GREMLIN Database
SPEB - Agmatinase
UniProt: P70999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (264)
Sequences: 5206 (3335)
Seq/√Len: 205.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_I108_M3.9521.00
215_I241_L3.7021.00
96_D124_K3.6601.00
92_E120_K3.2321.00
119_I158_A3.1951.00
220_L276_T3.0971.00
46_S76_D2.8741.00
92_E124_K2.8511.00
225_A273_T2.6221.00
217_I228_T2.4971.00
258_A284_M2.3091.00
181_E185_E2.2731.00
28_G49_R2.2171.00
130_A209_R2.1241.00
89_D93_E2.0571.00
27_Y98_I2.0411.00
217_I263_V2.0181.00
220_L241_L2.0141.00
46_S50_E1.9921.00
128_D209_R1.9631.00
238_S276_T1.9401.00
25_I103_K1.9041.00
213_V255_V1.8851.00
99_L121_A1.8721.00
92_E121_A1.8631.00
169_S172_I1.8611.00
116_W120_K1.8331.00
86_R90_M1.8231.00
134_F244_S1.8221.00
95_V118_V1.8201.00
189_H205_K1.8201.00
156_R160_E1.7791.00
260_L281_I1.7641.00
95_V107_G1.7601.00
134_F219_V1.7581.00
29_M107_G1.7491.00
100_E125_K1.7381.00
32_D42_R1.7271.00
29_M91_I1.7211.00
96_D100_E1.7171.00
108_M281_I1.7131.00
200_K204_P1.6921.00
197_E239_K1.6471.00
168_Y189_H1.6421.00
107_G118_V1.6321.00
219_V236_I1.6271.00
106_M258_A1.6081.00
48_I277_A1.6041.00
182_W186_N1.5981.00
25_I98_I1.5601.00
263_V277_A1.5471.00
29_M87_S1.5031.00
212_Y257_G1.4891.00
217_I260_L1.4851.00
172_I190_I1.4841.00
122_M129_L1.4711.00
224_H238_S1.4671.00
189_H201_E1.4671.00
237_T240_E1.4661.00
210_P254_N1.4571.00
219_V241_L1.4441.00
200_K247_E1.4391.00
99_L125_K1.4341.00
263_V273_T1.4181.00
23_D70_N1.4161.00
114_V261_V1.4141.00
128_D166_N1.4031.00
217_I225_A1.3961.00
92_E96_D1.3941.00
166_N209_R1.3941.00
88_L113_L1.3671.00
48_I263_V1.3631.00
246_H283_E1.3631.00
24_A285_L1.3621.00
47_R274_A1.3561.00
99_L122_M1.3541.00
83_N86_R1.3521.00
132_I248_I1.3131.00
192_K195_V1.3121.00
133_H169_S1.3081.00
49_R76_D1.3041.00
151_H230_T1.3031.00
25_I74_A1.3011.00
27_Y107_G1.2871.00
38_R267_Y1.2811.00
193_F197_E1.2791.00
202_V205_K1.2781.00
227_G273_T1.2751.00
47_R50_E1.2641.00
106_M281_I1.2601.00
197_E240_E1.2601.00
156_R182_W1.2551.00
126_Y256_K1.2521.00
227_G268_D1.2431.00
94_Y97_S1.2361.00
213_V258_A1.2331.00
198_P243_A1.2221.00
27_Y95_V1.2151.00
112_H214_T1.2131.00
201_E205_K1.2081.00
151_H229_G1.2011.00
98_I105_P1.1911.00
142_V157_K1.1881.00
157_K160_E1.1861.00
28_G75_G1.1801.00
242_L283_E1.1741.00
43_F266_V1.1601.00
121_A125_K1.1541.00
204_P207_A1.1491.00
28_G76_D1.1451.00
138_T175_G1.1411.00
131_I155_I1.1381.00
217_I277_A1.1281.00
118_V259_D1.1271.00
35_V41_S1.1261.00
49_R73_D1.1251.00
39_P43_F1.1221.00
49_R75_G1.1221.00
95_V105_P1.1211.00
80_P84_P1.1151.00
155_I169_S1.1111.00
96_D121_A1.1051.00
91_I107_G1.0981.00
150_S153_T1.0891.00
236_I244_S1.0711.00
96_D125_K1.0711.00
88_L117_P1.0671.00
26_L108_M1.0671.00
203_L207_A1.0641.00
87_S91_I1.0621.00
93_E97_S1.0611.00
86_R89_D1.0571.00
28_G73_D1.0561.00
225_A276_T1.0541.00
24_A104_F1.0531.00
