GREMLIN Database
YWHH - Uncharacterized protein YwhH
UniProt: P71000 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (148)
Sequences: 4419 (3031)
Seq/√Len: 249.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_T134_E3.1571.00
50_R87_E2.5851.00
55_Q109_E2.5601.00
139_E142_E2.5441.00
11_T17_N2.4961.00
76_F111_Y2.4851.00
29_V63_G2.3921.00
88_V99_V2.2681.00
71_K151_D2.2661.00
141_S149_W2.2591.00
51_G78_F2.2391.00
117_K149_W2.1011.00
75_T150_I2.0891.00
136_T139_E2.0711.00
30_E34_E2.0151.00
114_V151_D1.9441.00
84_S87_E1.9391.00
18_D134_E1.9201.00
59_I72_S1.8881.00
56_V91_Q1.8341.00
9_H13_W1.8151.00
123_F134_E1.7431.00
107_D145_F1.7251.00
13_W143_F1.6771.00
42_R119_F1.6641.00
20_T134_E1.6601.00
49_F72_S1.6181.00
41_S119_F1.6011.00
49_F67_I1.5541.00
85_P96_I1.5051.00
39_S42_R1.4901.00
44_A60_V1.4441.00
57_I72_S1.4371.00
104_L110_V1.4141.00
75_T148_V1.4051.00
41_S64_D1.3731.00
114_V118_R1.3711.00
8_T11_T1.3461.00
141_S146_S1.3351.00
24_T27_A1.3221.00
89_L95_E1.3091.00
48_S108_P1.2971.00
8_T12_Q1.2871.00
51_G55_Q1.2791.00
138_K141_S1.2731.00
19_V131_S1.2691.00
20_T123_F1.2531.00
68_D71_K1.2521.00
117_K138_K1.2501.00
53_G78_F1.2451.00
59_I152_V1.2361.00
51_G80_A1.2241.00
31_Q35_T1.2191.00
38_V123_F1.2171.00
65_A153_C1.2091.00
18_D121_T1.1911.00
111_Y152_V1.1861.00
44_A116_L1.1811.00
70_K74_Q1.1801.00
58_L104_L1.1791.00
7_R19_V1.1741.00
56_V108_P1.1691.00
42_R134_E1.1521.00
7_R11_T1.1471.00
112_L141_S1.1401.00
4_K8_T1.1381.00
57_I76_F1.1331.00
116_L149_W1.1241.00
50_R81_R1.1021.00
31_Q34_E1.0941.00
56_V83_L1.0921.00
47_L67_I1.0791.00
15_R143_F1.0741.00
49_F57_I1.0631.00
5_S105_A1.0601.00
10_F133_I1.0581.00
114_V117_K1.0511.00
42_R121_T1.0491.00
115_S118_R1.0381.00
87_E91_Q1.0291.00
50_R56_V1.0251.00
111_Y150_I1.0151.00
124_P135_L1.0061.00
57_I78_F0.9911.00
28_T31_Q0.9911.00
47_L82_M0.9811.00
109_E148_V0.9791.00
30_E40_L0.9771.00
34_E40_L0.9761.00
83_L91_Q0.9741.00
87_E90_E0.9551.00
126_C132_A0.9441.00
71_K74_Q0.9421.00
65_A115_S0.9241.00
36_I123_F0.9221.00
50_R54_D0.9121.00
91_Q108_P0.8961.00
128_S131_S0.8951.00
138_K142_E0.8911.00
89_L96_I0.8911.00
88_V96_I0.8881.00
51_G57_I0.8851.00
116_L122_V0.8801.00
13_W142_E0.8761.00
126_C133_I0.8680.99
113_D151_D0.8590.99
112_L116_L0.8560.99
26_S31_Q0.8480.99
38_V43_I0.8410.99
119_F122_V0.8340.99
135_L139_E0.8320.99
22_F26_S0.8280.99
48_S88_V0.8270.99
95_E129_R0.8230.99
120_Q136_T0.8210.99
23_E35_T0.8180.99
55_Q78_F0.8130.99
29_V40_L0.8080.99
