GREMLIN Database
RAPF - Response regulator aspartate phosphatase F
UniProt: P71002 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (322)
Sequences: 1172 (1060)
Seq/√Len: 59.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
237_Q240_D5.4681.00
197_Q200_D4.7171.00
277_K280_K4.4081.00
148_S164_A4.3861.00
229_G245_F4.1941.00
144_F163_Y3.9661.00
156_Q159_F3.7361.00
161_M188_F3.5621.00
268_I272_H3.1571.00
108_G124_F3.1181.00
272_H277_K2.9411.00
189_A205_F2.9131.00
193_L205_F2.8361.00
245_F267_L2.6341.00
320_I323_F2.5321.00
352_N355_K2.5191.00
269_T285_H2.4891.00
116_E119_S2.4561.00
355_K358_A2.3911.00
185_H204_H2.2971.00
272_H280_K2.2481.00
104_N123_F2.2161.00
246_K268_I2.1551.00
205_F227_N2.1331.00
164_A187_L2.0801.00
202_I228_I2.0671.00
189_A204_H2.0661.00
165_R188_F2.0391.00
145_F187_L2.0081.00
348_H361_L1.9941.00
229_G268_I1.9891.00
28_D31_Y1.9521.00
229_G241_A1.9361.00
358_A362_K1.9211.00
225_L244_Y1.8991.00
328_E362_K1.8851.00
232_K240_D1.8841.00
121_I151_Y1.8521.00
25_S28_D1.8431.00
121_I147_M1.8421.00
268_I284_Y1.8110.99
161_M192_F1.8110.99
148_S189_A1.7920.99
104_N126_K1.7880.99
242_I272_H1.7510.99
29_A36_I1.7510.99
343_V347_Y1.7360.99
47_Q50_H1.7340.99
107_R111_E1.7310.99
33_R37_K1.6710.99
182_L208_A1.6690.99
240_D243_P1.6630.99
188_F192_F1.6420.99
108_G127_A1.6170.99
147_M151_Y1.5640.98
280_K283_E1.5640.98
168_Y185_H1.5630.98
29_A32_L1.5370.98
209_Y225_L1.5270.98
166_Q169_E1.5240.98
202_I235_Q1.5090.98
202_I231_C1.4980.98
242_I275_L1.4770.98
221_M225_L1.4760.98
27_P38_Q1.4680.98
265_Y284_Y1.4650.98
189_A201_A1.4490.97
27_P31_Y1.4470.97
242_I271_I1.4330.97
34_R38_Q1.3990.97
345_K360_F1.3940.97
28_D35_E1.3820.97
124_F146_K1.3660.96
57_E61_N1.3240.96
64_L69_P1.3170.96
150_S154_M1.3150.96
342_D345_K1.3140.96
145_F184_C1.3130.95
225_L247_R1.3130.95
113_D117_Y1.3030.95
24_F27_P1.3020.95
26_I37_K1.3000.95
31_Y34_R1.2900.95
332_L335_D1.2840.95
209_Y221_M1.2840.95
190_T205_F1.2780.95
360_F364_E1.2540.94
102_Y106_F1.2530.94
61_N65_E1.2520.94
233_N238_Y1.2500.94
303_E335_D1.2500.94
358_A361_L1.2490.94
28_D32_L1.2460.94
144_F166_Q1.2410.94
147_M154_M1.2380.94
32_L35_E1.2360.94
225_L248_A1.2320.94
49_L53_Y1.2310.94
108_G123_F1.2240.93
344_A360_F1.2230.93
144_F265_Y1.2200.93
307_L311_Y1.2190.93
50_H54_S1.2100.93
52_Y56_M1.2090.93
120_A281_A1.1980.93
311_Y316_D1.1890.92
267_L270_Q1.1890.92
271_I275_L1.1890.92
299_I303_E1.1840.92
249_I264_A1.1810.92
147_M163_Y1.1730.92
124_F128_E1.1720.92
28_D38_Q1.1700.92
242_I268_I1.1650.92
356_A363_V1.1550.91
127_A143_F1.1540.91
309_S314_G1.1540.91
