YWHC - BACSU - GREMLIN Contacts

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YWHC - Putative zinc metalloprotease YwhC

UniProt:	P70995	Sequences: MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKKQGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLILAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRIIEDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	219 (194)
Sequences:	1653 (1255)
Seq/√Len:	90.1

BACSU - YWHC
SULSO - Q97ZW1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_L	144_F	5.776	1.00
35_Y	43_K	4.405	1.00
107_G	136_W	4.174	1.00
49_T	54_K	3.291	1.00
25_M	99_S	2.839	1.00
40_D	81_F	2.820	1.00
34_A	82_F	2.818	1.00
181_I	185_V	2.688	1.00
141_L	203_G	2.491	1.00
185_V	189_T	2.462	1.00
33_V	91_L	2.413	1.00
40_D	44_K	2.361	1.00
32_Y	36_K	2.327	1.00
42_A	76_P	2.288	1.00
158_R	176_E	2.238	1.00
28_L	31_A	2.113	1.00
79_R	82_F	2.100	1.00
94_I	159_I	2.081	1.00
35_Y	42_A	2.046	1.00
28_L	32_Y	2.027	1.00
26_H	30_H	2.025	1.00
28_L	48_L	2.017	1.00
84_K	87_L	1.918	1.00
94_I	98_V	1.859	1.00
171_K	174_Q	1.857	1.00
56_L	61_T	1.850	1.00
37_F	88_A	1.843	1.00
90_V	162_D	1.831	1.00
27_E	30_H	1.787	1.00
24_T	28_L	1.699	1.00
148_L	159_I	1.692	1.00
37_F	91_L	1.676	1.00
160_I	172_M	1.622	1.00
77_V	89_G	1.619	1.00
29_A	99_S	1.561	1.00
45_Q	76_P	1.536	1.00
18_T	22_S	1.524	1.00
99_S	103_L	1.514	1.00
104_A	141_L	1.483	1.00
157_Y	172_M	1.470	1.00
174_Q	177_S	1.467	1.00
82_F	92_V	1.454	0.99
18_T	132_F	1.441	0.99
90_V	94_I	1.432	0.99
18_T	136_W	1.431	0.99
85_P	88_A	1.417	0.99
195_V	199_M	1.399	0.99
26_H	155_D	1.399	0.99
152_P	157_Y	1.390	0.99
31_A	48_L	1.383	0.99
37_F	90_V	1.346	0.99
43_K	48_L	1.326	0.99
22_S	103_L	1.324	0.99
195_V	198_P	1.303	0.99
58_P	63_L	1.296	0.99
161_E	173_T	1.282	0.99
40_D	43_K	1.281	0.99
93_S	158_R	1.239	0.98
87_L	91_L	1.215	0.98
32_Y	35_Y	1.186	0.98
84_K	88_A	1.185	0.98
89_G	162_D	1.182	0.98
63_L	67_A	1.179	0.98
168_V	171_K	1.175	0.98
105_F	207_I	1.169	0.98
114_M	133_F	1.154	0.97
27_E	155_D	1.152	0.97
138_Q	142_V	1.151	0.97
60_G	71_W	1.136	0.97
164_V	168_V	1.133	0.97
30_H	147_N	1.129	0.97
59_F	64_I	1.128	0.97
53_I	58_P	1.121	0.97
26_H	75_I	1.118	0.97
30_H	72_A	1.115	0.97
30_H	96_G	1.110	0.97
59_F	63_L	1.105	0.97
132_F	136_W	1.079	0.96
30_H	155_D	1.078	0.96
26_H	96_G	1.074	0.96
30_H	75_I	1.072	0.96
90_V	97_P	1.056	0.95
44_K	81_F	1.056	0.95
179_G	182_V	1.055	0.95
86_R	166_P	1.052	0.95
30_H	95_A	1.041	0.95
89_G	93_S	1.038	0.95
18_T	107_G	1.034	0.95
64_I	71_W	1.033	0.95
179_G	183_F	1.028	0.95