135_D139_D1.0531.00
137_H218_D1.0501.00
118_V212_Y1.0491.00
210_P256_K1.0401.00
126_Y210_P1.0361.00
29_M114_V1.0211.00
79_L87_S1.0171.00
27_Y94_Y1.0151.00
264_A267_Y1.0141.00
140_L183_A1.0061.00
104_F258_A0.9921.00
97_S100_E0.9871.00
202_V206_L0.9851.00
115_S119_I0.9821.00
133_H214_T0.9761.00
197_E243_A0.9741.00
241_L280_I0.9590.99
213_V245_V0.9480.99
155_I167_V0.9430.99
39_P42_R0.9410.99
134_F236_I0.9410.99
151_H228_T0.9390.99
142_V156_R0.9330.99
73_D76_D0.9120.99
130_A166_N0.9110.99
41_S264_A0.9080.99
191_S196_L0.9070.99
122_M257_G0.9060.99
129_L256_K0.9020.99
138_T169_S0.8980.99
168_Y205_K0.8970.99
273_T277_A0.8970.99
95_V121_A0.8960.99
170_F202_V0.8960.99
215_I280_I0.8900.99
183_A188_M0.8890.99
138_T172_I0.8890.99
119_I131_I0.8850.99
24_A69_L0.8830.99
32_D40_G0.8790.99
152_S230_T0.8770.99
173_R222_P0.8760.99
115_S259_D0.8730.99
269_H272_Q0.8720.99
173_R221_D0.8680.99
128_D163_G0.8660.99
220_L238_S0.8660.99
23_D103_K0.8630.99
47_R51_V0.8630.99
131_I158_A0.8620.99
194_E243_A0.8610.99
136_A173_R0.8590.99
191_S195_V0.8580.99
115_S154_P0.8500.99
151_H262_E0.8480.99
81_F84_P0.8480.99
140_L159_A0.8480.99
98_I103_K0.8440.99
138_T190_I0.8400.99
162_I167_V0.8400.99
112_H151_H0.8350.99
141_R179_E0.8340.99
112_H262_E0.8280.98
130_A168_Y0.8250.98
228_T231_V0.8200.98
211_V254_N0.8140.98
184_K190_I0.8140.98
112_H259_D0.8130.98
265_P268_D0.8090.98
244_S247_E0.8090.98
74_A98_I0.8080.98
77_I90_M0.8070.98
272_Q276_T0.8060.98
58_Y63_D0.8050.98
194_E246_H0.8040.98
32_D38_R0.8040.98
27_Y105_P0.8030.98
131_I162_I0.8000.98
201_E204_P0.7980.98
174_S232_D0.7950.98
247_E252_E0.7920.98
203_L247_E0.7890.98
89_D92_E0.7840.98
195_V198_P0.7830.98
238_S242_L0.7820.98
130_A206_L0.7790.98
32_D41_S0.7790.98
93_E96_D0.7690.98
163_G166_N0.7690.98
281_I284_M0.7660.98
123_Y161_L0.7650.97
236_I241_L0.7640.97
91_I117_P0.7630.97
97_S101_K0.7630.97
118_V257_G0.7590.97
182_W185_E0.7590.97
122_M256_K0.7540.97
44_G229_G0.7460.97
134_F170_F0.7430.97
220_L224_H0.7420.97
224_H237_T0.7420.97
132_I170_F0.7420.97
132_I211_V0.7390.97
196_L240_E0.7370.97
213_V284_M0.7350.97
159_A164_P0.7260.97
32_D39_P0.7250.97
142_V148_P0.7180.96
105_P122_M0.7110.96
119_I129_L0.7090.96
167_V188_M0.7090.96
140_L182_W0.7090.96
107_G114_V0.7060.96
159_A165_H0.6980.96
222_P225_A0.6950.96
132_I168_Y0.6930.96
139_D262_E0.6900.95
113_L149_L0.6880.95
36_S151_H0.6830.95
143_D157_K0.6830.95
191_S205_K0.6820.95
212_Y259_D0.6810.95
138_T183_A0.6750.95
51_V274_A0.6730.95
203_L206_L0.6720.95
225_A263_V0.6690.95
132_I206_L0.6680.95
181_E184_K0.6670.94
118_V122_M0.6660.94
205_K208_G0.6650.94
30_P76_D0.6650.94
242_L280_I0.6640.94
44_G265_P0.6640.94
173_R232_D0.6620.94
44_G264_A0.6610.94
228_T264_A0.6590.94
26_L106_M0.6590.94
47_R271_E0.6580.94
227_G263_V0.6580.94
239_K243_A0.6560.94
243_A247_E0.6560.94
90_M94_Y0.6550.94
168_Y191_S0.6540.94