308_K312_L1.1520.91
349_E365_Q1.1440.91
238_Y271_I1.1410.91
31_Y48_D1.1280.90
82_S85_L1.1230.90
226_Y264_A1.1230.90
200_D203_S1.1170.90
25_S38_Q1.1120.90
36_I39_E1.1090.89
37_K40_L1.1060.89
246_K280_K1.1010.89
361_L365_Q1.0970.89
111_E123_F1.0940.89
55_L58_F1.0900.89
30_E34_R1.0900.89
34_R41_D1.0890.89
202_I232_K1.0820.88
28_D41_D1.0690.88
26_I30_E1.0660.88
191_N195_L1.0510.87
112_L124_F1.0460.87
207_K210_S1.0430.86
186_S227_N1.0420.86
31_Y35_E1.0410.86
40_L47_Q1.0400.86
26_I36_I1.0380.86
25_S31_Y1.0370.86
27_P34_R1.0330.86
249_I268_I1.0330.86
132_I140_K1.0310.86
30_E43_M1.0290.86
167_A170_I1.0240.85
50_H53_Y1.0210.85
178_N181_L1.0100.85
36_I40_L1.0090.85
55_L59_R1.0090.85
161_M191_N1.0080.84
344_A356_A1.0060.84
290_A293_Q1.0020.84
353_F356_A1.0020.84
146_K149_E1.0000.84
269_T288_G0.9980.84
48_D51_L0.9970.84
329_S348_H0.9970.84
46_D49_L0.9950.84
356_A359_Y0.9950.84
127_A227_N0.9850.83
208_A356_A0.9850.83
306_F317_E0.9820.83
297_D300_Y0.9750.82
61_N66_Y0.9750.82
208_A224_T0.9710.82
24_F28_D0.9690.82
269_T284_Y0.9680.82
266_F285_H0.9660.82
127_A131_L0.9600.81
336_L356_A0.9440.80
54_S61_N0.9440.80
29_A43_M0.9400.80
346_Y350_R0.9390.80
119_S122_K0.9380.80
105_F109_M0.9380.80
52_Y59_R0.9370.80
32_L41_D0.9360.80
24_F30_E0.9290.79
126_K129_S0.9270.79
29_A33_R0.9180.78
222_G248_A0.9180.78
228_I244_Y0.9170.78
355_K359_Y0.9140.78
167_A184_C0.9120.78
348_H357_S0.9110.78
104_N127_A0.9060.78
35_E39_E0.9030.77
341_I364_E0.9020.77
145_F266_F0.9020.77
323_F332_L0.8940.77
24_F197_Q0.8910.76
226_Y267_L0.8890.76
264_A296_G0.8860.76
305_E312_L0.8850.76
207_K211_M0.8830.76
357_S360_F0.8810.75
25_S33_R0.8780.75
340_A359_Y0.8750.75
247_R251_V0.8750.75
52_Y55_L0.8740.75
104_N185_H0.8650.74
106_F109_M0.8620.74
116_E168_Y0.8610.74
304_F316_D0.8580.74
311_Y314_G0.8560.73
40_L43_M0.8530.73
205_F220_L0.8530.73
112_L150_S0.8510.73
205_F276_G0.8510.73
273_Y285_H0.8490.73
144_F225_L0.8480.73
26_I44_E0.8480.73
262_P269_T0.8480.73
111_E119_S0.8480.73
233_N267_L0.8440.72
298_V301_L0.8410.72
351_K361_L0.8390.72
31_Y38_Q0.8390.72
120_A149_E0.8340.71
248_A259_P0.8310.71
152_Y164_A0.8290.71
33_R40_L0.8280.71
38_Q41_D0.8270.71
168_Y181_L0.8270.71
359_Y363_V0.8230.70
101_Y106_F0.8210.70
159_F272_H0.8130.69
79_P82_S0.8090.69
32_L39_E0.8080.69
312_L315_P0.8070.69
62_L65_E0.8070.69
239_E275_L0.8030.69
39_E43_M0.7960.68
108_G112_L0.7950.68
206_Q228_I0.7950.68
148_S151_Y0.7940.68
242_I246_K0.7940.68
211_M336_L0.7920.67
25_S42_Q0.7910.67
38_Q42_Q0.7900.67
101_Y127_A0.7880.67
26_I29_A0.7870.67
215_E218_P0.7870.67
93_A213_E0.7820.66