111_Y148_V0.8070.99
32_A132_A0.7890.99
34_E37_G0.7840.99
61_A152_V0.7840.99
9_H12_Q0.7790.99
21_E131_S0.7720.99
117_K141_S0.7680.99
117_K137_P0.7680.99
43_I132_A0.7630.99
22_F130_N0.7630.99
101_P140_L0.7620.99
44_A115_S0.7520.99
16_E139_E0.7490.98
40_L64_D0.7460.98
27_A31_Q0.7420.98
72_S80_A0.7360.98
29_V32_A0.7310.98
46_S58_L0.7290.98
102_F144_S0.7240.98
86_N89_L0.7190.98
36_I132_A0.7180.98
112_L146_S0.7160.98
10_F17_N0.7150.98
113_D153_C0.7140.98
22_F36_I0.7080.98
44_A122_V0.7060.98
7_R17_N0.7000.98
57_I80_A0.6990.98
102_F140_L0.6940.98
44_A119_F0.6920.97
112_L149_W0.6900.97
81_R84_S0.6890.97
112_L140_L0.6820.97
124_P140_L0.6820.97
85_P88_V0.6810.97
22_F25_S0.6760.97
25_S28_T0.6760.97
5_S8_T0.6740.97
51_G76_F0.6730.97
125_A132_A0.6630.97
92_T105_A0.6620.97
29_V43_I0.6610.97
15_R139_E0.6510.96
48_S83_L0.6500.96
49_F59_I0.6420.96
138_K149_W0.6400.96
10_F15_R0.6360.96
24_T31_Q0.6360.96
25_S31_Q0.6290.96
29_V33_A0.6220.95
61_A67_I0.6180.95
85_P89_L0.6180.95
123_F132_A0.6110.95
42_R120_Q0.6110.95
91_Q106_H0.6100.95
67_I152_V0.6070.95
6_V133_I0.6010.94
60_V112_L0.6000.94
59_I111_Y0.5990.94
38_V134_E0.5970.94
71_K75_T0.5910.94
17_N139_E0.5880.94
49_F80_A0.5850.94
137_P149_W0.5780.93
15_R18_D0.5780.93
59_I76_F0.5780.93
54_D78_F0.5740.93
58_L108_P0.5740.93
32_A38_V0.5730.93
11_T16_E0.5720.93
20_T121_T0.5670.92
93_G105_A0.5670.92
61_A153_C0.5660.92
39_S119_F0.5650.92
10_F143_F0.5640.92
30_E64_D0.5630.92
51_G54_D0.5580.92
47_L61_A0.5580.92
9_H143_F0.5520.91
104_L108_P0.5520.91
60_V124_P0.5510.91
4_K7_R0.5400.91
146_S149_W0.5370.90
59_I67_I0.5360.90
44_A113_D0.5350.90
42_R123_F0.5300.90
103_G108_P0.5290.90
114_V150_I0.5280.90
6_V19_V0.5270.89
118_R151_D0.5260.89
44_A61_A0.5250.89
62_A65_A0.5240.89
49_F82_M0.5240.89
21_E128_S0.5210.89
48_S92_T0.5180.89
61_A65_A0.5150.88
12_Q106_H0.5130.88
16_E136_T0.5130.88
50_R83_L0.5120.88
102_F133_I0.5120.88
6_V143_F0.5080.88
48_S99_V0.5070.88
50_R84_S0.5040.87
110_V144_S0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2z0xA 1 0.9745 100 0.204 Contact Map
3op6A 2 0.949 100 0.213 Contact Map
1dbuA 1 0.9363 100 0.219 Contact Map
1wdvA 1 0.949 100 0.226 Contact Map
1vkiA 2 0.9745 100 0.227 Contact Map
2dxaA 1 0.9682 100 0.231 Contact Map
1vjfA 1 0.9873 100 0.244 Contact Map
3memA 1 0.8917 100 0.346 Contact Map
2j3lA 2 0.9873 98 0.797 Contact Map
1z3eA 1 0.4968 42.5 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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