117_P121_A0.6530.94
143_D146_G0.6520.94
263_V274_A0.6490.94
38_R231_V0.6480.94
196_L244_S0.6480.94
131_I167_V0.6460.94
171_G219_V0.6450.93
29_M118_V0.6430.93
94_Y98_I0.6420.93
34_T111_E0.6380.93
271_E274_A0.6360.93
44_G47_R0.6340.93
115_S155_I0.6340.93
129_L210_P0.6300.93
170_F236_I0.6290.93
47_R265_P0.6280.93
24_A106_M0.6270.92
203_L208_G0.6240.92
177_K181_E0.6230.92
73_D77_I0.6230.92
106_M285_L0.6210.92
33_W87_S0.6200.92
31_M87_S0.6200.92
258_A281_I0.6190.92
183_A190_I0.6180.92
223_A238_S0.6170.92
199_L244_S0.6160.92
74_A94_Y0.6160.92
168_Y202_V0.6160.92
120_K158_A0.6150.92
127_P210_P0.6150.92
134_F213_V0.6110.92
50_E271_E0.6100.91
139_D218_D0.6090.91
51_V278_S0.6080.91
51_V271_E0.6070.91
283_E286_L0.6070.91
135_D218_D0.6060.91
22_A103_K0.6030.91
66_L71_F0.6010.91
71_F76_D0.5980.91
114_V214_T0.5960.90
112_H212_Y0.5960.90
199_L247_E0.5960.90
26_L71_F0.5940.90
214_T259_D0.5940.90
214_T261_V0.5910.90
77_I94_Y0.5900.90
112_H137_H0.5890.90
109_G114_V0.5890.90
90_M93_E0.5880.90
48_I278_S0.5870.90
159_A167_V0.5870.90
207_A254_N0.5860.90
140_L186_N0.5860.90
191_S201_E0.5850.90
133_H155_I0.5830.90
203_L252_E0.5820.89
268_D271_E0.5800.89
159_A188_M0.5800.89
234_G242_L0.5780.89
209_R254_N0.5750.89
123_Y127_P0.5750.89
35_V39_P0.5730.89
278_S281_I0.5680.88
21_E70_N0.5680.88
112_H261_V0.5670.88
48_I281_I0.5670.88
34_T84_P0.5650.88
211_V255_V0.5620.88
133_H230_T0.5620.88
123_Y129_L0.5570.87
25_I72_F0.5560.87
130_A210_P0.5540.87
61_Y64_R0.5540.87
202_V244_S0.5530.87
31_M84_P0.5520.87
143_D148_P0.5510.87
170_F196_L0.5510.87
115_S261_V0.5490.87
141_R230_T0.5440.86
95_V117_P0.5440.86
211_V253_V0.5440.86
123_Y166_N0.5430.86
243_A246_H0.5410.86
133_H154_P0.5410.86
145_E152_S0.5390.86
128_D210_P0.5390.86
33_W84_P0.5380.85
138_T180_F0.5330.85
260_L280_I0.5330.85
226_P273_T0.5320.85
59_S283_E0.5310.85
33_W36_S0.5270.84
87_S90_M0.5210.84
268_D273_T0.5190.83
138_T174_S0.5190.83
115_S212_Y0.5180.83
102_G125_K0.5180.83
193_F236_I0.5160.83
141_R152_S0.5160.83
227_G271_E0.5150.83
62_L65_D0.5140.83
138_T141_R0.5140.83
59_S62_L0.5130.83
152_S218_D0.5120.83
119_I162_I0.5110.82
116_W157_K0.5100.82
225_A228_T0.5090.82
43_F46_S0.5090.82
234_G238_S0.5090.82
199_L202_V0.5070.82
248_I253_V0.5060.82
276_T280_I0.5030.81
203_L253_V0.5020.81
99_L102_G0.5020.81
224_H276_T0.5010.81
123_Y162_I0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gq6A 5 0.9897 100 0.133 Contact Map
1wohA 5 0.9759 100 0.134 Contact Map
3m1rA 5 0.9655 100 0.135 Contact Map
3nioA 5 0.9586 100 0.137 Contact Map
3lhlA 3 0.9379 100 0.143 Contact Map
3niqA 5 0.9862 100 0.147 Contact Map
4mykA 3 0.9276 100 0.152 Contact Map
3pzlA 5 0.9724 100 0.16 Contact Map
4dz4A 5 0.9621 100 0.161 Contact Map
1xfkA 1 0.9655 100 0.171 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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