348_H360_F0.7790.66
102_Y131_L0.7790.66
28_D39_E0.7760.66
81_L84_L0.7730.66
52_Y58_F0.7720.65
337_E340_A0.7690.65
317_E327_L0.7680.65
54_S57_E0.7660.65
174_H215_E0.7650.65
128_E144_F0.7650.65
193_L230_L0.7620.64
46_D50_H0.7610.64
224_T351_K0.7600.64
223_R226_Y0.7590.64
24_F31_Y0.7580.64
165_R192_F0.7570.64
174_H236_S0.7550.64
213_E221_M0.7550.64
265_Y287_K0.7540.64
248_A251_V0.7470.63
28_D34_R0.7450.63
229_G244_Y0.7450.63
39_E44_E0.7450.63
25_S30_E0.7440.63
34_R37_K0.7410.62
109_M124_F0.7370.62
31_Y42_Q0.7370.62
278_I282_H0.7370.62
48_D53_Y0.7360.62
245_F263_Q0.7340.62
50_H55_L0.7310.61
152_Y191_N0.7280.61
265_Y288_G0.7260.61
79_P86_L0.7240.60
230_L233_N0.7240.60
232_K237_Q0.7210.60
357_S361_L0.7200.60
152_Y190_T0.7200.60
311_Y315_P0.7200.60
151_Y159_F0.7190.60
60_H64_L0.7190.60
313_S316_D0.7180.60
191_N229_G0.7170.60
351_K354_Q0.7150.60
49_L239_E0.7150.60
30_E37_K0.7140.59
30_E44_E0.7140.59
326_F329_S0.7130.59
324_F327_L0.7120.59
230_L245_F0.7090.59
339_F347_Y0.7090.59
34_R43_M0.7080.59
160_S191_N0.7070.59
120_A128_E0.7070.59
305_E310_L0.7020.58
143_F146_K0.7010.58
121_I154_M0.7000.58
50_H57_E0.7000.58
145_F152_Y0.6990.58
51_L62_L0.6990.58
26_I38_Q0.6970.58
159_F162_D0.6940.57
128_E131_L0.6930.57
30_E39_E0.6930.57
343_V352_N0.6930.57
192_F200_D0.6930.57
347_Y355_K0.6880.57
351_K356_A0.6860.56
161_M195_L0.6860.56
303_E306_F0.6830.56
35_E43_M0.6820.56
239_E325_D0.6810.56
26_I32_L0.6800.56
187_L193_L0.6790.56
180_R183_Q0.6790.56
117_Y150_S0.6770.55
127_A167_A0.6760.55
26_I35_E0.6730.55
307_L334_A0.6730.55
350_R358_A0.6720.55
354_Q358_A0.6720.55
270_Q342_D0.6700.55
165_R200_D0.6700.55
105_F146_K0.6670.54
337_E363_V0.6650.54
237_Q243_P0.6650.54
56_M59_R0.6630.54
228_I232_K0.6610.54
346_Y349_E0.6600.53
101_Y131_L0.6560.53
104_N130_K0.6560.53
31_Y37_K0.6540.53
144_F167_A0.6530.53
283_E287_K0.6530.53
328_E352_N0.6510.52
122_K216_K0.6470.52
59_R64_L0.6460.52
217_Q249_I0.6450.52
104_N201_A0.6440.52
149_E187_L0.6430.52
190_T227_N0.6390.51
218_P251_V0.6370.51
189_A208_A0.6360.51
84_L88_I0.6360.51
124_F307_L0.6360.51
217_Q221_M0.6330.50
353_F361_L0.6330.50
38_Q44_E0.6330.50
296_G299_I0.6310.50
108_G297_D0.6310.50
336_L340_A0.6280.50
233_N271_I0.6270.50
27_P57_E0.6260.50
312_L316_D0.6250.50
116_E236_S0.6190.49
62_L69_P0.6170.49
300_Y303_E0.6150.48
236_S287_K0.6150.48
167_A241_A0.6140.48
121_I124_F0.6130.48
262_P265_Y0.6080.48
61_N64_L0.6070.48
304_F335_D0.6070.48
65_E68_E0.6050.47
230_L234_S0.6030.47
321_Q324_F0.6020.47
31_Y47_Q0.6020.47
178_N214_A0.6010.47
111_E121_I0.6000.47
79_P87_E0.5990.47
63_M67_L0.5990.47
