.99
65_S73_G1.3490.99
224_S236_T1.3420.99
101_R105_G1.3420.99
92_T96_S1.3290.99
69_L77_D1.3290.99
133_P137_D1.3270.99
58_A61_L1.3260.99
410_T414_D1.3230.99
84_A91_V1.3230.99
301_V321_V1.3140.98
126_S132_C1.3090.98
66_D72_T1.3070.98
83_F90_T1.3040.98
80_G84_A1.2940.98
183_V192_V1.2870.98
197_L226_I1.2710.98
129_S135_I1.2700.98
130_D134_D1.2700.98
134_D137_D1.2680.98
155_S159_T1.2640.98
134_D139_T1.2640.98
71_Q74_P1.2600.98
318_E346_T1.2500.98
47_P51_V1.2480.98
198_P224_S1.2430.98
78_E89_G1.2400.98
76_P80_G1.2340.98
81_V84_A1.2330.98
379_Y389_V1.2210.98
116_N120_D1.2200.98
59_D62_S1.2200.98
126_S130_D1.2190.98
54_V57_N1.2130.97
130_D135_I1.2090.97
109_G117_A1.2080.97
52_A55_T1.2070.97
50_A53_N1.2050.97
44_V69_L1.2040.97
57_N61_L1.2020.97
55_T60_S1.1980.97
102_N105_G1.1970.97
43_F47_P1.1960.97
115_H131_D1.1950.97
44_V48_A1.1940.97
95_V99_P1.1850.97
296_L321_V1.1850.97
125_Y130_D1.1850.97
208_P252_H1.1840.97
239_L266_I1.1810.97
67_R72_T1.1800.97
100_V104_Y1.1780.97
72_T76_P1.1780.97
129_S132_C1.1540.97
46_D53_N1.1540.97
116_N121_Q1.1530.97
129_S133_P1.1490.96
43_F46_D1.1490.96
217_H243_P1.1460.96
418_A428_V1.1460.96
44_V47_P1.1420.96
129_S137_D1.1420.96
76_P87_L1.1340.96
41_E50_A1.1280.96
331_R349_D1.1240.96
256_Y284_V1.1230.96
259_T262_A1.1200.96
115_H122_V1.1190.96
45_V49_E1.1190.96
79_V84_A1.1150.96
52_A59_D1.1100.96
245_L258_F1.1070.96
70_I75_E1.1050.96
419_T427_I1.1010.95
420_R425_S1.0980.95
79_V90_T1.0960.95
215_V225_V1.0960.95
44_V51_V1.0920.95
218_P224_S1.0830.95
378_L409_F1.0810.95
85_V88_Q1.0800.95
121_Q124_Y1.0730.95
69_L73_G1.0720.95
93_L100_V1.0710.95
43_F51_V1.0700.95
135_I139_T1.0650.95
76_P79_V1.0620.94
337_E346_T1.0590.94
46_D50_A1.0590.94
51_V54_V1.0580.94
42_G47_P1.0480.94
161_V175_N1.0390.94
42_G49_E1.0340.94
286_I293_A1.0320.94
123_V134_D1.0250.93
73_G81_V1.0250.93
76_P85_V1.0200.93
183_V206_I1.0130.93
118_E131_D1.0120.93
112_S117_A1.0080.93
378_L388_S1.0020.93
174_A182_S1.0000.92
82_Q88_Q0.9990.92
48_A52_A0.9950.92
128_E131_D0.9930.92
410_T418_A0.9860.92
85_V89_G0.9830.92
217_H257_V0.9800.92
120_D124_Y0.9780.92
75_E81_V0.9760.92
41_E49_E0.9720.91
42_G45_V0.9700.91
103_Q106_Q0.9660.91
224_S233_V0.9630.91
198_P222_V0.9620.91
86_R89_G0.9620.91
80_G89_G0.9590.91
318_E337_E0.9590.91
404_A419_T0.9580.91
317_R346_T0.9580.91
126_S135_I0.9510.90
52_A62_S0.9430.90
117_A123_V0.9430.90
274_D277_I0.9430.90
131_D134_D0.9380.90
165_E169_V0.9350.90