103_L	107_G	1.027	0.95
106_I	115_H	1.024	0.95
27_E	100_N	1.010	0.94
89_G	158_R	1.009	0.94
15_L	135_I	1.009	0.94
198_P	202_A	1.006	0.94
27_E	147_N	1.006	0.94
90_V	163_L	0.994	0.94
98_V	102_I	0.991	0.94
78_N	81_F	0.989	0.94
107_G	137_I	0.982	0.93
167_G	171_K	0.981	0.93
35_Y	40_D	0.980	0.93
30_H	100_N	0.977	0.93
103_L	136_W	0.975	0.93
20_I	24_T	0.974	0.93
175_A	182_V	0.973	0.93
141_L	145_L	0.966	0.93
145_L	203_G	0.960	0.93
187_F	193_S	0.959	0.93
112_V	116_A	0.952	0.92
14_Y	135_I	0.951	0.92
189_T	198_P	0.948	0.92
169_R	173_T	0.947	0.92
85_P	89_G	0.943	0.92
199_M	203_G	0.939	0.92
199_M	202_A	0.926	0.91
107_G	133_F	0.913	0.91
13_P	17_I	0.907	0.90
139_L	143_L	0.905	0.90
166_P	170_A	0.902	0.90
167_G	170_A	0.899	0.90
26_H	147_N	0.899	0.90
141_L	200_L	0.899	0.90
25_M	103_L	0.895	0.90
102_I	106_I	0.890	0.89
141_L	204_R	0.883	0.89
152_P	175_A	0.883	0.89
149_L	196_L	0.880	0.89
77_V	82_F	0.880	0.89
15_L	139_L	0.874	0.89
26_H	72_A	0.872	0.88
144_F	148_L	0.866	0.88
100_N	140_N	0.865	0.88
45_Q	48_L	0.844	0.87
189_T	194_Y	0.840	0.87
42_A	45_Q	0.838	0.86
142_V	200_L	0.824	0.85
108_F	137_I	0.823	0.85
90_V	93_S	0.819	0.85
157_Y	161_E	0.818	0.85
172_M	176_E	0.816	0.85
27_E	72_A	0.810	0.84
34_A	81_F	0.810	0.84
171_K	175_A	0.809	0.84
151_L	182_V	0.806	0.84
170_A	174_Q	0.804	0.84
128_G	132_F	0.798	0.84
105_F	109_F	0.797	0.83
147_N	155_D	0.792	0.83
184_L	188_V	0.790	0.83
96_G	155_D	0.783	0.82
22_S	140_N	0.766	0.81
56_L	62_I	0.764	0.81
24_T	31_A	0.762	0.81
14_Y	128_G	0.758	0.80
46_G	49_T	0.754	0.80
190_P	193_S	0.753	0.80
180_F	184_L	0.753	0.80
77_V	92_V	0.752	0.80
169_R	172_M	0.747	0.79
186_L	192_G	0.744	0.79
57_D	73_R	0.739	0.79
106_I	201_N	0.737	0.78
33_V	36_K	0.732	0.78
31_A	76_P	0.727	0.77
159_I	165_P	0.717	0.77
165_P	168_V	0.712	0.76
170_A	173_T	0.710	0.76
145_L	207_I	0.707	0.76
72_A	75_I	0.705	0.75
134_S	204_R	0.696	0.74
196_L	199_M	0.695	0.74
161_E	172_M	0.683	0.73
202_A	205_D	0.682	0.73
82_F	85_P	0.681	0.73
152_P	181_I	0.681	0.73
168_V	172_M	0.679	0.73
185_V	192_G	0.677	0.72
151_L	179_G	0.670	0.72
56_L	69_F	0.670	0.72
56_L	72_A	0.665	0.71
125_F	128_G	0.663	0.71
47_R	55_H	0.663	0.71
27_E	75_I	0.661	0.71
104_A	137_I	0.655	0.70
111_L	134_S	0.653	0.70
61_T	68_G	0.648	0.69
32_Y	90_V	0.647	0.69
190_P	194_Y	0.645	0.69
47_R	143_L	0.644	0.69
204_R	208_L	0.643	0.68
37_F	97_P	0.643	0.68
63_L	68_G	0.642	0.68
67_A	146_F	0.639	0.68
25_M	50_L	0.633	0.67
11_L	15_L	0.632	0.67
36_K	87_L	0.630	0.67
146_F	183_F	0.630	0.67
108_F	207_I	0.625	0.66
175_A	179_G	0.624	0.66
