GREMLIN Database
YWHC - Putative zinc metalloprotease YwhC
UniProt: P70995 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (194)
Sequences: 1653 (1255)
Seq/√Len: 90.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_L144_F5.7761.00
35_Y43_K4.4051.00
107_G136_W4.1741.00
49_T54_K3.2911.00
25_M99_S2.8391.00
40_D81_F2.8201.00
34_A82_F2.8181.00
181_I185_V2.6881.00
141_L203_G2.4911.00
185_V189_T2.4621.00
33_V91_L2.4131.00
40_D44_K2.3611.00
32_Y36_K2.3271.00
42_A76_P2.2881.00
158_R176_E2.2381.00
28_L31_A2.1131.00
79_R82_F2.1001.00
94_I159_I2.0811.00
35_Y42_A2.0461.00
28_L32_Y2.0271.00
26_H30_H2.0251.00
28_L48_L2.0171.00
84_K87_L1.9181.00
94_I98_V1.8591.00
171_K174_Q1.8571.00
56_L61_T1.8501.00
37_F88_A1.8431.00
90_V162_D1.8311.00
27_E30_H1.7871.00
24_T28_L1.6991.00
148_L159_I1.6921.00
37_F91_L1.6761.00
160_I172_M1.6221.00
77_V89_G1.6191.00
29_A99_S1.5611.00
45_Q76_P1.5361.00
18_T22_S1.5241.00
99_S103_L1.5141.00
104_A141_L1.4831.00
157_Y172_M1.4701.00
174_Q177_S1.4671.00
82_F92_V1.4540.99
18_T132_F1.4410.99
90_V94_I1.4320.99
18_T136_W1.4310.99
85_P88_A1.4170.99
195_V199_M1.3990.99
26_H155_D1.3990.99
152_P157_Y1.3900.99
31_A48_L1.3830.99
37_F90_V1.3460.99
43_K48_L1.3260.99
22_S103_L1.3240.99
195_V198_P1.3030.99
58_P63_L1.2960.99
161_E173_T1.2820.99
40_D43_K1.2810.99
93_S158_R1.2390.98
87_L91_L1.2150.98
32_Y35_Y1.1860.98
84_K88_A1.1850.98
89_G162_D1.1820.98
63_L67_A1.1790.98
168_V171_K1.1750.98
105_F207_I1.1690.98
114_M133_F1.1540.97
27_E155_D1.1520.97
138_Q142_V1.1510.97
60_G71_W1.1360.97
164_V168_V1.1330.97
30_H147_N1.1290.97
59_F64_I1.1280.97
53_I58_P1.1210.97
26_H75_I1.1180.97
30_H72_A1.1150.97
30_H96_G1.1100.97
59_F63_L1.1050.97
132_F136_W1.0790.96
30_H155_D1.0780.96
26_H96_G1.0740.96
30_H75_I1.0720.96
90_V97_P1.0560.95
44_K81_F1.0560.95
179_G182_V1.0550.95
86_R166_P1.0520.95
30_H95_A1.0410.95
89_G93_S1.0380.95
18_T107_G1.0340.95
64_I71_W1.0330.95
179_G183_F1.0280.95
103_L107_G1.0270.95
106_I115_H1.0240.95
27_E100_N1.0100.94
89_G158_R1.0090.94
15_L135_I1.0090.94
198_P202_A1.0060.94
27_E147_N1.0060.94
90_V163_L0.9940.94
98_V102_I0.9910.94
78_N81_F0.9890.94
107_G137_I0.9820.93
167_G171_K0.9810.93
35_Y40_D0.9800.93
30_H100_N0.9770.93
103_L136_W0.9750.93
20_I24_T0.9740.93
175_A182_V0.9730.93
141_L145_L0.9660.93
145_L203_G0.9600.93
187_F193_S0.9590.93
112_V116_A0.9520.92
14_Y135_I0.9510.92
189_T198_P0.9480.92
169_R173_T0.9470.92
85_P89_G0.9430.92
199_M203_G0.9390.92
199_M202_A0.9260.91
107_G133_F0.9130.91
13_P17_I0.9070.90
139_L143_L0.9050.90
166_P170_A0.9020.90
167_G170_A0.8990.90
26_H147_N0.8990.90
141_L200_L0.8990.90
25_M103_L0.8950.90
102_I106_I0.8900.89
141_L204_R0.8830.89
152_P175_A0.8830.89
149_L196_L0.8800.89
77_V82_F0.8800.89
15_L139_L0.8740.89
26_H72_A0.8720.88
144_F148_L0.8660.88
100_N140_N0.8650.88
45_Q48_L0.8440.87
189_T194_Y0.8400.87
42_A45_Q0.8380.86
142_V200_L0.8240.85
108_F137_I0.8230.85
90_V93_S0.8190.85
157_Y161_E0.8180.85
172_M176_E0.8160.85
27_E72_A0.8100.84
34_A81_F0.8100.84
171_K175_A0.8090.84
151_L182_V0.8060.84
170_A174_Q0.8040.84
128_G132_F0.7980.84
105_F109_F0.7970.83
147_N155_D0.7920.83
184_L188_V0.7900.83
96_G155_D0.7830.82
22_S140_N0.7660.81