390_S393_G0.9350.90
118_E123_V0.9280.89
77_D81_V0.9260.89
43_F54_V0.9250.89
362_E367_Y0.9230.89
69_L72_T0.9190.89
62_S71_Q0.9150.89
82_Q87_L0.9100.88
205_E247_R0.9090.88
132_C137_D0.9080.88
83_F89_G0.9080.88
145_V148_P0.9050.88
55_T58_A0.9040.88
78_E84_A0.9030.88
241_Q259_T0.9020.88
285_A324_I0.8970.88
77_D91_V0.8920.87
41_E47_P0.8910.87
317_R348_I0.8890.87
46_D49_E0.8890.87
64_V70_I0.8880.87
115_H123_V0.8870.87
116_N133_P0.8840.87
117_A121_Q0.8840.87
41_E44_V0.8800.87
225_V237_I0.8790.87
46_D56_W0.8780.87
73_G79_V0.8780.87
250_P290_G0.8770.87
94_L104_Y0.8760.86
114_I117_A0.8750.86
77_D87_L0.8740.86
155_S182_S0.8710.86
165_E168_P0.8700.86
118_E136_S0.8700.86
128_E135_I0.8670.86
49_E57_N0.8670.86
47_P55_T0.8620.86
111_V115_H0.8610.86
59_D65_S0.8540.85
126_S134_D0.8540.85
124_Y130_D0.8520.85
197_L224_S0.8500.85
113_V116_N0.8480.85
130_D136_S0.8470.85
158_G163_V0.8420.84
388_S397_I0.8340.84
66_D73_G0.8340.84
280_E299_G0.8290.83
79_V88_Q0.8270.83
64_V71_Q0.8260.83
127_D131_D0.8250.83
397_I400_V0.8220.83
114_I122_V0.8220.83
47_P52_A0.8200.83
88_Q91_V0.8200.83
80_G86_R0.8190.83
334_Y377_Y0.8190.83
128_E133_P0.8190.83
120_D129_S0.8190.83
45_V69_L0.8160.82
105_G108_D0.8140.82
104_Y107_G0.8130.82
168_P411_P0.8110.82
175_N201_P0.8110.82
124_Y132_C0.8100.82
163_V205_E0.8080.82
45_V50_A0.8070.82
53_N59_D0.8070.82
173_T213_V0.8060.82
67_R70_I0.8050.81
152_S155_S0.8050.81
94_L108_D0.8050.81
160_I177_N0.8040.81
71_Q76_P0.8030.81
46_D60_S0.8030.81
112_S125_Y0.8010.81
123_V127_D0.8000.81
44_V53_N0.8000.81
80_G83_F0.7970.81
57_N63_C0.7960.81
76_P95_V0.7950.81
398_G401_P0.7920.80
197_L201_P0.7890.80
76_P89_G0.7870.80
130_D133_P0.7840.80
120_D123_V0.7810.79
159_T174_A0.7800.79
112_S116_N0.7730.79
67_R74_P0.7730.79
60_S63_C0.7690.78
364_E368_R0.7680.78
111_V114_I0.7680.78
59_D67_R0.7670.78
49_E53_N0.7670.78
83_F87_L0.7660.78
223_I246_I0.7650.78
122_V129_S0.7620.78
106_Q109_G0.7610.78
41_E51_V0.7610.78
63_C67_R0.7610.78
127_D130_D0.7590.78
72_T79_V0.7590.78
294_Y324_I0.7590.78
322_S345_L0.7570.77
100_V110_A0.7560.77
84_A87_L0.7550.77
175_N185_D0.7510.77
97_V103_Q0.7470.76
119_I125_Y0.7450.76
208_P248_F0.7400.76
96_S107_G0.7390.76
75_E78_E0.7380.76
97_V104_Y0.7360.75
132_C135_I0.7320.75
336_L362_E0.7300.75
140_I143_L0.7290.75
116_N119_I0.7280.75
124_Y128_E0.7270.74
55_T64_V0.7260.74
400_V427_I0.7260.74
50_A54_V0.7250.74
126_S136_S0.7250.74
165_E173_T0.7250.74
119_I133_P0.7240.74