186_L	190_P	0.624	0.66
74_P	146_F	0.623	0.66
180_F	183_F	0.623	0.66
131_Q	134_S	0.621	0.66
104_A	207_I	0.621	0.66
9_L	13_P	0.620	0.66
178_Y	182_V	0.617	0.65
108_F	112_V	0.614	0.65
112_V	115_H	0.614	0.65
10_S	13_P	0.613	0.65
17_I	129_L	0.612	0.65
113_L	117_Y	0.610	0.64
106_I	109_F	0.608	0.64
152_P	161_E	0.608	0.64
17_I	20_I	0.607	0.64
173_T	176_E	0.607	0.64
90_V	158_R	0.606	0.64
47_R	60_G	0.606	0.64
192_G	196_L	0.606	0.64
84_K	151_L	0.606	0.64
47_R	57_D	0.603	0.63
27_E	95_A	0.601	0.63
71_W	195_V	0.600	0.63
37_F	83_K	0.599	0.63
14_Y	131_Q	0.597	0.63
64_I	68_G	0.595	0.62
37_F	87_L	0.593	0.62
154_L	183_F	0.591	0.62
27_E	96_G	0.590	0.62
97_P	164_V	0.587	0.61
100_N	147_N	0.582	0.61
60_G	73_R	0.582	0.61
28_L	42_A	0.582	0.61
140_N	143_L	0.582	0.61
85_P	97_P	0.581	0.61
32_Y	42_A	0.580	0.61
93_S	162_D	0.578	0.60
59_F	71_W	0.577	0.60
181_I	189_T	0.577	0.60
205_D	208_L	0.577	0.60
35_Y	44_K	0.575	0.60
94_I	97_P	0.574	0.60
102_I	205_D	0.573	0.60
19_L	139_L	0.571	0.59
87_L	94_I	0.570	0.59
48_L	178_Y	0.568	0.59
55_H	73_R	0.568	0.59
95_A	100_N	0.568	0.59
194_Y	198_P	0.566	0.59
191_L	194_Y	0.564	0.58
111_L	130_D	0.562	0.58
42_A	72_A	0.561	0.58
30_H	154_L	0.559	0.58
15_L	181_I	0.559	0.58
146_F	154_L	0.555	0.57
175_A	178_Y	0.552	0.57
193_S	196_L	0.548	0.56
31_A	35_Y	0.546	0.56
47_R	73_R	0.542	0.55
23_F	28_L	0.537	0.55
175_A	180_F	0.537	0.55
158_R	161_E	0.537	0.55
184_L	187_F	0.536	0.55
72_A	76_P	0.536	0.55
127_T	131_Q	0.533	0.54
132_F	135_I	0.533	0.54
101_L	148_L	0.530	0.54
88_A	92_V	0.529	0.54
113_L	130_D	0.529	0.54
19_L	56_L	0.528	0.54
17_I	131_Q	0.526	0.53
28_L	49_T	0.526	0.53
152_P	180_F	0.525	0.53
159_I	200_L	0.524	0.53
87_L	90_V	0.520	0.52
21_V	99_S	0.519	0.52
73_R	140_N	0.519	0.52
133_F	136_W	0.517	0.52
70_G	179_G	0.513	0.51
201_N	205_D	0.513	0.51
55_H	76_P	0.512	0.51
23_F	31_A	0.511	0.51
108_F	172_M	0.509	0.51
15_L	18_T	0.509	0.51
72_A	100_N	0.508	0.51
164_V	172_M	0.507	0.51
86_R	169_R	0.506	0.50
157_Y	173_T	0.505	0.50
114_M	125_F	0.502	0.50
103_L	106_I	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b4rA	2	0.8128	99.9	0.613	Contact Map
4pd6A	3	0.484	16.9	0.956	Contact Map
2clyA	1	0	12.2	0.959	Contact Map
1l6jA	1	0.3014	5.3	0.965	Contact Map
1eakA	3	0.3288	3.8	0.968	Contact Map
8tfvA	1	0.0959	3.6	0.968	Contact Map
4xctA	1	0.3014	2.7	0.97	Contact Map
3ma2D	1	0.3059	2.1	0.972	Contact Map
2qi9A	2	0.6027	2.1	0.972	Contact Map
4wgvA	2	0.968	1.9	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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