56_L62_I0.7640.81
24_T31_A0.7620.81
14_Y128_G0.7580.80
46_G49_T0.7540.80
190_P193_S0.7530.80
180_F184_L0.7530.80
77_V92_V0.7520.80
169_R172_M0.7470.79
186_L192_G0.7440.79
57_D73_R0.7390.79
106_I201_N0.7370.78
33_V36_K0.7320.78
31_A76_P0.7270.77
159_I165_P0.7170.77
165_P168_V0.7120.76
170_A173_T0.7100.76
145_L207_I0.7070.76
72_A75_I0.7050.75
134_S204_R0.6960.74
196_L199_M0.6950.74
161_E172_M0.6830.73
202_A205_D0.6820.73
82_F85_P0.6810.73
152_P181_I0.6810.73
168_V172_M0.6790.73
185_V192_G0.6770.72
151_L179_G0.6700.72
56_L69_F0.6700.72
56_L72_A0.6650.71
125_F128_G0.6630.71
47_R55_H0.6630.71
27_E75_I0.6610.71
104_A137_I0.6550.70
111_L134_S0.6530.70
61_T68_G0.6480.69
32_Y90_V0.6470.69
190_P194_Y0.6450.69
47_R143_L0.6440.69
204_R208_L0.6430.68
37_F97_P0.6430.68
63_L68_G0.6420.68
67_A146_F0.6390.68
25_M50_L0.6330.67
11_L15_L0.6320.67
36_K87_L0.6300.67
146_F183_F0.6300.67
108_F207_I0.6250.66
175_A179_G0.6240.66
186_L190_P0.6240.66
74_P146_F0.6230.66
180_F183_F0.6230.66
131_Q134_S0.6210.66
104_A207_I0.6210.66
9_L13_P0.6200.66
178_Y182_V0.6170.65
108_F112_V0.6140.65
112_V115_H0.6140.65
10_S13_P0.6130.65
17_I129_L0.6120.65
113_L117_Y0.6100.64
106_I109_F0.6080.64
152_P161_E0.6080.64
17_I20_I0.6070.64
173_T176_E0.6070.64
90_V158_R0.6060.64
47_R60_G0.6060.64
192_G196_L0.6060.64
84_K151_L0.6060.64
47_R57_D0.6030.63
27_E95_A0.6010.63
71_W195_V0.6000.63
37_F83_K0.5990.63
14_Y131_Q0.5970.63
64_I68_G0.5950.62
37_F87_L0.5930.62
154_L183_F0.5910.62
27_E96_G0.5900.62
97_P164_V0.5870.61
100_N147_N0.5820.61
60_G73_R0.5820.61
28_L42_A0.5820.61
140_N143_L0.5820.61
85_P97_P0.5810.61
32_Y42_A0.5800.61
93_S162_D0.5780.60
59_F71_W0.5770.60
181_I189_T0.5770.60
205_D208_L0.5770.60
35_Y44_K0.5750.60
94_I97_P0.5740.60
102_I205_D0.5730.60
19_L139_L0.5710.59
87_L94_I0.5700.59
48_L178_Y0.5680.59
55_H73_R0.5680.59
95_A100_N0.5680.59
194_Y198_P0.5660.59
191_L194_Y0.5640.58
111_L130_D0.5620.58
42_A72_A0.5610.58
30_H154_L0.5590.58
15_L181_I0.5590.58
146_F154_L0.5550.57
175_A178_Y0.5520.57
193_S196_L0.5480.56
31_A35_Y0.5460.56
47_R73_R0.5420.55
23_F28_L0.5370.55
175_A180_F0.5370.55
158_R161_E0.5370.55
184_L187_F0.5360.55
72_A76_P0.5360.55
127_T131_Q0.5330.54
132_F135_I0.5330.54
101_L148_L0.5300.54
88_A92_V0.5290.54
113_L130_D0.5290.54
19_L56_L0.5280.54
17_I131_Q0.5260.53
28_L49_T0.5260.53
152_P180_F0.5250.53
159_I200_L0.5240.53
87_L90_V0.5200.52
21_V99_S0.5190.52
73_R140_N0.5190.52
133_F136_W0.5170.52
70_G179_G0.5130.51
201_N205_D0.5130.51
55_H76_P0.5120.51
23_F31_A0.5110.51
108_F172_M0.5090.51
15_L18_T0.5090.51
72_A100_N0.5080.51
164_V172_M0.5070.51
86_R169_R0.5060.50
157_Y173_T0.5050.50
114_M125_F0.5020.50
103_L106_I0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.8128 99.9 0.613 Contact Map
4pd6A 3 0.484 16.9 0.956 Contact Map
2clyA 1 0 12.2 0.959 Contact Map
1l6jA 1 0.3014 5.3 0.965 Contact Map
1eakA 3 0.3288 3.8 0.968 Contact Map
8tfvA 1 0.0959 3.6 0.968 Contact Map
4xctA 1 0.3014 2.7 0.97 Contact Map
3ma2D 1 0.3059 2.1 0.972 Contact Map
2qi9A 2 0.6027 2.1 0.972 Contact Map
4wgvA 2 0.968 1.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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