70_I74_P0.7240.74
75_E89_G0.7210.74
356_S359_Q0.7210.74
118_E124_Y0.7180.74
190_T267_G0.7180.74
77_D80_G0.7170.73
174_A179_Q0.7170.73
259_T266_I0.7160.73
122_V135_I0.7150.73
74_P81_V0.7140.73
120_D126_S0.7140.73
256_Y265_V0.7130.73
63_C68_C0.7130.73
406_D420_R0.7070.72
97_V100_V0.7070.72
122_V132_C0.7070.72
361_L389_V0.7070.72
223_I255_A0.7040.72
51_V55_T0.7030.72
87_L90_T0.7020.72
91_V104_Y0.7010.72
131_D135_I0.7010.72
386_L419_T0.6980.71
74_P82_Q0.6970.71
243_P257_V0.6960.71
324_I333_A0.6950.71
329_P332_Y0.6940.71
181_V204_I0.6940.71
78_E86_R0.6930.71
43_F52_A0.6910.71
114_I120_D0.6900.71
257_V264_Y0.6900.71
209_D212_A0.6890.70
67_R71_Q0.6880.70
280_E297_N0.6880.70
294_Y303_K0.6850.70
118_E122_V0.6840.70
244_R259_T0.6830.70
92_T98_S0.6830.70
204_I216_L0.6800.69
65_S79_V0.6780.69
191_V197_L0.6780.69
52_A60_S0.6760.69
383_T387_Y0.6750.69
181_V195_I0.6710.68
79_V87_L0.6710.68
371_T376_V0.6700.68
58_A64_V0.6700.68
198_P226_I0.6690.68
66_D104_Y0.6690.68
358_T361_L0.6660.68
365_G368_R0.6650.68
53_N56_W0.6630.67
132_C136_S0.6630.67
66_D70_I0.6620.67
92_T97_V0.6610.67
148_P151_G0.6610.67
97_V101_R0.6590.67
205_E248_F0.6580.67
111_V116_N0.6580.67
48_A62_S0.6570.67
115_H130_D0.6550.67
94_L107_G0.6540.66
42_G48_A0.6530.66
51_V63_C0.6530.66
349_D352_T0.6460.65
46_D65_S0.6460.65
63_C69_L0.6440.65
333_A350_L0.6440.65
115_H118_E0.6420.65
405_T409_F0.6420.65
247_R284_V0.6420.65
121_Q133_P0.6410.65
93_L97_V0.6410.65
174_A426_I0.6400.65
43_F49_E0.6380.65
422_I425_S0.6380.65
147_P152_S0.6370.64
72_T78_E0.6350.64
342_F346_T0.6350.64
124_Y129_S0.6340.64
178_D182_S0.6330.64
99_P104_Y0.6330.64
134_D138_I0.6330.64
162_L178_D0.6280.63
280_E300_I0.6280.63
94_L99_P0.6280.63
47_P58_A0.6280.63
57_N60_S0.6270.63
46_D52_A0.6260.63
122_V131_D0.6260.63
249_I326_T0.6260.63
67_R81_V0.6250.63
327_N332_Y0.6220.63
99_P106_Q0.6220.63
74_P79_V0.6210.62
54_V63_C0.6190.62
78_E88_Q0.6190.62
63_C72_T0.6190.62
50_A57_N0.6190.62
76_P97_V0.6170.62
330_E334_Y0.6130.61
100_V107_G0.6110.61
415_F428_V0.6110.61
96_S100_V0.6110.61
123_V126_S0.6100.61
43_F55_T0.6100.61
47_P56_W0.6090.61
66_D71_Q0.6050.60
54_V58_A0.6050.60
185_D192_V0.6040.60
161_V178_D0.6020.60
47_P59_D0.6010.60
58_A68_C0.6010.60
64_V74_P0.5990.60
87_L91_V0.5970.59
243_P258_F0.5960.59
96_S102_N0.5960.59
50_A69_L0.5930.59
156_V176_P0.5910.59
43_F68_C0.5900.59
296_L324_I0.5890.58
89_G94_L0.5890.58
69_L92_T0.5880.58
112_S120_D0.5860.58
42_G51_V0.5840.58