34_R279_D0.5990.47
181_L185_H0.5960.46
190_T230_L0.5950.46
249_I261_L0.5930.46
165_R224_T0.5930.46
172_K290_A0.5910.46
251_V294_K0.5910.46
145_F149_E0.5880.45
25_S34_R0.5870.45
35_E50_H0.5870.45
33_R42_Q0.5830.45
288_G304_F0.5820.45
39_E49_L0.5800.45
40_L50_H0.5790.44
306_F313_S0.5790.44
308_K313_S0.5790.44
344_A363_V0.5770.44
158_Y168_Y0.5760.44
188_F195_L0.5760.44
188_F204_H0.5740.44
345_K349_E0.5730.44
190_T224_T0.5720.44
279_D356_A0.5710.44
80_R283_E0.5710.44
212_A221_M0.5700.44
53_Y59_R0.5700.44
338_D342_D0.5690.43
340_A343_V0.5680.43
110_Y157_T0.5680.43
354_Q365_Q0.5660.43
352_N358_A0.5650.43
157_T192_F0.5650.43
306_F310_L0.5650.43
117_Y226_Y0.5650.43
347_Y352_N0.5630.43
79_P201_A0.5620.43
205_F228_I0.5600.42
205_F342_D0.5590.42
48_D52_Y0.5590.42
27_P41_D0.5590.42
106_F339_F0.5580.42
348_H353_F0.5580.42
64_L68_E0.5580.42
62_L66_Y0.5560.42
34_R40_L0.5500.41
171_Y180_R0.5500.41
245_F271_I0.5490.41
320_I327_L0.5480.41
284_Y288_G0.5480.41
47_Q57_E0.5470.41
209_Y227_N0.5460.41
61_N68_E0.5440.41
60_H63_M0.5430.41
30_E35_E0.5420.40
208_A288_G0.5420.40
317_E355_K0.5410.40
327_L339_F0.5410.40
183_Q186_S0.5390.40
299_I326_F0.5390.40
104_N116_E0.5380.40
349_E353_F0.5370.40
99_L103_F0.5370.40
27_P30_E0.5360.40
29_A239_E0.5360.40
195_L199_E0.5360.40
26_I47_Q0.5310.39
195_L352_N0.5300.39
309_S312_L0.5290.39
212_A220_L0.5280.39
108_G157_T0.5270.39
148_S191_N0.5260.39
239_E243_P0.5260.39
321_Q328_E0.5260.39
124_F149_E0.5250.39
247_R268_I0.5250.39
229_G267_L0.5230.38
307_L313_S0.5230.38
194_D226_Y0.5230.38
278_I329_S0.5230.38
25_S41_D0.5220.38
307_L310_L0.5210.38
129_S329_S0.5200.38
216_K219_Q0.5190.38
302_S350_R0.5180.38
188_F229_G0.5180.38
145_F186_S0.5120.37
353_F357_S0.5110.37
89_D96_T0.5110.37
308_K311_Y0.5110.37
33_R36_I0.5100.37
88_I340_A0.5090.37
24_F42_Q0.5090.37
25_S40_L0.5090.37
223_R227_N0.5080.37
184_C187_L0.5080.37
168_Y204_H0.5070.37
266_F327_L0.5070.37
342_D351_K0.5060.37
268_I288_G0.5040.36
315_P318_E0.5040.36
31_Y279_D0.5030.36
102_Y110_Y0.5030.36
208_A341_I0.5020.36
35_E44_E0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulqA 1 0.9869 100 0.262 Contact Map
4gyoA 2 0.9449 100 0.271 Contact Map
3q15A 2 0.958 100 0.278 Contact Map
4i1aA 2 0.9396 100 0.283 Contact Map
4gpkA 3 0.9055 100 0.338 Contact Map
1w3bA 2 0.8268 100 0.434 Contact Map
4l9pA 1 0.748 100 0.438 Contact Map
3q7aA 1 0.7375 100 0.439 Contact Map
3sf4A 1 0.8241 100 0.447 Contact Map
4ui9O 1 0.9685 100 0.448 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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