399_N427_I0.5830.58
92_T95_V0.5820.58
125_Y134_D0.5820.58
73_G84_A0.5820.58
83_F92_T0.5820.58
262_A276_S0.5810.57
111_V117_A0.5800.57
165_E207_T0.5750.57
68_C73_G0.5740.56
280_E304_V0.5730.56
68_C83_F0.5720.56
72_T85_V0.5710.56
197_L216_L0.5710.56
98_S103_Q0.5700.56
42_G50_A0.5690.56
175_N287_D0.5670.56
119_I139_T0.5660.55
174_A367_Y0.5650.55
78_E83_F0.5650.55
202_A219_N0.5640.55
419_T423_E0.5610.55
391_P396_V0.5610.55
43_F50_A0.5600.55
199_Y218_P0.5580.54
225_V268_I0.5560.54
49_E56_W0.5560.54
287_D290_G0.5550.54
96_S103_Q0.5550.54
166_P206_I0.5540.54
75_E87_L0.5530.54
121_Q127_D0.5480.53
101_R106_Q0.5480.53
76_P82_Q0.5480.53
59_D80_G0.5480.53
295_V302_Q0.5470.53
63_C71_Q0.5460.53
44_V57_N0.5460.53
45_V57_N0.5460.53
405_T422_I0.5450.53
61_L71_Q0.5440.53
90_T103_Q0.5440.53
121_Q136_S0.5430.52
75_E85_V0.5420.52
44_V70_I0.5420.52
290_G294_Y0.5410.52
145_V150_Y0.5400.52
75_E88_Q0.5400.52
119_I130_D0.5400.52
55_T59_D0.5390.52
66_D78_E0.5370.52
102_N107_G0.5360.51
178_D184_I0.5350.51
184_I426_I0.5350.51
130_D137_D0.5340.51
94_L98_S0.5340.51
68_C74_P0.5330.51
47_P68_C0.5320.51
397_I401_P0.5310.51
78_E85_V0.5310.51
44_V52_A0.5300.51
335_V342_F0.5300.51
58_A65_S0.5290.51
65_S90_T0.5280.50
218_P286_I0.5280.50
92_T99_P0.5280.50
48_A56_W0.5270.50
64_V73_G0.5260.50
92_T133_P0.5260.50
42_G61_L0.5240.50
126_S131_D0.5220.50
239_L264_Y0.5210.49
84_A90_T0.5200.49
391_P394_A0.5200.49
95_V100_V0.5190.49
88_Q92_T0.5190.49
381_G389_V0.5180.49
162_L174_A0.5180.49
111_V125_Y0.5180.49
126_S138_I0.5170.49
110_A127_D0.5160.49
78_E90_T0.5160.49
66_D120_D0.5150.49
124_Y127_D0.5120.48
120_D130_D0.5110.48
117_A129_S0.5110.48
354_T357_S0.5110.48
62_S65_S0.5090.48
49_E58_A0.5090.48
117_A122_V0.5080.48
97_V102_N0.5070.48
75_E80_G0.5070.48
89_G110_A0.5050.47
44_V49_E0.5040.47
68_C72_T0.5040.47
217_H369_M0.5040.47
163_V204_I0.5010.47
411_P415_F0.5010.47
421_F427_I0.5010.47
94_L100_V0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vyhC 1 0.6319 100 0.372 Contact Map
4u1eI 1 0.6585 100 0.399 Contact Map
1gotB 1 0.714 100 0.415 Contact Map
3j60g 1 0.7583 100 0.422 Contact Map
3ow8A 3 0.6253 100 0.428 Contact Map
1erjA 1 0.7295 100 0.432 Contact Map
4j87A 1 0.6208 100 0.438 Contact Map
4wjuA 1 0.7805 100 0.439 Contact Map
4j0xA 1 0.6741 100 0.442 Contact Map
4u7aA 1 0.6341 100 0.443 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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